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ORIGINAL ARTICLE: Evaluation of simulation skills of healthcare workers at a tertiary care center: A perspective to...
Sudha Bala, Aruna K Yerra, Sushma Katkuri, Karuna S Podila, Venkatesham Animalla
Journal of Family and Community Medicine, Year 2022, Volume 29, Issue 2 [p. 102-107]
DOI: 10.4103/jfcm.jfcm_23_22
BACKGROUND: Simulation-based training for healthcare providers was established as an efficacious training tool to sharpen the performance skills of nontechnical team as necessary for the prevention of errors and adverse events in the pandemic. To tackle this third wave, our institute started preparations with a faculty development course of simulation-based learning to evaluate participants' knowledge and skills and their attitudes and feedback. MATERIALS AND METHODS: As part of the simulation workshop, a module was developed to train the staff on recognizing and responding to acute coronavirus disease 2019 affecting adults and children. Case-based scenarios were provided in the application. Pretest and posttest questionnaires were administered to all trainees. The questionnaires included questions on knowledge, skills confidence and attitude marked on a 5-point Likert scale. Data were entered and analyzed using the Microsoft Excel 2018. Qualitative variables were expressed as percentages, whereas mean and standard deviations were computed for quantitative variables. Paired t-test was used to test the difference between pre and post test scores; P < 0.05 was taken as significant value. RESULTS: A total of 296 participants were included in the study. A statistically significant increase in knowledge and skills confidence scores was found from pre-test to post-test. The most significant improvement was found in the assessment of pediatric hemodynamic status and the management of fluid and electrolytes. The most interesting benefit to the participants was the acquisition of knowledge about the proper use of technology after the faculty development course. CONCLUSIONS: Such workshops play a crucial role in training healthcare workers, especially as preparation for the pandemic. Most participants suggested that there should be such workshops at regular intervals to enhance their skills confidence in handling emergency situations in the clinical settings.
REVIEW ARTICLE: Animal models - Mimicking the pain of trigeminal neuralgia
Sonu Gupta, Ravinder Nath Bansal, Surender Pal Singh Sodhi, Gursimrat Kaur Brar
Indian Journal of Pharmacology, Year 2022, Volume 54, Issue 2 [p. 138-145]
DOI: 10.4103/ijp.ijp_296_19
Trigeminal neuralgia (TN) is an episodic facial pain which feels like an electric shock of unilateral origin. This neuropathic disorder is an intensely stressful to bear for patient and impacts the quality of life. Most of the cases of TN arise when the root of fifth cranial nerve, i.e., trigeminal nerve is compressed after a few millimeters of its entry into the pons. This article describes various animal models and the role of biomarkers to study the underlying mechanisms of neuropathic pain in animal models as well as different modes of management of TN.
ORIGINAL ARTICLE: Blepharis persica increases testosterone biosynthesis by modulating StAR and 3β-HSD e...
Nilesh Gaikar, Nishit Patel, Samir Patel, Priyal Patel, Piyush Chudasama, Manan Raval
Asian Pacific Journal of Reproduction, Year 2022, Volume 11, Issue 1 [p. 27-34]
DOI: 10.4103/2305-0500.335859
Objective: To evaluate the effect of methanolic extract and ethyl acetate fraction of methanol extract prepared from the seeds of Blepharis (B.) persica on testosterone biosynthesis and also to elucidate the underlying mechanism. Methods: Forty-eight male Wistar rats were divided into eight groups (n=6 per group). Group I received 0.3% w/w gum acacia suspension p.o. and served as the normal control group. Group II was administered testosterone propionate in arachis oil i.m. as the positive control group. Group III to V received B. persica methanolic extract p.o. at doses of 50, 100 and 200 mg/kg body weight. Group VI to VIII received B. persica ethyl acetate fraction p.o. at doses of 50, 100 and 200 mg/kg body weight. The testis was used for biochemical estimation and histological studies. The effects of methanolic extract and ethyl acetate fraction of B. persica on testicular testosterone, mRNA expression corresponding to steroidogenic acute regulatory protein (StAR) and 3β-hydroxysteroid dehydrogenase (3β-HSD) along with 3β-HSD enzyme assay were evaluated in testicular tissues and sperm concentration. Ethyl acetate fraction of B. persica was subjected to column chromatography. In-vitro studies were performed using TM3 cell line at three dose levels (50, 100, 200 μg/mL), each for methanolic extract, ethyl acetate fraction and 2-benzoxazolinone for evaluation of their comparative effect on testosterone production. Results: Ethyl acetate fraction and methanolic extract of B. persica could elevate the testicular testosterone content compared to the normal control group. The treatment with methanolic extract and ethyl acetate fraction of B. persica increased the expression of mRNA corresponding to StAR by 6.7 fold and 10.6 fold, respectively, whereas the mRNA expression of 3β-HSD increased by 5.7 fold and 7.3 fold, respectively. Moreover, fraction and extract treatment exhibited increased 3β-HSD activity in the testicular tissues and were found to elevate sperm concentration in seminal fluid. The spermatogenic potential was further ensured by histological observations. 2-benzoxazolinone was isolated from ethyl acetate fraction and identified using spectral studies. It showed the ability to increase the testosterone content in the TM3 Leydig cells. Conclusions: Methanolic extract and ethyl acetate fraction of B. persica are able to increase the testicular testosterone in rats by elevating mRNA expression of StAR and 3β-HSD in testicular tissues, leading to increase the sperm concentration.
