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REVIEW ARTICLE: Exploring potential of Kushmanda Avaleha in respiratory illness – A comprehensive re...
Sheetal Sharma, Shreshtha Kaushik, Pramod Yadav, Galib Ruknuddin, Pradeep K Prajapati
BLDE University Journal of Health Sciences, Year 2022, Volume 7, Issue 1 [p. 27-34]
DOI: 10.4103/bjhs.bjhs_84_21
Respiratory ailments represent over 10% of all disability-adjusted life-years, a statistic that reflects the measure of active and productive life lost owing to a condition. A large number of Confections (Avaleha) have been recommended in various authoritative treatises by ancient seers for different respiratory disorders. Kushmanda Avaleha is one such multi-ingredient Ayurvedic formulation, which is advocated for the first time in Ashtanga Sangraha for Cough, Hiccups, Fever, Dyspnea, etc. Its chief constituent is Benincasa hispida Thumb. It has also been included in the Essential drug list published by the Ministry of AYUSH. Thus, this article is emphasized on compiling and exploring various classical references as well as reported current literature in various scientific journals and online databases about the therapeutic potential of Kushmanda Avaleha as well as its ingredients with special reference to respiratory illness. All the information has been placed here in comprehensive manner. Moreover, a number of studies have also been conducted and published which established the efficacy of its all ingredients in diverse respiratory pathologies through manifold mechanisms such as Bronchodilator, Anti-tussive, Mucolytic, etc. Therefore, on meticulous appraisal, it can be inferred that Kushmanda Avaleha is a complete care and an effective medication for various respiratory disorders.
ORIGINAL ARTICLE: Blepharis persica increases testosterone biosynthesis by modulating StAR and 3β-HSD e...
Nilesh Gaikar, Nishit Patel, Samir Patel, Priyal Patel, Piyush Chudasama, Manan Raval
Asian Pacific Journal of Reproduction, Year 2022, Volume 11, Issue 1 [p. 27-34]
DOI: 10.4103/2305-0500.335859
Objective: To evaluate the effect of methanolic extract and ethyl acetate fraction of methanol extract prepared from the seeds of Blepharis (B.) persica on testosterone biosynthesis and also to elucidate the underlying mechanism. Methods: Forty-eight male Wistar rats were divided into eight groups (n=6 per group). Group I received 0.3% w/w gum acacia suspension p.o. and served as the normal control group. Group II was administered testosterone propionate in arachis oil i.m. as the positive control group. Group III to V received B. persica methanolic extract p.o. at doses of 50, 100 and 200 mg/kg body weight. Group VI to VIII received B. persica ethyl acetate fraction p.o. at doses of 50, 100 and 200 mg/kg body weight. The testis was used for biochemical estimation and histological studies. The effects of methanolic extract and ethyl acetate fraction of B. persica on testicular testosterone, mRNA expression corresponding to steroidogenic acute regulatory protein (StAR) and 3β-hydroxysteroid dehydrogenase (3β-HSD) along with 3β-HSD enzyme assay were evaluated in testicular tissues and sperm concentration. Ethyl acetate fraction of B. persica was subjected to column chromatography. In-vitro studies were performed using TM3 cell line at three dose levels (50, 100, 200 μg/mL), each for methanolic extract, ethyl acetate fraction and 2-benzoxazolinone for evaluation of their comparative effect on testosterone production. Results: Ethyl acetate fraction and methanolic extract of B. persica could elevate the testicular testosterone content compared to the normal control group. The treatment with methanolic extract and ethyl acetate fraction of B. persica increased the expression of mRNA corresponding to StAR by 6.7 fold and 10.6 fold, respectively, whereas the mRNA expression of 3β-HSD increased by 5.7 fold and 7.3 fold, respectively. Moreover, fraction and extract treatment exhibited increased 3β-HSD activity in the testicular tissues and were found to elevate sperm concentration in seminal fluid. The spermatogenic potential was further ensured by histological observations. 2-benzoxazolinone was isolated from ethyl acetate fraction and identified using spectral studies. It showed the ability to increase the testosterone content in the TM3 Leydig cells. Conclusions: Methanolic extract and ethyl acetate fraction of B. persica are able to increase the testicular testosterone in rats by elevating mRNA expression of StAR and 3β-HSD in testicular tissues, leading to increase the sperm concentration.
