2014-09-01T13:35:48Z http://www.medknow.com/oai2
oai:medknow.com:68840 2006-01-01 all journal:Ayu
A pharmaceutical standardization of Makaradhwaja prepared by Astasamskarita Parada Patgiri, BJ Prajapati, PK Makaradhwaja is one of the most popular Kupipakwa preparations of Ayurvedic medicine. It is prepared by shuddha Swarna (Gold), Astasamskarita Parada (Mercury) and shuddha Gandhaka (Sulphur) in the ratio of 1:8:16 as ingredients. The present study was under taken to standardize the pharmaceutical procedure of Makaradhwaja prepared by Astasamskarita Parada on the level of temperature pattern and duration through Electric muffle furnace to obtain maximum yield. Total 28.32 % loss of Parada was observed during preparation of Astasamskara. The test sample of Makaradhwaja was prepared in three batches to maintain the Standard procedure by using specially designed vertical electric muffle furnace. 252.84g, 252.84g and 246.97g of Kajjali was used to produce the yield of Makaradhwaja 89.35g, 85.12g and 80.24g of respectively consuming time duration of 18.40 hrs, 18.20 hrs and 18.35 hrs respectively till switching off of the heating device. The average time duration required for complete process i.e. starting of heating to self-cooling stage [50΀ C] was about 37 to 39 hours. Medknow Publications 2006-01-01 http://www.ayujournal.org/text.asp?2006/27/1/1/68840 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68842 2006-01-01 all journal:Ayu
Role of Amrutbhallatak Avaleha & Karanjadi Lepa in the management of Ekakushtha (Psoriasis) Dave, AR Shukla, VD Psoriasis is a skin disease having unknown etiology and of chronic nature. It is relapsing and so it is a problem for medical science also. Every year more than 9 million cases of psoriasis are reported in the world. The paper deals with the role of Amrutbhallatak Avaleha & Karanjadi Lepa in the management of Ekakushtha (Psoriasis) on more than 60 cases. The ingredients of the Avaleha are Bhallatak, Guduchi & some other herbal drugs. They are Kaphavataghna and Rasayana. All the ingredients of Karanjadi Lepa are Kandughna & Kushthaghna. The duration of treatment was 90 days and all the patients were kept under strict dietary control during the treatment. The observation of effect therapy was encouraging. The Amrutbhallatak Avaleha orally was used with Karanjadi Lepa externally have got a positive effect in comparison of placebo group, which had less recurrence. The effect of therapy is presented in detail in full paper with elaborate discussion & conclusion. Medknow Publications 2006-01-01 http://www.ayujournal.org/text.asp?2006/27/1/16/68842 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68843 2006-01-01 all journal:Ayu
Phytochemical Investigations and Bioactivity Studies of the Stem Bark of Ficus Racemosa Linn Baxi, G Baxi, AJ Parikh, AR Powdered bark of Ficus recemosa Linn. was found to contain an active glycoside along with sterols, hydrocarbons, sugars and amino acids. Bioactivaty studies on the glycoside constituent P - β - d glucosyloxy benzoic acid showed antiinflammalory, antacid and antibacterial activities. Medknow Publications 2006-01-01 http://www.ayujournal.org/text.asp?2006/27/1/22/68843 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68841 2006-01-01 all journal:Ayu
Study on psychic factors in irritable bowel syndrome and its management with Kutajadi Avaleha & Medhya Rasayana Mer, RN Chandola, HM Oza, YK Manasikabhava (psychic factors) plays an important role in etiopathogenesis & symptomatology of psychic and psychosomatic disease conditions. Psychic factors- kama (desire), krodha (anger), shoka (grief), bhaya (fear), irshya (envy) etc. within physiological limit can be defined as Manasikabhava whereas crossing the physiological limit these are termed as Manasikavikara or psychic disorders. Moreover, body and mind are interdependent to each other. The personality of an individual whether introvert or extrovert has also a role to play in the disease process.Irritable Bowel Syndrome (IBS) is a psychosomatic disease condition where motility of intestine is disturbed with altered bowel habit, lower abdominal pain with distention relieved by passes of flatus. There is no detectable organic pathology in this disease. The symptoms are markedly influenced by psychological factors with stressful life style. Though it is difficult to have correlation between IBS & any particular disease in Ayurveda but many diseases described in Ayurvedic classics resemble with symptoms commonly found in IBS. A careful review of the clinical picture of various GIT diseases, described in Ayurveda reveals that some of the disorders definitely have some clinical symptoms observed in the patients of IBS e.g. Vataja & Kaphaja Atisara, Sangrahani, Pravahika, Pakvashayagatavata. However, Grahani Dosha - a stage found in samprapti of all these diseases may be considered as IBS. These patients of IBS are evaluated for their mental health based on Hamilton's Anxiety Rating Scale, Hamilton's Depression Rating Scale & Brief Psychiatry Rating Scale along with Ayurvedic parameters. Total 30 patients selected randomly and divided into two groups were treated with: 1) Kutajadi Avaleha - a classical herbal formulation 10gm twice a day for 45 days and 2) Kutajadi Avaleha as above along with Charakokta Medhya-rasayana granules 5gm twice a day for 45 days. Better therapeutic response has been observed in abdominal pain, gaseous distention and diarrhea with significant relief in disturbed psychic factors like grief, worry, anger etc. in Medhya-rasayana group. Medknow Publications 2006-01-01 http://www.ayujournal.org/text.asp?2006/27/1/9/68841 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68837 2006-04-01 all journal:Ayu
Effect of Azadirachta indica A. Juss. on Falciparum Malaria cases in Car-Nicobar Mehra, R Thirty patients of uncomplicated Plasmodium falciparum malaria completed a clinical trial of Azadirachta indica A Juss conducted in malaria endermic Tamalu & Orong villages of tribal pockets in Car-Nicobar District of Andaman & Nicobar Islands. The decoction of bark of Azadirachta indica. A. Juss made out of 50 gm crude powder was given thrice a day for four consecutive days. The cure rate was 100 percent with mean fever & parasite clearance time of 42.4 ΁ 17.5 & 37.6 ΁ 13.6 h respectively. Recrudescence/reinfection rate was 01%. Palpable spleen on day 0 became non-palpable within 21 days. Following the treatment, percentage of h aemoglobin varied marginally with no remarkable change in total & differential leucocyte count. Azadirachta indica A. Juss besides being a potent & fast acting schizontocidal drug, also reported gametocytocidal action on P. falciparum. AYU will supply 10 reprints free of charge to the Principal author whose paper is published, in case of multiple authors only the first author will be supplied the reprints. Medknow Publications 2006-04-01 http://www.ayujournal.org/text.asp?2006/27/2/26/68837 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68922 2006-04-01 all journal:Ayu
Managemónt of cancer and benign growth Ramakrishnamachariyar Rao, V Medknow Publications 2006-04-01 http://www.ayujournal.org/text.asp?2006/27/2/30/68922 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68838 2006-04-01 all journal:Ayu
A comparative study on the role of Medhya Rasayana Yoga and Dashamula Kwathadhara in the management of Vatika Shirahshula (Tension Headache) Dave, HR Ch., S Vyas, SN Dave, AR Ayurveda has discussed the Shirahshula (headache) as the most common complaints among all type of Shiroroga. The 21st century full with stressful life, worry, tension, anxiety, fear, grief, creates many psychosomatic disorders. Tension headache is one of them which can be compared with Vatika Shirahshula .In Ayurvedic texts mental factors like Bashpa (tears), Shoka (grief), Bhaya (fear), Trasa (desire) have been attributed in its aetiopathogenesis1. Based on symptomatology Vatika Shirahshula can be correlated with tension type headache defined as a bi-temporal and occipital pain. The pain increases in the evening with giddiness, disturbed sleep and loss of memory. In this study total 25 patients of Vatika Shirahshula divided into two groups were treated with: 1) Dashamula kwatha Shirodhara for 30 minutes duration in the morning for 21 days, 2) Medhyarasayana formulation (Brahmi, Shankhapushpi, Jatamansi, Pippalimula) for one month. The patients were subjected to the evaluation of cardinal sign and symptoms of Vatika Shirahshula on the basis of scores according to their severity, frequency and duration before and after the treatment. Result shows that Shirodhara provide very good results in chief complaints, manasabhava, Hamilton Anxiety Rating Scale (H.A.R.S), Hamilton Depression Rating Scale (H.D.R.S), with quantitatively relief measured with GSR-biofeedback instrument. Medhyarasayana provide better relief in blurring of vision, stiffness of neck, phonophobia, memory loss, dhairya, krodha, mana, medha and smriti. Medknow Publications 2006-04-01 http://www.ayujournal.org/text.asp?2006/27/2/36/68838 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68839 2006-04-01 all journal:Ayu
Clinical Trial of 'Onergy' in the Management of Male Sexual Dysfunction Brahmbhatt, R Parikh, HS Chauhan, VS Karkera, SG The efficacy of a Herbo-Mineral proprietary formulation "Onergy", along with placebo controlled clinical trials was evaluated in male patients suffering from sexual dysfunction. Within two weeks, statistically significant improvement in libido was observed as compared to the results of placebo without any side effects. Medknow Publications 2006-04-01 http://www.ayujournal.org/text.asp?2006/27/2/45/68839 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68833 2006-07-01 all journal:Ayu
A Toxicity Study of Makaradhwaja Prepared by Astasamskarita Parada Patgiri, BJ Prajapati, PK Ravishankar, B Makaradhwaja is a well known Ayurvedic medicine prepared by Kupipakwa method. It is prepared by using shuddha Swarna (Gold), Astasamskarita Parada (Mercury) and shuddha Gandhaka (Sulphur) in the ratio of 1:8:16 as ingredients. The present study was under taken to ascertain the safety aspect of the drug through acute and chronic toxicity studies. Acute toxicity study was carried out in Swiss albino mice and chronic toxicity study was carried out in Charles Foster albino rats at different dose levels. The parameters studied were ponderal, haematological, biochemical and histopathological. in case of chronic toxicity study, mortality and behaviour change in acute toxicity. In acute toxicity study the test drug did not produce mortality up to the dose of 480 mg kg-1 (orally) in mice. The result or data obtained during the study indicate no significant changes observed in hematological, biochemical and histopathological parameters except of mild increase in blood sugar level and mild fatty changes in liver. Medknow Publications 2006-07-01 http://www.ayujournal.org/text.asp?2006/27/3/55/68833 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68834 2006-07-01 all journal:Ayu
The Role of Amrita Bhallataka Avaleha and Virechana Karma in the Management of Amavata Sharma, P Baghel, MS Ayurveda has taken the foremost place in the management of crippling discase. Amavata is one of them. From the modern point of view, this disease looks similar to Rheumatoid arthritis in its clinical appearance. In the whole world rheumatic disease are commonest cause of physical impairment in society. The lives of more than one million people are physically impaired by rheumatic disorders and fifth of these are severely disabled. Due to its wide prevalence chronicity, morbidity, crippling nature and lack of effective drugs attract to look for suitable remedy of the disease Amavata. Bhallataka and Guduchi are the Rasayana drugs, so in general they improve the qualities of body element thereby curing the disease as well as maintaining the healthy state of the body. But, there were many side effects noted in previous research works on Bhallataka. So to search for better form or acceptable form of Bhallataka as well as to use combination of two Rasayana drugs, for the present study as Shamana therapy Amritabhallataka has been chosen. Which is mentioned in Bhavaprakash Madhyama Khanda 54/75-82. Virechana is mentioned in Chakradutta Chikitsa Sutra and many work with Virechana Karma on Amavata have been successfully carried out. So in this study Virechana has been conducted. Total 35 patients of Amavata were treated. These patients were randomly distributed into two treatment groups. Amritabhallataka without Virechana (14 patients) and Amrita Bhallataka with Virechana (11 patients) were taken. Out of above said group. The improvement was statistically highly significant in both the groups, but comparatively Shodhana group (group B) had better relief than Shamana group (group A) Amrita Bhallataka Avaleha was well tolerated by most of the patients (31), very minor side effects observed in few (4) patients. Medknow Publications 2006-07-01 http://www.ayujournal.org/text.asp?2006/27/3/63/68834 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68835 2006-07-01 all journal:Ayu
A Comparative Pharmaco - Clinical Study on Anti-Asthmatic Effect of Shirisharishta Prepared by Bark, Sapwood and Heartwood of Albizia Lebbeck Jaiswal, M Prajapati, PK Patgiri, BJ Ravishankar, B Shirisharishta is a compound formulation having main content as Shirisha. Shirisha (Albizia lebbeck Benth.) is a well known classical drug for the treatment of various types of diseases such as Shwasa, Kasa etc. The plant is reported to have various pharmacological properties like anti-asthmatic, antihistaminic, anti-protozoal etc. Most of the recent studies are reported about the pharmacological actions of it's bark, leaves, pods and fruits, but almost negligible references about the pharmacological action of it' heartwood are available. Nowadays Twak (bark) is commonly used for the preparation of Shirisharishta, but Sara (heartwood) is the part which is indicated in Asava Yoni. Shwasa Roga (Asthma) is one of the most common chronic diseases in the world. It may be defined as a disease in which the respiration is disturbed due to narrowing or obstruction in the channels. Bronchial asthma is a common disease affecting 10% to 20% of population. Considering the above facts in the present study Shirisharishta was prepared by Twaka (bark), Kastha (sapwood) and Sara (heartwood) of Shirisha. Pharmacologically Shirisharishta prepared by Sara shows significant result in anti-inflammatory and anti-tussive actions and significant increase in anti-histaminic activity while better activity profile in CMI suppression activity than the other two groups of Arishta. Clinical study on 41 patients also supports the experimental data in which Shirisharishta prepared by Sara shows better result in curing the disease Shwasa (Asthma). Medknow Publications 2006-07-01 http://www.ayujournal.org/text.asp?2006/27/3/67/68835 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68836 2006-07-01 all journal:Ayu
Combating the Toxicities of Chemotherapy with Rasayana: A Step Towards Integrated Oncology Mankad, Z Mankad, D Shukla, VD Cancer is one of the most dreaded disease of 20th century and spreading further with continuance and increasing incidence in 21st century. Any practical solution in combating this dreadful disease is of paramount importance. No cure should be hazardous than the disease, however chemotherapy opposes this principle and it further worsens the crippled cancer patients with its side effects. Therefore an integrated approach is needed to manage cancer and the chemotherapy induced side effects. At this stage Ayurveda offers Rasayana as the best tool to manage the chemotherapy induced toxicities like nausea, vomiting, alopecia and myelosuppression. Medknow Publications 2006-07-01 http://www.ayujournal.org/text.asp?2006/27/3/75/68836 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68827 2006-10-01 all journal:Ayu
A Clinical Study of Hyperlipidaemia and the Effect of Panchatiktaghana in its Management - A Double Blind Study Sapra, UK Thakar, AB Baghel, MS Vyas, SN Ravishankar, B A randomized, double blind, standard control study was done on 60 patients of hyperlipidaemia and the role of Ayurvedic drugs as Panchatikta Ghana (Combination of Adhatoda vasica, Azadirachta indica, Tinospora cordifolia, Solanum xanthocarpum, Trichosanthes dioica) and Shuddha Guggulu (Commiphora mukul) has been evaluated by dividing the patients in two groups. It was found that Shuddha Guggulu is superior to Panchatikta Ghana in reducing the lipids i.e. S.Cholesterol, S.Triglyceride, and S.VLDL. Both the drugs have significant effect in reducing the symptoms of Medodushti and in reduction of objective parameters like weight, BMI, body circumferences such as chest, abdomen, hip and pelvis circumferences etc. and skin fold thickness as Biceps, Triceps and Abdominal skin fold thickness. Medknow Publications 2006-10-01 http://www.ayujournal.org/text.asp?2006/27/4/80/68827 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68828 2006-10-01 all journal:Ayu
A Clinical Study on the Role of Pathyadya Vatak and Vidangadi Lepa in the Management of Ek-Kustha (Psoriasis) Mehta, CS Shukla, VD Psoriasis is a common skin disease affecting about 1-2% of general population. The word psoriasis is derived from the Greek word "Psora" and "Iasis". Psora means Itch or scale and lasis means condition. Acharya Charak has described the involvement of Vata and Kapha in Ekkushtha. In the present study Ekkushta is compared with psoriasis due to its maximum resemblance with it. The trial drugs in the present study are Pathyadhya Vatak and Vidangadi Lepa which have not been studied on Psoriasis till date as per our Knowledge. The effect of Placebo was also assessed to understand the Psychosomatic nature of the disease. The results of combination of Pathyadaya Vatak and Vidangadi lepa were highly encouraging. Medknow Publications 2006-10-01 http://www.ayujournal.org/text.asp?2006/27/4/85/68828 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68830 2006-10-01 all journal:Ayu
A Clinical Study on Aetiopathogenesis of Sthaulya (Obesity) and it's Management by Navaka Guggulu Srivastav, R Dave, AR Shukla, VD Sthaulya is a predominant metabolic disorder. It is described by Acharya Charaka in Ashtaunindita Purusha . In the present Study Navaka guggulu is taken for Clinical trial which is referred from Bhaishajya Ratnawali " Medoroga Chikitsa( 39/43). It mainly contains drugs like Sunthi, Marich Pippali, Chitraka, Haritaki, Bibhitaki, Amalaki, Musta, Vidanga and Shuddha guggulu. Almost all the drugs are having Katu rasa, laghu ruksha guna, Ushna veerya, Katu vipaka and Kapha Vata Shamaka properties which may be helpful in disintegrating the Samprapati of Sthaulya. Navaka guggulu showed encouraging results in reduction of weight, skin fold thickness, body circumference and associated signs and symptoms. Medknow Publications 2006-10-01 http://www.ayujournal.org/text.asp?2006/27/4/90/68830 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68831 2006-10-01 all journal:Ayu
A Clinical Study on Psyco-Somatic Management of Shukraavrlta Vata (Premature Ejaculation) with Rasayana Yoga and Shirodhara Cardozo, B Thakar, AB Skandhan, KP Ayurveda mentions diet (Ahara), sleep (Nidra) and Brahmacharya as the Tripods of life. Sex is a basic instinct, but sexual behaviour is a learned ability. The concept of Kama reveals that the recreational aspects like pleasure are equally important to its procreation aspects. Shukra Avrita Vata is a clinical condition characterized by Shukra Avega, Shukra Ativega and Nishphalatvam. It can be compared to Premature ejaculation (PE) a psychosexual orgasmic disorder. Sex lies in the mind and not between the legs. - Sigmund Freud. In the course of research involvement of the psycho-neuro- sexual axis (Vata, Shukra and Mana) was observed. Keeping this in mind 60 subjects were subjected to a Single blind placebo controlled clinical study consisting of three randomized parallel groups of 20 subjects each to tackle the problem on psychological (Group A- Placebo + psychological counseling), psychobiological (Group B- Rasayana Yoga + psychological counseling) and neuro-bio-psychological (Group C- Rasayana Yoga + Shirodhara + psychological counseling) platforms. Though statistically highly significant results, were observed in all three groups. The improvement in Group C was better compared to Group B with regards to Intra-vaginal ejaculatory latency time, voluntary control over ejaculation, patient satisfaction, performance anxiety and number of penile thrusts. In terms of partner satisfaction improvement in Group B was better compared to Group C. Medknow Publications 2006-10-01 http://www.ayujournal.org/text.asp?2006/27/4/94/68831 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68832 2006-10-01 all journal:Ayu
Pharmaceutical and Analytical Standardization of Loknath Rasa Saxena, RB In Ayurveda the metals are known and used as Rasayana and as therapeutic agents since ancient times (800 -1000 BC). Their use in therapeutic was very limited due to their non conversion into suitable pharmaceutical form i.e. these were in fine powder only which was made treating those to red hot state and quenching into some of the herbal extractive. Only six metals (Gold, Silver, Copper, Iron, Tin and Lead) had been recognized for their medicinal values and used internally. In 8 th/9th century AD and onwards, when the development of Rasashastra has taken place in the field of Ayurveda, many new pharmaceutical processing techniques along with equipments and drugs were evolved and developed which have revolutionized Ayurvedic pharmaceutical technology to such anexent that by using that metals could be converted to such a form which is considered must suitable for their internal use in the body. Loknath rasa is mostly indicated in the disease like Yakrtplihodara (Hepato - spleeno - megaly), Gulma (Abdominal tumour) and Sotha (Inflammation), though it is available in the market but quality may not be up to standard and if the same is used internally produces some toxic effects on the body. Loknath rasa was prepared in two different methods i.e. Gujaputa and Electric muffle furnace. Muffle furnace method is found good than Gujaputa. According to adulteration point of view, Loknath rasa was prepared separately by mardan (rubbing) on nagvalli rasa (Piper betel Linn) and tap water; and compared the analytical values. Iron, Aluminium and Calcium values are found higher in the Jala (water) mardan while Mercury, Sulphar, Magnesium and Sulphate are found less in different method of preparation. Medknow Publications 2006-10-01 http://www.ayujournal.org/text.asp?2006/27/4/99/68832 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68823 2007-01-01 all journal:Ayu
A Clinical Trial of the Efficacy of Kalashaka Yoga in Medo Vruddhi (Hypercholesterolemia) Ediriweera, E Ranbanda, KM Wellihinda, J High prevalence of Hypercholesterolemia in the society is mainly due to lack of exercises and high intake of fatty foods. It can be correlated with Medo Vruddhi, a disease described in Ayurveda. This clinical study deals with the management of Medo Vruddhi (Hypercholesterolemia) using Kalashaka Yoga. This is widely used by the eminent Sri Lankan Traditional Physician Family 'Ranbanda'. Kalashaka Yoga is prepared using 20Kg of bulb of Allium sativum, 20Kg of leaves of Murraya koenigii, 5Kg of seeds of Piper nigrum, 10Kg of leaves of Aporosa lindleyana, 10Kg of leaves of Olax zeylanica. These ingredients are dried, ground with Bees' honey and made into pills weighing 125mg. Hundred Medo Vruddhi (Hypercholesterolemia) patients were selected and randomly divided into two groups. First group was treated with two pills of 125gm of Kalashaka Yoga twice a day for twelve weeks. Second group was treated with placebo, prepared by roasted bran of rice ground with warm water and made into 125gm pills, given two pills twice a day for twelve weeks. The response to treatment was recorded and therapeutic effect was evaluated through symptomatic relief of the patients and lipid profile. Significant symptomatic relief in xanthomatosis, heaviness in the body, softness in the body, dyspnoea even on slight exertion, excessive hunger, snoring, less enthusiasm and statistically significant marked reduction in serum cholesterol, triglycerides, low density lipoprotein was observed in the group treated with Kalashaka Yoga. Medknow Publications 2007-01-01 http://www.ayujournal.org/text.asp?2007/28/1/1/68823 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68825 2007-01-01 all journal:Ayu
A comparative Pharmaceutico - Pharmaco - Clinical Study of Lauha Bhasma and Mandura Bhasma w. s. r. to its Panduhara Effect Sarkar, PK Prajapati, PK Choudhary, AK De, S Ravishankar, B Lauha Bhasma and Mandura Bhasma, the most frequently used Ayurvedic preparation of metallic iron, were prepared by classical as well as mechanical methods, to lay down standard operating procedure (SOP) for preparing these Bhasmas. Both the Bhasmas were chemically analyzed and pharmacologically and clinically investigated in iron deficiency anaemia. Analytical study of Lauha Bhasma and Mandura Bhasma revealed the presence of various proportions of important metals along with varied concentration of iron in these. The effect of both the Bhasmas in the management of Panduroga i.e iron deficiency anaemia in animal model as well as human were found to be statistically significant in comparison to the reference standard drug dried ferrous sulphate treatment group. Mandura Bhasma was found to be a better haematinic than Lauha Bhasma in comparison to reference standard drug. Medknow Publications 2007-01-01 http://www.ayujournal.org/text.asp?2007/28/1/11/68825 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68826 2007-01-01 all journal:Ayu
A Pharmacological Study on Hypnotic Activity of Mamsyadi Ghrita Singh, AK Ravishankar, B Chandola, HM This study has been carried out to find out whether pharmacological basis exist for the use of Mamsyadi Ghrita- sleep promoting formulation consisting of Nardostachys Jatamansi, Convolvulus pluricaulis, Withania somnifera and Valeriana jatamansi in equal ratio. Sleep promoting drugs are supposed to posses CNS depression activity and majority of such depressants normally possess anti-anxiety activity. Based on this premise the test ghrita has been studied on various experimental models such as Gross behaviour test, Open field behaviour test and Plus maze test etc. On Swiss albino mice. Gross Behaviour Study, Mamsyadi Ghrita showed mild hypoactivity. In Elevated Plus Maze Test, the drug produced significant decrease in the duration spent in open tunnel indicating pro-anxiety activity. In the Open Field Apparatus Study, Mamsyadi Ghrita showed no effect on number of squares crossed. On Hypnotic Potentiation Test, the present study showed nonsignificant but moderate prolongation. Medknow Publications 2007-01-01 http://www.ayujournal.org/text.asp?2007/28/1/17/68826 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68824 2007-01-01 all journal:Ayu
An Ayurvedic Management of Vulvovaginitis during Pregnancy Neelam Joshi, D Kumar, N Vulvovaginitis is more common problem of pregnant women that challenges the gynaecologist. It is an inflammatory condition of the vulva and vagina and characterized by vaginal discharge, pain & itching in external genital organs. Various pathogens are responsible for this condition such as bacteria, parasite, mycotic and virus. Any infection in birth canal may cause premature rupture of membrane and preterm labour resulting in pregnancy loss. Diagnosis is made on the basis of clinical features and presence of pathogens in wet slide study and vaginal swab culture. Treatment depends upon the causative organisms with systemic or local drugs. Aim of study was to see the efficacy of Panchavalkala ointment in vulvovaginitis during pregnancy. Total 50 cases were selected and divided into 2 groups according to the different treatment. Patients were called weekly interval to observe any change and findings were recorded. Results were assessed on the basis of symptomatic relief and absence of pathogens in wet slide study and vaginal swab culture. Panchavalkala ointment is more effective against Trichomonas Vaginalis & E. Faecalis in comparison to Triclovate ointment. Medknow Publications 2007-01-01 http://www.ayujournal.org/text.asp?2007/28/1/5/68824 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68819 2007-04-01 all journal:Ayu
A Comparative Pharmaceutico-Pharmaco-Clinical Study of Formulations of Tulsi Pills, Tulsi Arka and Tulsi Aerosol on Tamakashwasa Joshi, VR Pattagiri, BJ Prajapati, PK Asthma is a chronic inflammatory disorder of the air ways in which many cells play a role, particularly mast cells, eosinophils and T-lymphocytes.1. Tulsi is one among Shwasahara Mahakashaya described by Acharya Charaka2. Here an attempt has been made to observe the effect of the drug Tulsi by different formulations namely Vati, Arka and Aerosol. The study showed encouraging results in patients of Shwasa by Tulsi Aerosol followed by Vati and Arka. Medknow Publications 2007-04-01 http://www.ayujournal.org/text.asp?2007/28/2/23/68819 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68820 2007-04-01 all journal:Ayu
Effect of Arka Taila in the Management of Karnasrava w.s.r. to Otomycosis Patra, A Rajagopala, M Shah, A Karnasrava is one among the several diseases of ear. Otomycosis is one type of diffuse otitis externa, caused by fungus predominantly Aspergillus and Candida albicans. It is one among the several causes of Otorrhoea (Karnasrava). The symptoms found are itching, pain, discharge, deafness and tinnitus etc. It is most commonly seen in hot & humid climate; Jamnagar having the similar climatic conditions, Otomycosis is quite prevalent. Among the various local treatment procedures for Karnasrava, in this study karnapurana with Arkataila after Pramarjana was selected. The drug Arkataila is having ingredients i.e. Sarsapataila, Arkaswarasa & Haridra. Total 36 patients were registered and all the patients were randomly divided into two groups. G-I 32pts) treated with Arkataila & G-II(13pts) treated with Clotrimazole (candida) ear drops. Comparative effect was assessed between Arkataila & Clotrimazole in the management of Karnasrava-Otomycosis. Almost equally highly significant results were obtained in both the groups. Medknow Publications 2007-04-01 http://www.ayujournal.org/text.asp?2007/28/2/27/68820 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68821 2007-04-01 all journal:Ayu
A Pilot Study on Sports Medicine in Ayurveda with Special Reference to Sarira Bala Vriddhi Dave, P Vyas, H Vyas, M This study is under taken with the main aim to search out need, importance and utility of Ayurveda in the field of sports medicine and to assess the physical strength improving effect of Balya drug. For this purpose, all the direct and indirect references related to sports medicines from the various classics of Ayurveda were collected, analyzed, classified and re-arranged with valuable commentary in respect to modern era. For clinical study the subjects were selected who are active players of different type of sports. For the comparison of effect, healthy volunteers and placebo drug were also used. Four groups were made to evaluate the therapy. Four easily available, non controversial drugs from Balya Dashemani of Charaka Samhita were selected for applied study1. To make the drug palatable, the granule form was selected. To evaluate the effect of Balya drug, all body muscle strength test including upper and lower extremities, cardiac and all body muscles strength tests (for subjective assessment) were carried out. All the important haematological, biochemical and urine investigation were carried out before and after the completion the course of medicine for objective assessment. In the results; general body measurements, all body muscles strength and biochemical investigations were shown significant and highly significant results in healthy volunteers and sports person "Ashwagandhadi granule" groups respectively in comparisons to placebo drug groups.The drug "Ashwagandhadi granule" had shown highly significant results especially in sports person group. Medknow Publications 2007-04-01 http://www.ayujournal.org/text.asp?2007/28/2/32/68821 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68822 2007-04-01 all journal:Ayu
A Comparative Pharmaceutical and Analytical Study of Shirisharishta Prepared by Bark, Sapwood and Heartwood of Albizia Lebbeck Benth Jaiswal, M Prajapati, PK Patgiri, BJ Ravishankar, B Dhar, JK Suri, KA Satti, NK Three batches of Shirisharishta were prepared by using Twak (bark), Kastha (sapwood) and Sara (heartwood) of Shirisha, following classical method and analyzed. The pharmaceutical analysis revealed that the Shirisharishta prepared by Sara (heartwood) showed earlier onset and completion, better fermentation, 17 % more yielding, pleasant aroma and more alcoholic than others. The average pH was observed 4.74, 4.56 and 4.45 respectively in Shirisharishta prepared by bark, sapwood and heartwood and alcohol percentage was observed 3.93, 3.64 and 4.96 respectively. The HPTLC analysis was carried out to develop a fingerprint profile for the formulation. HPLC analysis showed the presence of epigallocatechin gallate, piperine and curcumin in all the three samples but maximum of their presence of percentage in heartwood preparation of Shirisharishta. Medknow Publications 2007-04-01 http://www.ayujournal.org/text.asp?2007/28/2/38/68822 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68815 2007-07-01 all journal:Ayu
Clinical Evaluation of Lohasava in the Management of Pandu Roga Gupta, V Reddy, K Ayurveda have veritable abundance of number useful drugs, belonging to herbal, animal, mineral origin used as a single drug or in compound formulations. Asava -Arishta having palatable taste, quick action longer shelf life and can be easily administered to the patients. In the present study Lohasava and its effect in the management of Pandu Roga is studied. Four different samples (I-IV) of Lohasava are prepared out of these four samples, three samples (I-III) contains Lauh Bhasma, while sample IV incorporated with Lauh Churna as per the original reference and all the different samples administered to the four different groups of anaemic patients, each group having 10 patients. Symptomatic relieve observed, in all the groups of patients, but it was also observed that patients of group III, having maximum symptomatic relief, than other groups. The various haematological parameters, are also improved in all groups, it is also noticed that sample I, II is found to be more effective, than sample IV in improving Hb level (p<0.05), while sample III, is better (p<0.01) than sample IV in increasing Hb level and total RBC count. Therapeutic efficacy of all the four samples has been found to be effective, in the management of Pandu Roga. Among them the sample III showing better efficacy, compared to all samples. Sample III has been prepared by fermenting in the china clay container. Medknow Publications 2007-07-01 http://www.ayujournal.org/text.asp?2007/28/3/49/68815 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68816 2007-07-01 all journal:Ayu
A Critical Study of 'Bhutebhyo Hi Param Yasmat Nasti Cinta Cikitsite' w.s.r. to Santarpanottha Prameha & it's Management Khandeparkar, G Vyas, M Vyas, H Acaryas lay emphasis on the significance of the Pancamahabhutas in understanding Shareera when they state their involvement from conception to death i.e. from the four Bhutas which enter Garbha1, the Pancabhautika Prakriti2, the Saddhatvatmaka Purusha3 termed as Cikitsadhikrita Purusha to the Pancabhautikatva of indriyas4, till death quoted as Pancatvagatam5, each of the above references show a special relevance to Mahabhutas. An attempt is made in this study to evaluate the utility and applicability of this principle of Pancamahabhutas in day to day practice. There are enough evidences in the treatises to prove that these Pancamahabhutas and the phenomenon of Panceekarana6 mentioned in terms of Samyoga dharmas7 was used to understand and treat diseases. In support of the above concept a study on the patients of Santarpanottha Prameha has been carried out by dividing them in two groups, Group A & Group B. Here the drugs were selected on the basis of the hypothesis that the vitiated gunas of one particular group of Mahabhutas can be countered with the administration of dravyas having opposite Mahabhautika guna dominancy8, i.e. Akasha, Vayu, Prithvi, or Agni. In Group A - Triphaladi Yoga was administered. In Group B - Citraka Curna was given9. The result was assessed after six weeks with the help of a specially prepared Proforma. All the important haematological, Biochemical & Urine investigations were done. Symptomatically significant results were found in Group A as compared to Group B. Medknow Publications 2007-07-01 http://www.ayujournal.org/text.asp?2007/28/3/57/68816 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68817 2007-07-01 all journal:Ayu
Pharmaceutical Standardization of Rasakarpura Mehta, NJ Ravishankar, B Prajapati, PK Rasakarpura, a Nirgandha type of Kupipakva Rasayana, used to cure skin disease. Although various references of Rasakarpura preparation are described in different Rasa Shastra classics but for the present study the reference of Rasatarangini (6/65-71) was selected. Rasakarpura is prepared with Parada, concentrated sulphuric acid and Saindhava Lavana in the ratio of 1: 1΍ and approx 1΍ respectively by using Valuka Yantra in Classical method within 9 hours of heat treatment and in Mechanized method by using electric muffle furnace (EMF) within 12 hours of heat treatment. Analytical study was done to find out its major chemical constitutes i.e. mercuric chloride along with sodium, magnesium and calcium as trace elements for product standardization. Medknow Publications 2007-07-01 http://www.ayujournal.org/text.asp?2007/28/3/61/68817 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68818 2007-07-01 all journal:Ayu
A Comparative Psycho-Neuro-Pharmacological Study on Guduchyadi Ghrita & Bhringarajadi Ghrita Rasayana Shukla, DN Shukla, V Ravishankar, B Chandola, HM This study has been carried out to compare the Psycho-neuro-pharmacological basis for the use of Guduchyadi Ghrita and Bhringarajadi Ghrita. Guduchyadi Ghrita Rasayana consisting of Guduchi (Tinospora cordifolia Linn), Apamarga (Achyrenthus aspera Linn), Vidanga (Embelia ribes Burm. F.), Shankhapushpi (Convolvulus pluricaulis Chois), Vacha (Acorus calamus Linn), Haritaki (Terminalia chebula Retz), Kushtha (Saussurea lappa C.B.Clarke ) and Shatavari (Asparagus racemosus Willd), has proven mental health promoting, memory enhancing, anti-stress, anti- depressant properties that may slow down the Aging process by counteracting stress. Bhringarajadi Rasayana consisting of Bhringaraja (Eclipta alba Hassk.), Krishna Tila (Sesamum orientale Linn.), Amalaki (Embelica officinalis Gaertn.), Mishri (Sugar) with proven adaptogenic, antioxidant, free radicals scavenger, immuno-modulator properties play a major role in the management of Aging process. Both the formulations are supposed to possess CNS activity, Anti-stress, adaptogenic and other pharmacological activities. Based on this promise the test Ghrita had been studied on various experimental models such as Gross behaviour test, Anti depressant test, Anti-anxiety test and Antistress adaptogenic test on Swiss Albino Mice and Charles Foster strain albino rats of either sex. On Gross behaviour study, both the test drugs showed hypoactivity. In the Anti depressant activity, Guduchyadi Ghrita showed significant decrease in the Mice Behavioral "despair" test, moderate decrease in Mice immobility in Chronic fatigue syndrome test and produced potentiation of L dopa effects. Bhringarajadi Ghrita showed no discernible Anti depressant and Chronic fatigue syndrome test though moderate potentiation of L dopa effect was observed. Guduchyadi Ghrita also produces antianxiety activity and Adaptogenic activity. None of the formulation was able to reverse stress induced Hypothermia. Slightly higher decrease in stress induced ulceration was observed with Guduchyadi Ghrita, however Bhringarajadi Ghrita had no effect. No statistically significant effect observed on Haematological, Biochemical parameter and DHEA-S (Dehydroepiandrosterone Sulfate). Guduchayadi Ghrita showed marginal elevation of DHEA-S level. Medknow Publications 2007-07-01 http://www.ayujournal.org/text.asp?2007/28/3/68/68818 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68811 2007-10-01 all journal:Ayu
A Comparative Study of Phalkalyan Ghrita by Oral Route and Matrabasti in the Management of Alpartava Sharma, RR Anand, N Pandya, MA In Ayurvedic classics all Gynaecological disorders are described under the umbrella of Yonivyapadas and Artava vikaras. As the disease Alpartava is not described in ayurvedic classics but it is a common symptom of various yonivyapadas such as Vatala,Arajaska etc. In modern science, Alpartava can be correlated with Hypomenorrhoea. Alpartava is a Tridoshaja vyadhi with predominance of Vata. Phalkalyan Ghrita having Tridoshashamaka (especially Vatashamaka), Artavajanana, Anulomana, Deepana,Rasayana etc. properties. Basti is considered as best chikitsa of vata1. For alpapushpa srava Anuvasana Basti should be given2. Matrabasti being a type of anuvasana basti so for present study Phalkalyan Ghrita as Matrabasti and Oral route was selected, very encouraging result were observed in Group A (Matrabasti+Oral) followed by Group B(Oral). Medknow Publications 2007-10-01 http://www.ayujournal.org/text.asp?2007/28/4/77/68811 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68812 2007-10-01 all journal:Ayu
Assessment of the principle "Purvah Purvoativriddhatvatvardhayeddhi Param Param" in Context of Rakta-Kshaya as Mentioned in Sushruta Samhita Dadu, V Dwivedi, RR Vyas, MK The literary study was carried out on the Chapter 15 of the Sutra Sthana namely the Doshadhatumalakshayavriddhivijnaniya Adhyaya of the Sushruta Samhita followed with the study of the applied aspect of one of the principles mentioned in the chapter. Thus, an effort had been made to prove the validity of the principle of the Dhatu Poshana. The patients with the complaint of the Rakta Kshaya as per the classics like the desire for the sour and cool substances, weakness et al were given the drug, Shatavari, Asparagus racemosa which was prepared in the Ksheerapaka form in appropriate dosage. This was designed so as to assess the effect of Rasa Vriddhi (Due to the drug which is well known to increase the rasa Dhatu) on the Rakta. To compare the efficacy the Standard control group consisting of the Nξra Siddha Ksheera (Milk prepared with water) was also made. The study showed good relief in the signs & symptoms of the disease. However, an improving trend was conspicuously seen in the laboratory/ objective parameters. Medknow Publications 2007-10-01 http://www.ayujournal.org/text.asp?2007/28/4/83/68812 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68813 2007-10-01 all journal:Ayu
A Clinical Study on Uccharaktachapa (Essential Hypertension) with Virechana and Shamana Yoga (A Herbal Compound) Bhuyan, G Baghel, MS Hypertension is a psychosomatic, haemodynamic disease also known as the silent or hidden killer. The incidence of Hypertension is very high in our country and has almost taken an epidemic shape. Over 10% people of India are affected with Hypertension, majority of them are from urban areas. For this study well-established 41 EHT patients were selected for this clinical trial from the OPD of I.P.G.T. & R.A. Hospital, Gujarat Ayurved University, Jamnagar and were administered with Virechana Karma and Shamana yoga (an herbal compound). Out of 41 cases, 10 were LAMA and remaining 31 cases completed the course of treatment. Overall effect of therapy shows that, out of 31 cases 2(6.45%) got complete relief, 18(58.06%) got marked relief, 10(32.26%) got moderate relief and 1(3.23%) case remained in improved category. Statistically highly significant results (P < 0.001) were found in all the parameters. Medknow Publications 2007-10-01 http://www.ayujournal.org/text.asp?2007/28/4/87/68813 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68814 2007-10-01 all journal:Ayu
The Role of Sugar and Jaggery in the Preparation of Khadirarista Dhruve, K Prajapati, PK Khadirarista was prepared as per classical method, modification was made that jaggery was used in few batches instead of sugar for pharmaceutical comparison. Fermentation occurred earlier and yield was more in Khadirarista prepared by sugar than Khadirarista prepared by jaggery. Both the Khadirarista were analyzed physico chemically. Difference in the Alcohol content between 1.61 to 5.13 and total sugar content between 27.59 to 39.50 suggests improper conversion of sugar. HPTLC pattern showed almost equal spots in both of the Khadirarista, prepared by sugar and jaggery. Medknow Publications 2007-10-01 http://www.ayujournal.org/text.asp?2007/28/4/94/68814 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68802 2008-01-01 all journal:Ayu
Effect of Sama Veda and Hard Rock Music on Growth of Human Cancer Cell Lines In Vitro Sharma, H Kauffman, E Stephens, R Sound affects the human physiology. Cells vibrate dynamically and may transmit information via harmonic wave motions. We compared the effects of 'primordial sounds' (Sama Veda from the Ayurveda system of natural health care), or hard rock music (AC/DC, "Back in Black"), and no sound on the growth of cells in culture. Five human tumor cell lines (lung, colon, brain, breast and skin) and one normal cell line (fibroblasts) were tested in triplicate for each of an average of four experiments. The recordings of Sama Veda and "Back in Black" were normalized to maintain the same maximum amplitudes, with no significant effect on the results. Primordial sound significantly decreased the average growth across cell lines (p = 0.005 ANOVA). In the presence of hard rock music, growth of cells was significantly increased (p = 0.03) but the effect was not consistent. We conclude that sound has an effect on the growth of neoplastic and normal human cells in vitro. Medknow Publications 2008-01-01 http://www.ayujournal.org/text.asp?2008/29/1/1/68802 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Comparative Pharmaceutico- Chemical Study of 1, 7 & 50 Avartita Ksheera Bala Taila Patgiri, B Krishnamurthy, MS De, S Singh, K Avartana is one such technique by which oleaginous medicaments can be reduced into small dosage form, meanwhile increasing its potency. Avartita Ksheera Bala Taila was prepared by Atibala mula (Abutilon indicum Linn.), Taila (Black sesame oil) and Ksheera (Amul Gold 9 SNF) were taken in the ratio of 1 : 3.2 : 4. The gradual shift from Taila paka siddhi lakshana ('Phenodgama') to Ghrita Paka Siddhi Lakshana ('Phena santi') in 19th Avartana was observed in pharmaceutical study. Average 2.24 % v/v weight gain was observed in total 50 Avartita of Ksheera Bala Taila. Loss on drying, Specific gravity and Refractive index were observed decline in successive Avartana but Saponification value was found increased. Medknow Publications 2008-01-01 http://www.ayujournal.org/text.asp?2008/29/1/19/68804 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68805 2008-01-01 all journal:Ayu
Effect of Simhanada Guggulu and Punarnavarista in Tamakashwasa (Bronchial Asthma) - A Clinical Study Byadgi, PS Tripathi, AC Tamakashwasa(bronchial asthma) is characterized by wheeze,chest tightness, dyspnoea, cough. It manifests due to exposure to dust, pollen grains, cold weather etc. Mainly vata and kapha is involved along with rasadhatu. Due to abnormality in the homeostasis of dosha and dhatu leading to development of ama (mainly sama rasadhatugata malarupi kapha) resulting into genesis of various reactions inside the pranavaha srotas. Present study reveals the efficacy of Simhanada Guggulu, punarnavarista, kunjal karma, pranayam in the management of tamakashwasa (bronchial asthma). Encouraging statistical data suggest the effective management of tamakashwasa by the selected therapy. Medknow Publications 2008-01-01 http://www.ayujournal.org/text.asp?2008/29/1/25/68805 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68806 2008-01-01 all journal:Ayu
Ethnobotanical uses and bioactivity studies of Scoparia dulcis Linn Ediriweera, E Ratnasooriya, W Scoparia dulcis Linn (F. Scrophulariaceae) is a common weed which is widely distributed in many tropical countries. It is claimed to possess many therapeutic potentials according to traditional and folkloric medicine some of which are experimentally proven. This article describes its ethnobotanical claims and published bioactivities therapy. Medknow Publications 2008-01-01 http://www.ayujournal.org/text.asp?2008/29/1/31/68806 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68807 2008-01-01 all journal:Ayu
Kati Basti - A Clinical Study Bharati Kumar, A Bhikshapati, T The classical Panchakarma is a purification process. But Keraliya - Panchakarma has been derived and evolved as a health-promotion system. Kati Basti is a specialized technique of Keraliya Panchakarma in which warm medicated oil is put on Kati (lumbo-sacral region) for a specified period of time (say 40 to 45 minutes) while the patient is lying prone. The present pilot, open, clinical study was launched with a view to observe the effect of Kati Basti in 27 patients of Katishoola (low backache)/ Gridhrasi (Sciatica). Luke warm Mahanarayana taila was filled up into the trough (temp. 40 degree approx) and was kept for to 45 minutes. The procedure was carried out regularly, daily for 7 to 15 days according to the severity of the disease. Maximum prevalence of disease was observed in middle aged (38-40) and elderly (58-68). Maximum number of patients presented with difficulty in walking and low backache. Maximum number of patients of Katishoola/Gridhrasi/both showed Vataj prakriti. 15 patients showed pain during straight leg raising. After Kati Basti patients showed improvement in symptoms like low backache, pain thighs & legs, difficulty in walking, numbness soles & legs. Out of 27 patients, 5 showed good response, 4 showed poor response & 2 were lama. Medknow Publications 2008-01-01 http://www.ayujournal.org/text.asp?2008/29/1/42/68807 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68808 2008-01-01 all journal:Ayu
Ayurvedic Management of Klaibya (Male Sexual Dysfunctions) with special reference to Manasa Bhava (Psychological Factors) Bhatt, NN Shukla, VD Vata is responsible for all the Chesta, particularly of the Indriyas i.e. Dasha Indriya and Mana which are the keys for normal Sexual functioning. In five types of Vata; Prana, Vyana and Apana causes the impairment of the functioning of these Indriyas. The chief factors causing the condition Klaibya are Vata, Sattva (Mental stability or Mano dosha), Dhatukshaya in general and Shukra Kshaya in particular, Shukravaha Srotodushti and Marmabhighata. In Charaka Samhita Acharya Charaka has also narrated that Kama, Krodha, Bhaya, Shoka etc. factors affects Shukra, Deha Bala and Sattva bala leading to sexual dysfunction. The Vyakulatva of Manasa is a cause for Akshamata of Kama i.e. incapacity of Sattva (Manasa). Keeping about this view in mind, for this study 136 patients were registered and among them120 patients have completed full course of treatment which were equally divided in to four groups. The best relief in the amelioration of cardinal signs and symptoms were recorded among patients of combined group therapy. Medknow Publications 2008-01-01 http://www.ayujournal.org/text.asp?2008/29/1/46/68808 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68809 2008-01-01 all journal:Ayu
Importance of media in Shodhana of Vatsanabha (Aconite) Sarkar, PK Subha Prajapati, PK Vatsanabha (aconite) is a poisonous plant drug used as medicine in Ayurvedic system of medicine. It is used after proper 'Shodhana' treatment by various media like cow's urine, cow's milk, goat's milk, Triphala Kwatha, etc. In the present study the media after Shodhana of Vatsanabha was analyzed physico-phytochemically. The results are suggestive of extraction of toxic alkaloids in the media during Shodhana and cow's urine as better media for Shodhana of Vatsanabha. Medknow Publications 2008-01-01 http://www.ayujournal.org/text.asp?2008/29/1/52/68809 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68810 2008-01-01 all journal:Ayu
