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ORIGINAL ARTICLE: Marker assay guided standardization of an ayurvedic concentrated polyherbal decoction “C...
Hariprasad Purushothaman, Ancily Davis, Migy John, Meerabai Palazhy Kalarikkal, Aswin Bhaskaran, Basil Eldho, Tenson Antony
Ancient Science of Life, Year 2017, Volume 37, Issue 1 [p. 24-30]
DOI: 10.4103/asl.ASL_188_17
Background: To establish a marker guided standardization technique to assess whether the marketed concentrated kaṣāyam (decoction) prepared in large scale is providing the same phytochemical values of a Laboratory Reference Standard (LRS) kaṣāyam prepared classically from raw materials of Pharmacopoeial quality. Objectives: Manufacturing and standardization of LRS 'Ciruvilvādi kaṣāyam', including marker assays and its comparison with four different marketed samples. Materials and Methods: pH, Brix and Total solids of samples were determined and compared. HPTLC profile comparison and quantitative comparison with HPLC were done with Gallic acid and Piperine as standards. Results and Conclusion: Results of Brix and Total solids imply that, the manufacturing process of sample IV was significantly different from other samples and LRS. pH value of sample III showed a significant difference as compared to other samples and LRS, indicating a difference in phytochemical contents. Quantification of Piperine and Gallic acid revealed that sample III has a very low Gallic acid concentration and zero Piperine concentration. Sample IV showed a very high concentration of Gallic acid when compared to other samples and LRS. Sample I, II and IV had piperine content but significantly lower when compared to the LRS. In conclusion, the samples (1-IV) which showed difference with the LRS should be made phytochemically comparable to in-house LRS or Pharmacopoeial standards by adopting the marker assay standardization technique. This method helps to identify and rectify the problems related to raw material, in process and finished product quality control.
CLINICAL TRIAL: A randomized double blind controlled study evaluating efficacy & Safety of vatika enriched co...
MM Kura, Arun Gupta, Ruchi Srivastava, SK Luthra
Ancient Science of Life, Year 2017, Volume 37, Issue 1 [p. 45-50]
DOI: 10.4103/asl.ASL_142_17
Background: Hair loss can be a stressful experience often associated with images of reduced self-worth, more in women than men. Dandruff may be associated with hair loss. Objective: To investigate the safety and efficacy of Vatika Enriched Coconut Hair Oil (VHO) on hair health in women with hair fall and dandruff. Methods: This was a double-blind, controlled study of 8 week duration conducted at Dermatology outpatient department of J.J. Hospital, Mumbai. Forty four (44) healthy female subjects with at least shoulder length hair and complaints of hair fall and dandruff were randomized equally into 2 groups. Members of one group massaged their scalps with VHO twice a week at night followed by washing the hair in morning with a supplied neutral shampoo. Control group used a marketed brand of coconut oil in a similar manner. Main Outcome Measures: Effect of VHO on hair fall, dandruff and hair health parameters such as shininess, blackness, roughness and tensile strength of hair. Secondary outcome assessed was overall subject safety. Subjects were followed up at days 14, 28, 42 and 56 days. Results: VHO was found safe and effective in controlling hair fall, dandruff and improving the overall condition of hair. VHO was found clinically better than coconut oil in controlling hair fall, dandruff, improving the tensile strength of hair and the shininess, blackness and roughness of hair. Global evaluation of therapeutic response by subjects and physician also showed a better efficacy of VHO than coconut hair oil. None of the subjects exhibited sensitivity to any of the study products and no adverse events were reported during the course of the study. Conclusions: Vatika Enriched Coconut Hair Oil is safe and effective in controlling hair fall and dandruff and improving the overall hair-health.
ORIGINAL ARTICLE: Analysis of ayurvedic clinical trials registered in clinical trials registry of india: retrospect...
Pravin M Bolshete
Ancient Science of Life, Year 2017, Volume 37, Issue 1 [p. 9-15]
DOI: 10.4103/asl.ASL_44_17
Context: Registration of clinical trials is recommended at or before the first participant enrolment. There is limited data available on the registration of Ayurvedic clinical trials in Clinical Trials Registry of India (CTRI). Aim: The aim of this analysis was to determine the proportion of retrospectively and prospectively registered Ayurvedic clinical trials in CTRI. Methods: This was a cross-sectional analysis of Ayurvedic clinical trials registered in CTRI. List of trials registered in CTRI was accessed from 2012 to 2016 (n= 4713; last accessed on 21 June 2016) and screened to identify Ayurvedic trials. Other AYUSH trials were excluded from the analysis. Following data was collected - registration type (retrospective/prospective), study site (state), postgraduate thesis (yes/no), type of trial (interventional/observational), and study design. Data was summarized using summary statistics. Results: A total of 507 (10.8%) Ayurvedic trials were included in this analysis. The registration of Ayurvedic clinical trials increased from 9.3% (2012) to 19.9% (2016). Of 507 trials, 373 (73.6%) were registered retrospectively and remaining 134 (26.4%) were registered prospectively. A total of 277 trials were part of postgraduate theses (220 retrospective; 57 prospective) and 229 were not (152 retrospective; 77 prospective); 481 trials were interventional (357 retrospective; 124 prospective); 320 were randomized (236 retrospective; 84 prospective). The 507 trials had 686 sites, highest being in Gujarat (38.3%), followed by Maharashtra (19.2%), and Karnataka (10.1%). Conclusions: Results from this study showed that majority of Ayurvedic clinical trials have been registered retrospectively, however there is increase in prospective registration. More than half of the study sites of CTRI registered trials were located in Gujarat, Maharashtra and Karnataka reflecting limited registration in other parts of India.