ORIGINAL ARTICLE: A Homoeopathic journey of epidemic/ pandemic diseases from Hahnemannian epoch to COVID-19: Review
Haleholi Manjula
DPUís Journal of Ayurved, Homeopathy and Allied Health Sciences, Year 2022, Volume 1, Issue 1 [p. 19-23]
DOI: 10.4103/jahas.jahas_2_22
As evidenced in Hahnemann’s writings, Epidemic diseases were successfully managed by homoeopathic system of medicine. In the footnote 17 of aphorism 33, Organon of medicine, where in Hahnemann explained the prevention of scarlet fever using Belladonna. Thereafter, many homoeopaths successfully managed several epidemics, at different points of time and at different parts of the globe. Even though Hippocrates used the notional axiom, Genius Epidemicus, Hahnemann utilized it successfully for the management of epidemics. In this review, all the available homoeopathic literature was searched to find out the historical evidence of the homoeopathic medicines which were successfully utilized during epidemics and pandemics. Presently, the entire world is facing novel COVID-19, as a pandemic disease since its emergence from Wuhan in late 2019. The conventional systems of medicines across the world have been trying to control the pandemic, but none have succeeded. Vaccinations are introduced for prevention of COVID-19, only on Emergency Usage Approvals, as the real data about their efficacy and the collateral damage induced by them, is yet to be studied. However, globally many homoeopaths have reported to have managed COVID-19 disease with different homoeopathic medicines. There have been different approaches towards the prevention, management and treatment of this pandemic, which have been subject of intense scrutiny and discussion, all over. The present review is aimed not only to bring forward the success stories of homoeopathy during the past epidemics, but also about homoeopathy being utilized for prevention, as well as treatment in the current pandemic.
EDITORIAL: Quality and safety of Ayurvedic medicinal plants is it the key to the success of therapeutic mana...
Tanuja Manoj Nesari
Journal of Ayurveda Case Reports, Year 2022, Volume 5, Issue 1 [p. 1-5]
DOI: 10.4103/jacr.jacr_30_22
ORIGINAL ARTICLE: Trends of chronic obstructive pulmonary disease diagnosis and treatment in rural setting in India...
Shital Patil, Gajanan Gondhali, Manojkumar Bhadake, Anil Jadhav
Journal of Association of Pulmonologist of Tamil Nadu, Year 2022, Volume 5, Issue 1 [p. 9-16]
DOI: 10.4103/japt.japt_8_22
Background: Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and mortality due to chronic respiratory illness in India. More than half of COPD patients were not getting adequate rationale inhalation treatment in primary to tertiary care setting. Materials and Methods: A prospective, observational, interview (questionnaire)-based complete workup COPD study conducted during June 2016 to June 2019 in the Department of Pulmonary Medicine, Venkatesh Chest Hospital, and MIMSR Medical College, Latur, screened 12,000 cases with chronic respiratory symptoms with cough, sputum production, and shortness of breath, and all cases were undergone spirometry and 6000 COPD cases were enrolled. In this study, we assessed disease knowledge and the methods of treatment offered to all patients before enrollment by applying questionnaire. Statistical analysis was done using single proportion test (Chi-square test). Observation and Analysis: We have observed that 3% of study cases were aware of their illness “COPD disease,” 54% are not knowing the disease or not counseled for COPD disease ever before, and 43% are not convinced as they are having COPD (categorized as “difficult patient”) (P < 0.0001). Inhalation treatment was offered in only 58% of COPD cases, levosalbutamol monotherapy in 31% of cases, levosalbutamol plus beclometasone in 18% of cases, and formoterol plus budesonide or salmeterol plus fluticasone only in 9% of COPD cases (P < 0.0001), latter being categorized as “difficult treatment” being costlier than former ones. We also observed irrational and exuberant use of oral medicines in 42% of COPD cases, theophylline in 16%, salbutamol in 7%, and oral steroids in 19%, and these medicines were preferred by treating doctors over inhalation treatment in spite of knowledge of inhalation treatment and categorized as “difficult doctor” (P < 0.0001). Conclusion: COPD is less efficiently evaluated and halfheartedly treated in rural setting, and more emphasis should be given to spirometry training for proper diagnosis and awareness regarding advantages of inhalation treatment over oral medicines.
ORIGINAL ARTICLES: Development and evaluation of Talisapatradi and Vyoshadi choorna lozenges: An ayurvedic tradition...