A Comparative Study on Vidangadi Churna and Trivritayukta Navaka Guggulu in the Management of Sthaulya (Obesity) Singh, A Nadkarni, M Vyas, SN Baghel, MS Sthaulya (obesity) is the most common metabolic disorder in affluent societies caused by excessive eating, lack of exercise and is a direct result of the modernization combined with lifestyle changes. The incidence of Diabetes mellitus, Hypertension, Angina Pectoris, and Myocardial Infarction etc. is higher among obese individuals. Acharya Charaka has included Atisthool in eight varieties of impediments, which are designated as 'Astha-Nindita Purusha'. He categorizes this problem under Santarpanajanita Vyadhi. Atisthool Purusha is said to suffer from the following eight defects; Ayurhasa, Javoparodha, Alpa-vyavayita, Daurbalya, Daurgandhya, Swedabadha, Ati-trisha, Ati-kshudha. In this study Vidangadi Churna and Trivrityukta Navaka Guggulu were given in tablet form in the dose of 1 gm twice a day for 30 days in the OPD of I.P.G.T. & R.A.,G.A.U., Jamnagar. Total 55 patients were registered for clinical trial of the study. Out of which, 39 patients completed the study. Total 15 patients of Vidangadi Churna group completed the full course, of which 5 patients showed mild improvement (33.33%), 4 patients showed moderate improvement (26.67%) and 1 patient showed marked improvement(6.67%). Total 24 patients of Trivrityukta Navaka Guggulu group completed the full course, among which 10 patients showed mild improvement (41.67%), 8 patients showed moderate improvement (33.33%) and 3 patient showed marked improvement (12.50%). Medknow Publications 2008-01-01 http://www.ayujournal.org/text.asp?2008/29/1/56/68810 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical Study on Psychic Traits in Stress Induced Chronic Insomnia and its Management with Mamsyadi Ghrita & Dashamula Kwatha Shirodhara Singh, AK Chandola, HM Ravishankar, B Thirty patients of stress induced chronic Insomnia (Anidra) have been studied to evaluate the role of psychic traits (Manasabhava) in etiopatho-genesis and management of disease. A compound herbal Ghrita based formulation consisting of Jatamansi (Nardostachys Jatamansi), Shankhapushpi (Convolvulus pluricaulis), Ashvagandha (Withania somnifera) and Tagar (Valeriana jatamansi) 20gms twice a day for six weeks has provided highly significant relief (p<0.001) on Sleeplessness (86.54%), Distress (89.28%) and Sleep Time (94.29%).In other group of patients Dashamula kwatha Shirodhara half an hour daily in morning for 21 days showed highly significant relief on Sleeplessness (61.29%),Distress (63.64%) , Sleep Time, Sleep Quality and Freshness after Awakening (100% each).Relief in mental health has been observed in both groups based on Hamilton's Anxiety Rating Scale, Hamilton's Depression Rating Scale, Brief Psychiatry Rating Scale and Manasabhav pariksha on Ayurvedic parameters. Medknow Publications 2008-01-01 http://www.ayujournal.org/text.asp?2008/29/1/9/68803 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Comparative Study of Hansa Mandura & Phalatrikadi Kwatha in the Management of Pandu w.s.r. to Iron Deficiency Anaemia Vyas, MG Dave, AR Shukla, VD Pandu is a disease characterized by pallor of body which strikingly resembles with 'Anaemia' of modern science. Rakta has been considered as a key factor for the Jeevana1, Varna Prasada2, Ayu3 and Mamsa Pushti2 of the body. Many a times it is seen that Rakta gets vitiated by Doshas, mainly by Pitta dosha as Rakta is Pittavargiya and disease like Pandu appear. In Ayurveda, Pandu is considered as a specific disease with its own pathogenesis and treatment.4 Thus an attempt has been made to study the disease Pandu Roga according to Ayurvedic text in the parlance of Iron Deficiency Anaemia. The commonest type of Anaemia that is met with in practice is Iron Deficiency Anaemia. Iron Deficiency anaemia has potential consequences i. e. IDA reduces the work capacity of individual and entire population and brings serious economic consequences and obstacles to national development. It is the only nutrient deficiency which is also significantly prevalent in virtually all industrialized nations. Children, Adult Male and Females suffer the most form of this malady. Large number of these patients could be easily and cheaply treated with single oral iron preparation those are also available in Ayurvedic Classical book. In modern medicine, there is good treatment for Anaemia with considerable result but that is only for acute deficiencies Anaemias. No significant therapy is there for chronic Anaemia which occurs due to metabolic defects. Ayurveda can provide better management in this area. Total 40 patients were registered in the study and were randomly divided in to two groups. In Group A (HM), 2 tab. of Hansa Mandura was given BD with Anupana of Takra and in Group B (PTK) 40 ml of Phalatrikadi Kwatha with Madhu was given twice a day on empty Stomach. The effects of therapy in both groups were assessed by a specially prepared proforma. The result obtained proved that, Group A (HM) showed better results than Group B (PTK). In Group A, 40% patients were completely cured and 60% were found with Marked Improvement, while in Group B only 7.14% patients got Complete Remission and Marked Improvement was observed in 35.71% patients. Medknow Publications 2008-04-01 http://www.ayujournal.org/text.asp?2008/29/2/100/68798 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Comparative clinical Study of Tiladi Kshara and Varunadi Ghrita in the management of Ashmari Mandal, AK Dwivedi, RR Manjusha, R Ravishankar, B Ashmari (urolithiasis) is third most common and distressing affliction of the urinary tract. It have peculiar tendency of recurrence even after surgery. The causes and mechanism of their formation is still obscure but various factors like age, sex, irregular food habit, metabolic disorders, sedentary life style, occupation, hydration status, nutritional deficiency, geography etc. may be responsible for the formation of stone. Detailed description of Ashmari is the specific contribution of Acharya Sushruta and he included it in the "Eight Mahagada". It may be owing to its potentiality to disturb the anatomy and physiology of urinary system. Total 29 patients with classical signs and symptoms with confirmed diagnosis by USG of KUB were treated in three divided groups for 60 days. 10 patients were treated with Tiladi Kshara, 500mg 1 capsule twice daily orally, 10 patients were treated with Varunadi Ghrita, 10gm twice daily orally and 9 patients were treated with Swarjika Kshara (as a control group), 500mg 1 capsule twice daily orally. After completion of trial for 60 days, it was observed that Varunadi Ghrita has provided highly significant relief in pain, burning micturition, dysuria, and haematuria whereas Tiladi Kshara has provided highly significant relief in pain, burning micturion and dysuria and Swarjika Kshara has provided highly significant relief in burning micturition only. After careful observation it can be concluded that Varunadi Ghrita possesses the properties to disintegration and expulsion of stone and can produce better relief in signs and symptoms of Ashmari than Tiladi Kshara. Medknow Publications 2008-04-01 http://www.ayujournal.org/text.asp?2008/29/2/107/68799 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study of aetiopathogenesis of Mootrakrichhra w.s.r. to Lower urinary tract infection in pregnancy and puerperium and their Management with Brihat Dhatryadi Ghanavati Kour, B Donga, SB Dei, LP Pandya, MA Urinary tract infection particularly lower urinary tract infection is one such disease, the frequency of which is only second to upper respiratory tract infection, but the incidence and degree of morbidity and mortality is greater than those of upper respiratory tract infections. According to WHO report, puerperal infections (including UTI) are an important cause of morbidity and mortality for mothers in developing nations. During pregnancy and puerperium, the symptomatic infections constitute most number of visits to obstetricians and are the most common bacterial infections during pregnancy. The symptoms of Lower urinary tract infections are nearer to those of Mootrakrichhra but it has not been described among Garbhini & Sootika Vyadhis. So, in the present study Mootrakrichhra has been tried to study w.s.r. to Lower urinary tract infection following the principle given by Acharya Charaka. So, for this study two groups were selected:- one with Brihat Dhatryadi Ghanavati and other with placebo. The improvement was statistically significant in Brihat Dhatryadi Ghanavati as compared to placebo group. Medknow Publications 2008-04-01 http://www.ayujournal.org/text.asp?2008/29/2/113/68800 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Clinical Study on Management of Vandhyatva Due to Anovulatory Cycle with Mahanarayana Taila Nasya and Uttarbasti Meera, R Pandya, MA Tanna, CH Dei, LP Donga, SB The term Vandhyatva (female infertility) is considered as one of the Vatik disorders among 80 types of Vata vyadhi in Ayurvedic texts. Mahanarayana taila mentioned in Yogatarangini in Vatarogaprakarana (38-47) in the form of Nasya and Uttarbasti, for failure to conceive is supposed to be one of the effective therapy in this field. A clinical study on 33 selected patients of female infertility having anovulatory factor, being diagnosed by TVS (Trans vaginal sonography for 2 consecutive cycles) were divided in to 3 groups, Gr-A-(n=11)for Nasya, Gr-B-(n=12) for Uttarbasti & Gr-C(n=10)-(placebo control)). In Nasya group 8 drops of Mahanarayana taila were administred in each nostril for 7days - 3days break and again for 7days, for two consecutive cycles after cessation of bleeding. In Group-B 5ml of Mahanarayana taila was administered in form of Uttarbasti, for consecutive 2cycles, for 3 days after cessation of bleeding. In Group C 500mg capsule filled with roasted wheat flour powder twice a day was administered for consecutive two cycles with water. In this study, 66.66% ovulation occured in Nasya administered group, 28.57 % ovulation occurred in Uttarabasti administered group and 25% ovulation occurred in control group. Medknow Publications 2008-04-01 http://www.ayujournal.org/text.asp?2008/29/2/118/68801 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Stambhana Guna (Checking Property) of Scoparia Dulcis Linn Ediriweera, E Galhena, G Liyanage, S Jayakody, J Hettiarchchi, H Ratnasooriya, WD Scoparia dulcis Linn (Family: Scrophulariaceae, Sinhala: Wal koththamalli, Sanskrit: Unknown) is a perennial herb, growing in many tropical countries including Sri Lanka. In Sri Lankan traditional medicine, it is used in the treatment of diabetes mellitus and in unspecified urinary diseases. Therefore, we thought it may possess Stambhana guna. If it has Stambhana properties, then it should impair mobility and flow of body fluids and thereby, induce Stambhana Kriya in Mutravaha Srotas (Antidiuretic action), Stambhana Kriya in Raktavaha Srotas (Haemostatic action) and Stambhana Kriya in Annavaha Srotas (Antidiarrhoeal action). The aim of this study was, therefore, to evaluate whether the decoction of S. dulcis (using several concentrations) possess antidiuretic action (using hydrated assay technique), haemostatic action (using Lee and White method) and antidiarrhoeal action (using castor oil induced diarrhoea) in rats, following oral administration. The results showed that decoction of S. dulcis possess marked antidiuretic (Stambhana Kriya in Mutravaha Srotas), blood clotting (Stambhana Kriya in Raktavaha Srotas) and antidiarrhoeal actions (Stambhana Kriya in Annavaha Srotas). Further, no toxic effects (in terms of overt signs of clinical toxicity, stress, behavioural abnormalities, hepatic or renal toxicity) were evident with subchronic administration of the decoction. It is concluded that Scoparia dulcis has Stambhana property as expected, and may be used in the treatment of Prameha (polyuria), Rakta Pitta (bleeding from different parts of the body) and Atisara (diarrhoea). Medknow Publications 2008-04-01 http://www.ayujournal.org/text.asp?2008/29/2/65/68791 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Clinical Study of Udavarta w.s.r. to Udara Vata Modhera, TK Baghel, MS Commonly word Udara is used for abdomen and Vata for Vata Dosha. Here, the term Udara Vata is used for Prakupita Vata in Udara. Means Udara Vata term is used for flatulence predominant condition. However, Udavarta terminology is very wide, hence it should not be used for the flatulence like common presentation. Hence Udara Vata has been studied under the broad term of Udavarta. Total 74 patients were registered in this study under two groups. In Group-A (treated group) 31 patients completed full course of treatment, were given Yavanikadi Vati 1g twice a day (2 tab b.d., Each tablet of 500mg) in Adhobhaktakala, with water for 1 month. In Group-B (control group), 30 patients have completed course. These patients were given Shankha Vati. Dose, Duration & Kala was same as in Group-A. Better therapeutic response has been observed in Udgara Bahulya (73.86%), Adhmana (74.32%), Shirah shoola (79.69%), Adhovata Sanga (62.26%) with highly significant relief in Group-A. Comparison of the therapies showed that overall better results observed in both groups but percentage improvement in Group A was better than Group B. Medknow Publications 2008-04-01 http://www.ayujournal.org/text.asp?2008/29/2/69/68792 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Critical Analysis of Mantra Chikitsa Pratap, G Narayana, PB Shetty, SK Ayurveda is not merely a compendium of therapeutics based on herbal, animal and mineral resources of medicament but deals with philosophy of life and living. According to Ayurveda concept we do not treat the symptoms, always the disease pathogenesis is given importance. Only when a pathogenesis is controlled, The disease will be subsided. Charaka and Vagbhata primarily classified the treatment procedure as follows ; 1. Daivavyapasraya (Divine therapy or Treatment by faith). 2. Yukthivyapasraya (scientific therapy or treatment upon reasoning). 3. Sattvavajaya (Psycho therapy - treatment by self control).In Daivavyapasraya, Daiva has been used in the sense of karmas, which are related to our previous life. Daivavyapasraya method creates confidence and removes the fearing and pessimistic tendencies. The following treatment in the shape of good deeds is recommended for disease caused by Daiva "Mantra, Aushadha, Mani, Mangala, Bali, Upahara, Homa, Niyama, Prayaschitha, Upavasa, Swasthyayana Pranipata and Yathragamana.The word Mantra literally means revealed sound. It means a sound or a combinations or sequence of sound developed spontaneously. Their power is not in the words themselves but in the sound vibrations created when they are uttered verbally. The source of Mantra power is twofold:1. Pertaining to its form. 2. To its content. The structure of Gayatri Mantra is in perfect tune with the science of cosmic sound. The great significance of Japa is not due to chance, or without any firm basis. Had it been so, such a large number of devotees and yogis of the Gayatri sadhana would not have been advised to waste time in practicing more and more japa for longer and longer durations. Medknow Publications 2008-04-01 http://www.ayujournal.org/text.asp?2008/29/2/74/68793 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Psycho-Pharmacological study on Antidepressant and Anxiolytic Effect of Brahmi Ghrita Deole, YS Ashok, BK Shukla, V Ravishankar, B Chandola, HM This research is carried out with the aim to study anti depressant and anxiolytic effect of Brahmi ghrita, which comprises Brahmi (Bacopa monnieri Linn),Vacha (Acorus calamus Linn),Shankhapushpi (Convolvulus pluricaulis Chois) and Kushtha (Saussurea lappa C.B.Clarke) processed in cow's ghee. Brahmi, which is the main ingredient of the formulation, is proven for its Tranquilizing, Smooth muscle relaxant, Nootropic, Nerve tonic, Adoptogenic, Anti stress, Anxiolytic, Anti depressant, Memory booster, learning facilitator effects. Vacha has sedative, analgesic and tranquilizing effects. Kushtha shows anticytotoxic, diuretic, hypolipidemic, hypotensive, spasmolytic, immunostimulant activity. Shankhapushpi has spasmolytic, hypotensive, sedative, anti inflammatory, antistress, anti anxiety effects. Considering these activities, Brahmi ghrita is studied on experimental models such as Gross behaviour test, Anti depressant test and Anti anxiety test on Swiss Albino mice of either sex. The trial drug showed mild hyperactivity in gross behaviour and dose dependent mild anxiolytic effect in open field behaviour and Elevated plus maze test. Dose dependent variation in effect of Brahmi ghrita is observed in behaviour despair test, as it is mild stimulant at lower dose and depressant at higher dose. It showed significant potentiation of L-DOPA activity in comparison to water control, but the effect was insignificant in comparison to ghrita control. Thus it showed complex nature of pharmacological activity. Medknow Publications 2008-04-01 http://www.ayujournal.org/text.asp?2008/29/2/77/68794 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Clinical study on Ayurvedic Principle of management of Rheumatoid Arthritis Parida, DK Baghel, MS Shukla, VD Amavata is a very distressing disease among joints disease. It occurs throughout the world in all climates and ethnic groups. Treatment provides symptomatic relief but the underlined pathogenesis is unchecked due to absence of effective drugs. There is no curative treatment found till today. Various mode of treatment modalities are being used in Ayurveda for the management of RA, like Swedana, Virechana, Basti, and internal medicines. Chakradutta has mentioned a complete line of treatment for the management of Amavata. In this study 85 patients were randomly selected in two groups as "A" & "B". Group A was provided Kaishore guggul and Group B provided with fully ayurvedic principles described by Chakradutta in Amavata context. It is revealed that group B had promising results. Medknow Publications 2008-04-01 http://www.ayujournal.org/text.asp?2008/29/2/84/68795 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Experimental Study of Vanga Bhasmas Hiremath, RR Pandey, BL Jha, CB Vanga Bhasma is an effective medicine of Ayurveda used for the treatment of various disorders. Its properties are Mehaguna, Medoguna, Balya, Brahana, Chakshushya etc. It has a wide range of therapeutics specially indicated in Sarva Prameha (all types of Urinary disorders). Vanga Shodhana was done by using Kadali kanda Swarasa and Nirgundi mixed Haridra churna. Three medias i.e. Apamarga and Kumari/ Haratala/ Parada are used for Marana process and prepared three different types of Vanga Bhasmas. This study has exercised the option to presuppose Balya property of Vanga Bhasmas to get reflected in simple parameters of structural and functional strength. Thus parameters of growth and general behavior, ability to sustain stress, effect on blood, proteins and ions have been included to asses Balya effect of Vanga Bhasmas on experimental animals and the result was found encourageous. Besides pharmacological activity the toxic potential of the therapy was also examined on above effects on long term and high dose as well as Histopathological changes on albino rats. No significant changes were observed on animal experiments. Medknow Publications 2008-04-01 http://www.ayujournal.org/text.asp?2008/29/2/88/68796 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Etiopathological study of Amlapitta and its Management with Chinnodbhavadi Yoga Ghana Vati and Medhya Rasayana compound Ch., S Kadlimatti, SM Thakar, AB Vyas, SN Amlapitta is a disease caused due to vitiation of certain attributes of Pitta like the Drava guna (fluidity) and Amla guna (sourness) causing Vidagdhajirna at the initial stages and later causes inflammation and corrosion of the Sleshmadhara kala of the Amashaya i.e. mucous membrane of the stomach and duodenum. In modern science it can be correlated that Vidagdhajirna is a type of simple dyspepsia and Amlapitta as gastritis. In this study total 42 patients of Amlapitta were registered, out of which 36 patients were completed the treatment. They were divided into two groups and treated with 1) Chinnodbhavadi Yoga Ghana Vati 500 mg tablets 2 T.I.D for 30 days.2) Medhya Rasayana Compound 500 mg tablets 2 T.I.D for 30 days. The patients were subjected to evaluation of cardinal sign and symptoms of Amlapitta on the basis of scores according to the severity before and after treatment. The results showed that Medhya Rasayana Compound provided very good results in the Roga bala, Agni bala, Deha and Chetasa bala. Medknow Publications 2008-04-01 http://www.ayujournal.org/text.asp?2008/29/2/93/68797 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68769 2008-07-01 all journal:Ayu
Clinical Study of Immunomodulatory Effect of an Ayurvedic Compound (Vayasthadi Yoga) in Children Jain, CM Meen The immune system plays a vital role in maintaining the body's overall health and resistance to disease. In children, the immune system is in immature state and thus, they are unable to protect the body from invaders. They are suffered from recurrent infections. These infections are suggestive of a deficiency in the local or systemic host defence. In this clinical study, an Ayurvedic compound "Vayasthadi Yoga" has shown statistically significant improvement in morbidity features - Running nose, Sore throat, Nasal obstruction, Enlarged tonsils, Cough, Dyspnoea, Fever and Diarrhoea. Medknow Publications 2008-07-01 http://www.ayujournal.org/text.asp?2008/29/3/123/68769 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Shireeshadi Ghanavati in the Management of Tamaka Shwasa Agarwa, S Baghel, MS Considering the high prevalence of the disease and the need to look for alternative medicine, a randomized open clinical trial on 29 subjects of Tamaka Shwasa (Bronchial Asthma), screened on the basis of clinical findings were allocated to two groups. Group A having 15 cases received the trial drug Shireeshadi Ghanavati (SGV) and 14 cases in Group B received Shwasa Kuthar Rasa (SKR) as a control drug. In SGV group, 13.33% of patients were observed with complete remission and 40% patients got marked improvement, 20% each were observed as improved as well as unchanged. The response was encouraging and left the scope for further study. Medknow Publications 2008-07-01 http://www.ayujournal.org/text.asp?2008/29/3/128/68770 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical study on psychic traits in stress induced insomnia (Anidra) and it's management with Tagaradi Kwatha & Mahishi Dugdha Shirodhara Vansh, B Chandola, HM Thirty three patients of stress induced insomnia (Anidra) have been subjected to evaluation of various psychic traits (Manasabhava) to see their role in etiopathogenasis and management of disease. The 21 patients have been treated with compound herbal formulation consisting of Tagar (Valeriana wallichi), Shankhapushpi (Convolvulus pluricaulis), Brahmi (Bacopa monnieri), Musta (Cyprus rotundas), Ashwagandha (Withania somnifera), Jatamansi (Nardostachys jatamansi), Munakka (Vitis vinifera), Raktachandana (Pterocarpus santalinus), Parpataka (Fumaria indica), Kutaki (Picrorhiza Kurroa), Dashmula, Amaltas (Cassia fistula). This has been given in the dose of 20 gm twice a day as coarse powder to prepare decoction by 'Chaturthavashesh' method mentioned by Sharangadhara for six weeks in one group.Remaining 12 patients were treated with bufallow milk Shirodhara, half an hour daily in morning for 21 days. These patients have been evaluated for their mental health and degree of stress based on Hamilton's Anxiety Rating Scale, Hamilton's Depression Rating Scale, Brief Psychiatry Rating Scale and Manasabhava Pariksha on Ayurvedic parameters. Tagaradi Kwatha provided highly significant relief (p<0.001) on Sleeplessness (44.06%), SleepTime (40.81%) and Freshness after awakening (42.42%) whereas bufallow milk Shirodhara provided highly significant relief on Sleeplessness (58.33%), Sleep Time (57.14%), Sleep Quality (84.21%) and Freshness after awakening (91.66%). Relief in mental health has been observed in both the groups in the patients of Insomnia. Medknow Publications 2008-07-01 http://www.ayujournal.org/text.asp?2008/29/3/133/68771 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Lacto-Vegetarian Diet Sharma, H Diet and Digestion are considered among major pillars of life in Ayurveda. Therefore the knowledge about quantity and quality of food with its effects on body becomes essential. Research studies are providing ample evidence of significant health benefits from meatless diet and from increasing consumption of fruits and vegetables. The present study reviews hazardous effects of meat based diet and it's role in causing various diseases. Also it throws light on health benefits of lacto vegetarian diet. Medknow Publications 2008-07-01 http://www.ayujournal.org/text.asp?2008/29/3/140/68772 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Comparative Study of Shatavari Ghrita and Goghrita Uttarbasti in the Management of Vandhyatva w.s.r. to Cervical Factor Kodinariya, CM Pandya, MA Vandhyatva has been described by the Acharyas in a very wide sense including Nidana and chikitsa. In curative aspect, so many treatments have been mentioned, but in which type of infertility or on which factor like Ritu, Kshetra, Ambu, Beeja, it will act, is not clearly mentioned. Now-a-days, it is the need of time to evaluate all the things separately. So, an effort has been made to study the effect of Uttarbasti on Cervical factor (Kshetra and Ambu dushti). For clinical trial, total 14 patients were selected in two groups to evaluate the therapy. Easily available and non controversial drugs like Shatavari Ghrita and Goghrita were selected. For desirable therapeutic drug concentration at the site of action, Intra Cervical Uttarbasti as a route of drug administration was selected. For diagnosis of Cervical cause, Cervical Mucus Test and Post Coital Test were done before and after treatment. To evaluate the effect of therapy, Sim's huhner and Moghissi's Cervical Mucus Scoring pattern was adopted. Significant results were found in both the groups, but Shatavari Ghrita showed better results in comparison to Goghrita. Medknow Publications 2008-07-01 http://www.ayujournal.org/text.asp?2008/29/3/144/68773 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Vyoshadivati and Rasanjanadi Taila Nasya on Pratishyaya-Rhinitis Vaghela, DB Singh, K Pansara, KN Narayana, B Gangama, M Pratishyaya i.e. Rhinitis means the condition in which continuous nasal discharge is found. It is the disease condition in which Kapha, Pitta and Rakta move along with the Vata in the same direction. Rhinitis is an acute illness having a few days duration accompanied by the inflammation of the mucous membrane of the nasal cavities and sometimes the pharynx & larynx also. The present study was done on 40 patients of Pratishyaya divided in four groups, with 10 patients in each group. Group-V was treated with Vyoshadi Vati & Group-R with Rasanjanadi Taila in Nasya form. Group-VR treated with the combination of Vyoshadi Vati orally, Rasanjanadi Taila in Nasya form. Group-C was a control group treated with placebo therapy. After enrolment of the patients, vital signs & symptoms of Pratishyaya such as nasal discharge, headache, nasal blockage etc. were studied before and after the treatment. The result of the study indicate that the 'VR' group bestowed highly significant relief in almost all the signs and symptoms of Pratishyaya-Rhinitis.'V' group and 'R' group also exhibited encouraging results. Medknow Publications 2008-07-01 http://www.ayujournal.org/text.asp?2008/29/3/149/68774 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Ayurvedic Management of Avascular Necrosis of the Femoral Head - A Preliminary Study Kadlimatti, SM Subbanagouda, PG Sanakal, AI Deshpande, M Among the many conditions that affect bones, Avascular Necrosis (AVN) is one in which bone tissue is necrosed (dead) due to the injury or any occlusion in the blood vessels nourishing the bone tissue. Avascular necrosis of the femoral head is the most common type of necrosis affecting the bones. AVN of the femoral head may be classified mainly into 2 types, 1. Post traumatic and 2. Idiopathic. The arteries supplying the femoral head are very narrow and hence are easily liable to injury followed by mere dislocation or a sub capital fracture (near the head) of the femoral neck. This leads to the lack of nourishment to femoral head resulting in necrosis. In the other type, the arteries become occluded for which the reason is not known. It may be asymptomatic in the beginning but, later mild to severe degree of pain is seen along with change in the gait. Management is not an easy task. The objectives of the treatment include the preservation of structure & function and relief of pain. Many surgical procedures like Drilling and Insertion of Bone Grafts, Modified Whitman or Colonna reconstruction and insertion of prosthesis is carried out. All these procedures are cost worthy and prognosis is very poor. An effort was made to evaluate the efficiency of Ayurvedic formulations in the conservative management of AVN of the femoral head. Four patients of Idiopathic AVN of the femoral head were treated with Tikta Dravya Siddha Ksheera Basti, Abha Guggulu and Ajasthi Bhasma. The results were encouraging. The therapy provided marked relief from pain, tenderness, general debility and improvement in the gait. The grade of AVN did not worsen and was maintained. The therapy is cost effective. Medknow Publications 2008-07-01 http://www.ayujournal.org/text.asp?2008/29/3/154/68775 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Comparative Clinical Study of Nirgundi Ghana Vati and Matra Basti on Amavata Mahto, RR Dave, AR Shukla, VD Amavata is seen most commonly in the patients due to their changing dietetic habits, social structure, environment and mental stress and strain. It is one of the commonest diseases among the crippling disorders caused due to the impairment of Agni. '?a' , which is manifested due to the derangement of Agni, gets lodged in Kapha-Sthanas with the help of vitiated Vyana Vayu producing stiffness, swelling, tenderness in the joints, making the person lame. Derangement of Kapha Dosha especially Shleshaka Kapha in Amavata producing joint pains and swelling with tenderness can be co-related with Rheumatoid Arthritis. The management of this disease is merely insufficient in other systems of medicine and patients are continuously looking with a hope towards Ayurveda to overcome this challenge. So, in the present study total 39 patients were registered and were randomly divided into two groups. In group A- Nirgundi Ghana Vati, 2 Vati twice/day was given for 30 days, while in group B- Matra Basti once a day in the format of 3 days interval after every 7 days of total 21 days course followed by Nirgundi Ganavati for 30 days. The Nidana, signs & symptoms, course of the disease were observed carefully to get idea about the Samprapti of the disease. The effects of therapy in both groups were assessed by a specially prepared proforma. The result of the study shows that Matra Basti group provided better relief as compared to Shamana group in the management of the disease. Medknow Publications 2008-07-01 http://www.ayujournal.org/text.asp?2008/29/3/160/68776 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Pharmaco-Therapeutic Study to Assess the Comparative Efficacy of Chakramarda & Gaumutra Bhavita Chakramarda on Vicharchika Vadi, AK Sharma, PP Ravishankar, B Patel, BR The study has been taken to assess the comparative efficacy of Chakramarda & Gaumutra bhavita Chakramarda on Vicharchika, through Pharmaco-therapeutic studies. After the Pharmacognosy of the drug, pharmacological studies like Immunomodulation activity (Effect on cell mediated immunity - CMI & effect on humoral anti body formation - SRBC), anti inflammatory activity and anti histaminic activity have been done , which suggested that weak anti inflammatory and moderate CMI suppression effect may be responsible. Pharmaceutical study with the experiments like Uniformity of tablets, Tablet Hardness, Disintegration time of tablet, Loss on drying, Water & Methanol soluble extractive, Ash value, pH value, Volatile oil, Qualitative Test & TLC of the drugs have been carried out and it suggests thatsame compounds were present in both the drugs. In the Clinical study Gomutrabhavita Chakramarda group has shown better results than other. Medknow Publications 2008-07-01 http://www.ayujournal.org/text.asp?2008/29/3/171/68777 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Hepato-Protective Effect of Triphala in Infective Hepatitis (Hepatitis B): A Clinical and an Experimental Study Sujata, N Kumar, S Gupta, GD Rai, NP "Are we sitting at the Volcano? Time to wake up." Liver is the hub of wheel of life. Liver is one of the extensively explored areas in Modern Medicine. Among the various diseases affecting it, Hepatitis-B virus infection is the most common cause. The clinical symptoms of Hepatitis-B are similar with those described under Kamala Roga in Ayurveda. Hepatitis-B, because of its potential to cause life-threatening complications like Cirrhosis, Ascites, and Hepatocellular Carcinoma, has been kept on the top of National Agenda in Public Health Administration. Hepatitis-B virus infects more than 2 billion people worldwide, out of which 360 millions are chronic carriers annually<sup>1</sup> . It is the 10<sup>th</sup> leading cause of mortality and Hepatocellular Carcinoma is the 5<sup>th</sup> most common cancer in the world which accounts for 1.2 millions deaths globally every year<sup>2</sup> . Western Medicine, despite its enormous success does not offer any promising cure and here the role of traditional systems of medicine cannot be overlooked. Ayurveda, the ancient science of life is enriched with ample amount of herbal drugs, which are tested and trusted and subjected to thorough clinical and experimental studies. The drugs have been proved safe and highly efficacious with almost no side effects and have been included in Pub-Med India and National Index of Medicine. A trial has been conducted as part of research program to evaluate the role and efficacy of Triphala in the management of Hepatitis-B. Total 44 cases of Hepatitis-B were registered, out of which 38 cases completed the treatment schedule .The result of treatment were found satisfactory in terms of clinical and biochemical parameters. Moreover, Experimental Study has also been carried to substantiate the above clinical findings and also evaluate the mode of action of trial drug. Medknow Publications 2008-07-01 http://www.ayujournal.org/text.asp?2008/29/3/176/68778 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Tikta Kshira Basti and Patrapinda Sweda In The Management of Cervical Spondylosis (Asthigata Vata) Shah, JP Thakar, AB Shukla, VD Cervical spondylosis is a degenerative disease of cervical spine. It is age related degenerative disorder but the incidence is increasing day by day due to faulty postures while working, sleeping, sitting and faulty dietary habits. According to Ayurveda this disease can be co-related as Asthigata Vata owing to its basic pathogenesis of bony degeneration .In the present study, the effect of Panchatikta Kshira Basti along with Asthishrinkhala Vati and Nirgundi Patrapinda Sweda along with Asthishrinkhala Vati were studied and compared.Both of these groups were also compared to Asthishrinkhala Vati (Shamana) Group. The result of combination proved better. In Neurological manifestation Basti proved better, whereas in symptoms like stiffness, pain, tenderness Patrapinda Sweda showed better results. Medknow Publications 2008-07-01 http://www.ayujournal.org/text.asp?2008/29/3/181/68779 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Clinical Study of Rajanyadi Vati in the management of Grahani Dosha in Annadavastha Panchal, K Anand, IP Patel, KS Childhood is a very tender but superb stage of human life. The effect on physical development and mental status of this period has its effect over rest of life. In day to day paediatric practice, paediatricians come across a good number of patients suffering from diseases related to gastrointestinal tract. The common symptoms of gastrointestinal tract disorder include abdominal pain, bowel disturbances (like diarrhoea, constipation), nausea, vomiting, abdominal distension, anorexia, chronic flatulence and failure to thrive due to disturbed digestion. Grahani Dosha is a disease entity related with gastrointestinal disorders, to which children are more vulnerable. It gives rise to number of long term as well short term complications from an aemia to failure to thrive, which can hamper the overall growth of child. In the present study 52 patients were registered and randomly divided into two groups. In Group A - Rajanyadi Vati (treated group) and Group B - Bhunimbadi Vati (standard control group) was given for 4 weeks. The etiological factors, sign & symptoms were observed carefully to elucidate the Samprapti (etio pathogenesis) of the disease. The effect of the therapy in both the group was assessed by a specially prepared proforma. In Group A (Rajanyadi Vati) 68.18% of patients were moderately improved, whereas in Group B, Bhunimbadi Vati showed mild improvement in 75% patients. Medknow Publications 2008-07-01 http://www.ayujournal.org/text.asp?2008/29/3/186/68780 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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National Pharmacovigilance Programme for Ayurveda, Siddha and Unani Drugs Galib Acharya, R It is a popular perception prevailing throughout the globe that, the traditional practices (let it be Ayurveda, Siddha or Unani) doesn't produce any adverse effects. The utilization of thesed drugs since thousands of years itself supports this notion. But, in present scenario, increased globalization of these practices has raised concerns about their safey and efficacy, whichcreated doubts on Indian heritage. To tackle these concerns, a system like Pharmacovigilance is needed to be established. Considering this, Dept. of AYUSH, Ministry of Health & Family Welfare, New Delhi launched Pharmacovigilance Programme for ASU Drugs and announced establishment of a National Pharmacovigilance Resource Centre at IPGT &RA, Jamnagar which will look after drug related incoveniences of traditional practices. The present article will provide a brief outlook of the programme since inception. Medknow Publications 2008-10-01 http://www.ayujournal.org/text.asp?2008/29/4/195/68755 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical Evaluation of 'Menorid Capsules' in the Management of Menopausal Syndrome Sharma, AK Khuteta, R Soni, A The study was conducted for the clinical evaluation of 'Menorid Capsules' (A Proposed Herbomineral formulation) in the management of Menopausal Syndrome on various scientific parameters. Thirty clinically diagnosed cases were selected from O.P.D. / I.P.D. of the National Institute of Ayurveda Hospital, Jaipur and S.M.S. Medical College attached Hospital, Mahila Chikitsalaya, Jaipur. The cases were randomly divided into three groups - Group I (Control Group - Oral Conjugated equine estrogen), Group II (Trial group - Menorid Capsules) and Group III (Placebo group - Capsules filled with Starch). It was observed that overall clinical improvement was maximum in patients of Group II. Overall improvement in Laboratory parameters was maximum in patients of Group I. Patients of Group III developed mild improvement in the feeling of wellbeing. The patients of Group I developed some adverse symptoms, but no adverse effects were reported in any of the patients of the Group II & III. From the current research project, it can be concluded that the trial drug 'Menorid capsules' is a safe, dependable and cost effective remedy for the management of the patients of Menopausal Syndrome. Medknow Publications 2008-10-01 http://www.ayujournal.org/text.asp?2008/29/4/201/68756 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Clinical Study on Effect of Brahmi Ghrita on Depression Deole, YS Chandola, HM Depression is the commonest psychiatric disorder affecting 121 million peoples worldwide. Vishada and Avasada are the two conditions in Ayurveda , which are similar to depression. Ayurveda is enriched with various 'Medhya rasayana drugs' in which Brahmi ghrita is one herbal formulation. A randomized placebo controlled clinical trial was carried out with the aim to evaluate the anti depressant and psychoactive effect of Brahmi ghrita on depression. Total 42 patients fulfilling the DSM-IV criteria for major depressive episode were registered for study. Out of 42, 35 patients completed the treatment. In these, total 25 patients were managed with Brahmi ghrita and 17 with placebo capsule. In the former group, 20 patients completed the treatment, whereas in the later,15 patients completed treatment. Specialized Ayurvedic rating scales like Manasa Pariksha Bhava, Manasa Vibhrama Pariksha as well as Hamilton Depression Rating Scale (H.D.R.S.) was adopted to assess the effect of therapy. The effects were also examined on Chief complaints and associated complaints of depression. When effect on H.D.R.S. was analyzed, Brahmi ghrita showed moderate improvement in 50% patients and mild improvement in 35% patients. Its total effect was statistically highly significant (p<0.005) as compared to placebo. Also, in overall effect, Brahmi ghrita resulted in moderate improvement for 40% patients and mild improvement for 55% patients, which is statistically significant at 1% level as compared to placebo. Medknow Publications 2008-10-01 http://www.ayujournal.org/text.asp?2008/29/4/207/68757 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Pharmacological Evaluation of Shinshapa (Dalbergia sissoo Roxb.) stem bark as Analgesic and Anti-inflammatory activities Rupani, A Patel, BR Shukla, VJ Ravishankar, B Sharma, PP Shinshapa (Dalbergia sissoo Roxb.) belongs to family Fabaceae. Stem bark of Shinshapa is mentioned in Gridhrasi (Sciatica) by Acharya Vangasena. It suggests that Shinshapa may have analgesic and anti inflammatory properties. No references available on Pharmacological activity in the form of Ghanavati of stem bark of Shinshapa. To provide experimental basis to it, this study has taken up. Shinshapa (Dalbergia sissoo Roxb.) Ghana vati (Dried water extract) as test drug and Parijata (Nyctanthes arbortristis Linn.) Ghana vati (Dried water extract) as reference standard drug were assessed for analgesic and anti inflammatory effect on Wistar strain albino rats and Swiss albino mice at a dose level of 200mg/kg po and 260 mg/kg po respectively. Dose fixation was done according to Paget and Barnes (1969). Anti inflammatory activity was evaluated by employing, Carageenan induced hind paw oedema in albino rats and Formaldehyde induced hind paw oedema in albino rats, while analgesic effect was evaluated by employing, Formaldehyde induced paw licking in albino rats and Tail Flick Response in mice. Result indicates presence of only the moderate effect in reference standard- Parijata and weak to moderate anti-inflammatory and moderate analgesic activity in the test drug- Shinshapa. Thus it can be suggested that this study failed to provide an un-equivocal experimental evidence as basis for their clinical efficacy in the treatment of Gridhrasi (Sciatica). Medknow Publications 2008-10-01 http://www.ayujournal.org/text.asp?2008/29/4/215/68758 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Random Estimation of Different Values in Musaka Taila from Iodine Value Saxena, RB Bio-science problem is very wide and deep. Mathematical application in various bio-sciences problems is emphasized. The simple and relative equations have been developed for the determination of different constant values from iodine value. Medknow Publications 2008-10-01 http://www.ayujournal.org/text.asp?2008/29/4/220/68759 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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The Role of Prasarani Taila Matra Basti and Vatari Guggulu in the management of Rheumatoid Arthritis Das, AK Vyas, SN Chandola, HM Ayu is defined as conjunction of body, mind, soul and senses. Each has been given due importance in the maintenance of health and prevention and cure of disease. Rheumatoid Arthritis (Amavata) is one of the crippling diseases, claiming maximum loss of human power. It is not only a disorder of locomotor system, but also is a systemic disease and named, after its chief pathogenic constituents i.e. Ama and Vata in Ayurveda. The main causative factor, Ama is the result of malfunctioning of digestive and metabolic mechanisms. The disease is initiated by the consumption of diets prepared with some ingredients of opposite qualities (Viruddha Ahara) and simultaneous indulgence in Viruddha Ahara in the pre-existence of Mandagni. Though, according to Ayurveda, Ama and Vata are chiefly pathogenic factors, Kapha and Pitta are also invariably involved in its pathogenesis. Primarily the pathogenesis (Samprapti) originates in the gastro-intestinal tract (Annavaha srotasa) then branches out through the Madhyama rogamarga, the middle aspect of pathogenic process of disease, with special inclination for Shleshma sthana especially articular joints (Sandhi). Rasa, Asthi and Majja Dhatus are primarily involved. Dushyas like Mamsa Dhatu, Snayu and Kandara are also affected. Sandhishoola, Sandhishotha, Inhibition of joint movement (Stabdhata) and intolerability on touch in joints (Sparshasahyata) are salient feature of the disease. The disease Amavata has a chronic course and malaise, anorexia, heaviness of the body nausea, fever etc. are responsible for crippling of the patients in the long run. In the present study, Matra Basti with Prasarani Taila, Vatari Guggulu are selected as the remedy of Amavata, due to properties like Amanashana, Vatashamana, Deepana, Pachana and Rasayana Prabhava.In the present study, 28 patients of Rheumatoid Arthritis divided into two groups were treated with Vatari Guggulu orally and along with Prasarani Taila Matra Basti for 30 days. The effects of therapy were assessed by a specially prepared clinical research proforma. The result showed that better symptomatic relief was observed in Matra Basti group in comparison to Vatari Guggulu group. Medknow Publications 2008-10-01 http://www.ayujournal.org/text.asp?2008/29/4/224/68760 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Comparative Study on Vrikka Samrakshanatmaka and Ashmarighna Effect of Tiladi Kshara and Varunadi Ghrita (Nephroprotective and Lithotripsic effect) Mandal, AK Dwivedi, RR Manjusha, R Ravishankar, B The kidneys play a very important role in the maintenance of homeostasis in the body. They perform several important functions like normal fluid and acid base balance, electrolyte balance, production and secretion of hormones and excretion of metabolic products. Kidneys are highly vascularized organs receiving around 20-25% of the cardiac output, because of this reason they are constantly exposed to xenobiotics including environmental pollutants, and hence are on the risk of nephrotoxicity. In Ayurveda several drugs are used as nephroprotectives, in this study the well known Ayurvedic compound formulations ' Varunadi Ghrita' and 'Tiladi Kshara' were used to evaluate the nephroprotective effect against gentamycin induced nephrotoxicity. Total 36 animals in 6 groups were taken and weighed. Test drugs and vehicles were administered to respective groups, after two hours, Gentamycin (60 mg./kg. I.P) was administered to all groups except water control group for 15 consecutive days. On 16th day animals were weighed again and sacrificed by cervical dislocation and severing the jugular veins. Blood samples and kidneys were collected for estimation of serum biochemical investigations and histopathological studies respectively. Accurately weighed kidney tissues were also taken and homogenate was prepared for the estimation of different biochemical investigations. The result in the context of the objective of the study emerges that Varunadi Ghrita possess moderate nephroprotective activity. However, the study could not provide basis for its relevance to the probable efficacy of the test drug in kidney stone induced nephropathy. Medknow Publications 2008-10-01 http://www.ayujournal.org/text.asp?2008/29/4/231/68761 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68762 2008-10-01 all journal:Ayu
Management of Kitibha (Psoriasis) by Some Indigenous Drugs Rai, PK Singh, OP Rai, NP Singh, SK Kitibha is a type of kshudra kushtha described in different Ayurvedic classics. It is a Vata-Kaphaja disorder. The clinical symptoms of Kitibha described in Ayurveda resembles with the clinical symptoms of Psoriasis. The clinical features of Kitibha described by Kashyapa represents remission, relapse and seasonal variation, which is present in Psoriasis. It is one of the most common dermatological problems of unknown etiology. It is a chronic, genetically determined, inflammatory and proliferative disease characterized by dry, well-circumscribed, silvery scaling papules and plaques of various sizes with spontaneous remission, relapse and seasonal variation. Lesions distributed all over the body with silvery scales, covering loops of dilated superficial capillaries underneath which are presented as tiny bleeding points on removal of scales (Auspitz's sign). It affects about 2% of world population. Various races and communities differ in the susceptibility to this disease. In India it affects about 1.5% of population including both the genders. It appears to be common in Europeans than in Orientals. Psoriasis like other skin disorder is a challenge to the medical sciences. In modern medicine there is no definite treatment for this disease. The medicines which are available to treat the disease are not very effective and cannot be used for long term management because of their local and systemic side effect as well as toxicity. Medicines which are used in Ayurveda are safe and being practiced since thousands of years. A large number of drugs are described in Ayurveda for the treatment of kushtha. Keeping this view in the mind, Guduchi and Bakuchi were selected as oral drugs and a Taila for local application which contains Tuvarak taila, Chakramarda beej, Snuhi ksheer and Gomutra was chosen. Medknow Publications 2008-10-01 http://www.ayujournal.org/text.asp?2008/29/4/235/68762 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Clinical Evaluation of Vrishya Effect of Kushmanda [Benincasa hispida (Thunb.) Cong.] Beeja Mishra, S Sharma, PP Pandya, TN Ravishankar, B Kushmanda is a well known plant since Vedic period. It is botanically known as Benincasa hispida (Thunb.) Cong. belonging to the family Cucurbitaceae. It has been highlighted for its Medhya, Mutral, Vrishya etc. properties by various Ayurvedic authors. Its seeds are used by some tribals for enhancing sexual power. The seeds of Benincasa hispida procured from Agra (U.P.) were authenticated in pharmacognosy laboratory of I.P.G.T. & R.A. to prepare granules in the pharmacy of Gujarat Ayurved University. Total 30 patients were randomly divided in two groups and treated with: Placebo - wheat flour tablet, 2 tab. twice daily with 3 gms of sugar and lukewarm water and Kushmanda seed granules, 6 gms twice daily with lukewarm water for 45 days. The assessment was done on the basis of changes in seminal parameters and sexual health parameters. The study revealed that Kushmanda seed granules increased penile erection, rigidity and orgasm etc. Medknow Publications 2008-10-01 http://www.ayujournal.org/text.asp?2008/29/4/239/68763 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Clinical Study on Pothaki - Trachoma Bavalatti, N Rajagopala, M Matalia, P Pothaki - Trachoma is one of the diseases, having multiple follicles in the lids resembling red mustard seeds, occurring mainly due to vitiation of Kapha Dosha. Trachoma is a specific communicable keratoconjunctivitis usually of chronic nature caused by the Chlamydia trachomatis. It is primarily affecting the superficial epithelium, characterized by formation of follicles, papillary hyperplasia and pannus; the natural resolution of which is by cicatrisation involving potentially considerable visual disability. The study was done on 49 patients of Pothaki-Trachoma. Pippalyadi eye drops were instilled in group A and Ofloxacin in group B as a standard control. After enrollment of the patients in the study, vital signs and symptoms of Pothaki-Trachoma such as discharge, itching, heaviness, swelling etc. were studied before and after the treatment. Amongst the registered patients 16 patients completed the course of treatment in group A and 15 patients in group B. In group A, 43.75% patients got moderate improvement, 50.00% got mild improvement and 6.25% were unchanged, whereas none of the patients were completely cured. In group B, 26.67% got marked improvement, 53.33% were moderately improved and 20% got mild improvement. Medknow Publications 2008-10-01 http://www.ayujournal.org/text.asp?2008/29/4/243/68764 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Comparative Evaluation of the Effect of Ayurvedic Psychotherapy and Cognitive Behaviour Therapy in the Patients of Depression Verma, V Tripathi, JS Depression is an important psychiatric disorder in medical condition. This can interfere significantly an individual's ability to function. The difficult life situation and unrealistic thinking are most important precipitating factors for depressive disorder in majority of cases. These problems cannot be tackled completely through pharmacotherapy unless their causes are rooted out completely by psychotherapeutic intervention. Cognitive behaviour therapy (CBT) is an established treatment for depressive illnesses. In the present study a comparative evaluation of CBT has been done with the Sattvavajaya, the Indian form of psychotherapy described in ancient medical literature of Ayurveda. The intra group comparisons based on the assessment of results on N-I scale, MHQ and Adjustment scale have been presented, which demonstrate comparable results. Medknow Publications 2008-10-01 http://www.ayujournal.org/text.asp?2008/29/4/248/68765 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Comparative Study of Virechana Karma and Kala Basti in the Management of Pakshaghata Vekaria, VM Shukla, VD Bhatt, NN Stroke is not a disease in itself but is heterogeneous group of disorders. Hemiplegia is one of the most frequent clinical presentations of stroke (CVA). Pakshaghata is clearly correlated with hemiplegia according to signs and symptoms described in various Ayurvedic literatures. Though ample research is being carried out for alleviating the disease and new avenues are being explored for treating early ischemic injury, yet the disease still remains incurable. In this study the line of treatment for Pakshaghata i.e. Virechana Karma as mentioned by Charaka has been studied. Basti Karma, the first line of treatment for Vata Vyadhi like Pakshaghata was selected for the study. After the completion of the study, comparative admirable results were observed by Basti Karma in contrast to Virechana Karma. Medknow Publications 2008-10-01 http://www.ayujournal.org/text.asp?2008/29/4/254/68766 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative study of Savarnakara Ghrita and Savarnakara Cream in the management of Kikkisa w.s.r. to Striae Gravidarum Joshi, J Donga, SB Pandya, MA Kikkisa is Tridoshaja Vyadhi clinically characterized by burning, itching, stretch marks on the body particularly on the abdomen, thighs and breast region. It is usually found in the second trimester of pregnancy particularly in the seventh month due to the overstretching. It can be correlated with Striae gravidarum from modern science. It is the major problem of modern cosmetic conscious era, where more than 90% of the women suffer from this condition. It makes much psychological distress to the women. Considering the above facts, for the present study 64 patients were selected for clinical study, out of which 57 patients completed the course of treatment and were randomly divided into three groups. Each group was further divided into two sub-groups i.e. preventive and curative. In group A, 10 gm of Savarnakara Ghrita was given twice a day for oral administration for two months. In group B, Savarnakara cream in sufficient quantity was given for local application twice a day for two months. In group C, wheat flour capsule (500 mg) was given twice with Krishna Mruttika Lepa twice a day for two months. Better therapeutic response had been observed in Group B than Group A. In Group C, the condition of most of the patients started deteriorating. It was found that therapy is more effective in preventive group than in curative group. Medknow Publications 2008-10-01 http://www.ayujournal.org/text.asp?2008/29/4/260/68767 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Comparative Study on the Efficacy of Mustakadi Avaleha and Gojihwadi Avaleha in the Management of Pratishyaya w.s.r. to Recurrent Upper Respiratory Tract Infections in Children Lokesh Anand, IP Patel, KS Pratishyaya is a complex disease involving several symptomatologies and diverse pathogenesis. It is well known for its recurrence and chronicity. Recurrence of the disease occurs because the Doshas reside in their latent stage (predisposing stage) & give rise to the same disease when aggravating factors are favourable. The specific features of a child like Dosha Dushya Malalpata, Saukumaryata, Aparipakwa Dhatu, Asampurna Bala etc. lower the immune status of the child & makes him/her more susceptible for repeated infections like Pratishyaya. Recurrent Upper Respiratory Tract Infections (RURTI) are can be corelated with Pratishyaya. URTIs include colds and influenza-like illnesses having significant impact on the health and academic performance of students.The textbook of modern medicine clearly states that there is no proper standardized treatment for URTIs & has lots of limitations. Injudiciously use of antibiotics & steroid to infants and young children leads to depression of immune system. Therefore, patients are continuously looking with a hope towards Ayurveda to overcome this challenge. In the present study, total 40 patients were registered and randomly divided into two groups. In group A, Mustakadi Avaleha & in group B, Gojihwadi Avaleha was given for 6 weeks.The Nidana, signs & symptoms were observed carefully to get idea about the Samprapti of the disease. The effects of therapy in both groups were assessed by a specially prepared proforma. The result obtained showed striking similarity. In both the groups, an apparent difference in all the sign & symptoms was observed. In Mustakadi Avaleha and Gojihwadi Avaleha group maximum number of patients i.e. 53.33% and 46.67% of patients respectively showed marked improvement. Medknow Publications 2008-10-01 http://www.ayujournal.org/text.asp?2008/29/4/266/68768 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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The Radioactivity-Magneto Radio Frequency-Activated Nano Excitations In Quality Growth Medicinal Plants Swarup, R The plants developed with the disease fighting inherited natural character on the basis of specific chemical condensations are called 'medicinal plants'. The drug potential of the medicinal plants however, is restricted with the limited concentrations of chemicals responsible for disease curing character. Making use of this criteria our experts in medical sciences developed the modern medicines as the dense concentrations of disease fighting chemical drugs either by chemical synthesis or extracting from the medicinal plants. Now, since such chemical condensations are not natural, hence they decay with time. In order to make the modern medicines sustainable, an extra combination of chemicals is artificially attached, hence their expiry date is elongated a bit. Since this extra attachment of chemicals is not natural, that is why the allopathic medicines become time barred and imposing side effects on the patients treated with these medicines. An attempt is being made to enrich the medicinal plants with the disease fighting chemicals having their grown up medicine-index (MI) under Radioactivity Magneto-Radio-Frequency (MRF) interactions activating nano-excitations in these species. The nano-structurings in medicinal plants had been experimentally confirmed by trans-conductance second derivative peak structures using their magneto-potential records under Radioactivity & MRF-perturbations. Radioactivity-MRF-Nano excitations on medicinal plants Aloe Vera, Catharanthus Roseus had grown up their medicinal index (MI), 11 & 8 times greater respectively. Medknow Publications 2009-01-01 http://www.ayujournal.org/text.asp?2009/30/1/1/68728 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Concept of Ritus and their effect on Bala Jangid, C Vyas, HA Dwivedi, RR A randomized Survey study was done on healthy volunteers to evaluate effect of Ritu on Bala, as mentioned in Charaka-Sutrasthana-6/8. According to which, the beginning of the Visarga kala i.e Varsha and the end of the Adana Kala i.e. Grishma Ritu mark the Daurbalya (Decreased Bala) of the Human being. While the end of Visarga Kala i.e. Hemanta and the beginning of Adana Kala i.e. Shishira Ritu signify maximum Bala and middle of the both Kalas i.e. Sharad & Vasanta Ritu respectively medium Bala is observed. To prove the validity of the principle Sutra, 95 healthy volunteers were registered, out of which 80 continued throughout the study period for the Bala assessment. The Bala assessment was performed with the help of a specific scoring pattern based upon 12 parameters (from Ayurveda as well as Modern science), in three different Ritus viz. - Hemanta, Vasanta and Varsha. The study illustrated significant to highly significant differences in the most of the parameters, which is supportive to the selected Sutra that the maximum Bala is found in Hemanta Ritu, medium Bala in Vasanta while minimum in Varsha Ritu. Medknow Publications 2009-01-01 http://www.ayujournal.org/text.asp?2009/30/1/11/68730 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Shirishadi Decoction and Snuhyadi Lepa on the patients of Vicharchika (Eczema) Kaur, M Chandola, HM Vicharchika, a Kshudra Kushtha though involves only epidermis, its tendency of recurrences continues to pose problems to the physician. In allopathic medicine, it can be co-related to Eczema, a disease which is resultant of delayed type hypersensitivity mediated by memory T lymphocytes in the skin and the clinical lesions may be acute (wet and edematous) or chronic (dry, thickened, and scaly), depending on the persistence of the insult . In this study, out of 46 patients registered, 33 completed the treatment. These patients were treated with : Shirishadi Decoction (30 ml) twice daily along with the local application of Snuhyadi Lepa for the duration of 60 days. Results of the study revealed that Shirishadi Decoction and Snuhyadi Lepa provides significant relief in the signs and symptoms as well as eosinophil count of the patients of eczema. Medknow Publications 2009-01-01 http://www.ayujournal.org/text.asp?2009/30/1/16/68734 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative drug trial on Santarpanottha Madhumeha Vishesha (Syndrome X) Sharma, L Sharma, I Syndrome-X has emerged as an area of special interest to medical faculty as it houses worst lifestyle pathologies in one patient. There being unknown common ground to Diabetes Mellitus, Hypertension, Obesity & dyslipidemia, the nomenclature adopted is Syndrome-X. As these diseases are observed to be led by Diabetes Mellitus, the other names of the syndrome are Metabolic Syndrome & Insulin resistant syndrome. This is why the Ayurvedic name attributed is 'Santarpanottha Madhumeha Vishesha'. The present study was aimed at observing & evaluating the common Nidana along with a comparative clinical study of two herbo-mineral compounds. 100 diagnosed patients of Syndrome-X were selected and randomly divided in two groups of fifty patients each; Group-A receiving Compound - A, Whereas Group-B receiving Compound - A with Medohara (Navak) Guggulu respectively. The vehicle for both the groups was Dashamoola decoction in a dose of 40 ml twice a day for 45 days. It was observed that most patients in group -B had significant improvement in Shrama, Prabhoot mootrata, Daurbalya, Vibandha, Kanthatalu shosha, Pipasadhikya & Sada. Medknow Publications 2009-01-01 http://www.ayujournal.org/text.asp?2009/30/1/22/68736 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study on the role of Brihat Dashamoola Taila Nasya and Laghu Sutashekhara Rasa in the management of Ardhavabhedaka w.s.r. to Migraine Parekh, H Rajagopala, M Migraine is one of the common causes of recurrent headache. According to IHS, Migraine constitutes 16% of the primary headache and affects 10-20% of the general population. The diagnosis is mainly based on clinical history. Moreover, unilateral headache with paroxysmal nature is the only symptom mentioned for the disease Ardhavabhedaka by ancient scientists. Ardhavabhedaka has been explained as Tridoshaja by Acharya Sushruta, Vata-Kaphaja by Charaka and Vataja by Vagbhatta. But the different quality of pain such as Toda, Bheda, etc. describes the Vishama nature of Vata dosha. A study in 2002 that analyzed over 800,000 cases of migraine reported that most migraines are not treated according to any expert recommendations or accepted evidence. Our Acharyas have mentioned Nasya Therapy as the master key for all urdhavajatrugata vikaras. Considering all such things the present study was selected, in which total 44 patients were registered and were randomly divided into two groups. In group A, Laghu Sutashekhara Rasa & group B, Brihat Dashamoola Taila Nasya along with Laghu Sutashekhara Rasa was given for 6 weeks. In group A & in group B, maximum number of patients i.e., 35% & 52.94% respectively showed marked improvement. Medknow Publications 2009-01-01 http://www.ayujournal.org/text.asp?2009/30/1/29/68737 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68742 2009-01-01 all journal:Ayu