EDITORIAL: Primary healthcare based on the framework of Indian traditional medicine
Subrahmanya Kumar Kukkupuni
Ancient Science of Life, Year 2017, Volume 37, Issue 2 [p. 55-56]
DOI: 10.4103/asl.ASL_59_19
ORIGINAL ARTICLE: Plant part substitution in Litsea Chinensis for medicinal use: A comparative phytochemical...
Bhavana Srivastava, Vikas Chandra Sharma, SC Verma, R Singh, AD Jadhav
Ancient Science of Life, Year 2017, Volume 37, Issue 2 [p. 57-62]
DOI: 10.4103/asl.ASL_168_16
Background: Medasakha (Litsea chinensis) is a medium sized tree, heartwood of which is extensively used in Ayurveda for the treatment of various diseases. Count of this species is declining in the wild and in future this species may be difficult to obtain for use in Ayurveda and other traditional systems of medicine. It is exploited mainly for its medicinal heartwood. Hence the use of alternative parts of this plant in place of its heartwood would be beneficial for its survival. Objective: Present study is carried out on L. chinensis to phytochemically evaluate the possibilities of using its small branches as a substitute to its heartwood. Materials and Methods: Physicochemical parameters and preliminary phytochemical screening were carried out using standard methods. Total phenolic and total flavonoid contents were estimated spectrophotometrically using Folin-ciocalteu and aluminum chloride method, respectively. CAMAG HPTLC system equipped with semi-automatic applicator was used for HPTLC profiling. n-Hexane, ethyl acetate and ethanol extracts of heartwood and small braches were developed in suitable mobile phase using standard procedures and visualized in UV 254, 366 nm and in white light after derivatization with anisaldehyde-sulphuric acid reagent. Results: Phytochemical analysis and HPTLC profile of different extracts of heartwood and small branches showed the presence of almost similar phytochemicals in both the parts of this plant which suggests that small branches may be used in place of heartwood and vice-versa after comparison and confirmation of same for pharmacological activities. Conclusion: This study provides the base for further study to use small branches of L. chinensis as a substitute to its heartwood.
ORIGINAL ARTICLE: Anti-inflammatory effect of Śirīṣāvaleha prepared by two liquid media on car...
Harmeet Kaur, Galib Ruknuddin, Mukesh Nariya, Biswajyoti Patgiri, Prashant Bedarkar, Pradeep Kumar Prajapati
Ancient Science of Life, Year 2017, Volume 37, Issue 2 [p. 81-85]
DOI: 10.4103/asl.ASL_11_18
Background: Steroidal and non-steroidal anti-inflammatory agents have several limitations, due to which people are moving towards use of traditional medicines. Considering this, the current attempt is aimed to evaluate in vivo anti-inflammatory effect of a poly-herbal formulation Śirīṣāvaleha prepared in presence of water and Kanji (sour gruel). Kanji is anticipated to bring extraction of more principles from the raw drugs and may improve therapeutic attributes of the drug. Considering this, Kanji was used as a liquid medium for preparation of Śirīṣāvaleha and was evaluated for anti-inflammatory activity in comparison to Śirīṣāvaleha prepared with water. Materials and Methods: The activity was screened in carrageenan induced rat paw oedema model in albino rats. The raw materials were collected; authenticated and trial formulations were prepared by following standard classical guidelines. Randomly selected animals were divided into four groups of six animals each. The test drugs were administered orally at a dose of 1.8 g/kg for five days. Phenylbutazone was used as standard anti-inflammatory drug for comparison. Results: Results showed the presence of pronounced anti-inflammatory activity in Śirīṣāvaleha prepared with water (SW) followed by Śirīṣāvaleha prepared with Kanji (SK). Conclusion: Study shows that both samples of Śirīṣāvaleha have anti-inflammatory effect.
ORIGINAL ARTICLE: Anatomical investigation of flower of Butea monosperma Lam.