Manas R Sahoo, Umashankar M Srinivasan, Ramesh R Varier
Journal of Reports in Pharmaceutical Sciences, Year 2022, Volume 11, Issue 1 [p. 110-117]
DOI: 10.4103/jrptps.JRPTPS_80_21
In Ayurveda, Talisapatradi choorna (TPC) and Vyoshadi choorna (VSC) are commonly used medicines for cough, cold, asthma, and rhinitis. These symptoms are due to upper respiratory infections of predominantly of viral origin. Currently, there are no effective medicines except indiscriminate uses of antibiotics, local anesthetics, and pain killers. The conventional formulation of TPC and VSC is difficult to administer so an easy manufacturing lozenge formulation was developed. The phytochemical analysis was done by preliminary thin layer chromatography (TLC) derivatization studies. High-performance thin layer chromatography (HPTLC) analysis confirmed the presence of herbal actives in the lozenge formulations. The TLC analysis results showed that TPC and VSC contain phytochemicals of flavonoids, steroids and phytosterols, and alkaloids family. The herbal actives were found to be stable in the final formulation without any interference with the excipients used in the formulation. The lozenges formulated from TPC and VSC are found to be promising alternatives to traditional form for the traditional Ayurvedic preparation. Compatibility study was done using Fourier transform infrared spectroscopy and HPTLC study.
ORIGINAL ARTICLE: Self-medication with modern and complementary alternative medicines in patients with chronic pain
Indu Jangra, Ashok Kumar Dubey, Ekta Arora, Basit Iqbal Peerzada
Journal of Research in Pharmacy Practice, Year 2022, Volume 11, Issue 1 [p. 19-24]
DOI: 10.4103/jrpp.jrpp_14_22
Objective: The study aimed to assess the prevalence, pattern, and determinants of the self-medication practices with modern and/or complementary and alternative medicine (CAM) therapies in patients with chronic pain. Methods: The descriptive cross-sectional study was conducted between August 2021 and January 2022 and assessed a representative sample of chronic pain patients visiting outpatient departments in India by administering a semi-structured questionnaire. The survey questionnaire consisted of forty multiple response items, including ten questions that assessed the subjects' sociodemographic profile, for example, age, sex, education, marital status, employment status, residence, and distance of home from any health care facility. The next part of the questionnaire evaluated the practice and determinants of self-medication for chronic pain with modern or CAM therapies. It included thirty questions assessing the reasons, duration, sources of information, procurement methods, preference for a particular system of medicine, knowledge about risks or drug interactions, rationality, perception of the subject, and communication with the physician, among other aspects of self-medication for pain. Findings: Out of the 325 respondents with chronic pain, those who practiced self-medication (237) were significantly more in number than those who did not (P < 0.05). Among those who self-medicated, the practice was significantly higher in urban participants living closer to healthcare facilities, with better economic backgrounds and higher education (P < 0.05). Modern medicine was the predominant choice of self-treatment for chronic pain compared to various CAM therapies (P < 0.05). Among the alternatives, homeopathic and ayurvedic systems of medicines were preferred. The main reasons for self-medicating were urgency, ease, previous prescriptions, and presumed mildness of the underlying disease. More than one-third of the respondents opined in favor of continuing self-medication in the future. Conclusion: The prevalent practice of self-medication for chronic pain may not be hazardous, but it can turn into a serious problem if not based on correct information. The inherent risks need to be minimized by increasing awareness, health education, and pharmacy regulations.
EDITORIAL: Integrative health and wellness – time to integrate wisdom from different types of medical ...
Chandrakant S Pandav, Hrushikesh Kedari, Tilak Mishra, Sunil H Thigale
Journal of Integrative Medicine and Public Health, Year 2022, Volume 1, Issue 1 [p. 1-4]
DOI: 10.4103/JIMPH.JIMPH_5_21
REVIEW ARTICLE ON MEDICAL EDUCATION: National Education Policy 2020 compliant multidisciplinary education and research universities fo...
Pradnya V Kakodkar, Shivasakthy Manivasakan
Journal of Medical Evidence, Year 2022, Volume 3, Issue 1 [p. 60-63]
DOI: 10.4103/JME.JME_107_21
A THOUGHT LEADERSHIP: A convergent and multidisciplinary integration for research in menopause
B Vaidya Ashok, A Vaidya Rama
Journal of Mid-life Health, Year 2022, Volume 13, Issue 1 [p. 5-8]
DOI: 10.4103/jmh.jmh_65_22
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