A Comparative Pharmaceutical Standardization of Taila and Ghrita preparations of Guduchi (Tinospora cordifolia) Vaghamshi, R Jaiswal, M Prajapati, PK Patgiri, BJ Guduchi (Tinospora cordifolia (willd) Miers.), is a well-known herbal drug used as a potent Rasayana (rejuvenating), Raktashodhaka (blood purifier), Kushthaghna (drug for skin diseases), Medhya (brain tonic) and Tridoshahara (pacify the three aggravated Doshas) drug in different dosage forms. Guduchi taila and Guduchi ghrita are examples of Sneha kalpana (Oleagenous formulations) described for the treatment of Kushtha roga (skin diseases) by Acharya Chakradatta. Thus in this study both Guduchi taila and Guduchi ghrita were prepared by utilizing Guduchi kalka, Guduchi kwatha and Go-dugdha along with Murchhita tila taila and Murchhita go-ghrita. All the samples were analyzed on various organoleptic, physicochemical and phytochemical parameters for developing the standards for the formulations. Total eight samples of Guduchi taila and five samples of Guduchi ghrita were prepared by following classical method to maintain process uniformity and to validate the standard procedure. Thin Layer Chromatography profile of the test formulations were also carried out to establish the chromatographic profile for the same. Thin Layer Chromatography study shows more number of spots in Guduchi taila in comparison to Ghrita preparation. Medknow Publications 2009-01-01 http://www.ayujournal.org/text.asp?2009/30/1/34/68742 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68744 2009-01-01 all journal:Ayu
A study on Shvasahara Karma of Tamalaki (Phyllanthus fraternus Webster) Sen, B Dubey, SD Singh, VP Tripathi, K Tamakashvasa as described in Ayurveda is a disease of Pranavaha Srotas (Respiratory system) involving multiple etiopathogenesis. The clinical features are nearly similar to that of Bronchial asthma described in Modern medicine. This study was designed to explore the therapeutic effect and synergistic action (if any) of a plant Tamalaki (Phyllanthus fraternus Webster). Tsmalaki is included in Shvasahara and Kasahara groups, used in many formulations prescribed in Shvasaroga in Ayurveda. Research works suggest its antihistaminic property in experimental model and effective in non bacterial upper respiratory disorders. The present study comprises 3 groups (each 10 patients). Group A was treated with trial drug Ghanasattva of P. fraternus Webster, 500mg, thrice daily, orally; while Group B was treated with modern standard drugs (a) Tab. Theo-asthalin, thrice daily, orally and (b) Asthalin inhaler, SOS and Group C as combination of both therapies. Total duration of treatment was 45 days. The observations reveal that, Group A has much better improvement in increasing Jaranashakti (t=7.57; p<0.001) and Ruchi (t=9.86; p<0.001) in comparison to Group B and Group C. Moreover, Group C was found more effective in reducing majority of sign-symptoms as such Breathlessness (t=9.00; p<0.001), Cough (t=6.47; p<0.001), Expectoration (t=9.00; p<0.001) Wheezing (t=7.96; p<0.001), Rhonchi (t=7.96; p<0.001), Jaranashakti (t=4.71; p<0.01) and Ruchi (t=6.68; p<0.001). Medknow Publications 2009-01-01 http://www.ayujournal.org/text.asp?2009/30/1/42/68744 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical Study of Anurjata Janita Pratishyaya (Allergic Rhinitis) & Comparative Assessment of Nasya Karma Shukla, VD Baghel, MS Allergic rhinitis is an atopic disease. Atopic allergy is a type-1 hypersensitivity reaction which produces IgE antibodies to allergens viz. pollen, dust, etc. In Ayurveda direct reference of allergic rhinitis is not available, but concept of allergy is scientifically explained under 'Asatmyaja Vyadhi' while its effects are explained in context of hereditary, Viruddhahara, Dushivisha and Ritu Sandhi. Various types of Pratishyaya are explained clearly in all samhitas. However, symptoms of Vataja pratishyaya like Tanu Nasa Srava, Shirashoola, Kshavathu etc. more related with symptoms of allergic rhinitis. In the present study, patients of allergic rhinitis are evaluated on the basis of general evaluaton scale consisting parameters like nasal obstruction, sneezing, itching etc. Total 69 patients were selected and randomly divided into 3 groups viz : 1) Shunthi tail Nasya for 14 days, followed by internal drug Sudha Haridra 2 gms TDS. for 21days; 2) Pradhamana Nasya with Katphal churna till samayaka shuddhi lakshana obtained ,followed by internal drug Shuddha Haridra 2 gms TDS for 21days; 3) Only oral drug Sudha Haridra 2 gms TDS for 21 days. It was observed that symptoms like sneezing, rhinohorrea, headache, itching were almost completely relieved in all groups. Medknow Publications 2009-01-01 http://www.ayujournal.org/text.asp?2009/30/1/47/68745 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Study on Guggulu with special reference to Analgesic Effect Dwivedi, A Dixit, SK Ayurvedic drugs containing Guggulu are predominantly used in Vataja disorders, where pain is the foremost symptom. Hence it was thought that Guggulu might be having analgesic effect. This research paper deals with various experiments on 20 albino rats to ascertain analgesic effect of Guggulu. Medknow Publications 2009-01-01 http://www.ayujournal.org/text.asp?2009/30/1/5/68729 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68747 2009-01-01 all journal:Ayu
An Experimental evaluation on Nephroprotective activity of Nagaradi Kashaya Meena, MK Kushwah, HK RajAgopala, M Ravishankar, B Kidneys are among the highly vascularised organs receiving around 20-25% of the cardiac output. Because of this reason they are constantly exposed to xenobiotics including environmental pollutants, many a times leading to impairment and damage to the kidney. In such a situation, availability of nephroprotective drugs would serve very important therapeutic purpose. In Ayurveda several drugs are used as nephroprotectives and this group of drugs acts as good non-specific cytoprotectives. In this context ayurvedic classical formulations, Ashmarihar kashaya (Siddha yoga samgraha chap. 18) and Nagaradi kashaya (Chakradatta chap. 28) were studied as nephroprotective agents in the present experimental study on Albino rats. The results were assessed by using a battery of parameters i.e. serum biochemical parameters, biochemical parameters in kidney homogenate and histopathological study of the kidney and heart. It was observed that the gentamicin and cisplatin induced nephropathy was mild to moderately antagonized by using Ashmarihara kashaya; while, no antagonism of nephropathy was noticed in Nagaradi kashaya as nephroprotective agents. Surprisingly, it was seen that, both drugs produce mild to moderate cardioprotective effect against gentamicin and cisplatin induced cardio-toxicity. Medknow Publications 2009-01-01 http://www.ayujournal.org/text.asp?2009/30/1/55/68747 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical Evaluation of Alambushadi Compound and its Vasti in the management of Amavata (Rheumatoid Arthritis) Tiwari, SK Singh, JP The study was conducted in 64 clinically diagnosed cases of Amavata (Rheumatoid Arthritis) with objectives of clinical evaluation of Alambushadi compound combined with the Alambushadi Niruha Vasti in the management of Amavata on the basis of various scientific parameters. Statistically significant improvement was observed in clinical, functional and hematological parameters in patients of group A (Alambushadi Group) and no improvement was observed over these parameters in patients of group B (Placebo group) after the completion of the course of treatment. Alambushadi Compound has been found to be an effective therapeutic regimen in the management of uncomplicated cases of Amavata with duration of illness less than 5 years. Medknow Publications 2009-01-01 http://www.ayujournal.org/text.asp?2009/30/1/62/68748 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Pharmacognostical investigation of unexplored leaf drug Delonix elata (L.) Gamble from folklore practice Wijayasiriwardena, C Sharma, PP Chauhan, MG Pillai, A Delonix elata (L.) Gamble (Poinciana elata Linn) commonly known as ''Sandesaro" in Gujarati, is a reputed folklore remedy used for arthritic disorders in many parts of Gujarat. Efforts were made to establish identity and quality of the leaf. Diagnostic microscopic characters were found to be long, narrow palisade cells, multicellular headed sessile glandular trichomes, crystal fibres and simple unicellular short trichomes. Quality parameters such as total ash (2.48 %) , water soluble ash (2.06%), acid insoluble ash (0.4 %), methanol soluble extractive (25.72%) have been established as per pharmacopoeial requirements. Qualitative tests indicated the presence of phenolic compounds and Thin Layer Chromatographic studies confirmed the same. Dravyaguna studies revealed its pradhana rasa as Kashaya and anurasa as Madhura. Medknow Publications 2009-01-01 http://www.ayujournal.org/text.asp?2009/30/1/68/68749 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Comparative Study on the Effect of Vidarikandadi vati and Kshirabala Taila Basti in the management of Karshya in Children Geeta Anand, IP Patel, KS Karshya is the most wide spreading health and nutritional problem in developing countries. Protein energy malnutrition is a possible condition which may be correlated with Karshya. The present study was undertaken to find out the effect of Vidarikandadi Vati and Kshirabala Taila Basti in the management of Karshya in children. Thirty patients were studied and randomly divided into two groups namely Group-A and Group-B. Group-A received Vidarikandadi Vati and Group-B received Kshirabala Taila Basti. Effect of drugs was observed at the end of thirty days. In group-A, 13.33% patients showed moderate improvement and 86.67% patients showed mild improvement, marked improvement was not found in this group. In group-B marked, moderate and mild improvement was observed in 13.33%, 73.33% and 13.33% respectively. It was concluded that Kshirabala Taila Basti is useful for the management of Karshya in children when compared to Vidarikandadi Vati. Medknow Publications 2009-01-01 http://www.ayujournal.org/text.asp?2009/30/1/73/68750 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Comparative Pharmaceutical Study of Guduchi Ghana Prepared by Kwatha and Aqueous Extract Umretia, B Patgiri, BJ Prajapati, PK Ravishankar, B The formulation 'Guduchi Ghana' was selected for the comparative study considering the market demand. The concentrated extracts of single or compound drugs are nowadays very familiar to the pharmaceutical industry. The concentrated form of any drug achieves more active constitutes than that of the powder of the raw material, even the dose is also comparatively lesser than that of the powder form. In the present study, Guduchi Ghana was prepared by two methods i.e. from Kwatha as per the reference mentioned in Siddha Yoga Sangraha and aqueous extract prepared by Soxhlet extraction procedure. Both the test drugs were prepared in three batches to maintain the Standard Operating Procedure (SOPs). Percentage yield of Guduchi Ghana prepared by Kwatha was obtained more (2.56 %) in comparison to the Soxhlet extraction method. Medknow Publications 2009-01-01 http://www.ayujournal.org/text.asp?2009/30/1/77/68752 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Aatreya Virachit Sara Samgraha Jakhmola, RK Library of Gujarat Ayurved University is rich in collections of manuscripts and many other valuable literatures. Total number of manuscripts in the library is 7350; it is preserved in university library as a property of Gulabkunverba Ayurvedic Society and Government of Gujarat. These manuscripts had been handed over to Government of Gujarat by the Ex. Princely State of Gondal Shri Bhagwat Sinhji. Efforts are being made by research scholars for their publication. One of such manuscript is 'Sarasangraha' written by Atreya and the Literary Research Unit has done the translation of the same in Hindi, along with comparative study, which is being published here. In this manuscript, the author has made every effort to make it as a book for common man so that he can utilize the knowledge for primary or initial/simple treatment. It is a compilation of different Samhita granthas and made a clinical book for public use. The author himself admits in the text that Anya granthat samasena likhitam sarasangrahah I Pathyatam tu visheshena yena vaidyabhidho bhavet II - means this book is a compilation of all the Ayurvedic literatures in concise manner so that the knowledge seeker can gain more clinical knowledge in one book. With regards to the time period of the manuscript, it is inscribed at the end of the manuscript 'Samvat 1920' and the transcripter was Shri Chaturbhuj Dave, a resident of Bhujnagar. He compiled this book by knowledge of Basic principle of Ayurveda and clinical subjects, after offering prayers to God Dhanvantari, he described the Nadi pariksha in the manuscript. Medknow Publications 2009-01-01 http://www.ayujournal.org/text.asp?2009/30/1/84/68754 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68708 2009-04-01 all journal:Ayu
Bhishak Chudamani Chakrapani Gaur, B Chakrapani was the great Commentator of Ayurveda, who has critically analysed & revealed many secrets hiddden in the verses of Charaka Samhita and Sushruta Samhita. He had excellent knowledge of Sanskrit language and grammer. The present article highlights some of the glimpses of initial four verses commented by Chakrapani on Charaka Samhita. This represents the ancient knowledge & wisdom of great Ayurvedic physicians as well as the skill to arrange a bucket of information into concise stanzas. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/106/68708 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Evaluation of Bhringarajadi Ghrita Rasayana in Premature Ageing Oza, DN Tanna, I Ravishankar, B Chandola, HM Ageing is a process of unfavourable progressive changes associated with decline in vigour affecting the quality of life. It tends to vary in different age groups by genetic factors, dietary habits, socioeconomic conditions, life style, occurrence of diseases etc. Active ageing involves every dimension of one's life: Physical, mental, social & spiritual and major challenge is to understand & promote the factors that keep people healthy as they grow older. In Ayurveda, decade wise ageing process has been described. It has two types: Kalaja jara (Timely ageing), which may be delayed by appropriate measure & Akalaja jara (Premature ageing), which is somewhat reversible by Rasayana therapy. The present study deals with efficacy of Bhringarajadi Ghrita Rasayana (Eclipta alba, Sesamum orientale Linn., Embellica officinalis Gaertn., Sugar, Cow's ghee), which has shown significant improvement on various clinical parameters related to premature ageing since ingredients of this formulation have proven adaptogenic, antioxidant, free radical scavenger, immunomodulator properties. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/109/68709 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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An approach of Ashwagandha + Guggulu in Atheromatous CHD associated with Obesity Mehra, R Prasad, M Lavekar, GS The Coronary Artery Disease or Coronary Heart Disease is the single biggest killer (60%) and the most common cause of maximum morbidity, ironically. Infact this is a disease whose control is most in our hands and it is most life style dependent. In accordance with the latest reports more than 13.7% of the adult population is suffering from coronary heart disease in India, and this figure is constantly on the rise year after year. The main cause of the disease is obesity in terms of enhanced circumference, deposition of cholesterol and fat in the inner smooth lining of the coronary arteries supplying blood to the heart resulting in their blockages and obstruction to blood flow through them. Atheromatous plaque is formed which constricts the flow of blood, oxygen, and nutrients to the heart muscles. With significant blockages, about 60% to 70% of the vessel wall and exertion the increased demand of blood by the heart is not met. More than 100 number of risk factors responsible for the development of CHD are documented. Williams in 1981 identified 246 risk factors that directly or indirectly lead to the development and onset of heart disease. The excess risk is closely related to the plasma concentration of LDL cholesterol and is inversely related to the plasma concentration of LDL cholesterol and is inversely related to the plasma HDL Cholesterol concentration. There is also a weak correlation between plasma triglyceride concentration and the incidence of coronary artery disease. Moreover, numerous clinical trials have shown that lowering high cholesterol concentrations by diet or drugs can reduce the risk of cardiac events. Moreover, many allopathic antihypertensive drugs have been shown to reduce coronary mortality but by less than might have been anticipated, possibly because many of these agents have potentially adverse effects on lipid and glucose metabolism. Ayurvediya care from both the preventive and therapeutic ways like primary protection in terms of Swasthya Vritta with Aushadha along with Pathyapathya and Ashwagandha+Guggulu provide tremendous results with secondary cardio protection by their anti hyperlipidamic, antiatherosclerotic, antihypertensive actions. All the patients already on prescribed allopathic medicine and cardiac diet were taken. An attempt to evaluate the efficacy of ayurvediya Ashwagandha+Shuddha guggulu in 500mg twice daily in 20 patients of atheromatous coronary hypertensive heart patients associated with obesity is made at Clinical Research Unit, Safadarjang Hospital New Delhi during 2007. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/121/68710 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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The conceptual and Applied study of Medha and Manas in Ayurveda Patel, N Vyas, M Vyas, H There are very few works done on the concept of Medha and Manas till today. So, the present study was carried out to describe the applied concept of Ayurvediya Mano-Vijnana, to assess Medha in classical direction and to assess the efficacy of Yashtimadhu Curna (Medhya Aushadha) and effect of Sattvavajaya Chikitsa on Medha. The subjects of the study were physically healthy volunteers between the age group of 16 to 25 years. They were divided into two groups. Selection and registration of volunteers was done by randomized open trial. In Group- A Yashtimadhu granules and in Group-B roasted Suji granules + Sattvavajaya Chikitsa were selected. For the assessment of Medha, P.G.I. Memory Scale, Recognition Cards of National Psychological Corporation, Agra was adopted and to assess the Manas Prakrti, a questionnaire was adopted with some modifications. In Group - A (Yashtimadhu group) 4.41% improvement was found which is statistically highly significant (<0.01) and in Group - B (Sattvavajaya Chikitsa group) 4.54% improvement is obtained which is statistically significant (<0.05). Yashtimadhu and Sattvavajaya Chikitsa, both were beneficial in promoting the 'Medha in healthy volunteers hence need is to conduct such a study on large number of patients for a longer duration. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/126/68711 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical evaluation of the role of Tikta Ksheera Basti and Ajasthi Bhasma in the management of Asthi Kshaya vis-a-vis Osteoporosis Kadlimatti, S Subbanagouda, PG Ayurveda explains health as an equilibrium of the Dhatus "Dhatu Samyam Arogata". Among the Dhatus, Asthi is blessed with the function of Shareera Dharana. Any derangement in Asthi results in disease. Asthi Kshaya is a condition in which there is Kshaya of the Asthi Dhatu. Asthi Kshaya may be compared to Osteoporosis, in which there is a decrease in bone mass leading to bone fragility and fractures. According to the principle of Ashrayaashrayee Bhava, when Vata increases Asthi decreases because, both are inversely proportional to each other. Classics mention the use of Basti prepared with Tikta Dravya, Ksheera and Ghrita for the treatment of Asthi Kshaya. To assess the efficacy of Tikta Ksheera Basti and Ajasthi Bhasma in the management of Osteoporosis, present study was undertaken on 40 patients of Osteoporosis. Patients diagnosed Osteoporotic by Bone Mineral Density test, were randomly divided into two groups, A and B consisting of 20 patients each. Patients of Group-A were administered Tikta Ksheera Basti in Kala Basti schedule (16 days) followed by Ajasthi Bhasma - 500 mg orally B.D. with milk as Anupana for 3 months. Patients of Group-B were given only Ajasthi Bhasma - 500 mg orally B.D. with milk as Anupana for 3 months. The combined therapy of Basti and Ajasthi Bhasma showed encouraging results in the subjective and objective parameters of Osteoporosis. The study shows that the Tikta Ksheera Basti and Ajasthi Bhasma are very effective in the management of Osteoporosis. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/131/68712 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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The Importance of Ksharasutra in the Management of Arsha (A study of 3586 Cases) Bhuyan, C Gupta, SK Dudhamal, TS To treat the cases of Arsha, there are many treatment modalities in medical science, but the question is of recurrence and complications. There are prevailing successful methods described to cure the piles in Ayurveda. Four types of treatment are available like Bheshaja, Ksharakarma, Agnikarma & Shastrakarma. Sushruta gives more emphasis on Ksharakarma. Ksharasutra therapy, is one of the most potentiated effort of ksharakarma for curing Arsha. It is a minimal invasive operative technique and requires fewer instruments. The procedure may be performed even under local anesthesia with minimal stay. In this research study, randomly selected 3586 cases suffering from Arsha of either sex were treated with Ksharasutra ligation (KSL) method under suitable anesthesia.Post operative management was carried out on usual line of management. The Apamarga (Achyranthus Aspera) Ksharasutra was prepared by standard scientific method. As per observations of the study maximum advantages were found like minimum hospital stay, no post operative hemorrhage, no adverse bowel effect and no post operative anal stenosis. Patients were able to return their normal works after one week. Recurrence rate was negligible and it had been found overall low cost effective procedure. Hence it is recommended for the management of piles to such a dense populated, poor socio-economic and developing country like India, where cost effect remains a matter for treatment. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/142/68713 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Traditional Medical Practices of Sri Lanka in Orthopaedic Treatment Ediriweeraa, E Grerub, DD Sri Lanka, is an island located between 5΀- 10΀ N latitude and 79΀- 82΀E longitude. There are a number of ancient Sri Lankan medical treatises which also include Orthopaedic Treatment in detail. Sri Lankan traditional physicians treat orthopaedic ailments very successfully. This survey was done to gather scattered knowledge in the island with the help of highly experienced traditional physicians who are involved in Orthopaedic treatment, olla leaves and text books. According to this survey several parts of the plants leaves stem barks, roots, flowers, entire plants are used to prepare medicine and these medicines are prepared in different ways such as 'Mellum', 'Beheth Roti', oil, cream, paste, sediments, thick liquids, 'Thel kiri' and 'Beheth Peni'. These various herbal medicines are used to reduce bruises, to speed up healing of fractured or cracked bones, to loosen stiffened joints and to correct the dislocations. Bandages prepared from bark of Allophylus cobbe, splints prepared from reeds of Bambusa vulgaris and bracts of Cocos nucifera are used for supporting and immobilising the traumatised parts and limbs. Traditional orthopaedic treatment in Sri Lanka is well developed and encompasses treatment of muscle sprains, dislocations and fractures, bruises and injuries incurred by people falling from trees. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/147/68714 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical Trial of Lepidium Sativum Linn (Chandrashura) in the Management of Sandhivata (Osteoarthritis) Raval, ND Pandya, TN Lepidium sativum is used in many part of Gujarat as an effective remedy for the disease Sandhivata, Amavata and Katishula. Ayurvedic texts as well as modern texts also reported its analgesic and anti inflammatory properties. In order to validate this claim, a detailed comprehensive study of seed of the plant is done. In this study total 98 patients were divided in two groups. Trial drug group was treated with Chandrashura churna and in placebo group, patients were given capsules containing starch for one month. The patients were subjected to the evaluation of cardinal sign and symptoms of Sandhivata on the basis of scores according to their severity, frequency and duration before and after treatment. Result shows that Chandrashura provides very good relief in cardinal signs and symptoms like Sandhishula(Pain in joint), Sandhishotha (Swelling), Sandhigraha (Stiffness), Sandhisphutana (Crepitus), Sparshashyata (Tenderness), and Aakunchan prasaranjanya vedana (Difficulty in movement). Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/153/68715 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Ayurvedic approach towards Cerebral Palsy Shailaja, U Jain, CM Cerebral Palsy is the leading cause of childhood disability affecting function and development. Its prevalence is approximately 1.5-2 cases per 1000 live births. Its incidence has not changed in the last more than 4 decades, despite significant advances in the medical care of neonates. Nearly 15-20 % of total physically handicapped children suffer from Cerebral Palsy. It is a condition which cripples the child during the course of growth and development. Based on its Lakshanas, the chief Dosha involved in Cerebral Palsy is identified as Vata, hence Nidana-panchaka are evolved accordingly and this disorder can be managed on the line of treatment of Vata Vyadhi. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/158/68716 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study on the management of Amavata (Rheumatoid arthritis) with Simhanada guggulu and Alambushadi churna tablet Debnath, SK Vyas, SN In this clinical study, 90 patients of Amavata (Rheumatoid arthritis) were registered from the O.P.D. & I.P.D., Deptt. of the Kayachikitsa, I.P.G.T. & R.A., G.A.U., Jamnagar. In Group-A, 40 patients completed the treatment out of 44 patients and 4 patients left the treatment before completion of the course and the treatment schedule was :- Alambushadi churna 4 tablets orally thrice daily with warm milk for 45 days (Each tablet containing 500mg Alambushadi churna) along with 1gm Simhanada guggulu orally thrice daily with warm water for 45 days and Shatapushpadi lepa applied locally over affected joints with warm water for 45 days. In Group-B, 40 patients completed the treatment out of 46 patients and 4 patients left the treatment before completion of the course. The treatment schedule was : Simhanada guggulu & Shatapushpadi lepa both given in same dose & duration as in Group-A. In Group-A maximum patients i.e. 65 % showed major improvement, while in Group-B maximum patients i.e. 50 % showed minor improvement. No side effects of the research drugs were observed during the clinical trial. Group-A therapy is more effective than Group-B therapy in this clinical study. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/164/68717 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Management of Cervical Erosion Neelam Kumar, N Cervical erosion, a benign lesion is sometimes much troublesome due to its chronicity and nature of recurrence. It is the replacement of the stratified squamous epithelium of the portio-vaginalis by the columnar epithelium of endocervix. Considering the feature of cervical erosion, it can be correlated with Garbhashayagrivagata Vrana. The treatment is designed to destruct overgrowth columnar epithelium either by chemical substances or cryosurgery or electric cautery. In Ayurvedic classics for destruction of any such lesion kshara is prescribed. Keeping these points in view, the present work a clinical comparative study has been made to assess the effect of Snuhi Kshara cauterization and electric cautery cauterization in cervical erosion cases. The Kshara and Electric cautery were applied locally on eroded cervix and results were assessed on the basis of epithelization of erosion and improvement in symptoms. The study reveals that Snuhi Kshara (Euphorbia neriefolia) cauterization showed better results than electric cautery cauterization. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/171/68718 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Toxicological evaluation of Cynoglossum glochidiatum Wall. ex. Benth (Tejaraj), a folklore aphrodisiac medicinal plant Acharya, RN Shukla, VJ Skandhan, KP Sharma, PP Ravishankar, B Roots of Cynoglossum glochidiatum Wall.ex. Benth of Family Boraginaceae identified as source plant of Tejaraj is being used by tribal people of Orissa (Kandha) for treating male sexual dysfunctions and infertility. A pharmacological study was carried out to evaluate toxic effect (if any) of the root of C. glochidiatum in two phases i.e. short term(15 days) in high dose(2500 mg./kg.) and long term (60 days) in human equivalent dose (500 mg./kg.) in albino rats. The parameters studied were ponderal, haematological, biochemical and histopathological changes. The test drug did not produce any mortality or significant toxic effect on different organs except for producing increase in blood urea level and moderate fatty degenerative changes in liver. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/175/68719 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Analysis of Phenolic acids in Different Market Samples of Vidanga (False black pepper) Nayak, SU Joshi, VK Maurya, S Singh, UP Vidanga (Embelia ribes Linn, Myrsinaceae) is a promising medicinal plant of high medicinal value documented in Ayurvedic classics, traditional Indian medicine. It is said to be the best against human pathogens. It is observed that in the crude drug market, substitutes and adulterants are commonly seen because of non-availability of genuine drug. Therefore, a market survey of Vidanga was done for the available species. Astonishingly it was seen that Embelia robusta Roxb. was found instead of E. ribes which is the botanically accepted species. Samples of Vidanga were collected from different parts of India and Pakistan, which were then subjected to HPLC analysis for the presence of phenolic acids. The analysis revealed higher level of phenolic acids in E.ribes than E.robusta, particularly cinnamic acid which is highly anthelmintic. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/181/68720 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Clinical evaluation of Haridra Khanda & Pippalyadi Taila Nasya on Pratishyaya (Allergic Rhinitis) Bhakti, C Rajagopala, M Shah, AK Bavalatti, N Allergic rhinitis is one of the most common and most prevalent ailment, familiar to all with an equal distribution more or less through out the world, rather without any exception to the developed and under developed countries. Bronchial asthma is the main complication of allergic rhinitis because patients of nasal allergy have four times more risk of developing bronchial asthma. In modern medical system a wide range of antibiotics and decongestants is available, but these drugs give only symptomatic relief. So it is need of hour to develop a treatment protocol, which helps the patients to overcome this pathetic condition hence this problem was selected for the study taking all these points into consideration. In this present study Pippalyadi taila for Nasya therapy and Haridra khanda as oral drug was selected. Total 32 patients were registered and randomly divided into two groups. In group A Haridra khanda and in group B Pippalyadi taila Nasya along with Haridra khanda were given for 2 months. The effect of therapy in both groups was assessed by a specially prepared proforma. In both the groups an apparent difference in all the signs and symptoms was observed. In oral group and combined group maximum number of patients i.e., 45.45% and 53.33% respectively showed marked improvement. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/188/68721 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Makshika in Ancient Literature Mohapatra, S Gupta, RK Jha, CB Makshika is one of the materials used since long, having therapeutic importance. Since the samhita period till the modern era of science and technology makshika has occupied an important position in Ayurvedic system of healing. It's a mineral of Copper, Iron and Sulphur. Therapeutic description of makshika is found in the literatures of samhita period but its detailed pharmaceutical description is found in the literatures of 7th Cent. AD and onwards. Bearing in mind, its high therapeutic ability many research works are going on in different leading academic institutions and reputed pharmaceutical sectors. In this current review article it is tried to highlight the makshika in ancient literatures and current researches, which will help the research workers in great extent. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/194/68722 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Comparative Study of Anu Taila and Mashadi taila Nasya on Ardita (Facial Paralysis) Thanki, KH Joshi, NP Shah, NB In present time, due to modern life style, anxiety, stress etc. reasons, incidence of Vatavyadhi like Pakshaghata, Ardita etc is increasing. Aggravation of Vata is responsible to cause Ardita. On the basis of its origin and symptoms mentioned in Sushruta Samhita, Ardita can be correlated with facial paralysis or Bell's palsy caused by involvement of VII cranial nerve. According to Acharya Charaka Nasya Karma (Navana Nasya) is the specific treatment of Ardita Roga. Bearing this idea in mind Nasya karma was selected in present study. The present study, patients, were divided into two groups. In one group, Nasya administered with Anu Taila, was taken as control drug and Mashadi Taila (Sha.S.Utt. 8/35-36) was taken as trial drug in second group. Nasya was administered, in a dose of 6 drops in each nostril for 15 days. Cardinal, Associated signs symptoms and also Doshanubandhita Lakshanas were observed before and after the treatment. To assess the voluntary movement present before and after the treatment as per House classification system of facial paralysis was adopted. If necessary and possible, heamatological and biochemical investigations were carried out before and after the treatment. In the result; both the drugs were found equally affective but Anu Taila was little more effective. In both groups, 50% patients were completely cured. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/201/68723 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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An Experimental Study on Hypolipidemic effect of some selected Ruksha Guna drugs Mishra, S Dwivedi, RR Ravishankar, B Ashok, BK Ayurveda as well as Philosophies accepted the Guna as the basic entity of the Srishti. Gunas can be classified under various categories like Adhyatmika Guna, Gurvadi Guna, Paradi Guna, Vishistha Guna. For the treatment purpose Gurvadi Gunas are widely used. Among them the Snigdha Guna and Ruksha Guna are widely used in the Samhitas. This study has been carried out to establish the Ruksha property drugs on animals as a hypolipidemic effect on induced hyperlipidemia animals. The drugs selected were having Ruksha property by Rasa panchaka. The drugs were Vacha (Acorus calamus Linn), Kushtha (Saussurea lappa C.B. Clarke), Haridra (Curcuma longa Linn), Daruharidra (Berberis aristata DC), Chitraka (Plumbago zeylanica), Karanja (Pongamia pinnata Pierre). All the drugs are having Lekhana property and Srotosodhaka karma due to Ruksha property. Based on this promise the test drug (Ruksha Guna) had been studied on various experimental models such as body weight, weight of liver, heart and kidney, food intake and faecal out put, water intake, total faecal fat content etc. The selected drugs are the representative of highest magnitude of Ruksha property which are able to influence Dipana and Pachana property and the test drug was administered with the simultaneous administration of hyperlipidemia inducing diet, but the biochemical values are found under control. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/205/68724 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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The Role of Media in the Preparation of Vanga Bhasma Jani, JH Patgir, BJ Ravishankar, B Prajapati, PK Vanga Bhasma is one of the renowned Ayurvedic metallic preparations commonly prescribed by the physicians; mostly in Prameha Roga (Urinary diseases). For its preparation, several media (Marana Dravya) and methods are recommended in Rasashastra texts, most of them are utilizing herbs as a media. Total 80 different methods are found described in classics for the preparation of Vanga Bhasma, out of which two methods are adopted for comparison through this present study. One of them was prepared through Jarana (combustion with herbs) and Marana (incineration), the application of heat by means of Upala (dry cow dung cakes) following the reference of Rasamritam (3/88-94) which is in common practice now a days. Another method is very unusual, in which application of heat was given by Vastraputa (heating by burning of cloths) without Jarana, as per the reference of Rasa Ratna Sammuchchaya (5/162). Though the second method found suitable for easy preparation but it is not useful for large scale manufacture. VMD of the Vastraputa Vanga Bhasma was 37.2 μm found which is larger than Vanga Bhasma (15.7 ΅m) prepared by Puta Method. For both the Bhasma XRD shows major phase as SnO<sub>2</sub> Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/211/68725 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Sanskrit Vangmay me Kalakalmrityuvijnana Jakhmola, RK Life & death are two expense of lifecycle, according to Darshanika birth is Vikriti (unnatural) & death as Prakriti (natural), as in case of earthanpot the earth is Prakriti & pot is Vikriti. After death of Panchabhautika sharira these elements set mixed & their respective physical Tatva. Whole comprehensive the ultimate fact, "The person his is born, his death is also certain." As in Shrimad Bhagwata Vasudev says to Kansa. Mrityurjanmavatam Veer Dehen Saha Jayate $ Adyavabdashatante Va Mrityurvai Pranienam Dhruvah $$ It means he valorous ! Death is born with the birth of organism (Living being). lt may occur today or after hundred years but is inevitable. Through this article for the acquisition of Purushartha chatustaya, to keep up to inspiration to set the longevity, the various aspects of intimacy death & various measures to overcome this has been given quick glance. One should make every effect to live long & healthy life using Devvyapashraya chikitsa, Yuktivyapashraya chikitsa & modern medical science. Important points of research paper are normally use of human being is fixed as hundred years in Shruti & Smrityadi Shastradi. The death of human, including Garbhavastha is accepted to be 101. The death occurring after setting used after enjoying full life is Kalamrityu & death cause by some (Agantuk Karnas) external causes is said to be Akalamritu. (Untimely death) Various cause of Akalamritu are describe in various Granthas. (Literature) Various Dristantas are included in this article. Which are mentioned as extraneous (Agantuk) the Trikalvettas accept death as Prakriti & birth as Vikriti & explain that it is natural that the earth pot after its destruction is transformed in to its Mula Swarupa (Root form) that is earth. Hence like this it is also natural that Sharira (Body) set merged in Mula Prakriti. Irrespective of the cause arisen for this. Right path should always follow to set happiness in this human life & Devvyapashraya chikitsa, Yuktivyapashraya chikitsa methodologies to set longevity. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/217/68726 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Ph.D. Awarded Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/221/68727 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Leaky Gut Syndrome, Dysbiosis, Ama, Free Radicals, and Natural Antioxidants Sharma, H The functioning of the gastrointestinal (G.I.) system has wide-ranging influences on the body that go far beyond the G.I. tract. According to Ayurveda-the ancient natural health care system of India - proper diet and digestion are one of the major pillars of health. Altered digestive functioning can lead to the production of Ama, a toxic material that initiates and promotes disease processes throughout the body. Optimal functioning of the G.I. tract requires proper mucosal integrity and a balanced microflora. Compromised mucosal integrity which leads to 'leaky gut syndrome,' and imbalances in the microflora known as 'dysbiosis,' result in the formation of Ama. Ama is also produced at other levels of the physiology, including the cellular level. Excessive formation of free radicals contributes to the formation of Ama. A variety of free radicals and reactive oxygen species (ROS) are produced during cellular metabolism. Excessive amounts of these reactive molecules can cause damage, starting the disease process. They are believed to be causative agents in nearly every disease. The ability to control their concentrations may be helpful for the prevention and treatment of many disorders. Antioxidants 'scavenge' free radicals and ROS, and render them harmless. Antioxidants can be lipid- or water-soluble; some are produced in the body and others are obtained from food or dietary supplements. Natural antioxidants range from vitamins to enzymes to herbal mixtures. Powerful antioxidants are present in the bioflavonoids found in concentrated form in Ayurvedic herbal mixtures known as Rasayanas. The use of these Rasayanas will be helpful in neutralizing the excessive free radical activity that contributes to Ama formation. However, the accumulated Ama in the body will not be removed by the use of Rasayanas and antioxidants alone. Other Ayurvedic methodologies are required to eradicate accumulated Ama. Rasayanas are best utilized to neutralize ongoing damage to the physiology and regenerate the system. Medknow Publications 2009-04-01 http://www.ayujournal.org/text.asp?2009/30/2/88/68707 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Compliance of Pharmacopoeial Quality Standards of Ayurvedic Medicine Sharma, SK In the era of commercialization of Ayurvedic drug sector, various issues about safety and efficacy as well as quality standards of herbal and mineral drugs are being raised at global level. Therefore development of universal standards for identification, preparation and manufacturing is utmost important. The Department of AYUSH, Government of India and its various research institutes in India have published standard formularies and pharmacopoeia for Ayurvedic single as well as compound drugs. The present article reviews these publications at a glance and also directs to standardize Ayurvedic preparations to make them accepted universally. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/221/68603 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical study on efficacy of the Traditional Sri Lankan Oil 'The Kakodumbaradi Taila' with selected Ayurvedic preparations on Shvitra (Vitiligo) Ediriweera, E Kalawana, O Karunarathna, N Nanayakkara, N Shvitra is a disease described in Ayurveda; which is produced by vitiation of Vata, Pitta and Kapha Doshas. The signs and symptoms of Shvitra are; non exudative white, red or coppery-red coloured patches on the skin, destruction of the skin, loss and discolouration of the hair, roughness, dryness, itching and burning sensation of the patches. It can be correlated with Vitiligo which is progressive whitening of the skin and hair characterized by the total absence of melanocytes in affected areas of the skin. This clinical study was carried out to scientifically evaluate the efficacy of the traditional Sri Lankan oil, 'Kakodumbaradi Thaila' which was used by Rev. Kirielle Gnanavimala, supplemented with selected additional Ayurvedic preparations namely; Thriphala Kwata, Shwetari Rasa, Kaishor Guggulu, Manibhadra Choorna and Ithriphal-E-Shahthira on Shvitra. These supplementary preparations were in-cooperated through experience, by Dr. Karunarathna. Thirty five Shvitra patients were selected and divided into two groups randomly. First group, which consists of twenty five patients, was treated with the aforesaid medicines and the second group, which consists of ten patients, was treated with the placebo. The duration of the treatment was 120 days. The response to the treatment was recorded and therapeutic effects were evaluated through symptomatic relief of the patients. Re-pigmentation of white patches was observed in the treated group and the other signs and symptoms of Shvitra (Vitiligo) were also reduced partially or completely during the treatment period. It was observed that Kakodumbaradi Thaila and aforementioned medicines are effective in treatment of Shvitra (Vitiligo). Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/225/68604 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Phytomorphological Differences of Male and Female Plants of Guduchi (Tinospora cordifolia (Willd.) Miers ex Hk.f. &Thom.) Jha, PK Chauhan, MG Pandya, TN Physical forms are the first impression by which the individuals are differentiated from each other in any organism and when it is applied with plants, phytomorphology comes to existence. Amid the various species of plants, somatic and sexual variations have been in core to make separate recognition. Sexual characters come to pompous position in case of diocious plants and Guduchi is one of them. They exhibit differences with physical forms in case of all parts as in aerial and underground viz., stem, leaf, aerial and underground roots etc. Veination is looped in leaves of male plants while it being incomplete in leaves of female plants, which becomes the characters to identify them separatly e. g. terminal marginal veination is looped in male plant unlike the female leaves where it is incomplete. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/232/68605 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Concept of Rasayana therapy with special reference to AIDS Das, B Kori, VK Baghel, MS The word Rasayana means the way for attaining excellence of Rasadi dhatus. The attributes of Rasayana therapy as mentioned in the Ayurvedic texts are to bestow longevity, impart strength, Oja and Bala etc. Oja is the factor responsible for Vyadhikshamatva (immunity) of an individual. Rasayana therapy has been classified differently in Ayurveda viz. i) Kutipraveshika (Indoor) Rasayana vidhi and Vatatapika (Out door) Rasayana vidhi ii) Kamya, Naimittika and Ajasrika Rasayanas iii) Shodhana and Shamana types etc. Achara Rasayana is also a variety of Rasayana therapy, which is just like a code of good conduct and habit. This is a non-drug approach to Rasayana. By this without using a pharmacological recipe, one can gain all the benefits of Rasayana. Acquired Immuno Deficiency Syndrome (AIDS) is a dreadful disease, constituting a great challenge to public health. The full consequence of this phenomenon may not be evident for several years because of the silent spread and slow evolution of this infection. The disease is as mentioned, produced due to the infection of HIV virus, which has the ability to destroy the T-helper cells that play an important role to maintain the immunity of the body. After the infection with HIV virus, the person gradually looses his immunity, as a result of which other opportunistic pathogenic organisms affect the person and gradually the health deteriorates and ultimately he dies with one of the manifestations. Therapeutics need to be found out to maintain the immune system of the body of the person suffering from HIV/AIDS. Rasayana drugs are considered to play a vital role in improving the immune system of the body, that way it may be helpful to promote the health of the person suffering from AIDS. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/238/68606 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Evaluation of Diet and Life Style in the Etiopathogenesis of Type - 2 Diabetes Patel, DV Chandola, HM Baghel, MS Joshi, JR The response to the psychological conditions varies person to person because each has different bodily and psychic constitution. Moreover, stressors play certain role in the development, progression, prognosis and treatment of disease. Stressful life-style affects one's mind and homeostasis of body by several psychosomatic mechanisms. Many psychosomatic disorders are wing sprouted-up with genetic disposition. Type-2 diabetes is one of such diseases, which is adversely affected by disturbed psychological conditions. Survey of 279 type-2 diabetes mellitus patients revealed that majority of the patients were taking milk, followed by curd, cheese, butter etc. Moreover, majority of patients had improper sleep and more than 3/4th female patients had attained menopause with negative mental attitude. These diabetic subjects had worry, depressed mood, anger, fear, apprehension and anxiousness up to a great extent. On Brief Psychiatry Rating Scale, psychological factors affected at various levels include: somatic concern, anxiety, emotional withdrawal, conceptual disorganization, tension, unusual thought content, excitement, disorientation etc. The data reflects that defective diet and disturbed mental health play an important role in etiopathogenesis of diabetes mellitus. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/243/68607 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical Evaluation of 'Chandramaradi Yoga' in Patients of Essential Hypertension Kumar, A Singhal, T Upadhyaya, BN High blood pressure, termed "hypertension" is a condition that afflicts almost one billion people worldwide and is a leading cause of morbidity and mortality. It has been called the "silent killer" for this reason. The majority of blood pressure readings are close to the mean value with fewer reading towards the limit of the range. As a result it is not possible to distinguish two separate groups of people as "hypertensive" and "normotensive". Therefore the threshold that defines hypertension is rather arbitrary. It would seem more appropriate to state that hypertension is a sustained level of BP above which treatment is more beneficial than harmful. In Ayurvedic classics no disease has been found which exactly simulates with essential hypertension. Previous researchers made their effort to simulate hypertension with the disease like Siragata Vata, Raktagata, and Avrita vataroga etc. The prime object of the present study was to evaluate the efficacy of 'Chandramaradi Yoga' in the patients of Essential Hypertension. The results of treatment were assessed as excellent, good, fair & poor at the end of 28 days of drug therapy. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/249/68608 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Comparative Study of Vamana & Virechana karma in Ekakushtha w.s.r to Psoriasis Parida, AN Bhatt, NN Dave, AR Shukla, VD Psoriasis is a disease which affects the skin and joints It commonly causes red scaly patches to appear on the skin. Psoriasis is a papulo squamous disorder of the skin, characterized by sharply defined erythemato squamous lesions. They vary in size from pinpoint to large plaques.The scaly patches caused by Psoriasis are called Psoriatic plaque. Psoriasis is hypothesized to be immune-mediated and is not contagious. The disorder is a chronic recurring condition which varies in severity from minor localized patches to complete body coverage. The cause of Psoriasis is not known, but it is believed to have a genetic component. Several factors are thought to aggravate psoriasis. These include stress, excessive alcohol consumption and smoking. Individuals with psoriasis may suffer from depression and loss of self-esteem. Due to chronic recurrent nature Psoriasis is a challenge to treat. Ekakushtha (Psoriasis) is a kshudra kushtha, Vata-Kapha predominant disease, Aswedanam, Mahavastum, Matsya shakalopamam, Krishna Aruna Varna are the typical sign & symptoms described under Kushtha Rogas. The study is carried out as a comparative study of Vamana & Virechana. The study was done on 35 patients of Ekakushtha (Psoriasis), where 30 patients were completed divided into two groups. In group-A Vamana was given to the patients and after Sansarjana karma, shamana yoga & Jivantyadi yamaka was given for 28 days. Total 18 patients were registered in Group A out of which 3 were dropped out. In group-B Virechana was given to the patients and after Sansarjana karma, Shamana yoga & Jivantyadi yamaka have given for 28 days. Total 17 patients were registered in Group B, out of which 2 were dropped out. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/255/68609 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Review on Official Requirements/Standards of Crocus Sativus L. (Saffron) Saxena, RB The question of standardization of quality control depends on the nature of saffron(king of spices; Family- Iridaceae) and compound drugs, on its source, which are the potent cause of variation in the properties and processes through which it is subjected to pass. With the globalization and urbanization, several lexicographers attempted for compendia of saffron in the medieval period, have given scope for substitution/ adulteration. Hence, the need of standardisation of traditional medicine (saffron) by applying scientific techniques is identified in the middle of the 20th century. For their requirement, quality grading was prepared by different countries and some of them applied. India and Spain have well prepared the standard values of saffron. Due to globalization, the quality grading is made according to specification in protocols proposed by International Standards Organisation (ISO). Different standards and objections in the official requirements/ standards of saffron have been reviewed. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/260/68610 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Process and Principles of Varnotpatti and Assessment of the Varnaprasadana in Tvakvaivarnya Savalia, S Vyas, H Vyas, M The present study has been undertaken to unfold the hidden facts about the concept of Varna, to apply this concept in practical field and to assess the efficacy of Kanakatailam Cream (Varnaprasadana drug) and Manjishthadi Ghanavati in Tvakvaivarnya. Patients from OPD of Basic Principles, Dept. of IPGT & RA were selected and randomly divided into two groups. The patients in Group A were given Kanakatailam Cream for 60 days. Patients in Group B were managed with Manjishthadi Ghanavati for the same duration. The Nidanas (causative factors), Lakshana (signs & symptoms) etc. of the disease were observed carefully on the basis of specially prepared research proforma to get idea about the Samprapti of the disease. Assessment of Varnaprasadana was done on the basis of relief in the scores given to sign and symptoms of the Tvakvaivarnya according to their severity. In Group - A (Kanakatailam Cream Group) 32.73% improvement was found, which was statistically highly significant (<0.001) and in Group - B (Manjishthadi Ghanavati Group) 38.01% improvement was obtained which was also statistically highly significant (<0.001). Both the drugs Manjishthadi Ghanavati and Kanakatailam cream have shown better results in improving the colour and decreasing the intensity of the darkness of patches. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/273/68611 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Vacha (Acorus calamus) as an Ayurvedic Premedicant Pande, DN Mishra, SK Previously many indigenous herbal drugs mentioned in Ayurvedic literature were experimentally screened on the animals and were also studied clinically on the patients as pre-anesthetic medication drug such as Brahmi, Sankhapushpi, Mandukparni, Jatamansi etc. Modern research workers had also proved their usefulness in the treatment of nervous and mental diseases. In the same chain of research work, Vacha was selected for this study and was used in the form of Ghanasatva. The clinical trial was carried on 40 healthy patients. The patients were divided into two groups randomly. The control and trial groups included 20 patients each of narrow age and weight distribution. The patients of group I (Control) were premedicated with Inj. Glycopyrrolate 0.2 mg IM and Tab. Phenergan 50 mg orally with one ounce of plain water. The patients of group II (Trial) were premedicated with Inj. Glycopyrrolate 0.2 mg I.M. and Vacha (Ghansatva) orally in recommended doses with one ounce of plain water 90 minutes prior to induction of anaesthesia. A standard anesthetic technique with pre oxygenation for 3 minutes & Nitrous oxide with Ether inhalation by spontaneous ventilation with Maggill's open circuit (Boyle's apparatus) was used. The following parameters were used to see the efficacy of the drug : Psychophysical effect before induction of anaesthesia, Cardio-respiratory and other reflex response during the course of subsequent anaesthesia & Post operative sickness in immediate post operative period up to two hours. On the basis of observations, it was concluded that Vacha controls the raised body temperature, produces good sedation and it may be helpful in the patients with preexisting hyperthermia. It does not produce any C.V.S. & Respiratory depression. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/279/68612 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Understanding and Treating Uchcha Raktachapa (Hypertension) in perspective of Vidhishonitiya Adhyaya of Charaka Samhita - A Clinical Review Dhamale, M Bhojani, MK Bhatted, S Dwivedi, RR Considering the high prevalence of the disease and the need to look for alternative medicine, Uchcha Raktachapa was screened in the light of Raktashrita Vyadhis mentioned in Vidhishonitiya Adhyaya of Charaka Samhita. Comparing the Hetu Skandha and Lakshana Skandha of Raktashrita Vyadhis with that of Uchcha Raktachapa (Hypertension), a striking similarity was revealed. To prove the practical approach of management revealed by the Aushadha Skandha of Raktashrita Vikara at Vidhishonitiya Adhyaya, a randomized open clinical trial on 30 uncomplicated subjects of Uchcha Raktachapa was allocated in 3 groups viz (A) Raktamokshana Group having 7 cases received blood letting therapy by Vene-Section, (B) Virechana Group having 12 cases were administered Anulomana with Haritakyadi Yoga and (C) Combined Group: 11 cases received Virechana (Anulomana), Rakta Mokshana along with Upavasa (Psychological Upavasa in terms of Meditation and Somatic Upavasa in terms of reduction in dietary intake). The overall effect of the therapies showed that Rakta Moshana proves more valuable in showing excellent response (28.5%) and combined therapy in marked response (81.81%). Both these therapies did not show any mild or no response. But in Virechana group, mild and no responses were also reported in few patients. The principle of line of management of Raktashrita Vikara applied to Uchcha Raktachapa produced the above results and thus Uchcha Raktachapa is proved as Raktashrita Vyadhi on parlance of Hetu, Lakshana and Aushadha Skandha. The response was encouraging and left the scope for further studies. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/284/68613 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Clinical Study to Access the Efficacy of Karaveer Taila on Kikkisa (Striae Gravidarum) Dhiman, K Sahoo, M Dhiman, KS Reproduction is an important part of the life of female. Some physiological, hormonal and metabolic changes occur in mother's body to accommodate and support the fetus throughout pregnancy. In response to these changes some ailments appear during pregnancy. Among the common ailments of pregnancy as recognized by various pioneers of Ayurveda, Kikkisa is a common disorder which appears on the abdomen during seventh month. If we look at the etiology of Kikkisa, it shows that various sages has compiled the same cause i.e. vitiation of tridosha due to the growing fetus which leads to burning sensation and itching as symptoms and stretch marks as a sign. Above said causative factors and symptomatology of Kikkisa has close resemblance with Striae Gravidarum (S.G.) as described in modern texts. In this study an attempt has been made to define Kikkisa, on scientific grounds vis-a-vis S.G. In present study, 30 clinically diagnosed Kikkisa patients were divided into two groups of 15 each and given Karaveer (Neriun indicum Mill.) taila for local application for 2 months trial period. Karaveer taila was prepared from leaves of Karaveer and Til oil as per the method of preparation of oil described in classics. Patients were assessed thoroughly for a total period of 3 months including 1 month follow up period. A statistically highly significant (p<0.001) decrease was observed in features of itching and colour of Kikkisa. No untoward reactions were observed in both the groups throughout the study period. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/295/68614 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Pharmaceutical Standardization of Naga Bhasma Tate, PM Patgiri, BJ Prajapati, PK Standard operating procedures (SOPs) should to be designed, implemented and set for all Ayurvedic drugs one by one for globalization Ayurveda. In this study, an attempt has been made to introduce SOPs for preparation of Naga Bhasma. Naga Bhasma was prepared three times by adopting two different methods. In the first method Parada and Gandhaka were taken as media, while the second method consists of Ashwattha (Ficus religiosa) and Manahshila (Realgar) as media. The percentage increase in the Naga Bhasma prepared by first method was 5.03%, while in case of Naga Bhasma prepared by second method was 6.09%. Raw drugs, in process materials and the final products were analyzed physico-chemically and comparison was drawn to lay down pharmacopoeial standards. The average percentage purity of Naga decreased from 97.38% to 81.44% after Shodhana. The percentage of (Pb) ead in Naga Bhasma was 28.29% and 30.80% respectively in first and second methods. Both the Bhasmas were in PbS form chemically with other elements in traces. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/300/68615 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Kshirapaka Kalpa with special reference to Arjuna Kshirapaka Ram, B Joshi, VK Ayurveda- the science of life is oldest repository of medical sciences of ancient India. It has two basic objects i.e. maintenance of health and cure of disorders, for this purpose number of Kalpanas (Pharmaceutical forms) are described in accordance with disorders. There are five basic pharmaceutical forms (Panchavidha kashaya kalpana) found in Charaka Samhita. Sushruta has told six forms (Shadvidha kashaya kalpana) including Kshira Kalpana. Thus it is obvious that Kshira Kalpana is original Kalpana referred in Sushruta samhita. In Ashtang Samgraha, similar five Kalpana have been described as found in Charaka Samhita with different names- Niryasa, Kalka, Niryϊha, Shita and Phanta. In conclusion Arjuna Kshirapaka was first time prescribed by Acharya Vrinda in Hridroga, the bark of Arjuna was used to prepare Arjuna Kshirapaka. Kshirapaka is one of the unique preparations of Ayurveda. In fact through this preparation, potency of a drug is transferred into milk. It is worthy to mention here that water soluble as well as fat soluble fraction of a drug dissolve in the kshirapaka kalpana. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/310/68616 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Comparative Study on Shatavari and Kukkutanda Twak Bhasma in Minimizing the Risk of Postmenopausal Osteoporosis Japee, (J Pandya, MA Postmenopausal period is a very vulnerable time for women, as she has to face inevitable scars of menopause amongst which the most disabling one is Osteoporosis. The present study was aimed to compare the effect of Shatavari and Kukkutanda twak bhasma in minimizing bone loss in menopausal and postmenopausal period. The duration of treatment was 10 weeks along with diet restrictions. The results of Shatavari were encouraging, as it has shown not only decrease in bone loss, but an significant increase in bone formation. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/317/68617 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical evaluation of Saptaparna (Alstonia scholaris L., R. Br.) on Essential Hypertension Bhogayata, K Sharma, PP Patel, BR The tribal people of Sikkim prescribe the decoction of bark of Saptaparna for the symptomatic relief in Hypertension and other Cardiac disease. Hypertension is one of the racial health problems in present era. No system of the medicine has succeeded to give complete relief in Hypertension. Based upon the tribal claim, the present clinical study was carried out on 30 patients of Essential Hypertension (EHT) in the O.P.D. of I.P.G.T. & R.A, Jamnagar. They were equally divided in two groups. In group-1 decoction of bark of Alstonia scholaris (L.) R. Br. was administered to 15 patients of essential hypertension in a dose of 15gm. twice daily for 21 days; whereas in group-2, 15 patients were administered with 250mg of Sarpagandha (Rauwolfia serpentina) Ghanavati twice daily. The result shows Saptaparna is relieving elevated Diastolic Blood Pressure (DBP) & somatic symptoms, where as Sarpagandha is more beneficial in reducing elevated Systolic Blood Pressure (SBP) & psychological symptoms. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/318/68618 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical Review on Infantile Colic Dash, D Jain, CM Infantile colic is one, which exhibits a symptom complex of paroxysmal abdominal pain presumably of intestinal origin associated with severe crying. It usually occurs in infants younger than 3 months of age. The important reason of this symptom is aerophagia. Infantile colic is defined according to wessel's criteria, but symptoms are restricted to crying for more than three hours a day, for more than three days a week, for more than three weeks. Ayurvedic classics describes the features of Udarashoola (colic) as the child rejects the breast, cries, sleeps in supine position, has stiffness of abdomen, feeling of cold and perspiration on face. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/323/68619 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Clinical Study on the Efficacy of Phalatrikadi Ghrita (Tarpana and Orally) on Timira - Presbyopia Gaur, DS Gupta, R Rajagopala, M Matalia, PD The diseases of the eye are much more important than any other physical disability since the loss of vision completely disables the patient. The most disastrous result of ocular disease is blindness. Of all the ocular diseases, Timira is considered to be the most important one, causing difficulty in vision. A good deal of care is required to be exercised in carrying out its proper diagnosis and treatment. It has been observed that the person who indulged in more near work e.g. working on computer monitor, tailoring work, embroidery work, working on microscope and other professionals requiring fine work develop Presbyopia at an early age. Due to all these factors Presbyopia is increasing day by day. The disease Timira - Presbyopia is Vata predominant Tridoshaja condition described under drishtigata rogas by various acharyas. The study was done on 37 patients of Timira- Presbyopia. Phalatrikadi ghrita was given in Group A Orally and Phalatrikadi ghrita was used in Group B as Tarpana & Orally. After enrollment of the patients in the study, cardinal symptoms of Timira - Presbyopia such as samipastha avyakta darshana, vihwala darshana, netrayasa and shirobhitapa etc. were studied before and after the treatment. Amongst the registered patients, 30 patients completed the course of the treatment. Comparatively more relief in signs and symptoms was found in combined group. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/327/68620 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Ashwagandha ghrita and Ashwagandha granules on lipid profile in albino rats Mishra, RK Ashok, BK Ravishankar, B Pandya, MA Present study deals with the effect of Ashwagandha Ghrita and Ashwagandha Granules on serum lipid profile and tissues in normal rats. Four groups of six animals each were made for experiment. Test drug and vehicles were administered for fifteen consecutive days. Serum lipid profile and tissue cytoarchitecture were analyzed as per standard protocol. Administration of both the test formulations did not influence serum lipid profile and also did not alter cytoarchitecture of liver, heart, aorta and kidneys. From data generated during study, it can be concluded that the Ashwagandha Ghrita and Ashwagandha Granules do not have the potential to alter serum lipid profile. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/333/68621 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study to evaluate the efficacy of Pippali Rasayana in certain respiratory disorders Bisht, D Sharma, YK Mehra, BL Two million people die per year due to pulmonary tuberculosis all over the world. The 15 million new cases are diagnosed every year in India, of which 90% have pulmonary tuberculosis. Chronic bronchitis is the second most common lung disorder after pulmonary tuberculosis equally prevalent in rural and urban areas. Similarly nearly 6% population suffers from Bronchial asthma in India. Respiratory system is one such in human body which gets affected from a variety of infections and condition may become worse when body lacks sufficient immunity. Though drugs like corticosteroids, bronchodilators, anti tubercular therapy offer relief but may have many side effects. In Ayurveda answer to these problems is Rasayana therapy. Role of Rasayana therapy with recent advancement can be adjusted in terms of immuno modulatory, cytoprotective, genoprotective, adaptogenic, stress reliever actions etc. In this study a textual formulation. 'Pippali Rasayana' was given for a period of 45 days after Koshtha shodhana to 15 patients diagnosed with common respiratory diseases. Control group of 12 patients was observed as such while taking their respective medications. A remarkable improvement was noted in clinical features as well as general conditions of these patients indicating the beneficial role of 'Pippali Rasayana' as adjuvant. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/337/68622 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Study on the Role of Parijata Vati in the Management of Gridhrasi w.s.r. to Sciatica Mungara, B Shukla, VD Dave, AR Bhatt, NN 'Gridhrasi' is one among the ' Vataja Nanatmaja Vyadhi' described by Acharya Charaka. It is a painful neuro muscular disorder, posing serious threat to the quality of life of most productive group of population in today's India. It indicates typical gait that resembles with a 'Gridhra'. The cardinal signs and symptoms of Gridhrasi are Ruka (pain), Toda (pricking sensation), Stambha (stiffness) and Muhurspandan in the Sphika, Kati, Uru, Janu, Jangha and Pada in order and restricted lifting of the legs. In Kaphanubandha, Tandra, Gaurav, Arochaka are present. The signs and symptoms seen in 'Gridhrasi' have resemblence with that of disorder 'Sciatica' in modern science. It is a very painful condition in which pain begins in lumbar region and radiates along the posterio-lateral aspect of thigh and leg. In the present study, total 45 patients of Gridhrasi were registered and divided into two groups. Patients of Group A were given Parijata Vati orally and in Group B, Parijata Vati was administered with Local Abhyanga and Nadi Swedana. Out of 45 patients, 36 completed the total course of treatment. Most of the patients responded favourably to the treatment in both groups, but better relief was observed in group B. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/342/68623 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Role of Agnikarma & Ajamodadivati in the Management of Sandhigata Vata w.s.r. to Cervical Spondylosis Sehgal, U Rajagopala, M Dwivedi, RR Bavalatti, N Sandhigata Vata is a common Vata predominant disorder found in all races. Cervical spondylosis is described as a degenerative condition of the cervical spine. It leads to pain, stiffness in the joints, pain radiates into shoulders and fore arm, headache, vertigo, giddiness, paraesthesia at the base of the thumb etc. In modern medical science, the role of analgesics, corticosteroids, surgical decompression, traction has been credited and discredited mainly because of their draw backs and limited benefits. In this study panchadhatu shalaka was used for Agnikarma. Its Ushna, Sukshma, Ashukari guna probably pacifies the vitiated Vata Kapha Dosha and removes Srotoavarodha. To control the degenerative process Ajmodadi vati was selected for internal use. In this clinical research work, 27 patients of Cervical spondylosis (Sandhigata Vata) were randomly selected and divided into two groups i.e. group A and group B , treated with Agnikarma and Ajamodadi vati orally respectively. Comparatively more relief was found in group - A. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/345/68624 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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The Critical Study of Philosophical Aspects of "Jalpakalpataru Teeka" with special reference to "Samanya-Vishesh Vad" (Part-I) Upadhyaya, OP Soni, R Ayurveda is eternal. The time, when all other civilization of the world was passing their childhood, the Indian civilization was attaining its highest altitude of knowledge. The Vedas are direct evidence of this, as there is no other literature in this world, that is more ancient than Vedas. Ayurveda is the integral part of Atharva Veda. Ayurveda is a treasure philosophical aspect. In every Ayurvedic Samhita there is parallel description of philosophical aspects with medical discussion. Therefore the question arises in mind that, is there any importance of these philosophical aspects in the field of treatment of diseases? If there is some importance then what is that? And, how it can be proved according to the present era? The Charaka Samhita is mainly a Medical text. The presence of Philosophy in this text, itself proves the importance of philosophy in the field of medicine, but there is need, to be explained, according to the present era. The widely accepted commentary on Charaka Samhita in the present time is, 'Ayurveda Dipika' written by 'Chakrapani'. Its time goes back to app. 1075 AD and there is an approximate time difference of 1000 years between Charaka and Chakrapani. After that, since twelve to nineteenth century, no authentic sanskrit commentary on Charaka Samhita is available. Again, in 19th century, the 'Jalpakalpataru Teeka' written by Kaviraj Gangadhar Rai, comes, which is the last Sanskrit commentary on Charaka Samhita at present. In this commentary, there is a deep discussion of Philosophical Subjects. There is a time difference of approximate 800 years between Chakrapani and Gangadhar Rai. The aim of this literary research is to find out the differences or specialities created or transferred, according to the era, especially in the Philosophical aspects, because of such a long time interval between Charaka and Chakrapani, and again between Chakrapani and Gangadhar Rai, and also, to discuss their importance in the field of medicine. The present study emphasize on the specialities of the 'Jalpakalpataru Teeka' in comparison with the 'Ayurveda-Deepika Teeka' on 'Samanya-vishesh Vad'. Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/350/68625 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Rationale of Ayurvedic Psychiatry Chandola, HM Medknow Publications 2009-07-01 http://www.ayujournal.org/text.asp?2009/30/3/359/68626 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Exploring Quantum Logic in Ayurveda with special reference to Srotovijnana of Ayurveda Singh, RH Ayurveda, the ancient science of life, health and cure originating from India adopts its own holistic biology based on the theory of Triguna, Tanmatra, Tridosha, Saptadhatus, Ojas, Agni, Ama and Srotas. It is distinctly different than the conventional modern biology which is largely based on reductionistic approach of classical Newtonian Physics, in contrast to Ayurvedic Biology - seems to be based on an integrative vision resembling Quantum logic of modern science. The present conceptual study aims to explore related issues with special reference to Srotovijnan of Ayurveda depicting a quantized inner transport system responsible to transport of the entire range of biological fluids, nutrients, energies, impulses, emotions, thoughts and all bio-factors, tangible or intangible. There is a need to study the fundamental and applied aspects of Ayurvedic Biology in depth with genuine interface of Ayurveda with science of today. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/360/68552 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Clinical Study of Kutaja (Holarrhena Antidysenterica Wall) on Shonitarsha Pal, A Sharma, PP Mukherjee, PK Shonitarsha (Bleeding piles) is a common chronic painful disease afflicts the mankind, having only surgical treatment (Haemorrhoidectomy) in modern science but recurrence is more often. Bleeding per rectum during defaecation with fresh blood not mixed with motion is the commonest symptom of Shonitarsha. Kutaja (Holarrhena antidysenterica Wall) is an important plant mentioned in Ayurveda used successfully in atisara, pravahika and arsha especially in Shonitarsha. The fine powder of the Holarrhena antidysenterica Wall stem bark was prepared and given to the patients in a dose of 4 gms twice a day for two weeks. The results of this study are subjective of significant efficacy of the drug in the symptom "stoppage of bleeding" in Shonitarsha. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/369/68554 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A Review on Herbs Used in treatment of Diabetes Mellitus by Sri Lankan Ayurvedic and Traditional Physicians Ediriweera, E Ratnasooriya, WD Diabetes mellitus has no known permanent cure and is highly prevalent worldwide. In traditional medicine and Ayurveda it is correlated with disease called Madhumeha. In Sri Lanka, Traditional and Ayurvedic physicians treat diabetes mellitus very effectively. Information was obtained from traditional and Ayurvedic physicians, Ayurvedic text books and old manuscripts. According to these, various parts of several herbs are used: flowers (Butea monospema), leaves (Adhathoda vasica), fruits (Momordica dioica), seeds (Syzygium cumini), stems (Tinospora cordifolia), stem bark (Ficus religiosa), root bark (Salacia reticulate ) roots (Oryza sativa), aerial roots (Ficus benghalensis), rhizome (Alpinia galanga) bulb (Allium sativum), creeper (Passiflora foetida) and entire plant (Scoparia dulcis). These are prepared in different forms like powders, decoctions, juices and pastes. Decoctions are made using single or multiple herbs. Multiple decoctions usually contain hyperglycaemic herbs such as Cyperus rotundus, Aloe vera to minimize drastic hypoglycaemic complications as usually evident with allopathic drugs. In addition, patients are recommended to consume antidiabetic herbs as food or drinks: as chyme (Osbeckia octandra), curries (Lassia spinos), salads (Centella asiatica), spices (Trigonella foenum-graecu), fresh fruits (Phyllanthus embelica), or as a drink (Camellia sinesis). About one hundred and twenty six plants belonging to fifty one families are used to treat diabetic patients in Sri Lanka. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/373/68555 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Evaluation of the role of Chitrakadi Vati in the management of Bandhyatva w.s.r to anovulation (as a consequence of unruptured follicle) Shukla, K Karunagoda, K Sata, N Pandya, MA Bandhyatva is a commonly increasing problem which any gynecologist has to face throughout his/her gynecological career. It affects the mental & physical health of a woman and disturbs her family as well as social life. In most of the Asian countries, it is treated as a stigma. Ovulatory factor is responsible for 30-40% cases of infertility. There are several ovarian factors responsible for this. Unruptured follicle is one of them. Here the follicle grows and matures up to a certain size, but doesn't rupture or if ruptures, not at the proper time. Thus, anovulation or improper ovulation takes place. In modern medical science, Inj. HCG (Human Chorionic Gonadotropin) is used to ovulate the mature follicle. In Ayurveda, there is no evidence of any database medicine for this purpose. So, an effort was made to find out some safer and cheaper Ayurvedic alternative of Inj. HCG to rupture the grown follicle at the required time. Chitrakadi Vati was selected for this purpose for its Agnidipaka and Pachaka properties, considering the ovulation, a result of physiological action of Agni. The study was carried out in 25 patients. Chitrakadi vati (500mg) 2 tabs t.i.d. from the day of matured follicle in at-least one ovary was administered in such patients till ovulation occurred. The maximum duration was 3 days. Ovulation study with USG was carried out from the 9th day of menstrual cycle till ovulation takes place. Highly significant results were found and considering the other effects of HCG and Chitrakadi Vati, it was proved as a better alternative of HCG to rupture the follicle. It also proved its efficacy for the purpose of Intra uterine insemination, when rupture of follicle is needed within certain required time limit. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/392/68556 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Psycho-Neuro-Pharmacological Evaluation of Kushmandadi Ghrita Ahir, Y Tanna, I Shukla, VJ Ravishankar, B Chandola, HM This research is carried out with the aim to study psycho-neuro-pharmacological evaluation of Kushmandadi ghrita which comprises Kushmanda (Benincasa hispida), Yashtimadhu (Glycyrrhiza glabra) processed in cow's ghee. Among them Kushmanda has been repeatedly mentioned as 'Medhya' and appreciated for its 'Chetasovikaranashanam' effect; Yashtimadhu is included among the four main Medhya Rasayana drugs and also used as routine remedy in the management of the mental illness. Cow's ghee is considered specially nutritive and increased intellectual faculties. Considering these properties, Kushmandadi ghrita was studied on various experimental models such as Gross behavior, Hypnotic potentiation, Anti convulsant activity, Anti psychotic activity, Anti depressant activity, Chronic fatigue syndrome, Anxiolytic activity & Nootropic activity on Charles Foster strain albino rats and Swiss albino mice. The trial drug showed complex pattern of CNS activity, anti-depressant, anti-anxiety and memory and learning enhancement activities. It also produced good effect on chronic fatigue syndrome. It is devoid of anti-convulsant, central muscle relaxant and anti-psychotic activities. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/397/68558 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68559 2009-10-01 all journal:Ayu
Role of certain herbal preparations in the management of Urinary Tract Infection Das, B Baghel, MS Urinary tract infection occurs due to the multiplication of micro-organisms in the urinary tract, when body defence mechanisms are decreased. Difficulty during micturition is the chief symptom of it. According to Ayurveda, it is known as 'Mutrakricchra'. In Ashtanga Samgraha, it is included under the Mutra apravrittijanya basti-gata vikara. Various antibiotics used in modern medical science to solve this problem became unsatisfactory due to the limitations of antibiotics and resistance of micro-organisms to it. However, in the present study an attempt has been made to overcome this problem by using the herbal preparations like Pashanabheda (Bergenea ligulata) churna and Mutrakricchra hara churna. Results of both the studies are found very encouraging. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/404/68559 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68560 2009-10-01 all journal:Ayu
Role of Manahshiladi Anjana and Jeevantyadi Ghrita on Linganasha - Cataract Rajagopala, M Singh, K Mankodi, HJ Bavalatti, N Cataract - Linganasha is defined as loss of transparency of lens developing as a result of altered physiological process within its substance. The disease Linganasha is mainly due to vitiation of Kapha Dosha. According to the 1992 the status report of DGHS, Govt. of India, Cataract alone is responsible for 81% cases of blindness. While the problem of blindness is global, its magnitude is much higher in India. Of the estimated 45 million, India alone has 12 million blind people. In this study patients were selected from the O.P.D. and I.P.D. of Shalya - Shalakya dept and randomly divided into three groups i.e. in Group-A Manahshiladi Anjana (Local application), Group-B Jeevantyadi Ghrita (Internal use) and in Group - C Rasanjana Netra Bindu and Godanti Cap. 500 mg. (Control group) were administered for 6 months. In this study total 195 patients were registered and 99 patients completed the course of treatment. Maximum relief was observed on Polyopia / Diplopia in Group A and B, whereas increase in the clinical features was found in Group C. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/409/68560 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68561 2009-10-01 all journal:Ayu
A Clinical study on Role of "Saptasamo Yoga and Darvyadi Yamak Malahara" in the management of Ekakushtha (Psoriasis) Galani, K Vyas, SN Dave, AR Psoriasis is considerd to be inherited as an autosomal dominant character with irregular penetrate. In present study psoriasis has been taken as Ekakustha, because it is more similar with psoriasis than any other type of Kushtha. Modern medical science treats psoriasis with PUVA and corticosteroids. But the disease recurrence and gives serious side effect like liver, kidney failure, bone marrow depletion. Present study was undertaken to provide safe and effective remedy for psoriasis. Shodhana, Shamana and Nidan parivarjana are main treatments for any disease. So, in present study Saptasamoyoga and Darvyadi yamak malahara have been selected as Shamana. Psychological stress is emphasized as one of the major triggering factor in the exacerbation of the disease. For clinical trial total 25 patients were selected.Three groups were made to evaluate the therapy. All the patients were diagnosed & assessed thoroughly on the basis of Ayurvedic classical signs & symptoms. Further diagnosis was confirmed by the presence of other symptoms & signs of Psoriasis described in modern texts e.g. Auspitz sign, Koebner phenomenon etc. All the signs & Symptoms were assigned scores, depending upon their severity to assess the effect of the drugs objectively. Both groups showed highly significant result on same symptoms but Group B shows better results than Group A. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/415/68561 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68562 2009-10-01 all journal:Ayu
Comparative clinical study on the efficacy of Amaranthus viridis Linn (Tanduliyaka) and Symplocos racemosa Roxb (Lodhra) on Asrugdara with special reference to Menorrhagia Karunathilaka, L Karunarathne, Y Kodithuwakku, ND Asrugdara is a broadly classified disease; include various diseased condition of menstrual cycle. It is highly prevalent gynecological disease and can be correlated with Menorrhagia. This clinical study deals with the management of Asrugdara using Amaranthus viridis and Symplocos racemosa. Total 52 patients were selected and randomly divided into 2 groups. Group A was treated with 5g of powder of A. viridis and group B, S. racemosa, twice a day for the duration of one month. Assessment criteria was based on the improvement in the score of cardinal symptoms and other common symptoms before, during and after the treatment. There was a statistically significant reduction observed in cardinal symptoms by both the drugs at the end of the treatment period. The other common symptoms were also successfully reduced. A. viridis was found to be more significant in comparison to S. racemosa, and it is more effective to relieve and control Asrugdara. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/421/68562 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68563 2009-10-01 all journal:Ayu
Management of Overweight and Obesity through specific Yogic procedures Deole, YS Vyas, GH Dash, SC Obesity is the most hazardous factor found in modern sedentary society. It is the main underlying cause of life threatening diseases like Coronary Heart Disease, Diabetes Mellitus, Atherosclerosis etc.Therefore it is important to control the increasing weight. The alternative therapies like Ayurveda, Yoga are being increasingly popular due to the limitations of allopathy. In the present study, the efficacy of certain yogic procedures is studied on the basis of subjective and objective paprameters of obesity. Statistically highly significant results are observed to decrease weight and Body Mass Index as well as subjective complaints of obesity by treatment through Yogic procedures. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/425/68563 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68564 2009-10-01 all journal:Ayu
Incidence of Tuberculosis in Jamnagar district of Gujarat & Role of Indigenous drugs to combat the disease Vyas, P Jaiswal, AK Ghanchi, FD Chandola, HM Tuberculosis is mainly affected by poor living condition, malnutrition; shanty housing and overcrowding. These are the main reasons for the spread of the disease which is not only affecting the health of our country, but the economy as well. Estimates of TB prevalence, incidence and mortality in the country are based on an analytical and consultative process that takes into account all information available on case notification, prevalence of infection and disease, proportion of smear positive cases, number of cases treated and untreated, mortality and demography. Women bear the brunt of the disease more than men. They ignore the disease initially fearing its interference in their daily chores. The social stigma of the disease adds to the burden for both men and women. Here the attempt has been made to study the prevalence of Tuberculosis in Jamnagar district from last four years. DOTS which underpins the Stop TB Strategy, was being applied in Jamnagar district in 2005; 19,13685 of the total population of Jamnagar district lived in areas where DOTS had been implemented by public health services. Here data were collected from TB unit which comes under DOTS. Data collection was coordinated with the help of Data entry operator, Statistical analyzer from District Tuberculosis Centre, Jamnagar. Data has been summarized to see the rate of notification, treatment outcome, age group wise distribution of patients and difference between male and female case notification. This study on Gender in Tuberculosis Research constitutes one of the remarkable information about condition of gender difference in Jamnagar district and that is more than twice between male and female notification rate. These findings also incorporated with The WHO Gender and Health Research Series have been developed by the Department of Gender, Women and Health (GWH). Data also reveals more than 90% cure rate of New Smear Positive Pulmonary Tuberculosis after implication of DOTS under RNTCP programme. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/436/68564 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68565 2009-10-01 all journal:Ayu
Pharmaceutical and Clinical Evaluation on Vangabhasma in the management of Madhumeha (Diabetes mellitus) Lagad, CE Ingole, R Madhumeha (Diabetes mellitus) is one of the most common, chronic ailment now a day. Many formulations are described in different texts to treat Madhumeha. Among these Vanga Bhasma is one of the most potent drugs. In present study, Vanga Bhasma was prepared strictly by following Rasashastriya procedure and finished product was examined on Ayurvedic as well as modern parameters. In clinical study, Vanga bhasma was administered to 30 diagnosed patients of D.M. and results are discussed in present article Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/443/68565 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Critical Analysis of the Concept of Asthi Kshaya vis-a-vis Osteoporosis Kadlimatti, SM Maheshwari, KS Chandola, HM 'AYURVEDA', "THE SCIENCE OF LIFE" is a time tested treasure of knowledge which explains human body as a congenial homeostasis of Dosha, Dhatu and Mala. The function of dhatus is dharana of the Sharira. Among the dhatus, Asthi dhatu is blessed with the function of sharira dharana. It gives shape to the body and protects the vital organs. Equilibrium of dhatus is health and their disequilibrium is disease. This disequilibrium may either be increase or decrease. Asthi kshaya (decrease in bone tissue) is a condition explained in Ayurveda, under the heading of ashtadasha kshayas. In Asthi kshaya there is diminution of Asthi dhatu. Similar to this, there is a condition known as Osteoporosis in western medicine which means 'Porous bones' or "the brittleness of the bones due to increased porosity from loss of mineral substance" causing decrease in the bone tissue & leading to increased risk of fractures. According to the principles of Aashrayaashrayee bhava, Asthi dhatu is the seat of Vata dosha and Asthi & Vata are inversely proportional to each other regarding increase and decrease. Increase of Vata leads to decrease of Asthi. Here, an effort is made to critically analyse the concept of Asthi kshaya mentioned in Ayurveda with special reference to Osteoporosis. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/447/68566 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68567 2009-10-01 all journal:Ayu
A Comparative Study of Durvadi Taila and Povidone Iodine in the management of Vrana Pankhaniya, LJ Sharma, PP Manjusha, R Vrana is one of the problems which have been managed by human being from beginning of civilization. The science of "Vrana Ropana" seems to be a serious matter of concern to the ancient healers. This fact can be very well understood while going through the surgical text - Sushruta Samhita where a good number of chapters deal with the science of Vrana alone. Vrana literally means a discontinuation of tissues. It is seen as debilitating and scaring disorder usually seen affecting the human being at any age. There are so many factors responsible to make healing process delayed. Though a variety of chemical substances have been evaluated and patented as wound healing agents, their inability to become successful drugs is due to the fact that these are able to act only at a particular step of the healing cascade. It is likely that more effective wound healing agent would be developed from natural products. The same thing is also being tried by Ayurvedic experts; present work is also a further step in this path under an herbal preparation named "Durvadi Taila",which is mentioned in Chakradatta and Bhaishajya Ratnavali in Vranashotha Roga Adhikara for the treatment of Vrana. In this research study total 34 patients were registered and treated in two groups, group A is Durvadi Taila treated group and Group B is Povidone iodine group as a standard control group. Encouraging results were observed in Durvadi Taila followed by Povidone Iodine. Study emerges that Durvadi Taila possess better wound healing properties. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/459/68567 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68568 2009-10-01 all journal:Ayu
Effect of Vamana and Ashtanga Lavana in the management of Madatyaya Sadalagi, SL Narayana, PB Shetty, SK Today Madatyaya is main social problem, leading to mortality and morbidity in turn leads to burden on nation's economy. To deal such social problem this study has been carried out. This study has been carried out on 38 diagnosed patients of Madatyaya. These selected cases were randomly distributed into two groups. Study group was managed by Vamana followed by Astanga Lavana in the dose of half Karsha which is (approximately equal to 6 gm), twice daily for the period of one month. Control group was managed by Vamana and Placebo in the dose of one capsule twice daily for one month. The follow up was for period of two months in both the groups. The result shows that marked improvement was not seen in any of the cases in both the groups, whereas 11.11 % had moderate improvement in Ashtanga Lavana group, and 5.88 % in Placebo group, where as 83.33 % had mild improvement in Ashtanga Lavana Group, and 41.17 % in Placebo Group. But only 5.55 % patient not got cured in Astanga Lavana Group, and 52.94 % in Placebo Group. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/463/68568 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68569 2009-10-01 all journal:Ayu
Role of an Ayurvedic Compound (Panduhara Yoga) in the management of Iron Deficiency Anaemia in Children Garai, AK Rai, M Kumar, A Pandu Roga (Anaemia) is one of the common problem in the developing countries like India specially in women and children. Iron deficiency anaemia (IDA) is the commonest form of anaemia in children. Allopathic iron preparations are gastric irritant and having common side effects of oral iron including nausea, abdominal pain and either constipation or diarrhoea. To find out a satisfactory answer for the problem an Ayurvedic herbo-mineral compound (Mandura Bhasma one part +Amalaki Churna ten parts) was formulated and named as Panduhara Yoga. According to Ayurveda, Mandura Bhasma (ferrosoferic oxide) and Amalaki (Emblica officinalis) are very good drugs to prevent and manage the cases of Pandu Roga in children. Amalaki is Rasayana and it contains Vitamin-C that helps in the absorption of iron. Amalaki can increase bioavailability of Mandura Bhasma and can prevent the common hazards of oral iron therapy. A single blind clinical study was conducted in children of IDA. Panduhara Yoga has been administered in the dose of 110mg/kg body weight in two divided doses with honey after food for a period of 6 weeks. Hemoglobin level was improved with mean increase of 1.19gm/dl in three weeks (8.12΁1.56g/dl to 9.31΁1.35g/dl, p<0.001), and 2.64gm/dl in six weeks (8.12΁1.56g/dl to 10.76΁1.11g/dl, p<0.001). After 6 weeks treatment with Panduhara Yoga overall 93.33% children showed very good improvement on clinical features, whereas 50% children showed very good improvement on blood hemoglobin level. The results suggest that Panduhara Yoga is significantly effective in the management of iron deficiency amaemia in children. No adverse effect has been noticed during the therapy. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/469/68569 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68570 2009-10-01 all journal:Ayu
A clinical study of Vyoshadivati and Pathadi Taila Nasya on Apinasa - Atrophic Rhinitis Vaghela, DB Singh, K Pansara, KN Narayan, B Gangama, M Among Nasagata Rogas most of the Acharyas described Apinasa including its complication which proves the seriousness of the disease. Acharya Sushruta clearly mentioned in Utttar tantra that Apinasa is the disease condition in which Vata and Kapha Dushti was observed. Atrophic Rhinitis is a chronic nasal disease characterized by progressive atrophy of the mucosa and underlying bone of the turbinates and the presence of a viscid secretion which rapidly dries and forms crust, which emits a characteristic foul odour sometimes called ozaena castench. In this study, 100 patients of Apinasa-Atrophic Rhinitis were treated in four groups. The 40 patients of 'V' group were treated with Vyoshadivati orally; the 20 patients of 'P' group were treated with Pathadi Taila in Nasya form. In group 'VP' the 20 patients were treated with Vyoshadi Vati and Pathadi Taila as a combined therapy. Group 'C' was a control group and 20 patients of this group were treated with placebo therapy. After the enrollment of the patients in the study,vital signs and symptoms of Apinasa-Atrophic Rhinitis such as nasal blockage, dryness of nose, nasal discharge etc. were studied before and after the treatment. The results of the study indicate that the "VP' group bestowed highly significant relief in almost all the signs and symptoms in comparison to 'V' and 'P' groups. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/475/68570 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68571 2009-10-01 all journal:Ayu
Identification of Common Problems and its Rasayana Treatment in Aged People Tiwari, BG Upadhyay, BN Aging is the deviation from the ideal state or in a decrease rate of return to ideal state or both. The maximum growth, which is achieved by a man, is up to 30 yr. It is an integration of change at molecular, cellular and whole organism level. This age related disease compromise quality of life in old age. Ayurvedic system of medicine is probably the first which efforts to protect life from disease and aging. Ayurveda describe much about the science of gerontology and Rasayana therapy. Rasayana Tantra is one of the eight major clinical disciplines of Ashtanga Ayurveda, which is exclusively devoted to the study of aging and its prevention. Rasayana therapy (Rejuvenation) affords a comprehensive physiological and metabolic restoration. The present study is designed to study the common symptoms of the aged people which are responsible to disturb the normal life span of aged people and their treatment. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/480/68571 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68572 2009-10-01 all journal:Ayu
Anti ulcer activity of Narikela Khanda & Narikela Khanda granules Baragi, PC Ashok, BK Patgiri, BJ Prajapati, PK Ravishankar, B Today in the modern era, gastric disorders like hyperacidity and gastric ulcers are a common clinical entity. This is also a major health problem with multifunctional etiology. Today there is need for a potent herbal formulation which can cure hyperacidity and ulcers. The present comparative experimental study was planned to see the anti ulcer activity of herbal compound formulations of Narikela Khanda and Narikela Khanda granules using pyloric ligation induced gastric ulceration in rats.Gastric ulcers were induced in albino rats by pyloric ligation. Effects of both the test formulations on different parameters in gastric juice like volume, pH, total and free acids, peptic activity, total carbohydrate (TC), total protein (TP) and also gastric mucosal damage were assessed. Both the formulations did not produce significant effect on gastric juice volume, free acidity, total protein, total carbohydrate, TC:TP ratio and ulcer index, however Narikela Khanda granules produced significant increase of gastric juice pH and significant decrease in total acidity and peptic activity. The study clearly indicates that Narikela Khanda possesses weak anti-ulcer activity, while Narikela Khanda granules possess moderate anti-ulcer activity against pyloric ligation induced gastric ulcers. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/484/68572 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68573 2009-10-01 all journal:Ayu
Applied study of Ushna and Sheeta Gunas w.s.r. to Amlapitta Mane, S Vyas, M Dwivedi, RR The present research work consists of conceptual, pharmacognostical, physico-chemical and pharmacological studies along with therapeutic (clinical) effects of the Ushna and Sheeta Guna Dravya in patients of Amlapitta. The properties Ushna and Sheeta Gunas are studied in all above parameters to find out some objectivity. On all these parameters it has been found that characteristics of Ushna and Sheeta Gunas are differentiable especially in clinical study in 185 Amlapitta patients. Patients having Drava Guna of Pitta dominancy were found to be significantly benefitted by Ushna Guna containing dravyas. And patients having Ushna Guna dominancy when treated with Sheeta Guna Dravyas were also found to be significantly benefitted. Hence it is found to be positively proved that there are few parameters at physico-chemical, pharmacological and also at therapeutic levels on which Sheeta and Ushna Guna can be objectively assessed. The study contains all these facts and values in figures. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/489/68573 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68574 2009-10-01 all journal:Ayu
A Comparative Study on the effect of an Indegenous Compound Drug & Matra-Basti in the management of Gridhrasi Kumari, A Mahto, RR Dave, AR Shukla, VD Gridhrasi is an intractable physical complaint, which carries little threat to life but it interferes greatly with living. People, who suffer from this affliction, can't stand or sit properly and the painful limb continuously draws his attention. A similar condition in modern parlance is Sciatic-syndrome or Sciatica. The chances of occurrence are expected to be increasing through the coming years due to the increasing tendency for computerization and also because of the hectic routines resulting in postural abnormalities, increasing body weight, mental stress, unwholesome diet etc., all of which lead to a fertile condition for the occurrence of Gridhrasi. As modern drugs have to be administered continuously for prolonged period, a need arises to search for safer drugs with similar efficacy. In this study, 34 patients received therapy were randomly divided into two groups. In group A -Oral capsule along with Local Abhyanga & Swedana, whereas in Group B Oral capsule & Matra Basti along with Local Abhyanga, Swedana were given. The result of the study shows that group B provided better relief as compared to group A in the management of the disease. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/495/68574 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Comparative Study of Prasarani [Merremia tridentata Hallier. f. (Convolvulaceae) and Paederia foetida Linn. (Rubiaceae)] in Amavata (Rheumatoid Arthritis) Rajashekhara, N Sharma, PP Vasanth, P Prasarani is one of the drugs used for treating Vata Rogas such as Ama Vata, Avabahuka etc. Among the different source plants of Prasarani, the plant Merremia tridentata Hallier.f. is mostly used in South India and the plant Paderia foetida Linn. in North India, hence taken in the present work for comparative study on Amavata. The disease Amavata resembles with Rheumatoid Arthritis (R.A.). Both the plants Merremia tridentata Hallier.f. and Paderia foetida Linn. have good effect on the disease Amavata. Among the two, the plant Paderia foetida Linn. has a better effect than Merremia tridentata Hallier.f. The plant Merremia tridentata Hallier.f. has a little more advantage over the plant Paderia foetida Linn.which possess offensive odour which will not reduce fully even after boiling. Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/503/68575 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68576 2009-10-01 all journal:Ayu
The Critical Study of Philosophical Aspects of "Jalpakalpataru Teeka" with special reference to "Samanya-Vishesh Vad" (Part-II) Upadhyaya, OP Soni, R Charak Samhita and Sushrut Samhita are main texts of Ayurveda. The acurate knowledge of these texts can not be gain without the knowledge of Sanskrit language. In this filed we are grateful to the commentators who write the commentaries on these Samhitas. Ayurveda is a treasure of philosophical aspect. In every Ayurvedic Samhita there is parallel description of philosophical aspects with medical discussion. Therefore the question arises in mind that 'is there any importance of these philosophical aspects in the field of treatment of diseases'? If there is some importance then what is that? And, how it can be proved according to the present era? The Charak Samhita is mainly a Medical text. The presence of Philosophy in this text, itself proves the importance of philosophy in the field of medicine, but there is need, to be explained, according to the present era. The widely accepted commentary on Charak Samhita in the present time is, 'Ayurveda Dipika' written by 'Chakrapani'. Its time goes back to app. 1075 AD. This is definitely a best, intellectual and deep commentary specially because of describing the Chikitsa Siddhantas (Basic Theories of treatment) in detail, but considering the fact that this commentary is some what lacking in the field of philosophical aspects, Gangadhar Roy, in 19th century, discussed philosophical aspects especially and deeply in his 'Jalp-Kalp-Taru' Commentary on Charak Samhita. He also discussed about the importance of these philosophical aspects in the field of medicine. In this paper the view of Acharya Chakrapani on Samanya Vishesh Vad is discussed in detail and compared with the views of Gangadhar Roy and the specialities of Gangadhar Roy are discussed in detail proving the fact - ^iqjk.kfeR;so u lk/kq loZa u pkfi dkO;a uofeR;oU,e~* Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/508/68576 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Primer of Ayurveda Nirmal, BM Medknow Publications 2009-10-01 http://www.ayujournal.org/text.asp?2009/30/4/516/68874 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Prajwalito dnyanamayah pradeepah... Baghel, MS Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/0/68185 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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From the desk of the editor Chandola, HM Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/0/68186 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68190 2010-01-01 all journal:AYU
Study of preparation and standardization of 'Maadhutailika Basti' with special reference to emulsion stability Savrikar, SS Lagad, CE 'Basti' is compared with conventional enema due to its similarity in procedure of administration. But in effect enema is a simple evacuation technique, whereas 'Basti' is a therapeutic measure considered as 'Ardha Chikitsa' i.e half therapy in the disease management. Constitution of 'Basti dravya' formulation specifically 'Aasthaapana Basti' has a direct impact on the end result of 'Basti' therapy. A systematic stepwise procedure of preparation of 'Aasthaapana Basti' is described in Ayurvedic Classics. The present study evaluates the significance of this procedure through standardization of 'Maadhutailika Basti', a type and standard of 'Aasthaapana Basti'. Four samples of 'Aasthaapana Basti' including the classical one were prepared for this study by replacement, exclusion and supplementation of honey in the formulation. A comparative study of physico-chemical characteristics of these samples was carried out. The stability of the constitution of 'Maadhutailika Basti' was also studied to assess the role of honey as a natural emulsifying agent. The study underlines the significance of the procedure described in the classics emphasizing the role of honey as a natural emulsifying agent in standardization of 'Maadhutailika Basti'. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/1/68190 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Concept of Ahara in relation to Matra, Desha, Kala and their effect on health Dangayach, R Vyas, M Dwivedi, RR For evaluation of the effect of Ahara on Health in relation to Matra, Desha and Kala, an interview based survey study was carried out by simple randomized selection of healthy and unhealthy individuals. It was found that consideraton of Matra, Desha and Kala in aspect of Ahara taking were found beneficial for health. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/101/68194 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Therapeutic uses of Swarnamakshika bhasma (A critical review) Gupta, RK Lakshmi, V Mahapatra, S Jha, CB Mineral drugs play an important role in Ayurvedic therapeutics. Looking to the superiority of the metals and minerals to that of herbal and animal drugs, the Rasavaidyas went on experimenting clinical trials over lot of metals and minerals and systematically separated some of them which were exclusively active therapeutically. Swarnamakshika is one such mineral which after proper purification and incineration become highly potent and utilised for diseases like Jwara, Pandu, Prameha, Shwasa, Kasa, Kushtha, Anidra, Apasmar etc. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/106/68191 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:68189 2010-01-01 all journal:AYU