EDITORIAL: Quality and safety of Ayurvedic medicinal plants is it the key to the success of therapeutic mana...
Tanuja Manoj Nesari
Journal of Ayurveda Case Reports, Year 2022, Volume 5, Issue 1 [p. 1-5]
DOI: 10.4103/jacr.jacr_30_22
EDITORIAL: The unresolved tragedy of neural-tube defects in India: The case for folate- and vitamin-B12...
Ravindra Motilal Vora, Asok C Antony
Journal of Indian Association of Pediatric Surgeons, Year 2022, Volume 27, Issue 1 [p. 1-8]
DOI: 10.4103/jiaps.jiaps_211_21
ORIGINAL ARTICLE: Effect of liquorice (root extract) mouth rinse on dental plaque and gingivitis – A randomiz...
Sakshi Sharma, Girish M Sogi, Vipin Saini, Tulshi Chakraborty, Jasneet Sudan
Journal of Indian Society of Periodontology, Year 2022, Volume 26, Issue 1 [p. 51-57]
DOI: 10.4103/jisp.jisp_517_20
Background: Around the world, an increasing number of people are turning towards nature by using the natural herbal products not only because they are inexpensive but also for better cultural acceptability, better compatibility with the human body and minimal side effects. This study assessed the effectiveness of liquorice (root extract) mouth rinse against dental plaque and gingivitis and compared it with 0.2% chlorhexidine (CHX) gluconate mouth rinse. Materials and Methods: A double-blind, concurrent parallel randomized controlled clinical trial (CTRI/2016/09/007311) of four months duration was conducted. Forty-four volunteers who met the inclusion criteria were randomized into two groups through the computer-generated random sequence. Based on in vitro minimum inhibitory and minimum bactericidal concentration evaluations on periodontal pathogens, a concentration of 20% (w/v) of aqueous liquorice root extract mouth rinse was prepared. Both the groups were asked to rinse with their respective mouthwash twice daily for 15 days. Gingivitis was evaluated using gingival index (GI), and dental plaque was evaluated using the Turesky modification of the Quigely Hein Plaque Index (PI). The evaluation was carried out at day zero, 8th and 23rd (15 days after intervention). Intra- and intergroup comparisons of indices for both the arms were done using the paired sample t-test and unpaired t-test, respectively. Results: There was a statistically significant (P = 0.000) reduction in mean PI and GI scores for both the groups after a follow up of 15 days. The intergroup comparison of plaque and gingival index scores for both the mouth rinse groups came out to be statistically significant (P = 0.000). Conclusion: Both liquorice and CHX gluconate mouth rinse restricted plaque accumulation and gingival inflammation. Considering the established side effects of long-term use of chemical formulations, the herbal mouth rinse preparation can promise to be an effective self-care therapy.
ORIGINAL ARTICLE: Clinical study to compare effect of Haridradi lepa and Shringatadi tailam along wit...
Rajveer Sason, Anita Sharma
Journal of Indian System of Medicine, Year 2022, Volume 10, Issue 1 [p. 12-18]
DOI: 10.4103/JISM.JISM_87_21
Background: Hair loss affects people of all gender, ages, and ethnicities, and it has both physical and psychological consequences. In today’s world, chemical hair treatments such as bleaching, straightening, relaxing, or permanent waving are very popular. Aims and Objectives: The purpose of this study was to evaluate the effect of Haridradi lepa and Shringatadi tailam along with Shwadanshtradi churna on hair loss and to research the literature on hair loss. Materials and Methods: A total of 90 patients with hair fall diagnosed clinically were enrolled and divided into two groups randomly. The duration of the trial was 2 months. There were 45 patients in each group. Cases were diagnosed using clinical signs of hair loss as described in classics. For male pattern baldness, the modified Norwood–Hamilton scale was used. For female hair loss, the Ludwig scale was used. Results and Conclusion: The percentage relief of the Sammuchya lakshnas (overall symptoms) was maximal 35.6% with P-value 0.0156 for the Study Group A patients and 44.6% with P-value 0.0136 for Study Group B patients, according to the research. The statistical study revealed that both groups improved significantly.
REVIEW ARTICLE ON MEDICAL EDUCATION: National Education Policy 2020 compliant multidisciplinary education and research universities fo...
Pradnya V Kakodkar, Shivasakthy Manivasakan
Journal of Medical Evidence, Year 2022, Volume 3, Issue 1 [p. 60-63]
DOI: 10.4103/JME.JME_107_21
A THOUGHT LEADERSHIP: A convergent and multidisciplinary integration for research in menopause
B Vaidya Ashok, A Vaidya Rama
Journal of Mid-life Health, Year 2022, Volume 13, Issue 1 [p. 5-8]
DOI: 10.4103/jmh.jmh_65_22
ABSTRACTS: 5th IUPHAR WCP-NP, 2019 INDIA & 51st Annual Conference of IPSCON-2019
Indian Journal of Pharmacology, Year 2021, Volume 53, Issue 7 [p. 1-191]
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