Ragunathan Muthuswamy, R Senthamarai
Ancient Science of Life, Year 2014, Volume 34, Issue 2 [p. 73-79]
DOI: 10.4103/0257-7941.153461 PMID: 25861140
Background: Butea frondosa Roxb. and Koen. syn. Butea monosperma Lam. (Leguminosae or Fabaceae) is a tree grows up to the height of 8 m at the age 50 years. Its flowers are being used in traditional medicine for the treatment of ulcer, inflammation, hepatic disorder, and eye diseases. Aims: The present study was aimed at establishing the microscopic characteristics of flower B. monosperma Lam. Materials and Methods: Histological evaluation of flowers was done using standard procedures. Images of microscopic characters were taken at different magnifications using Nikon Labphoto 2 microscopic Unit. Perkin Elmer 5000 an atomic absorption spectrophotometer was employed for elemental analysis. Results: In the study, microscopic characters of floral parts were investigated in transverse section and the flower powder. The current study reveals the presence of pollen grains, ovary (OV), and trichomes in their flower powder. Different cell components were studied, and their sizes were measured. Elemental analysis showed the presence of Zn 52.2 μg/g and Cu 36.3 μg/g were major contents, whereas Cr, Mn, and Pd were minor contents in dried flower powder. Conclusion: The current study paves the way to provide standard information related to the presence of essential elements in the flower. Microscopic characters of the flower and its quantitative measurement of cell components will help to identify the plant and also help to improvise the existing monograph of B. monosperma in the Ayurvedic pharmacopoeia.
EDITORIAL: The integration quagmire: Why we need to watch our steps
P Ram Manohar, Antonio Morandi, Antonella Delle Fave
Ancient Science of Life, Year 2015, Volume 34, Issue 3 [p. 123-125]
DOI: 10.4103/0257-7941.157144 PMID: 26120224
ORIGINAL ARTICLE: Effect of Calendula officinalis hydroalcoholic extract on passive avoidance learning and m...
Shirin Moradkhani, Iraj Salehi, Somayeh Abdolmaleki, Alireza Komaki
Ancient Science of Life, Year 2015, Volume 34, Issue 3 [p. 156-161]
DOI: 10.4103/0257-7941.157160 PMID: 26120230
Background: Medicinal plants, owing to their different mechanisms such as antioxidants effects, may improve learning and memory impairments in diabetic rats. Calendula officinalis (CO), has a significant antioxidant activity. Aims: To examine the effect of hydroalcoholic extract of CO on passive avoidance learning (PAL) and memory in streptozotocin (STZ)-induced diabetic male rats. Settings and Design: A total of 32 adult male Wistar rats were randomly allocated to four groups: Control, diabetic, control + extract of CO and diabetic control + extract of CO groups with free access to regular rat diet. Subjects and Methods: Diabetes in diabetic rats was induced by single intraperitoneal injection of 60 mg/kg STZ. After confirmation of diabetes, oral administration of 300 mg/kg CO extract to extract-treated groups have been done. PAL was tested 8 weeks after onset of treatment, and blood glucose and body weight were measured in all groups at the beginning and end of the experiment. Statistical Analysis Used: The statistical analysis of data was performed by ANOVA followed by least significant difference post-hoc analysis. Results: Diabetes decreased learning and memory. Effect of CO extract in retention test (after 24 and 48 h) has been shown a significant decrease in step-through latency and increase in time spent in the dark compartment part. Also the extract partially improved hyperglycemia and reduced body weight. Conclusion: Taken together, CO extract can improve PAL and memory impairments in STZ-diabetic rats. This improvement may be due to its antioxidant, anticholinergic activities or its power to reduce hyperglycemia.
ORIGINAL ARTICLE: Evaluation of Ratnaprash for its effect on strength, stamina and fatigue using swim endurance tes...
Arun Gupta, Satyendra Kumar, Rashmi Rajput, Ruchi Srivastava, Rajiv K Rai, J. L. N. Sastry
Ancient Science of Life, Year 2015, Volume 35, Issue 1 [p. 26-31]
DOI: 10.4103/0257-7941.165626 PMID: 26600664
Context: Traditional medicines have been considered as important resources for postponing fatigue, accelerating elimination of fatigue related metabolites and improving physical ability. Rasāyanās or rejuvenative therapies are mentioned as one of the eight clinical specialties in Ayurveda for attaining longevity, healthy life and regulation of bodily balance. Eventhough more detailed studies are needed to confirm the claims of benefits in the light of evidence based research, Ratnaprash, a herbo-mineral rasāyana formulation, is proposed here to be an antifatigue supplement that is good in promoting strength and stamina. Materials and Methods: In the present study, anti fatigue, strength and stamina enhancing properties of Ratnaprash were examined based on swim endurance capacity and the change in biochemical parameters in Swiss Albino mice. Treatment groups were orally administered Ratnaprash at various test doses (500, 1000, 2000 mg/Kg per day), while the control group received distilled water at similar dose volumes. Effect of therapy was evaluated after 28 days of treatment. Results: At the end of study period, the swimming times to exhaustion were longer in the treated groups than in the control group. Plasma lactate levels of treated groups were lower than those of the control group (P < 0.05) while tissue ATP levels were higher. These effects were dose dependent and the strongest effect was seen in groups treated at 1000 mg/Kg. Conclusion: Ratnaprash enhanced the forced swimming capacity of mice and exhibited elevated anti-fatigue activity, reduced blood lactate levels and increased tissue ATP levels in preclinical models in comparison to vehicle control, exhibiting possible role in increasing strength and stamina and contributing anti-fatigue activity.
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