Prevalence of touch sensation (Sparshanendriya-Vyapaktva) Kumar, A Singhal, T Upadhyay, BN There are much more topics in our Ayurvedic classics about which we have limited knowledge. Like this an another topic is Indriya. We don't know what is indriya or what are their sites. Are the organs by which we perceive sensation called Indriya or different from them? Acharya Charaka has told five types of Indriyas, Sparshanendriya, Chakshurendriya, Ghranendriya, Rasanendriya & Shravanendriya. He also described their sites, functions, composition, and their properties. But he also told that Sparshanendriya is the main Indriya and it is present in all Indriyas. Why Charaka told that Sparshanendriya is Vyapak in all Indriyas. Is this concept wrong or right? The answer is right & this concept can be proved by following means as described in this paper. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/111/68189 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Random estimate the values of seed oil of Cucurbita maxima by refractive index method Saxena, RB The crude oil having lower iodine and free fatty acids values has Aamdosha properties. These properties are present due to toxic and anti-toxic compounds. These compounds can be harmful for the special diseases and may be unsaturated, saturated, open chain etc. The adulteration can take part as catalytic action for the toxic effect for the special diseases. Toxic properties of oils are removed by different ingrediants and methods. C. maxima seed tail (mst) is used with food and medicine. The present paper deals with the study of oil by refractive index and equations. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/12/68196 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Principles and Practice of Ayurvedic Rheumatology Srivastav, PS Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/121/68187 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Role of different media in Karpanpatru Taila preparation Goyal, M Patgiri, BJ Ravishankar, B Prajapati, PK Total six samples of Karpanpatru Taila were prepared with Murchchhita and Amurchchhita Sarshapa Taila (mustard oil) by using three different liquid media i.e. Gomutra, Takra and Kanji by following classical method and analyzed. The pharmaceutical analysis revealed that the Karpanpatru Taila prepared with Murchchhita Sarshapa taila by using Kanji, Gomutra, Takra as a liquid media showed minimum loss i.e. 4.00%, 8,33% & 8.66 respectively in comparison to Amurchchhita Sarshapa Taila by using Kanji, Gomutra, Takra i.e. 5.5%, 10.68%, 12% respectively. Pharmaceutical drawbacks like excessive frothing and burning of eyes & nose were absent during the preparation of Karpanpatru Taila with Takra and Kanji while present in batch of Gomutra. Analytical study reveals that Acid value was negligible increased after even 6 month in the samples of Murchchhita Karpanpatru Taila while significant increased in the samples of Amurchchhita Karpanpatru Taila. Saponification value was decreased in the samples of Murchhita Karpanpatru Taila while increased in the samples Amurchchhita Karpanpatru taila. Microbial growth was found absent in all the samples of Karpanpatru Taila even after 6 months. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/15/68198 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Evaluation of Dhatri Avaleha as adjuvant therapy in Thalassemia (Anukta Vyadhi in Ayurveda) Singh, R Patel, KS Anand, IP Thalassemia is the commonest single gene disorder in India. About 10,000 infants with Thalassemia major are born every year. The present study was under taken with a hope to prevail better quality of life to the Thalassemic patients. Pallor being the chief complaint, a randomized controlled trial was undertaken with Dhatri Avaleha as it is specially mentioned for Pandu, Kamala & Haleemaka Roga. Children between age group of 1 to 15 years were randomly divided in two groups: Drug treated group (Group A) and Control group (Group B). Assessment was done on subjective and objective parameters after 30 and 60 days of treatment with follow up of two month. Statistically significant (P<0.01) result was obtained in Blood transfusion interval in group 'A' in comparison to group 'B'. Dhatri Avaleha may have a potential to increase blood transfusion interval and decrease secondary infection and thus it can be used as supportive therapy with modern medical management. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/19/68199 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of Ayurveda treatment regimen on Subfertility with poly cystic ovarian syndrome (PCOS) Karunathilaka, L Kodituwakku, ND Karunarathne, Y Poly Cystic Ovarian Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, resulting from insulin resistance and the compensatory hyperinsulinemia. This results in adverse effect on multiple organ systems and may result in alteration in serum lipids, anovulation, abnormal uterine bleeding and infertility. According to Ayurvedic view PCOS can be correlated with Aarthava Kshaya. It was revealed that most of subfertility patients who were presented Osuki Ayurveda Centre suffered from the PCOS. Therefore the present study was carried out for the clinical evaluation of the efficacy of Ayurveda treatment regimen on subfertility with PCOS. Total 40 patients were selected by using purposive sampling method. According to the Ayurveda theories of Shodhana, Shamana and Tarpana, the treatment was conducted in 3 stages for the duration of 6 months. The response to the treatment was recorded and therapeutic effects were evaluated by symptomatic relief and through Trans Vaginal Scan and LH, FSH hormone levels. The results revealed that, subfertility due to PCOS can be cured successfully by using this Ayurveda treatment regimen. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/24/68203 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical evaluation of Shilajatu Rasayana in patients with HIV infection Gupta, GD Sujatha, N Dhanik, A Rai, NP AIDS is one of the serious global health concerns caused by Human Immuno Deficiency(HIV) virus and is predominantly a sexually transmitted disease. Currently there is no vaccine or cure for AIDS still Anti Retroviral Therapy (ART) is successful. It reduces both the mortality and the morbidity of HIV infection, but is expensive and inaccessible in many countries. However intense the therapy may be, HIV virus is rarely eliminated, and drug resistance is a major setback during long-term therapy. The development of new drugs and strategies and exploring alternative systems of medicine for antiviral herbs or drugs is the need of the age to improve treatment outcomes. Ayurveda describes many diseases which incorporate HIV like illness e.g. Rajayakshma, Ojo Kshaya, Sannipata jwara etc. HIV infection affects multisystems, chiefly the Immune System which can be correlated to Ojo Kshaya. Rasayana Chikitsa is the frontline therapy employed to treat Ojus disorders. Therefore Shilajatu (Mineral pitch), Centella asiatica (Mandukaparni), Tinospora cordifolia (Guduchi) and Emblica officinalis (Amalaki), well known for their Immuno-modulator and antioxidant properties were selected to evaluate their role on immune system. The study was carried on 20 patients from OPD and IPD of Kayachikitsa, S.S.Hospital, IMS, BHU and was randomly allocated into Treated group (Shilajatu+ART) and Control group (ART). Treated Group responded better to ART both clinically and biochemically. The results show that Shilajatu decreases the recurrent resistance of HIV virus to ART and improves the outcome of the therapy Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/28/68205 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Role of Rasayana in cure and prevention of recurrence of Vicharchika (Eczema) Kaur, M Chandola, HM Generally, skin diseases run a chronic course and the recurrence is very common. Mandip and Chandola (2009) reported that Shirishadi Decoction administered orally and simultaneously Snuhyadi Lepa applied externally to the patients of Vicharchika (Eczema) provided complete remission to 18.2% patients, marked improvement to 42.4% patients and moderate improvement to 36.4% patients but the recurrence rate was very high i.e. 80%. Charaka, in the context of the treatment of Apasmara mentions that in all the chronic diseases, Rasayana drugs should be prescribed. As eczema is a chronic disease and its recurrences are very common, therefore, it was thought desirable to evaluate the role of the Rasayana drugs in the cure and prevention of the recurrence of Vicharchika (Eczema). In this study, total 38 patients of Vicharchika (Eczema) were registered, among which 31 patients completed the full course of treatment. These patients were first subjected to Koshtha Shuddhi done with Aragvadha (Cassia fistula) Hima administered orally at bedtime for initial eight days. Thereafter 30 ml of Shirishadi Decoction and 6 gm of Guduchi (Tinospora cardifolia) and Bhringaraja (Eclipta alba) powder was given with Ghrita. Both the drugs were given twice daily after meals orally. Simultaneously, Snuhyadi Lepa was applied on the eczematous lesions. Results of the study showed that addition of Rasayana drugs provided complete remission to 22.6% and checked the recurrence of the disease in the 89.5% patients of Vicharchika (Eczema). Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/33/68207 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Evaluation of Insomrid tablet and Shirodhara in the management of Anidra (Insomnia) Pokharel, S Sharma, AK The study was conducted in 30 clinically diagnosed patients of Anidra (Insomnia) with an objective of clinical evaluation of the efficacy of Shirodhara and Tab. Insomrid (proposed herbal formulation) in the management of Anidra (Insomnia). These patients were randomly divided into three groups of 10 patients each. In was observed that the patients of Group III treated with Tab. Insomrid and Shirodhara with milk showed highly significant improvements, whereas the Group II treated with Shirodhara and Group I treated with Tab. Insomrid also showed significant improvements. No adverse effects were noted in any of the patients during the trial period. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/40/68209 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Efficacy of Vasadi Syrup and Shwasaghna Dhuma in the patients of COPD (Shwasa Roga) Sharma, PK Johri, S Mehra, BL Chronic Obstructive Pulmonary Disease (COPD) threatens as emerging public health crisis. The two major drivers for this are the ageing of the world's population and the impressive, if deplorable, success of the multinational tobacco companies at forcing open world markets. One of the most striking aspect of COPD is that it is heterogenous. There are many different presentations with differing intensities of symptoms and even differing responses to the medication. Sorting out, what accounts for this phenomenon and how treatments can be best individualised, is of concern to both basic and clinical scientists. COPD is a leading cause of morbidity and mortality worldwide and results in a substantial economic and social burden to society. It is the sixth most common cause of death worldwide and expected to rise to third position by 2020. Several national and international agencies like WHO, GOLD, ATS, ERS etc. are working in a direction of finding some solution of this wicked problem. In Ayurvedic texts Shwasa Roga has been described having symptomatology close to COPD.A study was carried out in P.G.Deptt. of Kayachikitsa in R.G.G.P.G.Ayu.College Paprola, H. P. where the role and efficacy of two Ayurvedic formulations -Vasadi Syrup and Shwasaghna Dhuma was evaluated on 30 patients of COPD selected on the basis of fixed inclusion and exclusion criteria in two different groups. In both the groups drugs provided significant results based on subjective symptomatological criteria and objective spirometric criteria. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/48/68204 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical study on Sandhigata Vata w.s.r. to osteoarthritis and its management by Panchatikta Ghrita Guggulu Akhtar, B Mahto, RR Dave, AR Shukla, VD Sandhigata Vata is the commonest form of articular disorder. It is a type of Vatavyadhi which mainly occurs in Vriddhavastha due to Dhatukshaya, which limits everyday activities such as walking, dressing, bathing etc. thus making patient disabled / handicapped. It being a Vatavyadhi, located in Marmasthisandhi and its occurrence in old age makes it Kashtasadhya. Vata Dosha plays main role in the disease. Shula Pradhana Vedana is the cardinal feature of the disease associated with Sandhishotha with Vata Purna Druti Sparsha, lack of movements of the joints or painful movement of the joints. In this study total 49 patients having the complaints of Osteoarthritis were randomly divided into 2 groups. In Group A, patients were treated with Panchatikta Ghrita Guggulu Vati along with Abhyanga and Nadi Swedana and in group B patients were treated with only Abhyanga and Nadi Swedana. The data shows that Panchatikta Ghrita Guggulu along with local Abhyanga and Nadi Swedana i.e. group A has provided better relief in the disease Sandhigata Vata. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/53/68210 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Efficacy of Sri Lankan traditional decoction of Katuwelbatu Deduru Katukadi in treatment of Kaphaja Shira Shula (chronic sinusitis) Ediriweera, E Rathnayaka, R Premakeerthi, W Weerasinghe, K Kaphaja Shira Shula is one of the Shiro Roga. Chronic sinusitis is inflammation of the sinuses behind the forehead, cheeks, and eyes, which continues for a long time or keeps recurring. Kaphaja Shira Shula can be correlated with Chronic Sinusitis. The decoction of Katuwelbatu Deduru Katuka is mentioned in Watika Prakaranaya, a book on Sri Lankan Traditional Medicine. The ingredients of this decoction are Solanum xanthocarpum, Cuminum cyminum, Nigella sativa, Picroihiza kurrota and Clerodendrum serratum . But in this study Saussurea lappa is used instead of C. serratum with the experience of traditional physician, Weerasinghe. Aim of this study was to scientifically evaluate the efficacy of this decoction in Kaphaja Shira Shula. Eighty patients suffering from Chronic sinusitis were selected from Ayurveda Teaching Hospital, Borella, Sri Lanka and randomly divided into two groups. X-ray of Para nasal sinuses and total white cell count before treatment and after treatment were recorded. Group one was treated with 120 ml of decoction of Katuwelbatu Deduru Katuka and Group two with 120 ml of placebo twice a day for twenty one days. Partial and complete symptomatic relief and reduction in esinophil count in the blood were observed in the treated group. It is observed that decoction of Katuwelbatu Deduru Katukadiya can be used in treatment of Kaphaja Shira Shula (Chronic sinusitis) effectively. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/58/68208 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study on adhimantha and it's management with Nayanamrita Lauha and Triphaladi Varti Chauhan, DB Singh, K Mehta, AJ Adhimantha is a disease which has been mentioned by Sushruta as an intense feeling of the eye, wherein eye seems to be being extracted out and churned up alongwith the involvement of the half of the head in association with specific features of the particular Dosha involved. Glaucoma is a disease which is characterized by raised intra-ocular pressure, optic disc cupping and visual field defect. The clinical study was done on 79 patients of Kaphaja Adhimantha in 4 different groups. Group A was treated with Triphaladi Varti. Group B was treated with Nayanamrita Lauha. Group C was combined group wherein both Nayanamrita Lauha and Triphaladi Varti were given. Group D was treated with placebo eye drop (Saurastra Netra Bindu). After the enrolment of the patients for this study, signs and symptoms such as dimness of vision, heaviness in head, coloured haloes, optic disc changes, IOP and visual field changes were studied before, during and after the treatment. The study indicates that combined group showed better results as compared to other groups. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/62/68206 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical study of an Ayurvedic compound (Divyadi Yoga) in the management of Shayyamutrata (enuresis) Jain, CM Gupta, A Child health has assumed great significance in all over world. Its importance is being realized more and more by pediatricians and general public in developing as well as developed countries. Enuresis is defined as the voluntary or involuntary repeated discharge of urine into clothes or bed after a developmental age when bladder control should be established. The present clinical study was planned to evaluate the effect of Divyadi Yoga along with counseling in the management of Shayyamutra. Total 40 selected cases were divided into two groups, i.e. 20 in each group. One group of children were given the trial drug Divyadi Yoga (D1) with counseling and other group of children were given placebo Divyadi Yoga (D2) with counseling. Divyadi Yoga was given in the dose of 3-6 gms. twice a day with luke warm water. The result of the study showed that groups provided a highly significant. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/67/68202 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Process standardization of Rasamanikya Srimannarayana, K Patgiri, BJ Prajapati, PK Rasamanikya is a famous drug, frequently used by Ayurvedic physicians for Vata-Kaphaja diseases like Shwasa, Kasa and Kushtha (Skin disorders). Various methods of preparation have been found described in Rasa classics. Generally it is prepared by Shuddha Haratala which is kept between two thin transparent Abharaka Patra (mica sheets) in small scale and in sharava for large scale, heated up to desired level. There are so many methods and different liquid media have been found described for Shodhana of Haratala. Therefore the methods of preparation of Rasamanikya and Shodhana process of Haratala have been validated through various experiments. Tankana-treated Haratala (T. Treated) is found best for Shodhana process and final product too i.e. Rasamanikya in terms of pharmaceutical standards i.e. Ruby in colour, along with reproducibility of fixed quality. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/7/68195 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Role of 'Krishna Tila' and 'Arkapushpa Taila' uttarbasti in the management of Artavakshaya Trivedi, R Mishra, RK Pandya, MA Ayurvedic classics give importance to Shuddha Artava and mention that Artavadushti is one of the causative factors for infertility. Artavakshaya is not separately described as disease any where in Ayurvedic classics, of course, this doesn't desecrate Artavakshaya. Because, Acharya Charaka has quoted in Charaka Nidana Sthana, first chapter, that symptoms of a disease themselves also constitute as a disease. But sometime, because of their subordinate nature they are only symptoms and not disease. This quotation substantiates the stand of taking 'Artavakshaya' as disease in the present studies. There are many processes and methods available in Ayurvedic classics to alleviate Artavakshya. But it is yet, the on going research to find out a method of treatment, which is nearer to procurance of permanent cure without side effects. It is well known that Ayurvedic classics emphasize on both Shodhana and Shamana therapy. Since Vata plays key role in Yoniroga, Uttarbasti, being Vata shamana, is a specific treatment in diseased condition of Yoni. As Shamana therapy Kwatha preparation choose to evaluate its efficacy. In the present study total 37 patients were registered, out of them 6 patients were discontinued. One group of patients was administered Arkapushpa Taila Uttarbasti and Krishna Tila Kwatha simultaneously. It gave more significant result. Krishna Tila Kwatha was administered orally in other group. Placebo wheat powder was administered orally in third group. Uttarbasti and Kwatha were found highly effective when administered simultaneously. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/76/68200 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical study on Laksha Guggulu, Snehana, Swedana & traction in osteoarthritis (knee joint) Rajoria, K Singh, SK Sharma, RS Sharma, SN The objective of the present research was to study the efficacy of Laksha Guggulu, Snehana, Swedana & Traction in the management of Osteoarthritis (Knee joint). For the present work, 30 clinically diagnosed patients were selected and randomly divided into three groups. Group A treated with Laksha Guggulu orally, Group B treated with snehana & swedana traction, Group C treated with Laksha Guggulu, Snehana, Swedana & Knee Joint Traction. The various criteria worked upon were joint pain, oedema, tenderness, restriction of joint movement, stiffness, local crepitation, walking distance. Significant results were obtained on pain in joint movement, restriction in joint movement, joint stiffness , local crepitation nearly in all the groups with best result in combined group or group C. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/80/68192 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Evaluation of adaptogenic and anti-stress effects of Ranahamsa Rasayanaya-A Sri Lankan classical Rasayana drug on experimental animals Somarathna, K Chandola, HM Ravishankar, B Pandya, KN Attanayake, A Ashok, BK Various types of stress not only harm the mental function, but also cause diseases by weakening body defenses. Rasayana therapy has an advantage over the conventional Kayachikitsa treatment in such conditions, as it is capable of counteracting the stress, promote the adaptogenic abilities of the body, enhance mental endurance, etc. These are the some of parameters for evaluation the rasayana effect of a drug, therefore the same have been studied to assess the rasayana effect of Ranahamsa Rasayanaya (RR). Experimental models such as forced swimming induced hypothermia and stress induced gastric ulcer formation have been carried out befitting on Charles Foster strain albino rats to determine the rasayana effect of RR. Statistically highly significant decrease in forced swimming induced hypothermia and non-significant decrease in gastric ulcer formation were observed in the treatment groups, when compared to the stress control group. These results show the probable adaptogenic and anti-stress activities of the test drug. The study results support the claims made by the Sri Lankan traditional practitioners that, the test drug is a potent rasayana formulation. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/88/68201 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comprehensive review of cataract (Kaphaja linganasha) and its surgical treatment in Ayurvedic literature Dhiman, KS Dhiman, K Puri, S Ahuja, D Ayurveda the science of life, since its origin is serving the mankind throughout in health & disease state of life. Shalakyatantra, one of its specialized branch deals with the science of Ophthalmology, Otorhinolaryngology, Orodental surgery & Head; was contributed and developed by Rajrishi Nimi, the King of Videha , who was a colleague of Atreya, Punarvasu, Dhanwantri, Bharadwaja, Kashyapa etc. The available literature related to this speciality is reproduced from original text of Nimitantra in Uttartantra of Sushruta samhita. So Rajrishi Nimi deserves all the credit and regards for Shalakyatantra and for being the first eye surgeon on this earth. The fact regarding the technique of cataract surgery adopted by ancient surgeons is still a matter of debate. Most of the medical fraternity accepts cataract surgery of ancient surgeons as couching procedure but after going through forth coming pages, the prevailing concept will prove to be a myth. It started with extra capsular extraction through small incision during the period of Sushruta Samhita but later shifted to couching like technique by Acharya Vagbhatta. Secondly, the objective of this literary research paper is to find proper co-relation of the disease cataract to those mentioned in Ancient Ayurvedic classic. Linganasha has been inadvertently taken as cataract but this is neither logical nor in accordance with classics. We find detailed description of cataract's differential diagnosis, indications, contra- indications, pre/intra/post operative procedures and complication in ancient texts of Ayurveda. Not only this, vivid description of treatment of various complications of cataract surgery are also given. Needless to say, no other surgically treatable diseases & its complications except Kaphaja Linganasha are given this much attention. Medknow Publications 2010-01-01 http://www.ayujournal.org/text.asp?2010/31/1/93/68197 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Editorial Chandola, HM Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/133/72358 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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The effect of ghee (clarified butter) on serum lipid levels and microsomal lipid peroxidation Sharma, H Zhang, X Dwivedi, C Ghee, also known as clarified butter, has been utilized for thousands of years in Ayurveda as a therapeutic agent. In ancient India, ghee was the preferred cooking oil. In the last several decades, ghee has been implicated in the increased prevalence of coronary artery disease (CAD) in Asian Indians due to its content of saturated fatty acids and cholesterol and, in heated ghee, cholesterol oxidation products. Our previous research on Sprague-Dawley outbred rats, which serve as a model for the general population, showed no effect of 5 and 10% ghee-supplemented diets on serum cholesterol and triglycerides. However, in Fischer inbred rats, which serve as a model for genetic predisposition to diseases, results of our previous research showed an increase in serum total cholesterol and triglyceride levels when fed a 10% ghee-supplemented diet. In the present study, we investigated the effect of 10% dietary ghee on microsomal lipid peroxidation, as well as serum lipid levels in Fischer inbred rats to assess the effect of ghee on free radical mediated processes that are implicated in many chronic diseases including cardiovascular disease. Results showed that 10% dietary ghee fed for 4 weeks did not have any significant effect on levels of serum total cholesterol, but did increase triglyceride levels in Fischer inbred rats. Ghee at a level of 10% in the diet did not increase liver microsomal lipid peroxidation or liver microsomal lipid peroxide levels. Animal studies have demonstrated many beneficial effects of ghee, including dose-dependent decreases in serum total cholesterol, low density lipoprotein (LDL), very low density lipoprotein (VLDL), and triglycerides; decreased liver total cholesterol, triglycerides, and cholesterol esters; and a lower level of nonenzymatic-induced lipid peroxidation in liver homogenate. Similar results were seen with heated (oxidized) ghee which contains cholesterol oxidation products. A preliminary clinical study showed that high doses of medicated ghee decreased serum cholesterol, triglycerides, phospholipids, and cholesterol esters in psoriasis patients. A study on a rural population in India revealed a significantly lower prevalence of coronary heart disease in men who consumed higher amounts of ghee. Research on Maharishi Amrit Kalash-4 (MAK-4), an Ayurvedic herbal mixture containing ghee, showed no effect on levels of serum cholesterol, high density lipoprotein (HDL), LDL, or triglycerides in hyperlipidemic patients who ingested MAK-4 for 18 weeks. MAK-4 inhibited the oxidation of LDL in these patients. The data available in the literature do not support a conclusion of harmful effects of the moderate consumption of ghee in the general population. Factors that may be involved in the rise of CAD in Asian Indians include the increased use of vanaspati (vegetable ghee) which contains 40% trans fatty acids, psychosocial stress, insulin resistance, and altered dietary patterns. Research findings in the literature support the beneficial effects of ghee outlined in the ancient Ayurvedic texts and the therapeutic use of ghee for thousands of years in the Ayurvedic system of medicine. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/134/72361 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Studies on the physicochemical characteristics of heated honey, honey mixed with ghee and their food consumption pattern by rats Annapoorani, A Anilakumar, KR Khanum, F Murthy, NA Bawa, AS Honey and ghee are the two food substances used widely in our diet. In Ayurveda, it is quoted that heated honey and honey mixed with equal amount of ghee produce deleterious effects. Hence, it was of our interest to study the physicochemical characteristics and chemical constituents of heated honey and honey mixed with ghee, and their effect on daily food intake and organ weights of rats. The specific gravity of samples showed a significant decrease in honey and ghee samples heated to 140ºC. The pH of honey heated to 140ºC was elevated with a reduction in the specific gravity. There was a significant rise in hydroxymethyl furfuraldehyde (HMF) in 60º and 140ºC heated honey samples. The browning and total antioxidant of honey mixed ghee samples was significantly higher when compared to ghee samples. Further, the authors have also evaluated the effects of consumption of heated honey, ghee, honey mixed with equal amount of ghee and heated honey mixed with heated ghee in rats. The feeding of heated honey and honey mixed with ghee for 6 weeks showed no significant change in the food intake, weight gain and relative organ weights. The study revealed that the heated honey mixed with ghee produces HMF which may cause deleterious effects. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/141/72363 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:72368 2010-04-01 all journal:Ayu
Evaluation of some objective parameters for Ushna and Sheeta Gunas based on pharmacological study Mane, S Vyas, M Ravishankar, B Dwivedi, RR In the formation of a principle, the experimental study plays a pivotal role. After repeated experiments under the same conditions, if one finds the same results, then a principle is formed. Ayurvedic principles which were formulated on the basis of keen observations and through special senses need to be reassessed through contemporary scientific tools. The principles of Ushna (hot) and Sheeta (cold) Gunas (properties) need to be assessed and evaluated through various animal experiments so as to suggest parameters which can be suitable for the evolution of these Gunas. The present study is an attempt to find out the possibility of employing simple experimental parameters to assess these Gunas in selected drug substances and the data generated through this study were analyzed. The obtained results are encouraging to develop the same. All details are presented in this paper. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/147/72368 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:72374 2010-04-01 all journal:Ayu
Experimental evaluation of antidepressant effect of Vacha (Acorus calamus) in animal models of depression Tripathi, AK Singh, RH Depression is a common diagnosis throughout India. It is one of the major sequelae of modern lifestyle which is full of stress. Several drugs and therapies have been tried but a safe and effective treatment of depressive illness is yet not fully established. The main objective of this experimental study on animal models is to evaluate the antidepressant action of plant drug Vacha (Acorus calamus). The behavioral study was conducted and at the same time 5-HT receptor involvement was evaluated. The experimental study was done in rats to evaluate their Open Field Behavior (OFB), High Plus Maze (HPM) activity and 5-hydroxytryptamine (5-HT) receptor syndrome, before and after feeding Vacha. Concurrent Vacha administration in the depression model prevented the development of behavioral deficit in ambulation and rearing due to stress. Similarly, in High Plus Maze Test (HPMT), exploratory activity of rat was restored with Vacha administration. In adopted model of depression, when the animal was subjected to Vacha administration, the behavioural deficit was prevented very well as compared to stressed group. While eliciting the 5-HT syndrome, only two components out of five were influenced by Vacha, indicating that Vacha does not sensitize postsynaptic 5-HT1A receptors, which explains the behavioral deficit prevention in stressed rat group. Vacha definitely has antidepressant effects in animal model of depression. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/153/72374 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:72378 2010-04-01 all journal:Ayu
Infertility caused by tubal blockage: An ayurvedic appraisal Shukla, (K Karunagoda, K Dei, LP Tubal blockage is one of the most important factors for female infertility. This condition is not described in Ayurvedic classics, as the fallopian tube itself is not mentioned directly there. The present study is an effort to understand the disease according to Ayurvedic principles. Correlating fallopian tubes with the Artavavaha (Artava-bija-vaha) Srotas, its block is compared with the Sanga Srotodushti of this Srotas. Charak's opinion that the diseases are innumerable and newly discovered ones should be understood in terms of Prakriti, Adhishthana, Linga, and Aayatana, is followed, to describe this disease. An effort has been made to evaluate the role of all the three Doshas in producing blockage, with classification of the disease done as per the Dasha Roganika. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/159/72378 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Critical analysis of herbs acting on Mutravaha srotas Bhat, SD Ashok, BK Acharya, R Ayurveda has given prime importance to Mutravaha srotas (urinary system) and Srotogata Vikaras (urinary disorders). Being a system responsible for homeostasis of fluids in the body it also detoxifies the body by eliminating certain waste products through urine. When diseased, people produce symptoms such as, increased or decreased urine production, painful maturition, formation of stones, and thereby obstructed micturition, increased frequency of micturition, and so on. There are many herbs with varied actions specifically aimed at mitigating urinary system disorders. Drugs such as Jambu, Amrasthi, and the like, reduce the increased flow of urine, and hence, are considered as Mutrasangrahaneeya, whereas, drugs like Ikshu, Kustha, and so on, increase the flow of urine, and hence, are considered as Mutravirechaneeya. There are drugs like Padma, Utpala, and so on, which impart normal color to the urine and are known as Mutravirajaneeya dravyas. Asmarighna dravyas break down the calculi and remove them through the urine. These dravyas, when used under proper direction, help in relieving the pain and apathy caused by the disease. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/167/72379 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:72380 2010-04-01 all journal:Ayu
'Swapna' in the Indian classics: Mythology or science? Tendulkar, SS Dwivedi, RR There are many concepts in Ayurveda as well as the ancient sciences that are untouched or unexplored. One such concept is that of the Swapna (dreams). Being an abstract phenomenon it makes it difficult to be explained and understood; probably because of this the descriptions related to Swapna in the Indian classics are supported by mythology, to make them acceptable. Variations in these explanations are seen according to the objective of the school of thought; that is, in the ancient texts where dreams are used to delve into the knowledge of the Atman and are related to spirituality, its description in the Ayurvedic texts evolves around the Sharira and Manas. Although all these explanations seem to be shrouded in uncertainty and mythology; there definitely seems to be a logical and rational science behind these quotations. They only need research, investigation, and explanation on the basis of logic, and a laboratory. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/170/72380 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:72384 2010-04-01 all journal:Ayu
Shad Garbhakara Bhavas vis-a-vis congenital and genetic disorders Dhiman, K Kumar, A Dhiman, KS Despite the advancements in diagnostic techniques and therapeutic interventions, medical science has failed to keep the incidence of congenital malformations under control. Ayurveda, the ancient Indian medical system has given due emphasis on this and postulated various measures to minimize the risks. These measures start well before conception. According to Ayurvedic principles, proper preparation of the parents is an essential prerequisite for a healthy progeny. Pre-conception care is a set of interventions that identifies biomedical behavioral and social risks to the health of the mother and the baby. It includes both-prevention and management, emphasizing health issues that require action before conception, very early in pregnancy, for maximal impact. For meeting the objective of healthy progeny, Ayurveda scholars felt the importance of six procreative factors (Shadgarbhkarabhavas) such as Matrija, Pitrija, Aatmaja, Rasaja, Satmyaja, and Sattvaja. The conglomeration of these procreative factors is must for healthy progeny. The physical, mental, social, and spiritual well-being of the person, proper nutrition of the mother during pregnancy, and practice of a wholesome regimen, play a prime role in achieving a healthy offspring, thus structuring a healthy family, society, and nation. Negligence toward any of these factors becomes a cause for unhealthy and defective child birth. The present literary / conceptual study, thus focuses mainly on interpreting these observations, on the basis of modern scientific knowledge. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/175/72384 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:72388 2010-04-01 all journal:Ayu
A clinical comparative study of the management of chronic renal failure with Punarnavadi compound Prashanth, GS Baghel, MS Ravishankar, B Gupta, SN Mehta, MP India like any other country is facing a silent epidemic of chronic renal failure (CRF)- a facet of the health transition associated with industrialization partly fuelled by increase in sedentary lifestyle, low birth weight and malnutrition. Increasing figures by many folds seen is posing a difficult situation to overcome with respect to economy and health of the working and earning population of the nation. There is an urgent need to explore, highlight new interventions and modify modifiable risk factors as a basis for treatment strategies to prevent the development and progression of CRF. The present study was taken up to evaluate the role of trial formulation tab. Punarnavadi compound in the management of chronic renal failure. This was an open clinical comparative study in controlled circumstances wherein 67 patients were studied for two months in three groups- Group A (allopathic control), Group B (ayurvedic control) and Group C (ayurvedic test). It was a multi-centric study; patients were registered from Anandababa charitable dialysis centre, Jamnagar, Kayachikitsa O.P.D. of I.P.G.T. and R.A. Jamnagar and P. D. Patel Ayurveda hospital, Nadiad. Results were assessed on 15 parameters using Students (paired) 't' test. Group A patients showed comparatively better results in eight parameters- weight, platelet count, serum urea, serum uric acid, serum sodium, potassium, chloride and total proteins. Parameter Hemoglobin% showed better results in Group B patients and in Group C patients comparatively better results in six parameters viz.- quality of life (breathlessness, weakness, general functional capacity), total count, serum creatinine and serum calcium - were observed. Throughout the study, trial drug tab. Punarnavadi compound did not show any adverse drug reaction. The results of this study will help in developing a cheap and safe treatment for the management of CRF. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/185/72388 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical trial of Sri Lankan traditional decoction of Pitawakka Navaya in treatment of Kaphaja Shirsha Shoola (chronic sinusitis) Maragalawaththa, M Ediriweera, E Chandimarathne, PB Authentic Ayurvedic texts mention eleven types of Shiro Roga (diseases in head). Kaphaja Shirsha Shoola, which occurs due to vitiation of Kapha and Vata Dosha, is one of them. Chronic sinusitis is a chronic inflammation of sinuses. It can be correlated with Kaphaja Shirsha Shoola. Decoction of Pitawakka Navaya consists of nine ingredients. They are Bhoomyamalaka, Haritaki, Bharangi, Chavya, Pippali, Salarka, Guduchi, Shunti and Maricha. These herbs, which pacify vitiated Vata Dosha and Kapha Dosha, are used by traditional physicians in Sri Lanka to treat Kaphaja Shirsha Shoola (chronic sinusitis). However, no scientific studies have been conducted to evaluate the efficacy of Pitawakka Navaya in treatment of Kaphaja Shirsha Shoola. Hence, this clinical study has been conducted to evaluate its efficacy.. Sixty patients suffering from Kaphaja Shirsha Shoola were selected and examined. These patients were randomly divided into two groups of thirty patients each. First group was treated with 120 ml of decoction of Pitawakka Navaya twice a day for fourteen days. The second group was treated with 120 ml of placebo twice a day for fourteen days. After treatment, most of the patients' symptoms were completely or partially relieved. In less than 10% of patients, some symptoms were unchanged or aggravated. It is observed that traditional decoction Pitawakka Navaya is beneficial for Kaphaja Shirsha Shoola (chronic sinusitis). Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/193/72390 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:72393 2010-04-01 all journal:Ayu
A short-term intervention trial on HIV positive patients using a Sri Lankan classical rasayana drug - Ranahamsa Rasayanaya Somarathna, K Chandola, HM Ravishankar, B Pandya, KN Attanayake, A Rational use of Rasayana therapy, in the management of HIV infected individuals, could potentially stabilize the destructive control mechanisms, by modulating the psycho-neuro-endocrine-immune axis. The objective of the present study has been to determine the short-term effects of Ranahamsa Rasayanaya (RR) in HIV infected patients. A total of 27 patients with documented HIV infection were randomly assigned to two groups, Group A - 5 g of RR twice daily with cow's milk and sugar. Group B - Only routine modern therapy was continued, if any they were taking, including highly active anti-retroviral therapy (HAART). Absolute CD4 <sup>+</sup> T-cell and total lymphocyte counts were measured in these patients, registered under Group A. Only 21 participants completed the study protocol (In Group A, 15 patients and in Group B, 6 patients). Initial mean CD4 <sup>+</sup> T-cell count was 304.50 ± 43.36 cells/microliter, which increased to 430.44 ± 66.01 cells/microliter by 41.36% (P<0.05), measured among 9 patients out of 15, who received RR in Group A. The RR seemed to be a safer adjuvant in people with HIV infection with respect to absolute CD4 <sup>+</sup> T-cell count over a 90 days treatment. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/197/72393 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:72396 2010-04-01 all journal:Ayu
A comparative clinical trial on the role of Panchakarma therapy and Unmada Gajankusha Rasa in the cases of major depressive disorder vis-à-vis kaphaja Unmada Dubey, S Tripathi, JS Gupta, S Reddy, K Depression is a common but serious mood disorder which exerts wide range of physical, physiological and psychological impact. On the basis of the severity of disease, depression is classified under various categories. Of all the types of depression, major depressive disorder resembles the features of kaphaja Unmada. The patients of Kaphaja Unmada are dirty in appearance, their speech and activities are retarded and they prefer to remain in solitude and lonely places. The present study has been conducted in eighty patients of major depressive disorder dividing them into four groups, A, B, C and D using Vamana therapy and Unmada Gajankusha Rasa in the dose of 250 mg twice daily with water. The results were assessed on scoring of clinical symptoms and signs and by using Hamilton depression rating scale (HDRS).The results reveal the mild to moderate degree of response over various parameters which has been presented in detail in the article. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/205/72396 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study of Matra Vasti and an ayurvedic indigenous compound drug in the management of Sandhigatavata (Osteoarthritis) Shah, MR Mehta, CS Shukla, VD Dave, AR Bhatt, NN Sandhigatavata is described under vatavyadhi in all ayurvedic classical texts. Osteoarthritis is the most common articular disorder which begins asymptomatically in the second and third decades and is extremely common by age 70. Here Matra Vasti (therapeutic enema) was given with Bala taila as Vasti is the best treatment for vatavyadhies. It has vatashamaka and rasayana properties. Indigenous compound drug containing Guggulu, Shallaki, Yastimadhu, Pippali, Guduchi, Nirgundi, Kupilu and Godanti was given in one group along with Matra Vasti. In this study, 33 patients of Sandhigatavata completed the treatment. Patients were randomly divided into two groups. Sixteen patients in Group-A (sarvanga Abhyanga-swedana + matravasti) and 17 patients in Group-B (sarvanga Abhyanga-swedana+ matravasti + indigenous compound drug). The results of the study indicate that the patients of both the groups obtained highly significant relief in almost all the signs and symptoms of Sandhigatavata. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/210/72399 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:72402 2010-04-01 all journal:Ayu
Clinical observation on Greeva Stambha (cervical spondylosis) Chikitsa Bharti Katyal, S Kumar, A Makhija, R Devalla, RB Greeva Stambha (A Vataja Disorder) simulates cervical spondylosis, which is a chronic degenerative condition of the cervical spine. Keeping in view the increasing incidence of this problem in modern society with more of desk- workers; an observational study was conducted on 22 patients of Greeva stambha vis-a-vis cervical spondylosis selected from OPD/IPD of CRIA, Punjabi-Bagh, New-Delhi, satisfying the inclusion criteria. The Vatahara treatment viz. Maha Yogaraj Guggulu 500 mg BD, Panchguna tail for local use and Nadi sweda (Local steam with Dashmoola Kwatha) were given for seven days. The results were assessed on the basis of symptomatic improvement using visual analog scale. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/218/72402 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:72404 2010-04-01 all journal:Ayu
A clinical study on Krimidanta with reference to dental caries and its management with Jatipatradi Gutika and Yavanadi Churna Mansuri, M Rajagopala, M Bavalatti, N Dental caries is progressive destruction of enamel, dentine and cementum, initiated by microbial activity at the tooth surface. It is one of the major problems in dentistry. On the basis of clinical features, it can be compared with Krimidanta which is one among the eight diseases of tooth. In the management of Krimidanta, Krimighna, Vataghna and Ushna Veerya dravyas are to be used which can relieve the toothache and discoloration. In this study, the trial drugs used were Jatipatradi Gutika for Pratisarana and Yavanadi Churna for oral administration. In this study, the patients of Krimidanta (dental caries) were selected from OPD of Shalakya Department and allotted randomly in different groups. In Group A, the patients were treated with Jatipatradi Gutika for Pratisarana for 30 days. In Group B, the patients were treated with Yavanadi Churna orally and Group C patients were treated with combined therapy for 30 days. The clinical study has shown that combined therapy gives better results than individual therapies. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/223/72404 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Role of Uttara Vasti with Trivrit and Lasuna oil in the management of primary dysmenorrhea Jahan, S Sujatha, N Neelam Dysmenorrhea is one of the most common clinical entities encountered in regular practice by the gynecologists. Dysmenorrhea means painful menstruation. Fifty percent of the women suffer from dysmenorrhea. Primary dysmenorrhea is correlated with Udavartini yonivyapad in Ayurveda. No successful advances have been made in the line of management till today by western medicine. Therefore, a complete, comprehensive and holistic approach toward its understanding and treatment is the need of the age. In this series, Uttar Vasti, a unique panchakarma procedure, is studied for its role in yonivyapads. A research study was conducted to evaluate the efficacy of Uttar Vasti with Trivrit and Lasuna oil in Primary dysmenorrhea. Thirty-six diagnosed cases of Udavartini Yonivyapad, viz., primary (spasmodic) dysmenorrhea, were selected and randomly allocated into two groups. The effect of Uttar Vasti was compared with the commonly used non steroidal anti inflammatory drug (control group). Uttar Vasti with Operculina turpethum (Trivrit) and Allium sativum (Lasuna) oil has shown encouraging results in Udavartini yonivyapad. Statistically significant relief was seen in the intensity of pain and the successive cycles were less painful in the treated group as compared to control group. The mode of action can be attributed to anti-inflammatory (vatahara), vasodilatory (ushna virya) antispasmodic and laxative (anulomana) properties of the trial drugs. The present study shows Uttar Vasti as a safe and easy technique to treat dysmenorrhea like conditions without any side effects. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/228/72405 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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The role of Apamarga Kshara in the treatment of Arsha Dudhamal, TS Gupta, SK Bhuyan, C Singh, K As per the available treatment modalities of Arsha, the Kshara karma modality is the best one, taking into the consideration its convenience, easy adoptability, cost-effectiveness and curative results. Under this parasurgical procedure, various forms of external kshara application are used in treating the Arsha. These are Ksharasutra Ligation (KSL), ksharpatan, etc. KSL is a surgical procedure, while ksharapatan vidhi is local application and seems to be effective with an easy procedure. Several studies of ksharapatan had been conducted; so the time has come to specify the study of ksharapatan, e.g., according to degree of pile mass and different symptoms and signs. In this present study, apamarga (Achyranthus aspera Linn.) kshara, one among the best qualitative ksharas, was locally applied directly on the different sizes, shapes and degrees of Arsha, to find out its effectiveness with or without any untoward effect. A total of 30 patients were treated by local application of Apamarga kshara. The ksharapatan was done every day, for 7 days in 3 g dose, and the result was assessed thoroughly on the basis of observation according to the specially designed proforma. Apamarga kshara was prepared as per the standard method described in Ayurvedic texts. Patients suffering from Arsha were selected by simple random sampling method, with the complaints of bleeding per rectum, Vedana, Srava, kandu and prolapse. Lastly, it was concluded that ksharapatan had shown significant improvement in 1st and 2nd degree of pile masses without any side effect. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/232/72406 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study on "Computer vision syndrome" and its management with Triphala eye drops and Saptamrita Lauha Gangamma, MP Poonam Rajagopala, M American Optometric Association (AOA) defines computer vision syndrome (CVS) as "Complex of eye and vision problems related to near work, which are experienced during or related to computer use". Most studies indicate that Video Display Terminal (VDT) operators report more eye related problems than non-VDT office workers. The causes for the inefficiencies and the visual symptoms are a combination of individual visual problems and poor office ergonomics. In this clinical study on "CVS", 151 patients were registered, out of whom 141 completed the treatment. In Group A, 45 patients had been prescribed Triphala eye drops; in Group B, 53 patients had been prescribed the Triphala eye drops and Saptamrita Lauha tablets internally, and in Group C, 43 patients had been prescribed the placebo eye drops and placebo tablets. In total, marked improvement was observed in 48.89, 54.71 and 06.98% patients in groups A, B and C, respectively. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/236/72407 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative study of Agni karma with Lauha, Tamra and Panchadhatu Shalakas in Gridhrasi (Sciatica) Bakhashi, B Gupta, SK Rajagopala, M Bhuyan, C Sushruta has mentioned different methods of management of diseases, such as Bheshaja karma, Kshara Karma, Agni karma, Shastrakarma and Raktamokshana. The approach of Agni karma has been mentioned in the context of diseases like Arsha, Arbuda, Bhagandar, Sira, Snayu, Asthi, Sandhigata Vata Vikaras and Gridhrasi. Gridhrasi is seen as a panic condition in the society as it is one of the burning problems, especially in the life of daily laborers. It is characterized by distinct pain starting from Sphik Pradesha (gluteal region) and goes down toward the Parshni Pratyanguli (foot region) of the affected side of leg. On the basis of symptomatology, Gridhrasi may be simulated with the disease sciatica in modern parlance. In modern medicine, the disease sciatica is managed only with potent analgesics or some sort of surgical interventions which have their own limitations and adverse effects, whereas in Ayurveda, various treatment modalities like Siravedha, Agni karma, Basti Chikitsa and palliative medicines are used successfully. Among these, Agni karma procedure seems to be more effective by providing timely relief. Shalakas for Agni karma, made up of different Dhatus like gold, silver, copper, iron, etc. for different stages of the disease conditions, have been proposed. In the present work, a comparative study of Agni karma by using iron, copper and previously studied Panchadhatu Shalaka in Gridhrashi has been conducted. A total of 22 patients were treated in three groups. Result of the entire study showed that Agni karma by Panchadhatu Shalaka provided better result in combating the symptoms, especially Ruka and Tandra, while Lauhadhatu Shalaka gave better results in combating symptoms of Spanadana and Gaurava. In the meantime, Tamradhatu Shalaka provided better effect in controlling symptoms like Toda, Stambha and Aruchi. Fifty percent patients in Panchadhatu Shalaka (Group A) were completely relieved. In Lauhadhatu Shalaka (Group B), the success rate was 00.00%, and in Tamradhatu Shalaka (Group C), the percentage of success rate was 14.28%. After analyzing the data, Tamradhatu Shalaka was found to be more effective than Lauha and Panchadhatu Shalakas. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/240/72408 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical evaluation of selected Yogic procedures in individuals with low back pain Somarathna, K Vyas, GH Dash, SC The present study has been conducted to evaluate selected yogic procedures on individuals with low back pain. The understanding of back pain as one of the commonest clinical presentations during clinical practice made the path to the present study. It has also been calculated that more than three-quarters of the world's population experience back pain at some time in their lives. Twelve patients were selected and randomly divided into two groups, viz., group A yogic group and group B control group. Advice for life style and diet was given for all the patients. The effect of the therapy was assessed subjectively and objectively. Particular scores drawn for yogic group and control group were individually analyzed before and after treatment and the values were compared using standard statistical protocols. Yogic intervention revealed 79% relief in both subjective and objective parameters (i.e., 7 out of 14 parameters showed statistically highly significant P < 0.01 results, while 4 showed significant results P < 0.05). Comparative effect of yogic group and control group showed 79% relief in both subjective and objective parameters. (i.e., total 6 out of 14 parameters showed statistically highly significant (P < 0.01) results, while 5 showed significant results (P < 0.05). Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/245/72409 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Analytical study of Kuberaksha/Kantaki Karanja Patra Churna [Caesalpinia Bonduc (L.) Roxb. leaf powder] Prasad, GP Trimurtulu, G Reddy, KN Naidu, ML Caesalpinia bonduc (L.) Roxb. (Kuberaksha) is an Ayurvedic herb used in the management of malaria, liver disorders, worms, edematous conditions, etc. Based on classical Ayurvedic textual indications and recent pharmacological studies, its leaf powder was selected for studying its effect clinically on filaria. Before conducting the clinical trails, this leaf powder was subjected to certain chemical studies to find the pH, ash value, extractive values, High Performance Thin Layer Chromatography (HPTLC), etc. for standardization of the drug. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/251/72410 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Standard manufacturing procedure for syrup and tablet forms of Jwarahara Dashemani Kalsariya, BD Patgiri, BJ Prajapati, PK Jwarahara Dashemani (JHD) is mentioned by Acharya Charaka under the different categories of Mahakashayas (groups of drugs having similar pharmacological actions). For the present study, syrup and tablet forms of JHDs were prepared and analyzed. The formulations were prepared in various batches by following the standard manufacturing procedure (SMP). JHD Kwatha (2200 ml) and 1430 g sugar candy powder were heated (80-90 <sup>o</sup> C) together for 3.10 hours and 2200 ml syrup was obtained, whereas an average of 446 g of tablet was obtained from the mixture of 285 g Ghana and powder of sugar candy (125 g), JHD Dravyas (55 g) and talc (18 g). These formulations were subjected to various analytical parameters and the results were observed on the basis of preparation. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/255/72411 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Evaluation of antimicrobial activity of Rasaka Bhasma Shubha, HS Hiremath, RS Rasaka , one among the Maharasas, has been indicated in various diseases like Netrarogas, Prameha, etc. Lately, the use of Rasaka bhasma has been declined as an identification of Rasaka. The present study aims to prepare Rasaka bhasma from two different samples of Rasaka and undertake comparative antimicrobial activity study against Gram-positive and Gram-negative organisms by agar disk diffusion method. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/260/72412 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative study on growth pattern of Langali (Gloriosa superba Linn.) under wild and cultivated conditions Asha, KV Rajashekhara, N Chauhan, MG Ravishankar, B Sharma, PP Langali (Gloriosa superba Linn.), obtained from wild habitat and by experimental cultivation under three groups, viz., control, cultivated as per the modern agricultural guidelines and as per the norms of Vriksha-ayurveda was compared and analyzed. Methods of Vriksha-ayurveda give good result in the case of Langali in terms of yield. Failure of control groups both in seed and tuber batches denotes that this plant needs some treatment for vegetative propagation under artificial conditions. Ayurveda group may be considered as a better one in the assessment of reproduction capacity in terms of yield of seeds. Medknow Publications 2010-04-01 http://www.ayujournal.org/text.asp?2010/31/2/263/72413 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Editorial Chandola, HM Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/267/77146 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical trial of Sri Lankan traditional decoction of Pitawakka Navaya in the treatment of Kaphaja Shirsha Shoola Chandimarathne, PB Authentic Ayurvedic texts mention 11 types of Shiro Roga (diseases in the head). Kaphaja Shirsha Shoola, which occurs due to vitiation of Kapha and Vata Dosha, is one of them. Chronic sinusitis is a chronic inflammation of the sinuses. It can be correlated with Kaphaja Shirsha Shoola. Decoction of Pitawakka Navaya consists of nine ingredients; these are: Bhoomyamalaka, Haritaki, Barangi, Chavya, Pippali, Salarka, Guduchi, Shunthi and Maricha. These herbs, which pacify vitiated Vata Dosha and Kapha Dosha, are used by traditional physicians in Sri Lanka to treat Kaphaja Shirsha Shoola (chronic sinusitis). However, no scientific studies have been conducted to evaluate the efficacy of Pitawakka Navaya in the treatment of Kaphaja Shirsha Shoola. Hence, this clinical study was conducted to evaluate the efficacy of the decoction of Pitawakka Navaya in the treatment of Kaphaja Shirsha Shoola. Sixty patients suffering from Kaphaja Shirsha Shoola were selected and examined. These patients were randomly divided into two groups of 30 patients each. The first group was treated with 120 ml of decoction of Pitawakka Navaya twice a day for 14 days. The second group was treated with 120 ml of placebo twice a day for 14 days. After treatment, most of the patients' symptoms were completely or partially relieved. In <10% of the patients, some symptoms were unchanged or aggravated. It is observed that the traditional decoction Pitawakka Navaya is beneficial for Kaphaja Shirsha Shoola (chronic sinusitis). Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/268/77147 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical study on erectile dysfunction in diabetic and non-diabetic subjects and its management with Ficus relegiosa Linn. Virani, NV Chandola, HM Vyas, SN Jadeja, DB Healthy sexual functioning plays an essential role in maintaining the harmony and happiness in marital life. It provides a media to express love, which is the base for all sorts of creative activities. The absence of this function hampers the marital relationship, leading to frustration and, sometimes, ending in divorce, and causes inadequacy in performing the routine duties. In this study, 53 patients having diabetes mellitus were surveyed to find out the incidence of erectile dysfunction (ED). Considering the high prevalence of the disease and the need to look for alternative medicine, a clinical trial on 44 patients of ED was carried out. These patients were divided into two main groups: diabetic and non-diabetic, and were further divided into two subgroups as trial group and placebo group. In the trial group, Ashvattha Kshirpaka prepared with 10 g powder of its root bark, stem bark, fruit and tender leaf buds was given twice a day. In both the diabetic and the non-diabetic subjects, Ashvattha provided encouraging results on ED as well as on seminal parameters in comparison to the placebo. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/272/77148 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of Rasona Pinda in the management of Amavata (rheumatoid arthritis) Singh, JP Antiwal, M Vaibhav, A Tripathi, JS Tiwari, SK In the present clinical study, 63 patients of Amavata were registered from the Kayachikitsa out patient department/indoor patient department (OPD/IPD) of Sir Sunder Lal Hospital (Indian Medicine Wing), IMS, BHU, Varanasi-5. In group I (Rasona Pinda), 27 patients completed the study of a total of 33patients registered in the group (six patients dropped out mid-therapy). In group II (control group), 23 patients completed all three follow-ups out of 30 patients (there were seven dropouts in mid-therapy). In group I, complete remission in 29.6%, major improvement in 59.3% and minor improvement in change font so as to appear 11.1% were observed. In group II, complete remission in 13%, major improvement in 21.7%, minor improvement in 39.1% and unchanged in 26.9% of the patients were observed. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/280/77149 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Randomized placebo-controlled trial of Mustadi Ghanavati in hyperlipidemia Nadkarni, MA Vyas, SN Baghel, MS Ravishankar, B Hyperlipidemia is one of the major lifestyle disorders. Its role has been appreciated in the manifestation of serious diseases like ischemic heart disease, diabetes, stroke etc. These lifestyle diseases are a result of lifestyle factors such as overnutrition etc., which have been referred to as the Santarpanjanya Vyadhis in the classical texts. Mustadi Ghanavti is a modified form of the classical formulation Mustadi Kwath that has been advocated by Acharya Charaka for the management of Santarpanjanya Vikaras. This placebo-controlled randomized trial of Mustadi Ghanavati was carried out on 61 patients suffering from hyperlipidemia; of the 61 patients, 50 completed the entire course of treatment. The results of the study revealed that Mustadi Ghanavati decreased serum cholesterol by 22.4%, serum triglycerides by 19.6%, serum LDL by 18.2%, and serum VLDL by 4.2%; serum HDL increased by 5.6%. Thus Mustadi Ghanavati was able to effect a total improvement of 58.8% in the lipid profile. It brought about mild improvement in 42.86% of patients and moderate improvement in 14.28% of patients. Mustadi Ghanavati was also found to have a significant effect on other subjective as well as objective parameters considered for the study. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/287/77150 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Evaluation of the role of Nithyavirechana and Nayopayam kashaya in Tamaka Shwasa Prasad, MS Ramachandran, AP Acharya, GS Kamath, TS Man has been in steady attempt to find the solutions for the life-threatening and distressing disorders, which afflict the human race. One of such condition is "Tamaka Shwasa," which is recognized by the name bronchial asthma in contemporary discipline, wherein episodic attacks are the characteristic features, leaving the patient in pathetic situation. Therefore management of this acute respiratory condition is the long mission in the medical society of all types. There is abundance of medicines explained for Tamaka Shwasa in Ayurveda, and it is mentioned that combined Shodhana and Shamana therapy is more effective. Hence the present study is designed to evaluate the role of Nithyavirechana followed by Shamana in the form of Nayopayam kashaya in patients of Tamaka Shwasa. This was a single blind clinical study with pre-test and post-test design where in 20 patients suffering from Tamaka Shwasa of either sex between the age group of 16 and 60 years were subjected to the trial. These patients were treated with Nithyavirechana with Eranda thaila (castor oil) followed by oral administration of Nayopayam kashaya in a dose of 50 ml twice a day. The therapeutic effect of the treatment was assessed based on specific subjective and objective parameters. Results obtained were analyzed for the statistical significance by adapting paired 't' test. Statistical analysis established that Eranda thaila and Nayopayam kashaya are highly effective in counteracting the symptoms of Tamaka Shwasa. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/294/77151 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative clinical study of Nyagrodhadi Ghanavati and Virechana Karma in the management of Madhumeha Kumari, J Mehta, CS Shukla, VD Dave, AR Shingala, TM Diabetes mellitus is a common chronic metabolic disorder prevalent all over the world. Virechana is the Shodhana procedure that is specific for the elimination of vitiated Pitta and Kapha doshas. Thus, in the present study, the Virechana process has been selected prior to the administration of Shamana drug. Nyagrodhadi churna is mentioned in Chakradatta, which is modified into Ghana form for easy administration and dose maintenance. The present study was conducted in two groups: Group A, Nyogrodhadi Ghana vati (Shamana therapy) and Group B, Virechana and Nyogrodhadi Ghana vati (combined therapy). A total of 42 patients were registered for the present study, in which 34 patients completed the and eight patients were dropouts. After evaluating the total effect of the therapies, it was observed that the Virechana and Nyagrodhadi Ghanavati (combined therapy) provided better relief in the patients of Madhumeha in comparison with Nyagrodhadi Ghanavati (Shamana therapy) alone. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/300/77152 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative study of Dashamoola Taila Matra Basti and Tila Taila Matra Basti in Kashtartava (dysmenorrhea) Karunagoda, K Shukla, (K Donga, S Tanna, C Dei, LP Kashtartava is a broad term which covers all the problems and ailments that a woman may suffer from during or around menstruation. It includes both primary and secondary types of dysmenorrhea. For this study, however, we considered only primary dysmenorrhea under the term Kashtartava to cover a larger population and to make a pin-pointed assessment criteria. Thus, 40 patients in the age-group of 15-25 years suffering from primary dysmenorrhea were registered for the study. Of these patients, 35 completed the course of treatment. The selected patients were randomly allotted into two groups. Group A received Dashamoola Taila Matra Basti and group B received Tila Taila Matra Basti. These treatments were selected for the Vatashamaka, Yonishula Prashaman, and Shothahara properties of the drugs. The dose was 60 ml per day and the duration of treatment was for 7 days each cycle for two consecutive cycles. Results were assessed according to a specially prepared grading system for pain, Alpartava, Yatochitkaladarshana, Praseka, Chhardi, Vibandha, Shrama, Atisara, Vankshana, Kati, Janu Shula, Shiroshula, Swedadhikya, and Tamodarshana. Significant improvement was seen in symptoms in both groups, and on comparing the results in the two groups we found that the results were almost equivalent. There was complete remission of symptoms in 38.89% in group A and in 35.39% in group B, while there was marked improvement in 50% in group A and 47.65% in group B. However, there was a marked difference between the two groups with regard to recurrence of symptoms during the follow-up period of 2 months, with recurrence being significantly more in group B. The study suggests that Matra Basti can be a reliable treatment for relieving the symptoms of primary dysmenorrhea. We recommend that more research be done to confirm the findings of this study. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/305/77154 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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An assessment of Manasika Bhavas in menopausal syndrome and its management Santwani, K Shukla, VD Santwani, MA Thaker, G The present clinical trial was conducted to evaluate the efficacy of Shirodhara and Saraswatarishta as compared to hormone replacement therapy (HRT) in the management of menopausal syndrome, along with the assessment of Manasika Bhavas. The subjects were randomly divided into three groups. A total 48 patients were selected for the study, out of which 43 patients completed the study. Specialized Ayurvedic rating scales like Manasa Pariksha Bhavas as well as the Hamilton Anxiety Rating Scale, Hamilton Depression Rating scale, and Menopause Rating Scale were adopted to assess the effect of therapy. The effects were examined on the chief complaints as well as the associated complaints. Patients undergoing Shirodhara had better relief of the disturbances of Manasa Bhavas and psychic symptoms of menopause as compared to the other two groups. Saraswatarishta also showed encouraging results in managing the associated somatic symptoms and the psychic symptoms. Hence, we conclude that it can be used as an alternative therapy to HRT. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/311/77156 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Vasantic Vaman and other Panchakarma procedures on disorders of various systems Rawal, M Chudasma, KM Vyas, RV Parmar, BP Kapha is dominant and vitiated in Vasant ritu as it is described in Ayurveda. Acharya Chakrapani has said in chapter six, that not only Vaman, but all the five biopurification methods of the Panchakarma should be practiced in Vasant ritu. Out of the two best seasons in a year for purification, Vasant is better one. This pilot research study was carried out to see the effect of this biopurification process on different disorders. The results were marvelous, as symptomatically 58% relief was achieved. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/319/77160 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Role of Pradhamana Nasya and Trayodashanga Kwatha in the management of Dushta Pratishyaya with special reference to chronic sinusitis Chaudhari, V Rajagopala, M Mistry, S Vaghela, DB Dushta Pratishyaya is the chronic stage of Pratishyaya, which occurs due to neglect or improper management of the disease Pratishyaya. In modern science, chronic sinusitis can be correlated with Dushta Pratishyaya on the basis of the signs, symptoms, complications, and prognosis. Changing lifestyles, rapid urbanization, and the increase in cases of antibiotic resistance are responsible for the rise in the prevalence of sinusitis. In the present clinical study, 37 patients were registered and were randomly divided into three groups: A, B, and C; of the 37 patients, 31 completed the full course of treatment. In group A, Trayodashanga Kwatha with Madhu was given orally; in group B, Pradhamana Nasya with Trikatu + Triphala Churna was administered; and in group C (combined group), Pradhamana Nasya was administered initially, followed by oral Trayodashanga Kwatha with Madhu. In group A, complete relief was observed in 10% of the patients; in group B, marked improvement was observed in 81.82% of patients; and in group C, marked relief was observed in 60% of patients. In comparison to other groups (Group A and Group B), Group C showed percentage wise better results in most of the symptoms. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/325/77165 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Mahayavanala Roma Kshara and Dhanyaka Gokshura Ghrita in benign prostatic hyperplasia Vasava, YR Bhuyan, C Rajagopala, M Gupta, SK Dudhamal, TS Vatastheela is a disease of Mutravahasrotasa, one among the 12 types of Mutraghata disorders elaborated by Sushruta in his seminal work, the Sushruta Samhita. Vatastheela, as described in Ayurveda, closely resembles benign prostatic hyperplasia (BPH) of modern medicine in its signs and symptoms. It is a senile disorder and chiefly affects individuals above the age of 40 years. The symptoms are those of bladder outflow obstruction, with increased frequency of micturition, dribbling, hesitancy, and the features of chronic urinary retention. Surgical management has been accepted as the standard management but is associated with many disadvantages as well as complications, which may not be acceptable at this age. Conservative management with modern medicines is also not free from side effects. So, in this age-group, there is a need for much safer alternative method of management. In this regard, many works have been carried out and shown that the Ayurvedic approach, using natural medicines, is a far better approach. We carried out a comparative study of Mahayavanala Roma Kshara (MRK) and Dhanyaka Gokshura Ghrita (DGG), which are the compounds prescribed for Mutraghata in Ayurvedic literature. The patients were randomly selected from the OPD and IPD of IPGT and RA hospital, Jamnagar, Gujarat, and divided into two groups. In first group, one (500 mg) capsule of MRK was given twice a day with lukewarm water for 45 days; in second group, 10 gm of DGG was given orally twice a day with lukewarm water for 45 days. DGG showed significantly greater relief in the subjective parameters as per International Prostate Symptoms Score (IPSS) than MRK. However, reduction in the size of the prostate and in the volume of the post-void residual urine was found much better in the MRK group. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/332/77168 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Ayurvedic approach for improving reaction time of attention deficit hyperactivity disorder affected children Singhal, HK Neetu Kumar, A Rai, M Attention deficit/hyperactivity disorder (ADHD) is a behavioral disorder of children. It is the most common neurological disorder of childhood. The present study was conducted to examine the increase in attention span in 43 ADHD-affected children treated with different approaches. The reaction time was measured using a Vernier chronoscope (electronic). Selected children of both sexes in the age-group of 6-16 years were divided into three groups. In group A, 17 patients received syrup Ayurvedic compound I; in group B, 14 patients were treated with syrup Ayurvedic compound I + Shirodhara with milk; and in group C, 12 patients received syrup Ayurvedic compound II (placebo). The dose of the drug was 1.0 ml/kg body weight and the duration of treatment was 3 months. Group B showed highly significant (P<.001) improvement in total reaction time, while in group C the change was statistically nonsignificant P > 0.10. It was found that while the drug and Shirodhara were both effective in improving the reaction time of ADHD-affected children, the drug combined with Shirodhara was superior to the drug used alone. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/338/77169 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical effect of Matra Basti and Vatari Guggulu in the management of Amavata (rheumatoid arthritis) Khagram, R Mehta, CS Shukla, VD Dave, AR Amavata is the most crippling of the joint diseases. It occurs throughout the world in all climates and all ethnic groups. Though all the Doshas take part in the causation of this disease, Ama and vitiated Vata play the dominant role. The clinical features of rheumatoid arthritis, such as pain, swelling, stiffness, fever, and general debility, are almost identical to that of Amavata. Treatment provides symptomatic relief, but the underlying pathology remains unchecked because of the absence of effective drugs. In the management of Amavata all the acharyas have described the sequential employment of Dipana, Amapachan, Shodhan, and Shaman therapies. For this study, 118 patients of Amavata were randomly divided into two groups. The patients in group A (50 patients) were given Matra Basti with Brihat Saindhavadi Taila along with Vatari Guggulu; the patients in group B (53 patients) were given only Vatari Guggulu. All the patients responded favorably to the treatment in both the groups; however, patients treated with Matra Basti had better relief in most of the cardinal signs and symptoms of the disease. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/343/77167 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Comparative study of Upavasa and Upavasa with Pachana in the management of Agnisada Rajani, A Vyas, MK Vyas, HA Ayurvedic management is not only concerned with the cure of the diseased person, but is also meant to maintain the health of the healthy person because it is used for Dhatusamya. Langhana is the prime tool in the process of Dhatusamya. In this research study, Upavasa plus Pachana and Upavasa (among ten types of Langhanas) are applied in two different groups, using the random sampling method. Upavasa is taken as Hina Matra Bhojana - that is, gradually increasing the dose of Ahara (by Padanshika Krama) was applied on the basis of the Ahara Shakti of the Atura and status of the Agnisada. Furthermore, for the Pachana, Shunthi (Zingiber officinale) was selected. The subjects for the study were patients who had signs and symptoms of Agnisada and were between the age group of 20 and 60 years. In Group A (Upavasa plus Pachana) 83.77% and in Group B (Upavasa) 72.97% improvement was found, which was statistically highly significant (< 0.001). Upavasa plus Pachana and Upavasa were both found beneficial in promoting the Agni in patients with Agnisada. However, in the percentage-wise comparison Group A showed better result than Group B. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/351/77166 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study of Ashwagandha ghrita and Ashwagandha granules for its Brumhana and Balya effect Mishra, RK Trivedi, R Pandya, MA Good nutrition is the cornerstone of long life, good health, and proper development. Well-nourished children perform well in school, grow into healthy adults and, in turn, give their children a better start in life. Malnutrition, however, continues to be a significant problem, especially among children who can not fend adequately for themselves. Either due to various diseases or due to excessive indulgence in Karshyakara Nidanas pathological changes occur in the body, leading to manifestation of Karshya; in such situations, Brumhana therapy is indicated. This study was planned to evaluate the drug Ashwagandha for its Brumhana effect in children. A total 121 children were enrolled in the study, of which 111 completed the full course of treatment. The children were randomly separated into three groups;, groups A (Ashwagandha ghrita), B (Ashwagandha granules), and C (Placebo). The improvement was maximum in group A, i.e., the subjects receiving Ashwagandha Ghrita. However, childhood is a period of growth and therefore all the children responded to the therapy to some extent. There was good relief of the chief complaints and a trend for improvement was seen in supplementary parameters also. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/355/77164 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Urolithic property of Varuna (Crataeva nurvala): An experimental study Agarwal, S Gupta, SJ Saxena, AK Gupta, N Agarwal, S Despite modern techniques, the recurrence rate of Urolithiasis is approximately 50% within 5 years. Thus, there must be some drug that corrects the metabolic errors and prevents the formation of stone. In Ayurveda, a detailed description of urolithiasis is mentioned under the heading of Ashmari. A group of Ayurvedic drugs are described for the management of Urolithiasis, like Pashanbheda (Bergenia ligulata), Varuna (Crataeva nurvala), Kullattha (Dolichos biflorus), Gokshur (Tribulus terrestris), etc. in our ancient texts. The present work was designed to study the effect of Varuna (Crataeva nurvala) on the experimental model of urolithiasis (albino rats). The study was categorized into two groups: Group I, treated and Group II, control. In all albino rats, stone was surgically implanted into the urinary bladder. Estimation of the urinary and serum electrolyte done periodically and x-rays were exposed at a regular interval. This study suggests the decoction of Varuna (Crataeva nurvala) is effective in the management of urolithiasis. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/361/77161 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:77162 2010-07-01 all journal:Ayu
Antipyretic activity of Guduchi Ghrita formulations in albino rats Ashok, BK Ravishankar, B Prajapati, PK Bhat, SD The present pharmacological investigation was undertaken to study the anti-pyretic activity of Guduchi ghrita formulations in albino rats against yeast induced pyrexia. Seven groups of six animals were used for the experiment. The yeast induced pyrexia method was standardized first by injecting 12.5% yeast suspension (s.c) followed by recording the rectal temperature at regular intervals. Then the evaluation of anti-pyretic activity of Guduchi ghrita formulations was carried out by using this standard procedure. Both the Guduchi ghrita samples including vehicle significantly attenuated the raise in temperature after three hours of yeast injection. After 6 and 9 hours of yeast injection also both the Guduchi ghrita samples attenuated the raise in temperature in a highly significant manner in comparison to both yeast control and vehicle control groups. The data generated during study shows that both the Guduchi ghrita formulations having significant anti-pyretic activity. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/367/77162 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Analgesic effect of Lepidium sativum Linn. (Chandrashura) in experimental animals Raval, ND Ravishankar, B Lepidium sativum Linn, which is known as "Aselio" locally, is frequently used by the villagers for the treatment of Sandhivata (osteoarthritis), with good therapeutic relief. Here, we have to observe the analgesic activity of the seed of Lepidium sativum Linn in albino rats and Swiss albino mice with different parameters. The analgesic study was performed with acetic acid-induced writhing response in mice, formaldehyde-induced paw licking response in rats and tail flick response in mice. Experiments were carried out in two groups - therapeutic dose group and double dose group - with comparison with the control group. In the acetic acid-induced writhing syndrome, latency of onset was highly significantly increased in the therapeutic dose group and significant increase was found in the double dose group. In the formaldehyde-induced paw licking response, the test drug produced significant inhibition of neurogenic pain in the double dose group and significant inhibition of inflammatory pain in the therapeutic dose group. In the tail flick response, the test drug produced a mild to moderate effect in the therapeutic dose group and also in the double dose group. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/371/77163 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Botany, taxonomy and cytology of Crocus sativus series Saxena, RB Saffron is produced from the dried styles of Crocus sativus L. (Iridaceae) which is unknown as wild plant, representing a sterile triploid. These belong to subgenus Crocus series Crocus sativus - series are closely related species; and are difficult to be separated taxonomically and have a complex cytology. Botany of C. sativus - series, taxonomy of their species and their infraspecific taxa are presented, and their distribution, ecology and phenology; full description and chromosome counts are provided with key to their identification. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/374/77153 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Impact of Bhavana Samskara on physico-chemical parameters with special reference to Gandhaka Rasayana prepared by different media and methods Mitra, S Prajapati, PK Shukla, VJ Ravishankar, B Gandhaka Rasayana is frequently used in the management of different skin disorders (Kushtha). It is a herbo-mineral preparation prepared by Shuddha Gandhaka Bhavit with 11 herbal drugs in a serial manner for eight times each. Therefore, it was used as a model drug and four samples were prepared by adopting different methods and media. The physicochemical parameters were evaluated. The effect of increasing the number of Bhavana (lavigation) on particle size of the drug was examined. Similarly, an attempt was also made to differntiate the structure (surface anatomy) of the drug with Bhavana and without Bhavana by using a very sophisticated x-ray photo electron spectrometer (XPS) study. Overall, a remarkable difference was observed in the samples with Bhavana and without Bhavana. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/382/77155 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:77157 2010-07-01 all journal:Ayu
Pharmaceutical study of Lauha Bhasma Singh, N Reddy, K In the present research paper, the work done on pharmaceutical study of Lauha Bhasma conducted in the Department of Rasa Shastra under the postgraduate research programme is being presented. The pharmaceutical processing of Lauha Bhasma was performed by following samanya shodhana, vishesha shodhana and marana of Lauha. Under the process of marana, three specific pharmaceutical techniques were followed, viz. bhanupaka, sthalipaka and putapaka. During the putapaka process, an electric muffle furnace (EMF) was used. The temperature of puta was studied in two batches, viz. in Batch I, a temperature of 800°C was maintained whereas in Batch II, a temperature of 600°C was maintained. The purpose behind selecting two temperatures was to validate the process of marana of Lauha and to determine an ideal temperature for the preparation of Lauha Bhasma in EMF. It is found that after 20 puta at a temperature of 600°C, the Lauha Bhasma was prepared properly. The entire characteristic of Lauha Bhasma, like "pakwa jambu phala varna," varitar, etc. was attained at 600°. At a temperature of 800°C, the process could not be carried out smoothly. The pellets turned very hard and brassy yellow in color. The desired color was attained only after decreasing the temperature in further puta. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/387/77157 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Role of media in the preparation of Apamarga Ksharataila Gohil, H Dhruve, K Prajapati, PK Generally, Tailas and Ghritas have been prepared by using Kalka (paste) and Drava dravya (liquid media usually SwaRasa or Kwatha). However, Apamarga Kshara taila is prepared by using Apamarga Kshara drava (the alkali is obtained after dissolving it in water, after obtaining it by burning, dissolving, and filtration of the same plant). Therefore, to evaluate the role of the media during the preparation, the Taila was prepared in different samples by using the fresh and dry paste of Apamarga along with SwaRasa and Kwatha of Apamarga. All the samples were tested through various analytical parameters, that is, pH, acid value, iodine value, saponification value, and soon. Finally, it was found that Apamarga Kshara taila prepared by using fresh Kalka and Ksharajala was better and it was also an easy pharmaceutical procedure. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/391/77158 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Physiological aspects of Agni Agrawal, AK Yadav, CR Meena, MS Agni is the invariable agent in the process of Paka (digestion, transformation). Ingested food is to be digested, absorbed and assimilated, which is unavoidable for the maintenance of life, and is performed by the Agni. Different examples are available in our classics to indicate that Pitta is the same as Agni, but some doubt arises behind this concept, that Pitta is Agni. Agni is innumerable because of its presence in each and every paramanu of the body. But, the enumeration of the number of Agni varies in various classical Ayurvedic texts. According to the functions and site of action, Agni has been divided into 13 types, i.e. one Jatharagni, five Bhutagni and seven Dhatvagni. Jatharagni is the most important one, which digests four types of food and transforms it into Rasa and Mala. The five Bhutagnis act on the respective bhutika portion of the food and thereby nourish the Bhutas in the body. The seven Dhatvagni act on the respective dhatus by which each Dhatu is broken into three parts. In this way, the entire process of transformation consists of two types of products - PRasad (essence) and Kitta (excrete). The former is taken for nourishment while the latter one is thrown out, which otherwise defiles the body if it stays longer. Medknow Publications 2010-07-01 http://www.ayujournal.org/text.asp?2010/31/3/395/77159 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Globalization of Ayurveda: New horizons! Chandola, HM Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/399/82023 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Historical development of basic concepts of Ayurveda from Veda up to Samhita Thakar, VJ Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/400/82024 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:82026 2010-10-01 all journal:Ayu
Effect of Triphaladi Avaleha as an adjuvant therapy in the management of Thalassemia Jadhav, SB Anand, IP Patel, KS Thalassemia is the most common inherited single-gene (autosomal recessive) disorder in the world. Scientists worldwide predict that thalassemia will become a considerable health issue in the next century. It is a new disease entity for Ayurvedic medicine, and hence, it is called Anukta Vyadhi in Ayurveda; but we can understand it by careful scrutiny of the clinical presentation and the investigation results described in the available literature. Modern medical management is aimed at maintaining the hemoglobin level at 10 - 12 g/dl. A post-transfusion hemoglobin level of 9.5 g/dl is said to be sufficient to maintain active life. Thus, blood transfusion therapy is the only treatment, but it can result in hemosiderosis (iron overload), a complication with a fatal outcome. The transfusional iron overload is compounded by increased intestinal absorption of iron. The most important factors associated with survival, and also those deciding the outcome of bone marrow transplant (the only curative therapy) are, age at which chelation therapy is introduced and the success with which serum ferritin is maintained below 2500 ng/ml. Iron chelators used in modern medicine to achieve this goal are expensive and associated with side effects, and hence, associated with poor adherence to the treatment. The present study is an endeavor to explore the efficacy of Triphaladi Avaleha as an iron chelator in the management of thalassemia, in comparison to a control group managed by routine modern therapy. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/403/82026 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:82027 2010-10-01 all journal:Ayu
A comparative study of Kaishora Guggulu and Amrita Guggulu in the management of Utthana Vatarakta Ramachandran, AP Prasad, SM Prasad, UN Jonah, S Vatarakta is the major example of Vata vyadhi, caused due to avarana pathology. The scenario of Utthana Vatarakta occurred owing to the margavarana pathology, which can very well be correlated with atherosclerotic peripheral arterial disease. The literature enlists a number of Guggulu prayogas in the management of Vatarakta. An additional cavernous revise was indispensable to bring out the precise outcome of these products. Keeping these visions in mind, the particular comparative study was performed with Kaishora guggulu and Amrita guggulu, which are explained in the same context. This is a single-blind comparative clinical study with a pre-test and post-test design, wherein a minimum of 30 patients of either sex, suffering from Utthana Vatarakta, in an age limit of 16 to 70 years, were selected and randomly categorized into two groups. The 15 patients of group A were treated with oral administration of Tab Kaishora guggulu 1 g thrice a day and the group B patients with Tab Amrita guggulu of the same dose pattern with anupana of lukewarm water. The therapeutic effect of the treatment was assessed in both the groups based on specific subjective and objective parameters. The results obtained were analyzed statistically in both the groups and the comparative effect was assessed using the unpaired "t" -test. In the present study, 80% of the patients from both the groups had madhumeha (Diabetes mellitus), shonita mada (Hypertension) or both. Fifty percent of the patients in group A and nearly 60% of the patients in group B, suffering from Utthana Vatarakta, had the habit of smoking. In both the groups, a statistically significant improvement was observed in all the criteria of assessment. The outcome of the study revealed an identical therapeutic efficacy of Kaishora guggulu and Amrita guggulu in Utthana Vatarakta. The use of Kaishora guggulu or Amrita guggulu as shamana Aushadhas was a perfect selection in the management of rakta margavaranajanya Utthana Vatarakta. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/410/82027 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:82029 2010-10-01 all journal:Ayu
Efficacy of Rasayana Avaleha as adjuvant to radiotherapy and chemotherapy in reducing adverse effects Vyas, P Thakar, AB Baghel, MS Sisodia, A Deole, Y Cancer is the most dreadful disease affecting mankind. The available treatments such as chemotherapy and radiotherapy have cytotoxic effects, which are hazardous to the normal cells of the patient, causing many unnecessary effects. This further leads to complications of the therapy, impaired health, and deterioration of quality of life, resulting in mandatory stoppage of the treatment. In the present study, the efficacy of an Ayurvedic formulation, Rasayana Avaleha, has been evaluated as an adjuvant medication to modern radiotherapy and chemotherapy. A total of 36 cancer patients were registered in this trial and were divided into two groups, group A and group B. In group A, the patients were treated with radiotherapy and chemotherapy along with adjuvant Rasayana Avaleha (RT + CT + RA), while in group B only radiotherapy and chemotherapy (RT + CT) were given, as the control group. After assessing the results, it was observed that Rasayana Avaleha gave better results in controlling the adverse effect of chemotherapy and radiotherapy in comparison with the control group. Therefore, Rasayana Avaleha has proved to be an effective adjuvant therapy in protecting patients from the adverse effects of chemotherapy and radiotherapy. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/417/82029 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Kumari Taila Uttar Basti on fallopian tube blockage Shukla, (K Karunagoda, K Sata, N Dei, LP The present study was carried out to evaluate the role of Uttar Basti in tubal blockage, in order to establish it as a safer and cost-effective Ayurvedic treatment modality. The criteria for selection of patients and assessment of results were unilateral or bilateral tubal blockage diagnosed in hysterosalpingography (HSG). A total of 16 patients in the reproductive age group were registered for the study, with 62.50% unilateral and 37.50% bilateral tubal blockage. Fifteen patients completed the course of treatment. The patients with an evidence of active infection or chronic diseases were excluded. Kumari Taila was selected for its Vata Kapha Shamaka and Lekhana properties. The dose of Uttar Basti was 5 ml with duration of two consecutive cycles (six days of Uttar Basti in each cycle with an interval of three days in between). Uttar Basti was administered, after cessation of menstruation, to the screened patients, through hematological, urinary, and serological (HIV, VDRL, HBsAg) investigations. The tubal blockage was removed in 80% of the patients, and 40% of the patients had conceived within the follow-up period of two months. The results suggest that Uttar Basti is a highly significant treatment modality for tubal blockage, with no apparent complications. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/424/82031 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Management of Amavata with 'Amrita Ghrita': A clinical study Lekurwale, PS Pandey, K Yadaiah, P Amavata is a disease caused due to the vitiation or aggravation of Vayu associated with Ama. Vitiated Vayu circulates the Ama all over the body through Dhamanies, takes shelter in the Shleshma Sthana (Amashaya, Sandhi, etc.), producing symptoms such as stiffness, swelling, and tenderness in small and big joints, making a person lame. The symptoms of Amavata are identical to rheumatism, which include rheumatoid arthritis and rheumatic fever. It is observed that rheumatism is an autoimmune disorder, which is among the collagen disorders having strong and significant parlance with Amavata. Various drug trials were already carried out on Amavata, yet there is a lacuna in the management of Amavata. Hence, in the present clinical study, 28 patients were selected and kept on 'Amrita Ghrita'. All the patients were investigated for complete blood count (CBC), rheumatoid arthritis (RA) titer, Antistreptolysin O (ASO) titer, C-reactive protein (CRP) titer, platelet count, urine routine, and microscopic, before and after treatment. The collected data was distributed according to age, sex, and prakruti, and a t-test was applied for the clinical assessment of the subjective and objective parameters of 'Amrita Ghrita,' and it has shown significant reduction in the positivity of the RA titer (t > 5.09, at the 0.001% level), ASO titer (t > 4.08, at the 0.001% level), and CRP titer (t > 4.82, at the 0.001% level), and weight gain (t > 5.12, at the 0.001% level), as also an increase in Hb% (t >9.22, at the 0.001% level), and platelet count (t> 5.90, at the 0.001% level), and decrease in ESR (t > 9.70, at the 0.001% level). Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/430/82033 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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The role of psychic factors in pathogenesis of essential hypertension and its management by Shirodhara and Sarpagandha Vati Kundu, C Shukla, VD Santwani, MA Bhatt, NN This clinical trial was conducted to evaluate the efficacy of Shirodhara and that of Sarpagandha Vati in essential hypertension. A total 47 patients were selected for study, out of which 40 patients (20 in each group) completed the course of treatment. Study subjects were randomly allotted into two groups, with one group being treated with Shirodhara and the other with Sarpagandha Vati. Specialized Ayurvedic rating scales like Manasa Pariksha Bhava as well as the Hamilton Anxiety Rating Scale were adopted to assess the effect of therapy. The effects of treatment on the chief complaints and the associated complaints were also evaluated. The results in the Shirodhara group were better than that in the Sarpagandha group. Although both Sarpagandha Vati and Shirodhara helped in reducing systolic and diastolic pressures, the effect of Shirodhara was more marked. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/436/82035 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical trial of Pippali (Piper longum Linn.) with special reference to Abheshaja Pathak, M Vyas, H Vyas, MK The classification of Dravya has been undertaken in many ways, but according to the medicinal value, they are mainly divided into two - Bheshaja and Abheshaja. No study has been documented on Abheshaja to date as per the scholar's knowledge. Therefore, the present study was carried out to understand the concept of Abheshaja by a practical study. The drug Pippali (Piper Longum Linn.) has been contraindicated to be used for a longer duration. A clinical study was carried out on patients with Kaphaja Kasa, to evolve and assess if the drug acts as Abheshaja or not, and if yes, then under what circumstances. The patients of Kaphaja Kasa had been selected by the random sampling method. They were randomly divided into two groups - Group A and Group B. In Group A, test drug Pippali Churna was administered. Group B was a standard control group and Vasa Churna was given to this group. The dose of both the drugs was 4 g B.I.D. The result was assessed after three weeks of drug administration with the help of a specially prepared proforma. All the important hematological, biochemical, urine, and stool investigations were carried out. There was no adverse drug reaction (ADR) observed after the administration of Pippali in this particular study. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/442/82038 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of Shatapushpa (Anethum sowa Kurz.) powder in the management of Artava kshaya (oligomenorrhoea) Ghose, A Panda, PK A clinical trial was carried out on 30 oligomenorrhoea [Artava Kshaya] patients aged between 15 and 35 years having complaints of irregular, scanty and painful menstruations. The patients were registered from OPD and IPD of Gopabandhu Ayurveda Mahavidyalaya Puri. They were administrated Satapuspa churna for three months in a dose of 5 g twice daily with cow grita. The specific investigations were done in order to exclude TB endometritis, endocrine disorders, diabetes and heart disease. The clinical assessment was carried out in thirty days intervals. It is inferred that the study discloses the effect of satapuspa churna on irregularity of interval of menstruation [90.47%], duration of menstruation [79.37%], amount of blood flow [90.00%] and pain during menstruation [100.00%] which were highly significant in clinical study. No untoward side effect was noticed during clinical trial. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/447/82039 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study on the role of ama in relation to Grahani Roga and its management by Kalingadi Ghanavati and Tryushnadi Ghrita Sorathiya, AP Vyas, SN Bhat, P Grahani and Agni are having Adhara-Adheya-Sambandha. Grahani is described as an Agni Adhishthana by most of the acharyas. Mandagni is a root cause of Ama Dosha and it is the crucial factor for manifestation of most of the diseases. Among them, Grahani is the prime disease of gastro-intestinal tract and seen often in day-to-day practice. A total of 66 patients were randomly divided in three groups and treated with: A) Kalingadi Ghanavati, three vatis of 500 mg twice daily with takra, B) Tryushnadi Ghrita, 10 g twice daily before meal with lukewarm water and C) Combination of both the drugs for 14 days. An assessment was done on the basis of Rogabala, Dehabala, Agnibala, and Chetasabala. The study revealed that combination proved better results than those of individuals. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/451/82041 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study of Nirgundi Ghana Vati and Matra Basti in the management of Gridhrasi with special reference to sciatica Ali, M Shukla, VD Dave, AR Bhatt, NN Gridhrasi can be equated with sciatica, where pain, weakness, numbness, and other discomforts along the path of the sciatic nerve often accompanies low back pain. It is a common affliction of adults, costing billions of dollars in healthcare and resulting in more lost days of work than any other illness but the common cold. A herniated disc, spinal stenosis, piriformis syndrome, etc., can all cause sciatica. The treatment available for sciatica in modern medicine is not very satisfactory.The role of research in Ayurveda is to elucidate the underlying principles and to explain them in modern parameters. The present study was aimed at establishing clinically the effect of Nirgundi (Vitex negundo) Ghan Vati (dried water extract) alone as well as in combination with Matra Basti in the management of Gridhrasi. A total of 119 patients were registered for the study, out of which 102 patients completed the treatment: 52 patients in group A (Nirgundi Ghan Vati) and 50 in group B (Nirgundi Ghan Vati + Matra Basti). The results show that both treatments had an effect on Gridhrasi, but there was better relief of the signs and symptoms in group B. Matra Basti and Nirgundi Ghan Vati might both contribute to different extents in the recovery of the patient. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/456/82042 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical evaluation of the efficacy of Khadiradi yoga avachoornana in Kachchu with special reference to genitoinguinal intertrigo Mamatha, KV Shubha, U Jain, CM Kachchu is a simple localized dermatological infection of the genitoinguinal region, which occurs because of unhygienic observance, and manifests in the form of inflammation followed by secondary bacterial or fungal infections that can be best correlated to genitoinguinal intertrigo. Even though it rarely causes systemic manifestations, its mere presence itself is disturbing because of intractable itching and pain. It may delay the proper healing of the episiotomy wound and may cause difficulty in walking because of severe pain. Candida powder is the highest selling medicine for the intertrigo, as the incidence of intertrigo is as high as 40% in some particular seasons. In the Ayurveda fraternity, there is no established preparation that can be preserved safely in all the epochs of life in females and which is easy to apply. After understanding the disease in the perspective of the ayurvedic and modern medicinal systems, Khadiradi yoga choorna - a new ayurvedic formulation - was prepared on the basis of stringent ayurvedic principles. Hence, an attempt has been made to study the efficacy of the khadiradi yoga avachurnana <sup>1</sup> in Kachchu, with special reference to genitoinguinal intertrigo in females. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/461/82043 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study to assess the efficacy of Triyushnadi Anjana in Kaphaja Abhishyanda with special reference to vernal keratoconjunctivitis Dhiman, KS Sharma, G Singh, S Vernal keratoconjunctivitis / spring catarrh is a variety of exogenous allergic conjunctivitis, which is a very troublesome ocular disease of childhood and in the adolescent age group. The child suffers from intense itching, grittiness, discharge, redness, lacrimation, photophobia, and so on, thereby, decreasing his learning hours. The troublesome features are aggravated in the spring season / hot climate that lasts for years together and rarely persists after adolescence. Mast cell stabilizers, topical Nonsteroidal anti-inflammatory drugs (NSAIDs), and steroids are the available treatment options that too with symptomatic relief and potential side effects, which limits the long-term use of these medicines. The clinical picture of vernal keratoconjunctivitis / spring catarrh is very similar to Kaphaja Abhishyanda, and Triyushnadi Anjana Bhaishajya Ratnavali (B.R.), and its treatment was clinically tried on the patients attending the Netra Roga OPD of the R.G. Government P.G. Ayurveda College Hospital at Paprola (H.P.). A proper protocol and performa was adopted with strict inclusion and exclusion criteria. In the first phase, a pilot study was conducted on 38 clinically diagnosed patients with vernal keratoconjunctivitis, and it gave 100% relief in photophobia, foreign body (FB) sensation, and lacrimation, with marked relief in other features. Encouraged by this pilot work, Triyushnadi Anjana (TA) and 2% sodium cromoglycate (mast cell stabilizer) eye drops in the second-phase clinical trial on 32 patients were tried clinically to evaluate the comparative efficacy. In the second clinical trial, the patients were randomly divided into two groups and Group I was given sodium cromoglycate 2% eye drops and Group II was given TA. The outcome of this study verified the results of the first phase pilot study, and on comparison of the results of the two groups in the second clinical study it was observed that the TA-treated group showed better results. Transient irritation in the eyes was reported by all patients after application of TA, which was relieved by keeping the eyes closed for a few minutes. None of the patients reported any adverse action of the trial drug. Thus, it can be concluded that TA is a safe, cost-effective, and potent Ayurvedic alternative in the treatment of vernal keratoconjunctivitis / spring catarrh. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/466/82044 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study on Akshitarpana and combination of Akshitarpana with Nasya therapy in Timira with special reference to myopia Gupta, DP Rajagopala, M Dhiman, KS Myopia, commonly referred to as shortsightedness, is the most common eye disease in the world with substantial social, educational, and economic impact. Some of the clinical features of Timira can be correlated with myopia. An open randomized clinical trial was conducted to evaluate the role of Tarpana with and without Nasya in patients suffering from myopia. In total, 41 patients were registered in two groups, out of which 30 patients completed the treatment. In Group A, Tarpana with Mahatriphaladya Ghrita and in Group B, Nasya with Abhijita taila followed by Tarpana with Mahatriphaladya Ghrita was administered. After enrollment of the patients in the study, the cardinal signs and symptoms of Timira - myopia, that is, visual acuity, clinical refraction, were evaluated before and after the treatment. Comparatively, more relief in the signs and symptoms were found in the Nasya group followed by the Tarpana group. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/473/82045 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effects of Ayurvedic treatment on forty-three patients of ulcerative colitis Patel, MV Patel, KB Gupta, SN Ulcerative colitis is a chronic idiopathic inflammatory bowel disease with a relapsing nature. It is a very challenging disease affecting a patient during the most active period of his life i.e. 20 to 40 years of age. The main features are ano-rectal bleeding with increased frequency of bowel evacuation, general debility and with abnormal structural pathology in the descending colon, particularly sigmoid colon. In modern medical science, there is no permanent curative and safe treatment for this disease. This study can be helpful for reducing the need of steroids and surgical processes in the patients of ulcerative colitis. A clinical study of 43 patients of ulcerative colitis has been conducted at the O.P.D. (outdoor patient department) and I.P.D. (indoor patient department) of the P D Patel Ayurveda Hospital, Nadiad. They were given Udumbara kvatha basti with oral Ayurveda medicaments including Kutaj ghan vati, Udumbara kvatha, and combination of Musta, Nagakesara, Lodhra, Mukta panchamrut rasa for a one-month period. Results were analyzed statistically by using the 't' test. In this study, it was observed that the symptoms and signs, daily dose of steroids and other anti-inflammatory drugs were reduced by more than 75% with a highly significant result. The hemoglobin level was also increased. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/478/82046 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative study of efficacy of Tugaksheeree[Curcuma angustifolia Roxb.and Maranta arundinacea Linn.] in management of Amlapitta Rajashekhara, N Sharma, PP Amlapitta is a disease caused by increase of Amla Guna of Pitta. Starch obtained from the rhizomes of two plants viz., Curcuma angustifolia Roxb. (Fam. Zingiberaceae) and Maranta arundinacea Linn. (Fam. Marantaceae) are used as Tugaksheeree. In the present clinical study, the efficacy of Tugaksheeree was studied on 67 patients of Amlapitta. A 0 total of 84 patients suffering from Amlapitta were selected from the O.P.D. and I.P.D. sections in the department of Dravyaguna, I.P.G.T. and R.A., Hospital, Jamnagar, and were randomly divided into two groups. Thirty four patients completed the treatment course in Group I, and 33 patients completed the treatment course in Group II. The efficacy of drug Tugaksheeree was studied through internal administration of the starches of C. angustifolia Roxb. (Fam. Zingiberaceae) in Group I and M. arundinacea Linn. (Fam. Marantaceae) in Group II with the dose of 4 g TID with water for 30 days. Both the drugs were found highly effective in treating Amlapitta. They significantly relieved the cardinal symptoms viz., Avipaka, Tikta-amlodgara, Daha, Shoola, Chhardi and the associated symptoms viz., Aruchi, Gaurava, Udaradhmana, Antrakujana, Vit bheda, Shiroruja, Angasada, and Trit. Statistically significant increase in body weight was noticed in both the groups. This may be because the drugs corrected the Agni and acted as Brihmana and Dhatupushtikara. Both the drugs did not produce any side effects. Therefore, both these drugs (C. angustifolia Roxb. and M. arundinacea Linn.) can be used as substitutes for each other. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/482/82047 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A study on Apabahuka (frozen shoulder) and its management by Laghumasha taila nasya Das, B Ganesh, RM Mishra, PK Bhuyan, G Apabahuka is a disease that usually affects the Amsa sandhi (shoulder joint).It is produced by the Vata dosha. Even though the term Apabahuka is not mentioned in the nanatmaja Vata vyadhi, Acharya Sushruta and others have considered Apabahuka as a Vataja vikara. Amsa shosha (wasting of the shoulder) can be considered as the preliminary stage of the disease, where loss or dryness of sleshaka kapha from amsa sandhi occurs. For the present study, Marsha nasya with Laghumasa Taila was administered to 15 patients for seven days, and the following results were obtained. After treatment, 53.33% relief was found on Bahupraspandita hara, 26.66% on Shoola, 30.00% on Stambha, 60.00% on Atopa, and 37.50% on wasting of muscles. On the overall effect of therapy alone, one (6.60%) patient got marked improvement, eight (53.33%) got moderate improvement, four (26.66%) were improved, and two (13.33%) patients remained unchanged. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/488/82048 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Evaluation of immunomodulatory effect of Ranahamsa Rasayanaya - A Sri Lankan classical rasayana drug, on experimental animals Somarathna, KI Chandola, HM Ravishankar, B Pandya, KN Ashok, BK Immunity plays a key role in maintaining the health of an individual. Therefore, the rational modulation of the immunity through psycho-neuro-endocrine-immune (PNI) axis is useful for the prevention as well as for the curing of the diseases. As immunomodulation is a parameter for evaluation of the rasayana effect of a drug, the same has been studied to assess the rasayana effect of Ranahamsa Rasayanaya (RR). Experimental models such as antibody formation against sheep red blood cells (SRBC) and cell mediated immunity (CMI) have been carried out befitting on Wistar strain albino rats to determine the immunomodulatory effect plus rasayana effect of RR. Statistically significant increase in body weight, nonsignificant increase in antibody formation against SRBC, highly significant decrease in CMI were observed in the treatment groups, when compared to the standard control group. These results show the probable immunomodulatory and anabolic activities of the test drug. Outcome of these studies validate the strong rasayana effect of the test drug claimed by the traditional practitioners of Sri Lanka. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/495/82040 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Experimental evaluation of Hingusauvarchaladi Ghrita and Saptavartita Hingusauvarchaladi Ghrita with special reference to their anticonvulsant activity Joseph, CR Ilanchezhian, R Incidence of epilepsy is 0.3 to 0.5% in different populations throughout the world, and the prevalence of epilepsy has been estimated at 5 to 10 persons per 1000. Scanning of the Ayurvedic classics reveals that 90% of the formulations mentioned to have action on sajnavaha srotas are ghrita-based formulations. Ghrita because of its yogavahi guna, incorporates the qualities of the drugs added to it without losing its own qualities. In the present study Hingusauvarchaladi ghrita and saptavartita Hingusauvarchaladi ghrita have been selected, to prove their anticonvulsant activity experimentally on albino mice, by the chemoshock method. The observations recorded have been analyzed by one-way ANOVA followed by Scheffe's test, statistically. Saptavartita Hingusauvarchaladi ghrita has shown better anticonvulsant activity in comparison to Hingusauvarchaladi ghrita. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/500/82037 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative pharmacological evaluation of Taila (oil) and Ghrita (ghee) prepared with Guduchi (Tinospora cordifolia) Vaghamshi, R Jaiswal, M Patgiri, BJ Prajapati, PK Ravishankar, B Shukla, VJ Guduchi (Tinospora cordifolia wild miers) is a well-known medicinal plant, which is abundantly used in different ayurvedic formulations utilizing varieties of media. The drug has properties like Rasayana (rejuvenating property), Krimighna (anthelmintics), and Kushtghna (used in skin disorders), as described in ayurvedic literature. Taila (oil) and Ghrita (ghee) are used as media in Ayurvedic Sneha (oleaginous) formulations. Both the test drugs, Guduchi Taila and Ghrita, are prescribed in Vatrakta (gout) and also indicated for Kushtha (skin disorder). With all these details, the Guduchi Taila and Guduchi Ghrita samples, prepared by using Taila and Ghrita as media, have been subjected to comparative pharmacological investigations, to assess the impact of the media on the expression of pharmacological activity. The formulations have been evaluated for immunomodulation, anti-inflammatory, and anti-stress activities. Both the formulations have been found to be active in most of the experiments, however, with the change of media, their results vary at different levels. Taila prepared from Guduchi was found to have an immunostimulating activity. The formulation prepared with Ghrita exhibited an anti-stress effect with an immunosuppressing activity. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/504/82036 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Preparation and physicochemical analysis of Rasaka Bhasma Shubha, HS Hiremath, RS Rasaka , which is one among the Maharasas, is an ore of zinc and has been used to extract Yashada in ancient times. It has a wide range of therapeutic applications, including in diseases like Prameha, Streeroga, and so on. The practice of Rasaka Bhasma preparation has declined with time due to various reasons. The present study aims to identify the genuine samples of Rasaka, prepare Rasaka Bhasma by subjecting it to Shodhana and Marana, and undertake a physiochemical analysis of the prepared Bhasma with an eye toward the standardization of Rasaka Bhasma. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/509/82025 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Standardization of Gaja Puta and Ardha Gaja Puta in the preparation of Vanga Bhasma Parmar, DK Patgiri, BJ Prajapati, PK The Vanga Bhasma is an important one amongst the metallic Bhasmas. Mainly Gaja Puta, Ardhagaja Puta and Laghu Puta have been described for Marana of Vanga. The medicines, which are prepared from Gaja Puta, are said to be the best ones (Mahagunavidhayaka). Gaja Puta is commonly used in the preparation of almost all the Bhasmas. There are a few references found in classics regarding Ardhagaja Puta, but not any reference regarding its detail description, therefore, the effort was made to standardize both the Putas with regard to Vanga Bhasma. In the present study, Vanga Bhasma was prepared by Gaja Puta and Ardhagaja Puta. For Marana of Vanga, it was found that the Ardhagaja Puta is more convenient than Gaja Puta with respect to color and particle size analysis of Bhasma after Jarana procedure of Vanga. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/511/82028 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A critical review of concept of aging in Ayurveda Devi, D Srivastava, R Dwivedi, BK Ayurveda has a holistic approach toward all the miseries of man and aging is one of these. It is classified as one of the natural and Yapya (palliative) diseases. It is the process of becoming old and decaying. As age advances, several changes take place in the body, in the external appearance, in the condition of Dosha, Dhatu, Mala, Agni, Oja, and so on, as well as in the mental and cognitive functions. Elderly people are susceptible to several chronic diseases also. The problems of the elderly are becoming a matter of great concern as increased life expectancy due to better medical services and improved technology is resulting in an increasing population of the aged. By the year 2020, the World will have more than one billion people aged 60 and over, and more than two-thirds of them will be living in the developing countries. A major concern related to the rapid increase in the population of the aged is that there will be an increase in the prevalence of chronic diseases and disabilities, both being conditions that tend to accompany the aging process. This burden is increasing day by day. In the Ayurvedic texts, a comprehensive description has been given of aging. The aim of this conceptual article is to compile and re-evaluate the various principles related to different aspects of aging. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/516/82030 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical review of different formulations of Vasa (Adhatoda vasica) on Tamaka Shwasa (asthma) Gupta, A Prajapati, PK Vasa (Adhatoda vasica Linn.) is a well known and easily available drug in almost all the seasons. Easy availability of any drug gains popularity among physicians as well as pharmaceuticals and this is the reason why almost every Kalpana of Vasa is found described in the Ayurvedika text. The different dosage forms of Vasa like Kvatha, Avaleha, Sneha, and Sandhana have been used for the treatment of Shwasa Roga. A number of research studies have been performed on different formulations of Vasa and its effect on Shwasa Roga. Therefore, a review study has been carried out on the Vasa extract, Vasa Avaleha (prepared from Svarasa and Kvatha), Vasa Ghrita, Vasarishta, and Vasakasava on Shwasa Roga, to know which formulation is better. It was found in the review that Vasa Ghana, Vasa Ghrita (1), and Vasa Avaleha have shown good results on Tamaka Shwasa. Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/520/82032 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Description of Mutra Pariksha (urine examination) in Atreya Virachita sara sangraha Jakhmola, RK Medknow Publications 2010-10-01 http://www.ayujournal.org/text.asp?2010/31/4/525/82034 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Thirst areas of research in Ayurveda Sharma, ML Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/1/85709 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A review on management of warts in Ayurveda Omprakash Babu, G Human papilloma virus (HPV) is one of the common causes for the warts and most people will experience with this infection at some point in their life. In Ayurveda, warts can be compared with Charmakeela. The diagnosis is based on clinical examination and usually straight forward by visual inspection. The treatment of warts has to be done with endurance and careful selection of procedure according to the type and site of the disease; otherwise, it may lead to cosmetic derangement or recurrence of the ailment. Indications for treatment include pain, interference with function, cosmetic embarrassment, and risk of malignancy. Regarding the management of this disease, different types of treatment procedures are explained in contemporary science. In Ayurveda also, various treatment principles explained like administration of drugs internally, external application of drugs and parasurgical procedures [i.e. Raktamokshana (blood letting), Ksharakarma (chemical cauterization) and Agnikarma (thermal cauterization)]. These indigenous treatment methods are minimal invasive procedures which do not cause the scar formation, no recurrence and found to be more beneficial in the treatment of warts. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/100/85739 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative review study of Sneha Kalpana (Paka) vis-a-vis liposome Singh, N Chaudhary, A Ayurvedic dosage forms are very exclusive in its pharmaceutics and therapeutics. Sneha Kalpana is a group of products of medicated taila and ghee, these drugs are treating very wide range of diseases among patients of all age groups. Liposomal system of drug delivery is a new invention in conventional system of medicine. This system is also covering a high degree of objective of therapeutics at different targets successfully. Probably, here is very distinctive similarity between these two on account of their aqueous and oleaginous origin. Most likely, these are two faces of same coin. A brief survey of literature is done here to explore possibilities of further investigation in benefit of mankind by applying wisdom of both fields together. In fact, this is a review paper based on certain hypothesis which may be established or rejected factually by further researches. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/103/85740 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Standard manufacturing process of Makaradhwaja prepared by Swarna Patra-Varkha and Bhasma Khedekar, S Patgiri, BJ Ravishankar, B Prajapati, PK Makaradhwaja is an important Kupipakwa Rasayana. It is prepared by using Swarna (gold), Parada (mercury) and Gandhaka (sulfur) in different ratios, i.e. 1:8:16, 1:8:24 and 1:2:4, respectively. The amount of Gandhaka in the Jarana process is directly proportional to the increase in therapeutic efficacy and reduces the toxicity of the product. Specific temperature pattern for the preparation of Makaradhwaja has been followed. In the present study Swarna, Parada and Gandhaka were taken in the ratio 1:8:24, respectively, and 12 h of heating for a specified amount of Kajjali (i.e., 400 g) in a Kacha Kupi 1/3 <sup>rd</sup> of its capacity. There are some controversies regarding the form of Swarna (i.e., Swarna Patra Swarna Varkha or Swarna Bhasma) used in the preparation of Makaradhwaja. Therefore, in the present study, the samples of Makaradhwaja were prepared by Swarna Patra, Varkha and Bhasma in different batches. It was found that the use of Varkha produced a good-quality product along with the maximum amount of gold, i.e. 268 ppm, in comparison with Patra, i.e. 131 ppm, and Bhasma, i.e. 19 ppm, respectively. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/109/85741 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Pharmacognostic study of Lepidium sativum Linn (Chandrashura) Raval, ND Pandya, TN Pharmacognosy is the study of naturally occurring biological substances, principally those derived from plants that find use in medicine. The word "Pharmacognosy" is derived from the Greek "Pharmacon," "a drug" and "gignosco," to acquire knowledge of. It is closely related to both botany and plant chemistry and both originated from the earlier scientific studies on medicinal plant. The plant kingdom still holds many species of plants containing substances of medicinal value which have yet to be discovered large number of plants constantly being screened for their possible pharmacological value. The plant Chandrashura is being used for the treatment of Amavata, Sandhivata, and Katishula successfully. Here, an attempt is made to study the plant pharmacognostically; the part taken for study is the seed. Diagnostic features of seed and seed powder were also worked out and the details were presented. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/116/85742 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Understanding personality from Ayurvedic perspective for psychological assessment: A case Shilpa, S The study of personality has fascinated psychologists since a long time. Personality as an area of study has grown so much that a wealth of literature is available. On the other hand, the socio-ethnic dynamics of human race in the emerging global village context provoking psychologists to develop a personality theory which can treat certain basic components of personality as invariants, so that irrespective of culture, race, and nativity could still be able to study personality which will have universal applicability and relevance, is still far away. In the above emerging backdrop, "Ayurveda" has perhaps an important role to play as it can enable providing a theoretical and empirical base of personality traits and types. These Ayurvedic concepts are applicable to all human beings irrespective of caste, color, sex or race. Therefore, it is interesting to build on the Ayurvedic knowledge which has already given us so much since time immemorial, and validate some of these issues related to personality from psychological perspective. There are already certain efforts in understanding Sattva, Rajas, and Tamas Gunas. It can be furthered so that a comprehensive personality picture can be generated, which can have implications for health, career, education and many other dimensions of life. The present paper is a theoretical attempt in developing such a personality proposition which can be validated. Thus, the present paper only builds a theoretical framework for their possible empirical validity. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/12/85716 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Chronic toxicity study of Butea monosperma (Linn.) Kuntze seeds in albino rats Donga, S Shukla, VJ Ravishankar, B Ashok, BK Mishtry, IU In the present study, toxic effects of powder of seeds of Butea monosperma (Linn.) Kuntze were evaluated for a period of 3 months in albino rats. Control group received distilled water. The powder suspension was orally given to the treated group at a dose of 800 mg/kg/day for 90 days. Parameters like body weight, weight of important organs, biochemical, hematological parameters, bone marrow cytology and histopathology of vital organs were studied. Test drug administration did not affect the body weight, organ weight and bone marrow cytology to a significant extent. Among the 18 hematological parameters studied, significant changes were observed in three parameters, namely, significant decrease in hemoglobin content, red blood cell count and hematocrit. Of 16 biochemical parameters studied, significant changes were observed in 5 parameters, namely, decrease in total protein, albumin, bilirubin and significant increase in very low density lipoprotein and triglyceride. The histopathology of 18 organs revealed changes such as fatty changes, glomerular congestion and tubular hemorrhage in the kidneys, decrease in the cellularity of the spleen, epithelial disruption in jejunum, decrease in spermatogenesis in the testis, epithelial proliferation in ventral prostate and decrease in epithelial proliferation in the uterus. Thus, toxicity profile obtained from the present study shows that B. monosperma seeds are likely to produce toxic effect when administered in a powder form. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/120/85743 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Description of Seasonal regimen in Atreya Virachita Sara sangraha Jakhmola, RK In Atreya Virachita Sara sangraha written by Atreya 6 Datta (seasons) Viz. Hemanta, Shishira (winter), Vasanta (spring), Grishma (Summer), Varsha (Rainy) and Sharada (Autumn) were described in a realistic way. Along with this, there is elutriations of specific Roga-Doshas which occur in a particular season and their treatment for maintenance of health along with this pathya-apathya (wholesome diet-behaviour) and vyayama is indicated. Emphasizing the Ritucharya, greater importance is given to Ahara and vihara according to particular Ritu, time of vitiation of Doshas as per season & time of pacification of Doshas are also described. Along with this importance daily regimen for a particular season is also described. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/126/85744 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A review on role of prakriti in aging Purvya, MC Meena, MS Ayurveda is an eternal science with absolute principles, and prakriti is one of these. It plays an important role in the selection and establishment of every factor for which a person is going to interact from conception till death, e.g. lifestyle, diet planning, etc. Prakriti stands for nature of the body in terms of dosha and is decided at the time of conception according to the predominance of dosha. It does not change during the whole life and is responsible for the physical and mental characteristics of an individual. This prakriti is of seven types according to tridosha. The individuals of specific prakriti exhibit biological variations in terms of structure, function, behavior, individual response to internal and external environmental stimuli, susceptibility to different diseases, etc. Aging is a process of decaying and included in natural diseases. In our body, Pitta or Agni is responsible for the various types of pathological conditions. Although aging is a natural pathological condition, Pitta plays an important role in its causation like other pathological conditions. It is clearly indicated in Charak samhita that persons having Pitta predominance personality tend to suffer early with decaying process and other changes of aging. Through this article, we have made an attempt to reevaluate the interrelationships between prakriti and aging. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/20/85719 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical study on the efficacy of Chandra Kalka with Mahadalu Anupanaya in the management of Pakshaghata (Hemiplegia) Hemiplegia is a highly prevalent disease and can be correlated with Pakshaghata, a disease described in Ayurveda. In Sri-Lankan traditional system of medicine, Chandra Kalka with Mahadalu Anupanaya are used successfully in the management of early stage of Pakshaghata and mentioned in Vatika Prakaranaya, a book on traditional medicine. So far, no scientific studies have been performed to evaluate the efficacy of Chandra Kalka with Mahadalu Anupanaya. This study was conducted at Kurunegala Ayurvedic Base Hospital, Sri-Lanka. Thirty patients were selected and randomly divided into two groups. The first group consisted of twenty five patients and treated with one pill of (250 mg) Chandra Kalka with 40 ml of Mahadalu Anupanaya three times a day for fourteen days as an internal therapy. Second group consisted of five patients who were treated with placebo in single blind method. The response to the treatment was recorded and therapeutic effect was evaluated through symptomatic relief of the patients. In the group of patients treated with the above drugs, statistically significant reduction was observed in symptoms such as slurring of speech, swallowing difficulties, fasciculation of tongue, and mouth deviation. In view of this observation and results obtained in this study, it is concluded that the above drug is a very effective traditional preparation that could be used in early stage of management of Pakshaghata, providing speedily and positive effects with a powerful action in controlling symptoms of Pakshaghata. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/25/85720 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Need of new research methodology for Ayurveda Baghel, MS Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/3/85711 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of Mehamudgara vati in type 2 diabetes mellitus Tanna, I Chandola, HM Joshi, JR In type 2 diabetes, insulin resistance is the main problem that is associated with a cluster of conditions such as obesity and hyperlipidemia. The present study was designed with the objective to evaluate the role of Mehamudgara vati (MMV), which was expected to work at the level of Medodhatwagni due to its Medohara properties, to have an effective control on type 2 diabetes. To fulfill the objective, known patients of type 2 diabetes attending the OPD and IPD of Kayachikitsa Department, IPGT and RA, were selected and were divided in two groups. In Group A, MMV was given 3 tab. thrice a day with lukewarm water for 3 months and in Group B, the patients who were already taking modern antidiabetic treatment, although their blood sugar level was not well under control, were additionally given MMV in the same manner. The formulation has shown a highly significant decrease in the fasting and post-prandial blood sugar level. The formulation has also shown a synergistic action when combined with the modern antidiabetic drugs due to its known hypolipidemic, hypocholesterolemic, hepatoprotective, antihyperglycemic, antistress, antioxidant and immunomodulatory activities. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/30/85722 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Observations on Vamana procedure in healthy volunteers Gupta, B Mahapatra, SC Makhija, R Kumar, A Jirankalgikar, N Padhi, MM Devalla, RB Vamana Karma is one of the five Pradhana Karmas of Panchakarma which is successfully used in treating Kaphaj disorders. Panchakarma is also indicated in healthy states. (C.Su. 16/13-16) for Shodhana. Textual references are available in Ayurvedic classics, but the procedure needs to be validated in the modern times when Ahara Shakti, Bala and Agni of the individuals have decreased considerably. So the effect of procedure was observed in 30 healthy volunteers of age group 18 to 60 years. Lakshanik, Vaigiki, Maniki and Antiki Shuddhi were observed and vomitus was analyzed macroscopically, microscopically and chemically. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/40/85723 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative study of Rasona Rasnadi Ghanavati and Simhanada Guggulu on Amavata with special reference to Rheumatoid arthritis Mahto, RR Dave, AR Shukla, VD The present study was aimed to assess the clinical effectiveness of Rasona Rasnadi Ghanavati and Simhanada Guggulu along with Rasona Rasnadi Lepa in Amavata, and to compare the effect of these two therapies in the treatment. Total 101 patients of Amavata were registered for the present study and were randomly divided into two groups. In group A- Rasona Rasnadi Ghanavati 2 Vati thrice/day was given for 3 months, while in group B- Simhanada Guggulu 2 Vati thrice a day for 3 months was adminstered. Along with this, Rasona Rasnadi Lepa was applied locally over affected joints twice daily in both groups. The effects of therapy in both groups were assessed by a specially prepared proforma. The results of the study showed that both the groups showed significant relief in symptoms; however, compared to Simhanada Guggulu, Rasona Rasnadi Ghanavati showed better result in the management of Amavata. Simhanada Guggulu or Rasona Rasnadi Ghanavati along with Rasona Rasnadi Lepa can be used as an effective ayurvedic intervention in the treatment for rheumatoid arthritis. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/46/85724 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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AYU: The unique platform for Ayurvedists Chandola, HM Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/5/85712 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Ayurvedic management in 130 patients of diabetic nephropathy Patel, K Gupta, SN Shah, N Diabetic nephropathy is a specific form of renal disease. It is a major cause of renal insufficiency and ultimately of death. The present study has been carried out to prove the efficacy of Ayurvedic drugs in the management of diabetic nephropathy, which can be helpful in reducing the need of dialysis and avoiding or delaying renal transplantation. A total of 130 patients of this disease were treated in IPD (Group A) and OPD (Group B). Ayurvedic formulations including Gokshuradi Guggulu, Bhumyamalaki, Vasa and Shilajatvadi Vati were given to all the patients for 2 months. Group A patients were given special planned food. Results were analyzed statistically using "t" test. In group A patients, highly significant reduction was found in the values of serum creatinine, blood urea and urinary excretion of albumin. Marked improvement was found in the patients' general physical well-being, together with reduction in symptoms, in group A patients. This shows the importance of Pathyapathya in Ayurvedic management of the disease. This management may bring some new hope to the patients of diabetic nephropathy, which usually terminates to chronic renal failure and ultimately to death. Further studies are being carried out in this regard. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/55/85727 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of Coleus forskohlii (Willd.) Briq. (Makandi) in hypertension of geriatric population Jagtap, M Chandola, HM Ravishankar, B Hypertension is the most common psychosomatic disorder affecting 972 million people worldwide. The present clinical study deals with the effect of Makandi (Coleus forskohlii (Willd.) Briq.) Ghana vati and tablets of its powder in hypertension found in the geriatric age group (50-80 years). A total of 49 hypertensive patients fulfilling the diagnostic criteria were registered in two groups-Group I (Ghana vati) and Group II (Churna tablet). Out of 27 enrolled patients of group I, 21 patients completed the treatment. In Group II, out of 22 registered patients, a total of 20 patients completed the treatment. The effect of the therapy was assessed on the basis of changes in the systolic and diastolic blood pressures, in both sitting and supine positions; with Manasa Bhava Pariksha, Manasa Vibhrama Pariksha, symptomatology, geriatric signs and symptoms, and a brief psychiatric rating scale. Analysis of the results showed that the treatment in both the groups had been found to be good. It can be stated that Makandi, either in Ghana vati form or in churna tablet form, is an effective remedy for the treatment of hypertension. On analyzing the overall effect, 76.19% patients in Group I and 75.00% patients in Group II were mildly improved. Comparatively the overall treatment with group I was found to be better. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/59/85729 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Symbiohealth-Need of the hour Basisht, GK A symbiotic relationship between Allopathy (Modern medicine) and Ayurveda is fundamental in creating a health care system that is : (a) more effective than either system used alone, (b) less expensive, (c) less toxic and (d) more likely to create a healthier society. The fundamental basis of Allopathy is "offense thinking," corresponding to Newton's physics, which makes it an excellent disease management system; on the other hand, Ayurveda is based upon "defense thinking" and corresponds to Quantum physics, and is an excellent system for prevention of disease and for protection and rejuvenation of health. A judicious use of the two systems in group practice will provide better care to the masses. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/6/85715 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical evaluation of the efficacy of Shvitrahara kashaya and lepa in vitiligo Dhanik, A Sujatha, N Rai, NP Vitiligo is a progressive, idiopathic, pigmentation disorder of the skin, characterized by hypopigmented white lesions. PUVA therapy is the treatment of choice in the modern system of medicine. In Ayurveda, Shvitra or Kilasa is the term employed to describe hypopigmentation disorders of the skin. Shvitra is caused by various dietic and behavioral factors which aggravate the tridoshas, especially the Kapha dosha vitiating the Meda dhatu. Many Ayurvedic drugs are well known for the regeneration of melanocytes, among which Bakuchi is one. The present study was planned to study its efficacy in the regeneration of melanocytes. The outcome of treatment in 50 cases of Shvitra vis-à-vis vitiligo receiving Shvitrahara kashaya and Shvitrahara lepa was analyzed and compared. Group I (n = 25) patients were treated with Shvitrahara kashaya and Shvitrahara lepa; Group II (n = 15) patients received Shvitrahara lepa only; and the remaining 10 patients of Group III used both (Western medicine) oral psoralens and UV-A therapy. Assessment was done after 6 months with bi-monthly follow-ups. Out of 25 cases in Group I, 17 showed 80% improvement (t = 7.65; P < 0.01) in the surface area, number of lesions, pigmentation and associated symptoms like itching; out of 15 patients in Group II, 10 showed partial repigmentation, i.e. 50% (t = 5.72; P < 0.01) response was observed. In Group III, 90% response (t = 6.14; P < 0.001) in repigmentation and number of lesions as well was noted but eight patients developed adverse effects like sunburn, severe itching and gastric upset on taking oral psoralen. On the basis of results and observations, it can be concluded that Ayurvedic formulation containing Bakuchi is efficacious and has no untoward effects when compared to oral psoralens and UV-A therapy. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/66/85731 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study of Panchakola Siddha Yavagu in the management of Agnimandya More, SD Dwivedi, RR This research is carried out with the aim to study Agnidipana effect of Panchakola Siddha Yavagu which comprises Pippali (Piper longum), Pippalimula (root of Piper longum), Chavya (Piper chaba Hunter), Chitraka (Plumbago zelynica) and Nagara (Zingiber officinale) which are all in equal proportion processed in six times of water. A randomized open clinical trial on 47 patients of Agnimandya has been screened on the basis of clinical findings and the patients were allocated to two groups. Group A having 29 cases received the trial drug (Panchakola Siddha Yavagu) and 18 cases in Group B received simple Yavagu with roasted rice powder as the control group. Special scoring pattern was done for the assessment of Agnimandya state. Complete cure of the patient was found in 17.24% of the patients, 34.48% patients were improved moderately as well as markedly, whereas mild improvement was observed in 13.80% patients by treatment with Panchakola Yavagu. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/70/85733 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A study on Tailabindu pariksha-An ancient Ayurvedic method of urine examination as a diagnostic and prognostic tool Sangu, PK Kumar, VM Shekhar, MS Chagam, MK Goli, PP Tirupati, PK Indian traditional medicine, Ayurveda has a great history. Researchers in India have tried to corroborate ancient wisdom with the modern scientific practices. Tailabindu pariksha is a diagnostic tool of urine examination developed by the medieval Ayurvedic scholars, and also throws a light on the prognosis of the disease condition. This study aims at using this ancient wisdom to diagnose the medical conditions and to study about their prognosis, and studying about how it can be applied to modern medical practice and its limitations. For the purpose of the study, 30 volunteers were divided into 3 groups. Group I consisting of healthy volunteers, group II of those patients who suffer from curable conditions and group III consisting of patients suffering from chronic diseases which can be regarded as incurable. The urine collection, oil drop instillation and evaluation, were all done according to the guidelines laid down in Ayurvedic practices. Upon the evaluation of the color, appearance, consistency and pattern of oil drop spreading in different patients of different groups, it could be seen that the data could be correlated to what has been provided in the literature in majority of the cases. In today's modern medical practices, there is a plethora of urine diagnostic examinations available. These act as an added financial burden to the patients. In the midst of this, making use of Tailabindu pariksha for urine examination, will not only prove economical, but also is a time-tested and scientifically proven method. More in-depth studies on larger groups of patients, suffering from various diseases need to be done to standardize the procedure and make it scientifically more acceptable. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/76/85735 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative study on efficacy of Bharangyadi Avaleha and Vasa Avaleha in the management of Tamaka Shwasa with reference to childhood asthma Gohel, SD Anand, IP Patel, KS Ayurvedic concept is of the opinion that Tamaka Shwasa (Bronchial Asthma) is a Yapya Vyadhi. The etiopathogenesis, signs, and symptoms of Tamaka Shwasa may be correlated with Bronchial Asthma. Each child reacts differently to the factors that trigger asthma and treated symptomatically. Asthma is the most common chronic allergic disorder in childhood and third leading cause of hospitalization under the age of 15 years. As it is a Kapha-Vata predominant disorder, Ayurvedic medicine may help to decrease the recurrence, improve immunity, and check symptoms naturally. With this aim, a clinical study was undertaken on two groups for duration of 6 weeks. The drugs Bharangyadi Avaleha and Vasa Avaleha were given orally, separately in both the groups. All the patients were kept under strict dietary control during the treatment. The observation on effect of therapy was encouraging and showed less recurrence. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/82/85736 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of Panchamuladi Kaala Basti (enema) in the management of Amavata (Rheumatoid Arthritis) Baria, R Joshi, N Pandya, D Amavata (Rheumatoid Arthritis) has been a challenging problem to the medical field. Various treatment protocols are applied in this disease with partial success. In present clinical study, 12 patients of clinically proven Amavata (Rheumatoid Arthritis) were treated with Panchamuladi Kaala Basti to evaluate its efficacy. All clinical Ayurvediya nidanadi parameters and American Rheumatism Association guidelines for Rheumatoid Arthritis were followed. Before treatment and after treatment, analysis was done and results were calculated statistically using paired 't' test. Results obtained are encouraging and indicate the efficacy of Panchamuladi Kaala Basti over Amavata (Rheumatoid arthritis), exploring many aspects of this clinical entity. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/90/85737 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical study of Manjishthadi Ghrita in vrana ropana Baria, J Gupta, SK Bhuyan, C Healing of vrana (wound) is either primary or secondary by nature. Secondary healing requires more attention than primary healing. Basically, two things, shodhana (making free from undesirable healing factors) and ropana (closure of wound), are desirable for proper healing. Many drugs have been described in classics for healing, but none of them is capable of healing the wound individually. Hence, to fulfill the aim, manjishthadi ghrita was prepared with the help of 7 drugs having vrana ropana effects and was evaluated clinically for its healing properties in this study. It was used topically in postoperative wounds, mostly of ano-rectal cases, twice a day, for 21 days. The follow-up period was 1 month to observe the healing as well as vaikritapaham (reduced deformity) properties and any untoward effects of the drug. A randomized control clinical trial was done. Out of 45 patients, 24 patients in group A were treated with "Manjishthadi Ghrita" (treated group), while 21 patients in group B (standard group) treated with povidine iodine ointment. Better result was observed in the treated group in comparison to the standard group. No adverse effect was observed in any patient. Manjishthadi ghrita can be prescribed as a local healing agent for common wound. Medknow Publications 2011-01-01 http://www.ayujournal.org/text.asp?2011/32/1/95/85738 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Extending Ayurveda further….thinking beyond the possibilities… Chandola, HM Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/139/92538 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Prakriti -based medicine: A step towards personalized medicine Chatterjee, B Pancholi, J The concept of personalized medicine has been around for as long as people have been practicing medicine. From Charaka to Hippocrates, all have practiced the personalized approach for treating a disease. In the 21 <sup>st</sup> century, personalized medicine is all about DNA. Whereas the single nucleotide polymorphism (SNP) and epigenetic factors influence drug response and form the basis of personalized medicine, the tridosha theory forms the basis of Prakriti-based medicine. It is well established by now that western allopathic medicine is excellent in handling acute medical crises, whereas Ayurveda has successfully demonstrated an ability to manage chronic disorders that Western medicine has been unable to cure. With effective integration of 'omics' Prakriti-based medicine can play a vital role in this changing scenario of global health wisdom as Ayurveda offers its modalities by way of ahara (diet), vihara (lifestyle), and aushadhi (medication), which are the three pillars of prakriti-based medicine making it a holistic science. Prakriti-based medicine and other traditional medicine systems have the potential to offer remedies to the challenging health issues like adverse drug reactions, drug withdrawals, and economic disparities among few. An integrative global approach could do wonders to health sciences benefiting a broad spectrum of patients. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/141/92539 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Comparative studies of Bhanumati and Nibandha Samgraha with special reference to Arista Vijnana (prognostic science) Goswami, PK Ayurveda is serving the mankind for centuries with a holistic approach. This system has preached to treat the diseases which are only curable by the physicians. It has advised the physicians to strictly avoid treating the incurable diseases. In order to assess the incurability of the diseases or the incurable state of a patient; this system has preached the signs and symptoms of incurability which are known as arista-vijnana, which have been described in Brhattrayi of Ayurveda. Though Caraka has placed them in a separate section of his treatise, Cakrapani and Dalhana have also spent a considerable portion in their commentaries dealing with arista-vijnana. They were two renowned scholars who have commented with a depth of wisdom on Susruta Samhita. In this paper, the author has tried to present the comparative and critical comments of both commentators based on Bhanumati and Nibandha Samgraha, respectively, over arista-vijnana as described in Sutrasthana of Susruta Samhita. Dalhana was greatly influenced by Caraka Samhita with regard to the prognostic science. On the other hand, Cakrapani repeatedly recognized the superiority of the indriya-sthana of Caraka Samhita with regard to analysis of prognostic science. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/147/92540 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comprehensive outlook of Sannipata Panja, AK Chattopadhyaya, A Chaudhuri, S Nomenclature of the disease on the basis of vitiation of the body humors is stressed in ayurveda. Sannipatika, i.e., 'conglomeration of vitiated tridosa' is the final stage of process of manifestation of disease. In this specific state of pathogenesis, the disease becomes more advance and mostly irreversible. A detailed scientific study of Sannipatika-avastha has been documented in classics. Comprehensive analysis of sannipata-state and its ways of presentation is the main theme of the current article. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/154/92541 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A survey on etiopathological correlation of Krimi (intestinal helminths) and Pandu (anemia) Tengse, VG Baghel, MS Vyas, SN Joshi, JR A survey study was aimed to find etiopathological status of intestinal helminths and also to accomplish its association with clinical condition Pandu. The survey samples included population of five schools and two localities in and around Jamnagar. The study was conducted on 337 subjects, of whom 36.20% cooperated to give stool samples to pathology laboratory; more than half of the samples surveyed were suffering with various parasitic infestations and one-third of the total subjects were found at risk to develop Pandu. Ascariasis patients were found in 71.14%, a potent cause of Pandu. Enterobius vermicularis was found in 19.05%, while Hymenolepis nana in 6.35%. 77.77% were in the age group of 10 to 20 years, 58.73% were male, 93.65% patients were Hindu, 80.95% of the patients had secondary level of education, dominancy of rural habitat was in 77.77%, and 39.68% each were from lower and lower middle class. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/165/92543 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Evaluation of diet and life style in etiopathogenesis of senile dementia: A survey study Chaudhuri, K Chandola, HM Kumar, R Ravishankar, B Mind and body are inseparable entities and influences each other until death. Many factors such as stress, anxiety, depression, negative thoughts, unhealthy life style, unwholesome diet etc., disturb mental and physical wellbeing. Senile dementia is the mental deterioration, i.e, loss of intellectual ability associated with old age. It causes progressive deterioration of mental faculties, e.g., memory, intellect, attention, thinking, comprehension and personality, with preservation of normal level of consciousness. Two major types of senile dementia have been identified, namely that due to generalized atrophy in the cortical area of the brain (Alzheimer's type) and that due to vascular disorders mainly due to stroke. According to DSM-IV (diagnostic and statistical manual of mental disorders), the essential feature of dementia is the development of multiple cognitive deficits that include memory impairment and at least one of the following cognitive disturbances such as aphasia, apraxia, agnosia, or a disturbance in executive function. For the present study, a standardized questionnaire in the form of proforma incorporating types of foods (madhura, amla and lavana rasayukta ahara etc.) and life style (divaswapna, ratrijagarana and manasika bhavas etc) is prepared. To assess manasika bhava, Hamilton Anxiety Rating Scale, Hamilton Depression Rating Scale, Brief Psychiatry Rating Scale, and standardized gradations of anumana pariksha of manasika bhavas mentioned by Charaka at Vimana Sthana 4/8 were adopted. In this study, most of the patients had disturbed sleep, tendency to indulge in defective dietary habits and kapha vitiating diets and life style. On Hamilton Anxiety Rating Scale, patients had anxiety, tension, depression, difficulty in concentration, and memory. On Hamilton Depression Rating Scale, these patients had anxiety, depression, and hypochondriasis. On Brief Psychiatry Rating Scale, psychological factors affected include: anxiety, depression, somatic concern and tension, etc. The data reflects that unwholesome diet and disturbed mental health plays an important role in etiopathogenesis of senile dementia. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/171/92554 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical evaluation of Vardhamana Pippali Rasayana in the management of Amavata (Rheumatoid Arthritis) Soni, A Patel, K Gupta, SN Amavata is described as a difficult to cure (Krichhrasadhya) disease in Ayurveda. Pain in joints with swelling is a cardinal feature of this disease. It can be correlated with rheumatoid arthritis described in modern medical science. In conventional medical science, steroids and some nonsteroidal anti-inflammatory drugs are used for its management, but they cause certain dangerous side effects in the patients. Ayurveda promises an excellent therapy for it. The present clinical trial was conducted with the same objective to provide a safe, economical and effective therapy to the patients of Amavata. The present study was conducted in 73 patients having classical symptoms of Amavata. The patients were given Vardhamana Pippali Rasayana for 15 days. Patients with any other acute or chronic systemic illness or infection were excluded from the study. The observations and results obtained were analyzed statistically applying the "t" test. All the patients experienced up to 50% relief from the signs and symptoms of Amavata after the therapy. The drug might have produced its beneficial effects in the patients of Amavata due to its Agnideepana, Amapachana, Vatashamaka and Rasayana effects in the body. A significant decrease in the erythrocyte sedimentation rate in all the patients was also noticed. All the results obtained were highly significant statistically. Thus, it can be implicated that the Vardhamana Pippali Rasayana has a lot of beneficial effects in the patients of Amavata. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/177/92555 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A study on Vasantika Vamana (therapeutic emesis in spring season) - A preventive measure for diseases of Kapha origin Bhatted, S Shukla, VD Thakar, A Bhatt, NN Panchakarma is the most essential part of Ayurveda treatments. It is preventive, preservative, promotive, curative and rehabilitative therapy. Ayurveda believes in strong relationship between macrocosm and microcosm and states that the seasonal changes will influence the biological systems resulting into the accumulation and aggravation of particular Dosha in a particular season like accumulation and aggravation of Kapha in Hemant Rutu (winter season) and Vasant Rutu (spring season) respectively, accumulation and aggravation of Pitta in Varsha Rutu (rainy season) and Sharad Rutu (autumn season) respectively. Vasantika Vamana is done in spring season approximately in the month of March and April for the elimination of vitiated Kapha Dosha which in turn helps to prevent the forth coming Kapha disorders and associated Pitta disorders or diseases originating or settled in the place of Kapha like bronchial asthma, allergic bronchitis, rhinitis, sinusitis, migraine, hyperacidity, indigestion, anorexia, obesity, overweight, dyslipidemia, diabetes mellitus, acne vulgaris, psoriasis, eczema, urticaria etc. In this study, a total of 89 persons were registered and 69 volnteers/patients undergone classical Vamana Karma without any major complications. Average minimum, maximum, total dose and total days of Snehapana were 36.40 ml, 187.21 ml, 578.59 ml and 5.01 days respectively. Average quantity of Madanaphala, Ksheera, Yashtimadhu Phanta and Lavanodaka was 5.81 g, 1130.29 ml, 3202.9 and 2489.13 ml respectively. The results were encouraging; hence, further studies may be conducted including large population in this direction. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/181/92562 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study of Devadarvyadi-Vati on Grahani Dosha in children Patel, RV Kori, VK Patel, KS Childhood period is considered as the period of rapid growth and development, as it is the crucial stage of establishing future. Gastro-intestinal disorders show high prevalence in pediatric practice. These conditions generally produce chronic illness. Grahani Dosha is a disease related with Agnidushti. This condition is seen more in childhood period due to faulty dietary habit and changing lifestyle. The present paper deals with study on etiopathogenesis of Grahani Dosha and evaluates the efficacy of Deavadarvyadi-Vati. The etiological factors and symptoms were observed carefully to make clear etiopathogenesis. Total 32 patients (3-12 years) were registered and randomly divided into two groups. In Group A Devadarvyadi-Vati (treated group) and in Group B Bhunimbadi-Vati (control group) given for 4 weeks with Koshna Jala. In Group A (Devadarvyadi-Vati), marked improvement was observed in 21.43% of the patients, moderate improvement was observed in 57.14% of patients and mild improvement was observed in 21.43% of patients. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/187/92568 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study on the role of Ksara Vasti and Triphala Guggulu in Raktarsha (Bleeding piles) Mehra, R Makhija, R Vyas, N Shonitarsha is a common affliction which has been described and treated since the beginning of human civilization. Hemorrhoidal cushions are a part of normal anatomy but become pathological when swollen or inflamed. Treatment of piles in modern medicine is hemorrhoidectomy which results in repeated recurrences. Ayurveda provides a cure and prevents recurrences. Present study was carried out using a combination of Apamarga Kshara Basti and Triphalaguggulu. The results of the clinical assessment of the indigenous formulation on 129 patients with bleeding piles are reported in this paper; 55 patients of a total of 129 showed marked relief. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/192/92572 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:92579 2011-04-01 all journal:Ayu
Protective effect of Yashtimadhu (Glycyrrhiza glabra) against side effects of radiation/chemotherapy in head and neck malignancies Das, D Agarwal, SK Chandola, HM One of the very common side effects of Radiation/Chemotherapy especially of the head and neck malignancies is mucositis. Cancer therapy or the cancer itself may cause changes in the body chemistry that results in loss of appetite, pain, nausea, vomiting, diarrhea and very common mucositis which makes eating difficult. Loss of appetite is followed by an undesirable loss of weight due to insufficient amount of calories every day which can lead to loss of muscle mass and strength and other complications by causing interruptions of medical therapy, impeding effective cancer therapy. Mucositis cause decreased immunity and quality of life as well as poor tolerance to surgery and altered efficacy of Chemotherapy and Radiotherapy. The present study is designed with the objective to minimize the radiation induced mucositis, skin reaction, xerostomia, change in voice etc. with an Ayurvedic preparation Yashtimadhu Ghrita (processed ghee). Total 75 patients were randomly divided into four groups and drugs were administered: Group A with local application of Yashtimadhu powder and honey in the oral cavity for few minutes prior to radiotherapy along with oral intake of Yashtimadhu Ghrita; Group B with only local application of the Yashtimadhu powder and honey in the oral cavity; Group C patients administered with only local application of honey in the oral cavity; Group D on conventional modern medication controlled group. All these patients under four groups had received Radiotherapy and Chemotherapy for maximum duration of 7 weeks. Mucositis and Skin reactions were observed in 100% of patients with varying degree. The intensity of Radiation and Chemotherapy induced mucositis was reduced to a great extent by the trial drug. Yashtimadhu (Glycyrrhiza glabra) can be used effectively in prevention and treatment of oral mucositis post radiation and chemotheraphy in patients of cancer, especially of the head and neck region. It proves beneficial in two ways: (i) there were no interruptions in the treatment, and (ii) food intake was not severely affected leading to maintenance of nutritional status of the patients. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/196/92579 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Conceptual and applied study of Snigdha and Ruksa Guna with special reference to Rasa-raktagata Sneha (hyperlipidemia) Mishra, S Dwivedi, RR Ravishankar, B Ayurveda as well as Philosophy accepted the Guna as the basic entity of the Sristi. The Maha Gunas, i.e., Sattva, Raja, and Tama are the prime energy, from where the universe evolves, along with human beings. Dravya and Guna both have a Samavayi relationship in which Gunas reside in Dravya and have a secondary place to it. Guna has multifold meanings according to its use, in social, cultural, philosophical, and literary fields. The concepts of Ayurveda are expressed with Gunas. Samanya and Visesa are usually expressed in terms of Gunas; the classification, description, and function of Dravyas depends upon Guna; Karmas are manifested forms of Guna and Samavaya is the eternal, intimate relation of Dravya and Guna. The principles like Triskandha (Hetu, linga, ousadhi) of Ayurveda also narrated by Gunas, Hetus are narrated in the terms of Guna; the Laksanas are the reflections in the status of Gunas of bodily elements, and Cikitsa is in the form of administration of Viparita Gunas. The increased elements are treated by opposite Guna. So if Ruksa Guna is increased then it is to be managed by Snigdha Guna and vice-versa. So diseases can be treated by applying the Gunas, and drugs for the required patient can be selected by applying these Gunas. In support of the above concept, a study on the persons of Rasa-raktagata Sneha (hyperlipidemia) has been carried out assuming that the condition is an increased state of Snigdha Guna and treatment is done using Ruksa property drugs. Patients were divided into two groups, i.e., treatment group (Ruksa Guna drugs) and control group (placebo). The results were assessed after 45 days with the help of a specially prepared pro forma. All the important hematological, biochemical, and urine investigations were done. According to subjective and objective criteria, significant results were found for Group A as compared to Group B. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/200/92586 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:92588 2011-04-01 all journal:Ayu
Clinical effect of Nirgundi Patra pinda sweda and Ashwagandhadi Guggulu Yoga in the management of Sandhigata Vata (Osteoarthritis) Joshi, A Mehta, CS Dave, AR Shukla, VD Sandhigata Vata is one among the 80 Nanatmaja Vata Vyadhies. Sandhigata Vata and Osteoarthritis have common symptoms, and hence, both are considered as similar entities by a majority of Ayurvedic scholars and same has been adopted here. Osteoarthritis is the most common joint disease among human beings today. In this study, a total of 116 patients were registered, out of them 101 patients had completed the full course of treatment, while 15 patients left against medical advice. The 101 patients of Sandhigata Vata were treated in two groups. Group A: In this group 50 patients of Sandhigata Vata were treated with Nirgundi Patra pinda sweda for 21 days and Ashwagandhadi Guggulu Yoga 3 g/day for 45 days was given orally. Group B : In this group 51 patients of Sandhigata Vata were treated with only Ashwagandhadi Guggulu Yoga 3 g/day for 45 days. To assess the effect of the therapy objectively, all the signs and symptoms of Sandhigata Vata were given a score, depending upon their severity. Also functional tests like walking time, climbing stairs, and joint movement, were measured as a criteria for assessment. Both the groups showed good results, but Group B showed better results in comparison to group A. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/207/92588 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Efficacy of leech therapy in the management of osteoarthritis (Sandhivata) Rai, PK Singh, AK Singh, OP Rai, NP Dwivedi, AK Osteoarthritis (degenerative joint disease) is the most common joint disorder. It mostly affects cartilage. The top layer of cartilage breaks down and wears away. Osteoarthritis is of two types, primary (idiopathic) and secondary. In idiopathic osteoarthritis, the most common form of the disease, no predisposing factor is apparent. Secondary OA is pathologically indistinguishable from idiopathic OA but is attributable to an underlying cause. In Ayurveda the disease Sandhivata resembles with osteoarthritis which is described under Vatavyadhi. The NSAIDs are the main drugs of choice in modern medicine which have lots of side effects and therefore are not safe for long-term therapy. Raktamokshan, i.e., blood letting is one of the ancient and important parasurgical procedures described in Ayurveda for treatment of various diseases. Of them, Jalaukavacharana or leech therapy has gained greater attention globally, because of its medicinal values. The saliva of leech contains numerous biologically active substances, which have antiinflammatory as well as anesthetic properties. Keeping this view in mind we have started leech therapy in the patients of osteoarthritis and found encouraging results. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/213/92589 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of "Bhadra Mustadi Paste" and "Nagaradi Kwatha Gandusha" in Shitada (Gingivitis) Unadkat, R De, S Manjusha, R Shitada is one of the Dantamulagata Rogas mentioned by Acarya Susruta under the heading of Mukha Rogas. It is characterized by symptoms like spontaneous bleeding, halitosis, blackish discoloration of gums, and so on. The symptomatology of Shitada can be compared with gingivitis, which is caused mainly by the accumulation of debris, plaque, and calculus at the tooth margin due to ignorance of oral care. It can progress into periodontitis - the disease in which the firmness, contour, and position of the gums are altered and teeth become mobile. The prevalence of gingivitis is as high as 50% in most of the population. In the present study, a total of 33 patients were registered in three groups. Bhadramustadi yoga has been used in paste form for local application along with Nagaradi Kwatha Gandusa in Group A and in powder form for Pratisarana along with Nagaradi Kwatha Gandusa in Group B. In Group C (Control) Sphatika Jala was used. The patients were diagnosed and assessed on the basis of Ayurvedic as well as modern classical signs and symptoms. Further assessment was done with the different indices used in modern dentistry. All the signs and symptoms were given a score depending upon the severity, to assess the effect of the drugs objectively. The effect of therapy was highly significant in group A in most of the signs, symptoms, and indices; and in group B it was highly significant in some signs and symptoms. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/218/92590 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Comparative clinical evaluation of Kshara Sutra ligation and hemorrhoidectomy in Arsha (hemorrhoids) Gupta, ML Gupta, SK Bhuyan, C Arsha (hemorrhoids) is engorgement of the hemorrhoidal venous plexus, characterized by bleeding per rectum, constipation, pain, prolapse and discharge. It is manifested due to improper diet, prolonged standing and faulty habits of defecation causing derangement of tridosha, mainly vata dosha. Vitiated dosha localizes in guda vali, pradhana dhamani and mansdhara kala and vitiates twak, mansa, meda and rakta, resulting in the annavaha sroto dushti. Modern management of arsha needs, mainly, a surgical approach, i.e. hemorrhoidectomy, wherein the result was found to be less satisfactory. In this regard, to determine a solution for satisfactory cure, the kshara sutra ligation method in arsha was studied in comparison with hemarrhoidectomy. Kshara sutra ligation in arsha was employed in 35 patients, and 26 patients were dealt with hemorrhoidectomy. The study revealed a better result of the kshara sutra ligation-treated group in comparison with hemorrhoidectomy. The observations revealed that maximum advantages like minimum hospital stay, no bleeding during or after operation, no post-operative anal stenosis, a low cost-effective and more acceptable to different categories of people, etc. were recorded in the kshara sutra-treated group. Statistically, kshara sutra ligation for arsha was found to be highly significant and effective management. No adverse effects were noted during the follow-up period. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/225/92591 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical evaluation of Kushmanda Ghrita in the management of depressive illness Chandre, R Upadhyay, BN Depressive illness has been considered as a problematic mental illness since antiquity. The treatment modalities of depressive illness are of many kinds. Use of Medhya Rasayana drugs is a unique method of treatment described in Ayurveda for depressive illness. Kushmanda (Benincasa hispida) is one of the Medhya Rasayana as described by Bhava Mishra. Ghrita is also considered as Medhya Rasayana by almost all Acharyas. Keeping this background Kushmanda Ghrita has been selected as a trial drug to treat the patients of depressive illness. The study was carried out in 35 clinically diagnosed cases of depressive illness by using DSM-IV diagnostic criteria of depressive illness. All patients were given 20 ml of Kushmanda Ghrita in two divided doses morning and evening with 40 ml of lukewarm water for a period of one month. It has shown statistically significant results with psychometric parameters-Hamilton depression rating scale (t = 24.36, P < 0.001), Hamilton anxiety rating scale (t = 26.20, P < .001), immediate memory span direct (t = 4.35, P < 0.001), and indirect test (t = 3.43, P < 01) along with clinical symptoms. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/230/92592 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical evaluation of Basti administered by Basti Putak (Pressure method), Enema pot method (Gravity fed method), and syringe method in Kshinashukra (Oligozoospermia) Juneja, YM Thakar, AB The objective of this study was to determine which method of administration of Basti is more efficacious. The study design was open randomized clinical trial and main outcome measures are Administration time, Retention time, Pervasion of Basti, Semenogram study, and Sexual parameters. The result: Sperm count was increased by 70.75% in Basti putak group and 54.07% in Enema pot group. Overall average retention time of Asthapana Basti and Anuvasana Basti was 1.5 times more in Basti putak group than the Enema pot group. The conclusion of this study was that Basti putak is more efficacious than Enema pot method. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/234/92593 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study on the role of Agnimanthadi compound in the management of Sthaulya (obesity) Goyal, R Kaur, M Chandola, HM Sthaulya (obesity) has become so common in the World's population that it is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health. It exacerbates a large number of health-related problems, both independently and in association with other diseases. Therefore, this study was carried out at PG Hospital, IPGT and RA, Jamnagar to evaluate effect of Agnimanthadi compound in the patients of Sthaulya. For this purpose 83 patients of Sthaulya were selected out of which 15 patients were dropped out. Remaining 68 patients were treated in two groups. Among these, 38 patients of Sthaulya were treated with Agnimanthadi compound administered orally in the dose of four capsules of 500 mg three times a day with lukewarm water before meal. Remaining 30 patients of Sthaulya were kept as placebo control and were administered orally two placebo capsules of 500 mg filled with starch, three times a day with lukewarm water before meal. The duration of the treatment in both the groups was 7 weeks with follow-up for 2 months. Analysis of overall effects of both the groups showed that Agnimanthadi compound provided markedly better reduction in weight, BMI and other signs and symptoms in the patients of obesity in comparison to the control group. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/241/92553 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Pharmacognostic evaluation of leaves of certain Phyllanthus species used as a botanical source of Bhumyamalaki in Ayurveda Sharma, SK Sheela, MA Today, World over, there is a great deal of interest in Ayurvedic system of medicine and thus the demand for various medicinal plants in the production of Ayurvedic medicines is ever increasing. Due to varied geographical locations where these plants grow, a great deal of adulteration or substitution is encountered in the commercial markets. Histological studies of the plant drugs are not only to study the adulterants but also are indispensable in accurate identification. Microscopic observations of the Phyllanthus species revealed the occurrence of anisocytic and paracytic type of stomata in Phyllanthus amarus, while only anisocytic type of stomata is present in P. fraternus and P. maderaspatensis. Epidermal cell walls of P. amarus and P. fraternus are wavy and straight walled epidermal walls are observed in P. maderaspatensis. In India all the above-mentioned species of Phyllanthus are called " Bhumyamalaki" and they are being used in the treatment of various liver disorders. However, all the species of Phyllanthus doesn't have the active constituents responsible for the treatment of liver disorders. In the present investigation by using simple micro techniques accurate identification of different species of Phyllanthus has been established. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/250/92552 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Pharmacognostic evaluation of leaf of Cordia macleodii Hook., An ethnomedicinally important plant Bhide, B Shukla, VJ Acharya, RN Plants of ethnomedicinal importance have contributed for the development of many new pharmacologically effective molecules/chemical entities to modern medicine. India, the country having one of the richest biodiversity of its flora in its forest, with numerous tribal inhabitants, is able to contribute a lot from ethnomedicine to the ailing humanity. Cordia macleodii Hook. (Boraginaceae), an ethnomedicinal plant has been highlighted for its wound healing, aphrodisiac and hepatoprotective activities. It is a medium-sized tree, known as Panki/Shikari by the tribals, rarely found in the forests of Orissa, Chhattisgarh and Madhya Pradesh. So far, the plant has been studied neither for its pharmacognostical characters nor for its pharmacological actions except its hepatoprotective activity. Hence, it has been selected for a detailed investigation which includes pharmacognostic study of its leaf to find out the diagnostic characters and preliminary physicochemical analysis. Results of the study will help in identifying the plant pharmacognostically. Presence of alkaloids, glycosides and tannins were found during the study. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/254/92551 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Evaluation of comparative free-radical quenching potential of Brahmi (Bacopa monnieri) and Mandookparni (Centella asiatica) Mukherjee, S Dugad, S Bhandare, R Pawar, N Jagtap, S Pawar, PK Kulkarni, O Ayurvedic texts describe rejuvenate measures called Rasayana to impart biological sustenance to bodily tissues. Rasayana acting specifically on brain are called Medhya Rasayana. Brahmi is one of the most commonly practiced herbs for the same. Yet there exist a controversy regarding the exact plant species among Bacopa monnieri L. Penn (BM) and Centella asiatica (L.) Urban (CA) to be used as Brahmi in the formulations. Though the current literature available has suggested a very good nootropic potential of both the drugs, none of the studies have been carried out on comparative potential of these herbs to resolve the controversy. Free-radical scavenging potential for these plants is studied to find out their comparative efficacy. The study revealed a very good in vitro free-radical scavenging properties of aqueous and ethanolic extracts of both the plants as evidenced by FRAP, DPPH, reducing power, and antilipid peroxidation assays. It can be concluded from the studies that both the plants, although taxonomically totally different at family level, showed similar type of in vitro activities. The total phenolic and flavonoid contents also revealed a significant similarity in the two plants. The in vitro study supports the Ayurvedic concept of BM and CA having a similar potential. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/258/92549 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Preparation of Dhatryarishta by Dhatri Swarasa and Dhatri Kwatha Madavi, SS Patgiri, BJ Prajapati, PK Dhatryarishta has been described for the first time in Charaka Samhita, in the context of Panduroga. The same reference is available in Chakradatta, Bhaishajya Ratnavali, and Sahastrayogam too. Generally Dhatri Swarasa [Amalaki (Emblica officinalis Gaertn.)] is used in the preparation of Dhatryarishta as per classical reference, but fresh Amalaki is not available in every season, so in the present study, Amalaki Kwatha (decoction) is used instead of Swarasa. A total of 13 batches of Dhatryarishta were prepared, out of which nine batches were prepared with Dhatri Swarasa and four batches with Dhatri Kwatha. For Dhatryarishta prepared by using Dhatri Swarasa, three methods were applied and in Dhatryarishta prepared by using Dhatri Kwatha two methods were applied. The study revealed that Dhatryarishta could only be prepared by using Amalaki Swarasa as quoted in the classics and not by using Amalaki Kwatha. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/265/92548 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Pro blood clotting activity of Scoparia dulcis in rats Ratnasooriya, WD Scoparia dulcis Linn (Family: Scrophulariaceae, Sinhala: WalKoththamalli) is a perennial herb growing in many tropical countries including Sri Lanka. Traditional Physicians in rural down south areas apply crushed S. dulcis plant on cuts and bruises to stop bleeding. S. dulcis may also have Rakta Sthambhana property. The study on effect of decoction (water extract) of S. dulcis on blood clotting time in rats was carried out to investigate this. Two groups of rats, 12 males and 42 females were used in this experimental study. Forty-two female rats were assigned into seven equal groups (n = 6/gp). Different doses of DE (25, 50, 100, 1000, 1500 mg/kg) (group 1-5) or 2 ml of distilled water (DW) (group 6) were orally administered. 0.1 ml of vitamin K was injected intramuscularly (group 7) as reference drug to seventh the group. Twelve male rats were assigned into two equal groups (n = 6/gp), 2 ml of distilled water (DW) and doses of DE (1500 mg/kg) were orally administered. Clotting time was determined on the Days 1, 2, and 7 using Lee and White method. In the DE treated groups with all doses, there was no reduction in clotting time on the Day 1 but a significant reduction of clotting time (P < 0.05) was observed on the Days 2 and 7. In the group treated with vitamin K, there was no significant reduction in clotting time on Day 1 or 2, but there was a significant reduction in clotting time on Day 7. It is concluded that S. dulcis has proclotting activity (rakthasthambhana property) and this was faster than vitamin K. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/271/92547 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Immunomodulatory activity of Vachadhatryadi Avaleha in albino rats Rajagopala, S Ashok, BK Ravishankar, B The present study is carried out to evaluate the immuno-modulatory activity of Vacha Dhatryadi Avaleha in albino rats. Vacha Dhatryadi Avaleha was prepared by classical method and evaluated for humoral antibody formation and cell-medicated immunity in established experimental models. Test formulation was administered at the dose of 900 mg/kg and parameters like hemagglutination titer, ponderal changes, histopathology of immunological organs and immunological paw edema were recorded. Vacha Dhatryadi Avaleha significantly enhanced antibody formation and moderately suppressed the immunological edema. The present study concludes that Vachadhatryadi Avaleha has immunopotentiating activity. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/275/92546 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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The effect of Emblica officinalis diet on lifespan, sexual behavior, and fitness characters in Drosophila melanogaster Pathak, P Murthy, NA Hegde, SN Drosophila is an excellent organism to test Ayurvedic medicines. The objective of our study was to explore the potential of Emblica officinalis drug on longevity, sexual behavior, and reproductive fitness of Drosophila melanogaster using adult feeding method. Increase in the lifespan, fecundity, fertility, ovarioles number, and developmental time was observed in both parents and F1 generation, but not in the F2 generation in experimental culture (control + E. officinalis). According to the Duncan's multiple range test and ANOVA, there is a significant difference between two cultures. It was also noticed that E. officinalis influence some fitness characters in Drosophila along with sexual behavior. Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/279/92544 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Ayurveda and herbs in dental health Saini, R Sharma, S Saini, S Medknow Publications 2011-04-01 http://www.ayujournal.org/text.asp?2011/32/2/285/92542 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Ayurveda: Think globally... act locally… Chandola, HM Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/297/93901 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Report on the status of Indian medicine and folk healing-with a focus on the benefits that the systems have given the public Chandra, S Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/299/93902 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Ayurpathy: A modern perspective of Ayurveda Katiyar, CK Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/304/93903 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:93904 2011-07-01 all journal:Ayu
"Ayurpathy": Misconceived and unwarranted Singh, RH Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/306/93904 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:93905 2011-07-01 all journal:Ayu
Development and standardization of Mysore Tridosha scale Shilpa, S The authors have developed a personality scale to assess Tridoshas i.e. Vata, Pitta, and Kapha from psychological perspective in human beings. The Tridoshas are composed of the Pancha Mahabhutas, but one or the other Dosha is dominant singularly or in combination. There can never be a state when one or the other Pancha Mahabhutas and consequently the Tridoshas are absent totally. All five are essential to sustain life. Vata Dosha is composed of Akasa and Vayu Mahabhuta. Pitta Dosha is composed of Tejas or Agni and Ap Mahabhuta. Kapha Dosha is composed of Ap and Prithvi Mahabhuta. Although Tridosha is studied, understood, and applied in Ayurveda, the present authors have tried to validate the same from the domain of psychology. Since the authors are not from the domain of Ayurveda but of Psychology, there are some constructs that are not amenable for psychological testing which have been ignored. Only those constructs that can be used by psychologists to assess the psychological aspects of the Dosha Prakriti have been used to build items for the assessment of personality. In this process, the psychometric properties of the scale are established. The scale assesses the psychological manifestation of the Tridoshas, which was the basic objective. The standardization procedure involved in the development of the Mysore Psychological Tridosha Scale is herewith delineated. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/308/93905 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:93906 2011-07-01 all journal:Ayu
Effect of dietary, social, and lifestyle determinants of accelerated aging and its common clinical presentation: A survey study Chandola, HM Ravishankar, B Aging is unavoidable and natural phenomenon of life. Modern gerontologists are realizing the fact that aging is a disease, which Ayurveda had accepted as natural disease since long. Rate of aging is determined by one's biological, social, lifestyle, and psychological conditions and adversity of which leads to accelerated form of aging (Akalaja jara or premature aging). The aim of this study is to identify potential factors that may accelerate aging in the context of dietry factors, lifestyle and mental makeup. The 120 diagnosed subjects of premature-ageing of 30-60 years were randomly selected in the survey study. Premature ageing was common among females (75.83%), in 30-40 age group (70%), 86.67% were married, had secondary level of education (36.66%), house-views (61.67%), belongs top middle class (58.33%) and engaged in occupations that dominating physical labour (88.33%). The maximum patients are constipated (60%), had mandagni (80%), vata-kapha prakriti (48.33%), rajasika prakriti (58.33%), madhyama vyayama shakti (73.33%), and madhyama jarana shakti (85.83%). Collectively, 43.33% patients were above normal BMI. The more patients had anushna (38.33%) and vishamasana dietary pattern (25.83%), consumed Lavana (88.33%) and Amla rasa (78.33%) in excess on regular basis. Some patients had addicted to tobacco (11.67%) and beetle chewing (5.83%). The maximum patients had no any exercise (79.17%) and specific hobby (79.17%) in their leisure times. Analyzing Hamilton Anxiety and Depression Rating Scales revealed that 39.80%, 37.86%, 33.98%, 24.27% and 18.44% patients had insomnia, depression, tension, GIT symptoms and anxious mood respectively. These data suggest that certain social, dietary and lifestyle factors contribute towards accelerated ageing among young individuals. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/315/93906 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Efficacy of Ashwagandha (Withania somnifera Dunal. Linn.) in the management of psychogenic erectile dysfunction Mamidi, P Thakar, AB Erectile dysfunction (ED) has been defined as the persistent inability to attain and maintain an erection sufficient to permit satisfactory sexual performance. By 2025, men with ED will be approximately 322 million, an increase of nearly 170 million men from 1995. The present study was aimed to evaluate the efficacy of Ashwagandha (Withania somnifera) in the management of psychogenic erectile dysfunction. In this study, a total of 95 patients with psychogenic erectile dysfunction satisfying the DSM IV TR diagnostic criteria were selected, out of them 86 patients completed the course of treatment. In Trial Group, Ashwagandha root powder and in Control group, Placebo (Wheat powder) were given for 60 days. Treatment selection and its allocation were done by following computerized randomization plan. Criterion of assessment was based on the scoring of International Index of Erectile Function (IIEF) Scale. Paired and Unpaired t test were used for statistical analysis. In Trial group (n=41), 12.6% and in Control group (n=45), 19.11% of improvement was observed with the significance of (P<0.001). There was no significant difference (P>0.05) found in between the two groups. Both Ashwagandha and Placebo provided no relief (<25% improvement on IIEF) in psychogenic erectile dysfunction. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/322/93907 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A pilot study to clinically evaluate the role of herbomineral compound " Rakatchap Har" in the management of essential hypertension Nandha, R Singh, H Moudgill, P Kular, G The aim of the present study was to investigate the clinical efficacy of a herbomineral medicine Rakatchaphar (Each 500 mg cap contains Sarpgandha 150 mg, Shankhpushpi 75 mg, Jatamansi 75 mg, Jahar Mohra Khatai Pishti 75 mg, Moti Pishti 75 mg, Ras Sindoor 50 mg) in essential hypertension, an observational prospective study was done at Shri Ashutosh Maharaj (SAM) Ayurvedic Treatment and Research Centre, Noormahal. Ninety-eight patients in the age group 28-76 years with essential hypertension without any co-morbid illness were included in the study. Patients were treated with cap Rakatchaphar 500 mg twice a day. Blood pressure (BP) was monitored on subsequent follow-up visits at 2, 4, 6, and 8 weeks. Change in Diastolic BP (DBP), Systolic BP (SBP), and Mean BP (MBP) were analyzed statistically by Student's t test, ANOVA, and Post hoc Bonferroni test. On first visit the mean SBP, DBP, and MBP was 164.16±17.27, 101.88±9.20, and 122.27±10.57 mm Hg, respectively. After 8 weeks of therapy there was a statistically significant fall in SBP (122.98±11.36), DBP (80.90±8.57), and MBP (94.86±9.24) in mmHg (P value <0.0001). Rakatchap Har offers an efficacious and safe combination of natural products available for the treatment of hypertension. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/329/93908 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study of some Ayurvedic compound drugs in the assessment quality of life of patients with Eka Kushtha (psoriasis) Mehta, CS Dave, AR Shukla, VD Psoriasis is a chronic disease that can have substantial psychological and social impact on patient's life. Psoriasis has been shown to affect health-related Quality of Life to an extent similar to the effects of other chronic diseases such as depression, myocardial infarction, hypertension, etc. The modern treatment options not only provide temporary relief but also have serious side effects. Thus, the chronic and recurring nature of the disease hampers the Quality of Life to a great extent. In the present study, patients were randomly divided into two groups. Koshtha Shuddhi was done by Eranda bhrushta haritaki (6 g at night with ushnodaka) in patients of both the groups for 3 days before starting the treatment. A total of 111 patients were selected for the present study and were grouped into two. Patients of group A (45) were given "Navayasa rasayana leha" and "Dhatryadhyo lepa" for external application. Stress is a well-known precipitating factor of Psoriasis. Hence, to study the efficacy of Medhya rasayana drugs, patients of group B (49) were given Medhya rasayana tablet along with the application of Dhatryadhyo lepa. The duration of the study was 3 months and follow-up was done for one month. Both the groups showed equally good results on improving the quality of life in the patients in terms of Dermatology life quality index and Psoriasis disability index. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/333/93909 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:93910 2011-07-01 all journal:Ayu
Prevalence of Adhyashana in patients attending IPGT and RA Hospital and its effect on health Vyas, HA Dwivedi, RR Adhyashana is a technical term of Ayurveda, which means eating before digestion of previous food. All the ancient classics describe the ill effects of Adhyashana. Charaka mentioned it as a prime causative factor for Grahani dosha. It is also said that Adhyashana can cause severe and incurable diseases or even death. All these references indicate the importance of Adhyashana as one of the health destroying factors, and yet this subject remained untouched by the Ayurvedic scientists for research. The present study was carried out to search the prevalence of Adhyashana in the patients of various diseases. For this purpose a survey study was planned and a total of 235 subjects attending outpatient and inpatient department of the Institute for Post Graduate Teaching and Research Hospital were surveyed. Among these patients 62.98% were found to be habituated to Adhyashana. Purishvaha Srotodushti was found in a maximum number of patients, which was 42%. Status of the disease was Krichchhra saadhya in maximum of these patients. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/340/93910 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Ayurveda in critical care: Illustrating Ayurvedic intervention in a case of hepatic encephalopathy Rastogi, S Srivastav, PS Ayurvedic interventions have largely been considered helpful in chronic debilitating conditions where active management of a clinical condition is not required. It is for this notion; Ayurvedic therapies have never been approached in any critical care condition requiring an active management. A perception that herbo-metallic components of various Ayurvedic drugs may actually harm the patients who are in compromised vital status has further added to this apprehension against use of such medicines in critical care. Contrary to the conventional belief, we observed a case of grade three hepatic encephalopathy with severely compromised liver function that was successfully treated with Ayurvedic therapy containing many heavy metal containing compounds. The liver function got improved in this case following the Ayurvedic intervention. The symptomatic improvements in this case were also identifiable through biochemical tests showing the functional status of liver. This case therefore is worthy of taking a note for possible inclusion of Ayurvedic interventions in critical care where Ayurvedic therapies are discarded without being given a chance of getting evaluated. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/345/93911 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:93912 2011-07-01 all journal:Ayu
A clinical study on the effect of Arka Taila in the management of Karnasrava (Otomycosis) Palmer, KK Vaghela, DB Manjusha, R Karnasrava is the condition characterized by discharge from Karna and occurs mainly due to Avarana of Vata Dosha. Otomycosis denotes diffuse otitis externa due to fungal infection in ear. Otomycosis being one of the causes of Karnasrava was selected for the study. The present study is done on 28 patients of Karnasrava, who were grouped in to two with 14 patients in each group. Group-A was treated with Arka Taila Karnapurana and Group-B with Clotrimazole ear drops (standard control). The signs and symptoms were studied before and after treatment. Result of the study indicates that Arka Taila and Clotrimazole are equally effective in all the signs and symptoms of Karnasrava (Otomycosis). Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/349/93912 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Atibalamula and Bhumyamalaki on thirty-three patients of diabetic neuropathy Patel, K Patel, M Gupta, SN Diabetic neuropathy is a relatively early and common complication affecting approximately 30% of diabetic patients. According to Ayurvedic principles there is involvement of Vata and Pitta Dosa in diabetic neuropathy. Bhumyamalaki (Phyllanthus niruri) is a plant which shows possibility to pacify these two Dosas. Another plant Atibala (Abutilon indicum) has also Vata pacifying qualities. Present study has been carried out to study the effects of Bhumyamalaki and Atibala on 33 patients of diabetic neuropathy. All the patients have been given Bhumyamalaki Churna 3 g twice a day and decoction of 10 g of Atibala-mula twice a day for 30 days. Neuropathy analyzer machine has been used for exact recording of sensory perception of vibration, cold and hot sensations before and after treatment. Changes in numbness, tingling, burning sensation and pain in lower limbs have also been assessed before and after treatment. Results have been analyzed statistically by applying the 't' test. It can be stated from the results that use of Bhumyamalaki and Atibalamula in the patients of diabetic neuropathy can revert the diminished sensory perception and can reduce the symptoms significantly. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/353/93913 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study of Haritaki and Saindhava Lavana in Kaphaja Kasa with special reference to Samyoga Guna Rout, AK Dwivedi, RR In clinical practice, Guna which are to be with Bhisak are mainly the Paradi Gunas which can also be called as Miscellaneous Gunas. As rightly quoted by Acarya Caraka, for getting success in the treatment Paradi Gunas are the best. The Sutra quotes "Sidhyupaya Cikitsayam" which means that Cikitsa i. e. Dhatusamya will be done mainly with the help of Paradi Gunas. Thus in this study an attempt was made to know the comparative effect of Haritaki and Saindhava lavana alone and Samyukta effect in Kaphaja Kasa. Three groups were made for proper evaluation of the therapy. In Group-A Haritaki Tablet 2 gm/ twice a day (500 mg tablet x 4), In Group-B Saindava Lavana Curna 2 gm/ twice a day and in Group-C Haritaki + Saindhava lavana Tablet 4 gm/twice a day (500 mg tablet x 8) was given. Results were assessed after 7 days with the help of a specially prepared proforma. The hematological, Urine and Stool investigations were carried out. In subjective and objective criterias, significant results were found in Group-C as compared to Group-A and Group-B. Based on the results, it can be concluded that the combined (Samyoga) effect of Haritaki and Saindhava lavana is much efficient than the single drug therapy. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/357/93914 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative clinical study of Shatapatrayadi churna tablet and Patoladi yoga in the management of Amlapitta Kumar, J Dave, AR Vyas, MG Amlapitta is a very common disease caused by Vidagdha Pitta with features such as Amlodgara, Hrid Kantha Daha, and Avipaka. This is a burning problem of the society. Irregular and improper food habits, and busy stressful lifestyle is one of the main culprit. Amlapitta is the GI disorder described in Ayurvedic texts that closely resembles with Gastritis in modern science. In chronic stage, it may lead to ulcerative conditions. In this study, total 41 patients were registered and were randomly divided into two groups. In group A, Shatapatrayadi churna tablet and in group B Patoladi Yoga tablet were given for 1 month. The Nidana, signs, and symptoms were observed carefully to get idea about the Samprapti of the disease. The effect of Patoladi Yoga on Roga Bala is 65.79%, 62.11% on Agni Bala, and 63.35% on Deha and Chetasa bala. The overall relief was 63.75%. The effect of Shatapatrayadi tablet on Roga Bala was 71.94%, 73.15% on Agni Bala, and 77.68% on Deha and Chetas Bala. The overall relief was 74.25%. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/361/93915 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Rasanjana Madhu Ashchyotana in Netra Abhishyanda (Mucopurulent Conjunctivitis) Bhardwaj, A Tanwar, M To evaluate the comparative efficacy of Ayurvedic formulation a Rasanjana Madhu (RM) eye drops and Honey Rose (HR) water eye drops in Netra Abhishyanda in mucopurulent conjunctivitis, the current study is planned. Total of 35 patients attending the outpatient department of Shalakya Tantra at R. G. G. Postgraduate Ayurvedic College, Paprola, Distt. Kangra, Himachal Pradesh with characteristic features of Netra Abhishyanda were selected for the present study. Twenty patients were given trial drug, i.e., RM eye drops, while 15 patients were given HR eye drops. Random sampling technique was adopted for the present study. The duration of the treatment was 7 days with 1 week follow-up. Patients receiving the trial group demonstrated reduction of redness, burning sensation, lacrimation, photophobia, foreign body sensation, discharge, and congestion, which were statistically significant with 93% patients cured or markedly improved category. Signs and symptoms stated above were also statistically reduced with HR eye drops, probably because of well-documented hygroscopic and bacteriocidal properties of honey. Based on the study, it can be concluded that, RM eye drops are very effective in the management of Netra Abhishyanda viz. Infective conjunctivitis. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/365/93916 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical effect of Kukkutanda Twak Bhasma in the management of Swetapradara Panda, G Mohapatra, KB Swetapradara is an important gynecological disorder nowadays. Most women in the reproductive age group complain about white discharge. Due to white discharge, they are prone to so many other symptoms, such as backache, itching in vulva, and burning micturition. According to Ayurveda, swetapradara is caused by the vitiation of Kapha and Vata dosha. Kukkutanda twak is also said to be Kapha Vata shamaka and swetapradara shamaka. In Ayurveda so many drugs are mentioned in the treatment of swetapradara. Among them Kukkutanda twak bhasma is a good medicine. In this clinical study Kukkutanda twak bhasma has shown statistically significant improvement in white discharge, backache, itching, anemia, weakness, and urinary tract infection. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/370/93917 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Evaluation of anti-depressant and anxiolytic activity of Rasayana Ghana Tablet (A compound Ayurvedic formulation) in albino mice Deole, YS Chavan, SS Ashok, BK Ravishankar, B Thakar, AB Chandola, HM In recent years, many Ayurvedic formulations are being researched to provide an effective antidepressant and anxiolytic drug in the field of psycho-pharmacology. The present study was planned to evaluate the anti-depressant and anxiolytic activity of Rasayana Ghana Tablet comprising three herbs Guduchi (Tinospora cordifolia Miers), Aamalaki (Emblica officinalis Garten) (RGT) and Gokshura (Tribulus terrestris Linn). Swiss albino mice were divided into four groups of six animals each, comprising of both male and female in each group. Group I received water served as normal control (WC), group II received vehicle and served as vehicle control (VC), group III received Rasayana Ghana tablet and group IV received standard drug diazepam (2 mg/kg) for anxiolytic study in elevated plus maze and standard antidepressant imipramine (5 mg/kg) for anti-depressant activity in behavior despair test. Rasayana Ghana tablet along with ghee and honey as vehicle is found to be having antidepressant and anxiolytic activity in experimental animals. Thus, this formulation can be used in prevention and treatment of depression and anxiety. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/375/93918 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Psychotropic activity of Argyreia speciosa roots in experimental animals Galani, VJ Patel, BG Argyreia speciosa (L.f.) Sweet (convolvulaceae) commonly known as Briddhadaraka is regarded as a "Rasayana" drug in the ayurvedic system of medicine to cure diseases of nervous system. In this study, hydroalcoholic root extract of A. speciosa was subjected to evaluate psychotropic effects in classical experimental models. Effect of the extract on spontaneous motor activity, pentobarbital-induced sleeping time, motor coordination, exploratory behavior, and apomorphine-induced stereotypy were investigated in mice. Effect of the extract on catalepsy and haloperidol-induced catalepsy were studied in rats. Preliminary phytochemical and acute toxicity screenings were also performed. The extract (100, 200, and 500 mg/kg, p.o.) significantly decreased spontaneous motor activity, exploratory behavior, and prolonged pentobarbital sleeping time in mice. The extract also remarkably attenuated the intensity of apomorphine-induced stereotypy but had no effect on motor coordination. The extract produced catalepsy and potentiated haloperidol-induced catalepsy in rats. These results provide evidence that the hydroalcoholic extract of A. speciosa roots may contain psychoactive substances that are sedative in nature with possible neuroleptic properties. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/380/93919 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Study on the diuretic activity of Euphorbia fusiformis Buch.-Ham. in albino rats Ashok, BK Bhat, SD Shukla, VJ Ravishankar, B The present study was undertaken to evaluate diuretic activity of Euphorbia fusiformis root powder in Wistar strain albino rats. Randomly selected animals were divided into three groups of six animals each. The root powder was suspended in distilled water and administered orally at a dose of 90 mg/kg therapeutically equivalent dose (TED) and 180 mg/kg (TED × 02) to overnight fasted rats. The diuretic activity was evaluated by determination of urine volume and urinary electrolyte concentrations. Test drug showed significant increase in urine volume and urinary electrolyte excretion in a dose-dependant manner. Thus, from this study, it can be concluded that roots of E. fusiformis possess diuretic activity. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/385/93920 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Antioxidant and anticancer evaluation of Scindapsus officinalis (Roxb.) Schott fruits Shivhare, SC Patidar, AO Malviya, KG Shivhare-Malviya, KK Several methods exist for the treatment of cancer in modern medicine. These include chemotherapy, radiotherapy, and surgery; most cancer chemotherapeutants severely affect the host normal cells. Hence the use of natural products now has been contemplated of exceptional value in the control of cancer. Plant-derived natural products such as flavonoids, terpenes, alkaloids, etc., have received considerable attention in recent years due to their diverse pharmacological properties including cytotoxic and cancer chemopreventive effects. Looking into this, the antioxidant and anticancer evaluation of Scindapsus officinalis (Roxb.) Schott fruits has been attempted to investigate its antitumor activity. The collection and authentication of the plant material mainly fruits and their various extractions was done. Identification of plant's active constituents by preliminary phytochemical screening was carried out. An in-vitro cytotoxic assay using the brine shrimp lethality assay with brine shrimp eggs (Artemia salina) at a dose of 1-10 μg/ml with the fruit extract was performed by the method described by Mayer et al. Cell viability using the Trypan blue dye exclusion test at a dose of 20, 40, 80, 120, and 160 μg/ml dissolved in DMSO (final concentration 0.1%), and cytotoxicity using the MTT assay where viable cells convert MTT into a formazan salt were performed. All pharmacological screening for acute toxicity and anti tumour studies using EAC 1 x 10 <sup>6</sup> cells/mouse treated Swiss albino mice at a dose of 100 and 200 mg/kg/day orally was carried out. Biochemical and antioxidants predictions from various parameters like hematological, RBC, WBC count, PVC, total protein, Tissue Lipid Peroxidation, SOD, CATALASE, GPx, GST levels and anti tumour activity of Scindapsus officinalis were observed. The data was statistically analyzed by one-way ANOVA followed by Dunnett's and Tukey's multiple comparison test. The antitumor effect of the extract is evident from the increase in mean survival time (MST) lifespan, reduction in the solid tumor volume, and also the reversal of altered hematological parameters almost equal to normal. The methanolic extract (100-200 mg/kg/day orally) was found to be cytotoxic on human cancer cell lines. In addition, the methanolic extract had an antioxidant effect as reflected by a decrease in LPO, GST, and GPx (oxidant enzymes), and an increase in SOD and catalase. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/388/93921 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Study on the diuretic activity of Veerataru Kwatha in albino rats Patel, BR Ashok, BK Ravishankar, B The purpose of the present study was to evaluate the diuretic activity of Veerataru [Dichrostachys cinerea (Linn.)] Kwatha in experimental animals by following the standard procedure. Randomly selected animals were divided into three groups of six animals each. The root of Veerataru was administered orally in the form of Kwatha at a dose of 5.4 and 10.8 ml/kg. Parameters like volume of urine, pH of urine and urinary electrolyte concentrations like sodium, potassium and chloride were studied. Veerataru Kwatha increased the urine output in a dose-dependent manner. However, it did not affect the urinary electrolyte concentrations. From the present study, it can be concluded that the root of Veerataru has diuretic property. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/395/93922 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Pharmacognostical study of Tamalaki (Phyllanthus fraternus Webster), a herb used in Tamaka-svasa Sen, B Dubey, SD Tripathi, K Tamalaki is a herbacious medicinal plant, described in Ayurvedic texts in many occurrences with different properties, actions, uses and synonyms, supposed to indicate more than one species commonly used in practice. Modern scholars mostly suggest Phyllanthus fraternus Webster (syn. P. niruri Linn.), P. amarus Schum. and Thonn. and P. urinaria Linn. as the source plants of Tamalaki. In this study, an attempt has been made to designate P. fraternus as the source plant of Tamalaki used in the treatment of Tamaka-svasa (Bronchial asthma) and other respiratory disorders by analyzing therapeutic uses, actions, properties, taste, synonyms as well as pharmacognostical characters. Smooth capsule, six tepals, less and short fibrous root, pentagonal outline with wing-shaped young stem are some of the specific characters observed in this species. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/398/93924 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Shodhana (processing) on Kupeelu (Strychnos nux-vomica Linn.) with special reference to strychnine and brucine content Mitra, S Shukla, VJ Acharya, R Kupeelu (Strychnos nux-vomica Linn.) commonly known as nux vomica is a poisonous plant used extensively in various ayurvedic formulations, with great therapeutic significance. Ayurveda recommended the administration of Kupeelu only after purification in different media like cow's urine (Go mutra), cow's milk (Go dugdha), cow's ghee (Go ghrita), Kanji (sour gruel), and so on. Apart from the classical methods some other methods are also adopted by the traditional practitioners using castor oil (Eranda taila), ginger juice (Ardraka swarasa), in the purification of Kupeelu seeds. In the present study an attempt has been made to purify the seeds by performing two different methods (one classical and another traditional) using Kanji and Ardraka swarasa as Shodhana media. This study reveals that both the methods studied reduce the strychnine and brucine contents in comparison to the raw seeds as determined by high performance thin layer chromatography (HPTLC). After purification in Kanji and Ardraka swarasa, the strychnine content was reduced by 39.25% and 67.82%, respectively, and the brucine content in the purified seeds was also found to have decreased by 17.60% and 40.06%, in comparison to the raw seeds. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/402/93923 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A progressive review of Sandhana kalpana (Biomedical fermentation): An advanced innovative dosage form of Ayurveda Chaudhary, A Singh, N Dalvi, M Wele, A Sandhana kalpana (biomedical fermented formulations) are one of the best dosage forms of Ayurveda in practice since thousands of years. In order to prepare these medicaments, certain sets of conditions are prearranged, which lead to fermentation. Thus, products bequeath with self-generated ethyl alcohol, which potentiate these preparations (Asava-Arishta), pharmaceutically and therapeutically. Commonly, medicinal and commercial components of these formulations are prompting many researchers to contribute in manufacturing, quality control, safety, and efficacy of these formulations. To cope up with this, literature related to Asava-Arishta has been surveyed from the Vedic period to recent publications of Government of India, ie, Ayurvedic Formulary of India, and presented briefly here. In this review paper, we have discussed pioneering facts such as nature and amount of carbohydrate, type of containers, optimum temperature, variety and relevance of initiator of fermentation, manufacturing, regulatory rules, and business aspects of Asava-Arishta. After going through this basic information, any academician or researcher may show a way to further strengthen this dosage form. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/408/93925 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Modified Ksharasutra Chikitsa for 'Shambukawarta Bhagandara' Harit, MK Dwivedi, AP Horse-shoe Fistula is a big challenge for both Modern and Ayurvedic Surgeons. We can correlate this with 'Shambukawarta Bhagandara' described by Sushruta. Here, fistula forms secondary to an ischiorectal abscess and both the ischiorectal fossae are involved. Also, they open posteriorly into the anal canal, at the 6 o'clock position, and are associated with a big cavity lying superior (above the levatorani). Therefore, in such a clinical feature neither Fistulotomy ('Wanley operation') nor 'Ksharasutra' treatment alone, prove useful. After going through this, we can say that there is a definite need for newer surgical innovative techniques, to tackle this challenging disease. An integral approach of 'Fistulectomy along the arms of the Horse-shoe fistula with Ksharasutra ligation' in the remaining track connected to the anal canal, and drainage of the postanal space abscess, proved to be very successful. We have tried the same technique with very good results. No recurrence was found in the patients during the follow-up period of three years. The given diagrammatic presentation of the plan of surgery will help to understand the procedure. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/418/93926 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A critical review of the philosophical concepts of Carakopaskara commentary Panja, AK Upadhyaya, OP Chattopadhyaya, A Philosophy is the prime specialty as it fulfills the ultimate goal of life with the depiction of the liberation of the soul. The human body composed of mind, other sensory organs along with five proto-elements, is to be treated from the clinical applicability of the philosophical series of events. The current review is the categorical analysis of the philosophical thought depicted in "Carakopaskara commentary" of Pandit Jogindranath Sen in the purview of underlined theme of Caraka Samhita and classical orthodox philosophy. Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/422/93927 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of different Avaleha in the management of Tamaka Shwasa (Bronchial Asthma) Gupta, A Prajapati, PK Avaleha , which are generally elegant preparations, can be used for both preventive and curative purposes. Many research works have been carried out on different Avalehas. A number of studies with different Avalehas and their respective clinical efficacy in Tamaka Shwasa (Bronchial Asthma) have been carried-out at Department of Rasashastra and Bhaishajya Kalpana, IPGT & RA, Jamnagar. A review has been carried out of such works to know the better one. In the work, it has been found that highly significant (P<0.001) results on Shwasakastata were found in all the groups, except in the Kamsa Haritaki Avaleha (B) group which was insignificant (P<0.02). Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/427/93928 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Mehamudgaravati and type 2 diabetes mellitus Wiwanitkit, V Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/432/93929 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Authors' reply Tanna, I Chandola, HM Joshi, JR Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/432/93930 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Tailabindupariksha of the urine Joob, B Wiwanitkit, V Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/433/93931 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Authors' reply Sangu, PK Kumar, V Shekhar, MS Chagam, MK Goli, PP Tirupati, PK Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/433/93932 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Vamana procedure Wiwanitkit, S Wiwanitkit, V Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/434/93933 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Authors' reply Gupta, B Mahapatra, SC Makhija, R Kumar, A Jirankalgikar, N Padhi, MM Devalla, RB Medknow Publications 2011-07-01 http://www.ayujournal.org/text.asp?2011/32/3/434/93934 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Nourishing the tree of Ayurveda: Enriched with specialty! Chandola, HM Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/443/96111 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Exploring progression of Ayurveda Basisht, G Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/445/96112 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Water purification prescribed in Ayurveda Skandhan, KP Amith, S Singh, K Authors present here water purifying methods for drinking purpose by employing few kinds of flowers, a traditional knowledge available in India from the classics of Ayurveda, the oldest system of medical practices. A simple method is designed to conduct a study for finding out the efficacy of the said method. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/448/96113 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Nisshesha rechaka pranayama offers benefits through brief intermittent hypoxia Malshe, PC Hypoxia has been a frightening term for doctors and medical students because of the possibility of damage to cells, tissues and organs. However, we now know that brief, episodic hypoxia gives rise to several adaptive responses. These responses in general prepare the body for better tolerating such hypoxic episodes, and also offer protection against several other types of insults. Indeed, scientists at the erstwhile U.S.S.R. have developed what is known as 'hypoxia therapy' and reaped the benefits of brief intermittent hypoxia for the last several decades. In India, yogic treatment of various diseases is common. A lesser known but important variety of Pranayama is 'nisshesha rechaka', which may be described as breath holding at residual volume. Studies done at our centre have demonstrated that Nisshesha rechaka is the easiest way to produce brief, intermittent hypoxia. There is therefore reason to believe that Nisshesha rechaka pranayama may offer benefits through this mechanism. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/451/96114 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Basavarajeeyam: A historical perspective Nishteswar, K Basavarajeeyam is an important handbook for an Ayurvedic physician of Andhra region. It is a bilingual work and the content was presented in Sanskrit and Telugu languages. With regard to the place and date of Basavarajeeyam there is no common opinion among the present day scholars. Pt Govardhana Sharma Changani in his introduction to the Sanskrit version of Basavarajeeyam exposed a historical profile of Basavrajeeyam picturising him as Basava who was a staunch follower of Veerashaivism and a contemporary of king Bijjala (end of 12 <sup>th</sup> cent. AD). The same statement is carried out in the works of Ayurvedic Itihasa written by Atredeva Vidyawalkan and Acharya Priyavrata Sharma. It appears that the historical evidence shown by these scholars is one sided and cannot stand any reason. Basavraju stated that he had started writing this work after a thorough study of many works such as Charaka, Nithyanatheeyam (1360 AD), Revenakalpam, Pujyapadiyam, Bahatam, Kashikhandam (1435 AD) etc. Basavraju has faithfully reproduced certain chapter of Vaidyachintamani, which is considered to be a work of 15 <sup>th</sup> century. Basavraju not only mentioned Phirangiroga in the index of diseases described by him at the end of the book, but also indicated Phirangichekka (Madhusnuhi) in the management of Meharoga and Granthi. By this evidence Basavarajiyam should be considered as the work of post Bhavaprakasha period. Basavraju indicates in the Gulmaroga Chikitsa that Sankhadravaka should be administered in the dose of 'Ekanni'. The name Ekanni was given for a copper coin which came in to circulation of money during British India produced from Madras mint (1794 AD). Based on these internal evidences, it can be safely concluded that Basavraju belong to 18 <sup>th</sup> century. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/458/96115 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A critical review of antiquity, authorship and contents of Haramekhala: A medieval work on humanities Archana, I Bhat, JG Ayurvedic science of life is one of the great contributions of India to the systems of health science. Apart from classical medical works, much information related to this Indian system is found elsewhere in other branches of science, such as Philosophy, Joutishya, Natya, Kavya, etc. Still much Ayurvedic information is clubbed in other compilations meant for general purpose. However, it is unfortunate that not all such works came into lime light; and still remain in the dark for many reasons. Haramekhala written by Mahuka is one such work, which contains Ayurvedic information along with various other themes, such as cosmetics. The author Mahuka lived in Dharanivaraha rajya of central India during Chapa Dynasty in 9 <sup>th</sup> -10 <sup>th</sup> century A.D. Haramekhala also known as Prayogamala comprises of five Paricchedas written in Prakrita language, later added by translations in Sanskrit called Chaya and foot notes in Sanskrit called Tika. The detail about this book is described in this article. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/461/96116 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Ritucharya : Answer to the lifestyle disorders Thakkar, J Chaudhari, S Sarkar, PK Ritu , the season, classified by different features expresses different effects on the body as well as the environment. Ayurveda has depicted various rules and regimens (Charya), regarding diet and behavior to acclimatize seasonal enforcement easily without altering body homeostasis. The prime principle of Ayurvedic system of medicine is preventive aspect, can be achieved by the change in diet and practices in response to change in climatic condition. This is a very important aspect of preventive medicine as mentioned in Ayurvedic texts. Lifestyle disorders are very common in the present era, basically originating from lack of following seasonal regimens due to lack of concentration in seasonal characteristics. A firm scientific analysis is the base, which holds true even on date. In this review article, various regimens in diet and lifestyle as mentioned in the classics of Ayurveda and their importance on lifestyle disorders has been discussed. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/466/96117 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Study of Vaikalyakara Marma with special reference to Kurpara Marma Muley, SK Ingale, NN Bhingare, SD This study was undertaken to study Kurpara Marma in relation to its Vaikalyakara effects when injured. The location of Kurpara Marma was found with the help of the description of Marma in Ayurvedic texts, dissection of the elbow joint, and with help of X-ray documentation. Total 80 patients having trauma to elbow joints due to various causes such as fall, road traffic accident, direct trauma on elbow joint, history of trauma a year back, and injury due to burn were included in this study. These patients were observed for 3 months for any changes in symptoms. In Sushruta Samhita, it was stated that an injury to the Kurpara Marma ends in Kuni (dangling of the hand), swelling, loss of power, restricted movements, and muscle wasting and associated symptoms like tingling sensation, heaviness, syncope, sweating, dizziness, and vomiting. After analysis of data, i.e., after analyzing the percentage of all symptoms on admission as well as after 3 months, it was found that all 80 patients, i.e., 100% had swelling and loss of muscle power. A total of 72 patients, i.e. 90% had dangling of hand on admission. After 3 months, 40 patients (50%) still remained with the dangling of hand. Seventy-two patients had restriction in flexion and extension deformity which still remained in 50% of patients. Hence, it was proved that Kurpara (elbow joint) is definitely a Vaikalyakara Marma. Disabilities like restriction of movements, swelling, and atrophy were remains of an injured elbow joint inspite of best surgical treatment. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/472/96118 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical evaluation of Boswellia serrata (Shallaki) resin in the management of Sandhivata (osteoarthritis) Gupta, PK Chandola, HM Ravishankar, B Sandhigata vata is described under Vatavyadhi in all Ayurvedic texts. Charaka was the first to describe separately "Sandhigata anila", but it was not included under 80 types of nanatmaja vatavyadhi. Osteoarthritis is the most common degenerative joint disease that begins asymptomatically in middle age with progressive symptoms in advancing age. Majority of people by the age 40 years may develop osteoarthritis, especially in weight bearing joints. Females are prone with 25% prevalence, whereas males have a prevalence of 16%. In the present study, 56 patients fulfilling the diagnostic criteria of Sandhigata vata, divided into two groups. Patients of first group were administered with 500 mg capsule of Shallaki, 6 g per day (in three divided doses) with lukewarm water (n=29) and the second group) capsule Shallaki as above along with local application of Shallaki ointment on the affected joints (n=23). After a course of therapy for 2 months, symptomatic improvement was observed in both the groups at various levels with promising results in the patients of first group. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/478/96119 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effects of Ayurvedic treatment on 100 patients of chronic renal failure (other than diabetic nephropathy) Patel, MV Gupta, SN Patel, NG Chronic renal failure (CRF) refers to an irreversible deterioration in renal function, which develops over a period of years. This initially manifests only as a biochemical abnormality. CRF is considered when glomerular filtration rate (GFR) falls below 30 ml/min. The conventional approach of management includes dialysis and renal transplantation, which are not affordable by Indian population mainly due to economic reasons. Therefore, exploration of a safe and alternative therapy is needed, which proves to be helpful in reducing the requirement of dialysis and in postponing the renal transplantation. A clinical study of 100 patients of CRF was conducted at OPD and IPD of PD Patel Ayurved Hospital, Nadiad. They were given Niruha basti of Punarnavadi kvatha daily with oral medicaments including Goksuradi guggulu, Rasayana churna, and Varunadi kvatha for 1 month period. The patients of CRF, having diabetic nephropathy as a cause, were excluded since a separate study for diabetic nephropathy is being conducted. Results were analyzed statistically using the "t " test. The symptoms and signs, serum creatinine, blood urea, urine albumin level were reduced, which were found to be statistically highly significant on "t " test. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/483/96120 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative study on Vamana Karma with Madanaphala and Krutavedhana in Ekakushtha (Psoriasis) Patel, JR Bhatted, S Vamana Karma (therapeutic emesis) is the best therapy for the elimination of vitiated Kapha Dosha. In the present clinical practice Madanaphala (Randia dumetorum) is mainly used for Vamana Karma. Apart from Madanaphala, five other drugs, and in total 355 formulations are described in Charaka Samhita; one of them is Krutavedhana (Luffa acutangula) kalpa (formulations). Krutavedhana is specially indicated in Gadha (compact) Dosha condition like Kushtha (skin diseases), Garavisha (slow poison), and so on, for Vamana Karma. The present study aimed to observe the effect on Vamana Karma and by that its effect on Ekakushtha (Psoriasis). Krutavedhana Beeja Churna (seed powder) was given with Madhu (honey) and Saindhava (rock salt) as Vamana Yoga (emetic formulation), to compare it with Madanaphala Pippali Churna (seed powder). After the Sansarjana Krama (special dietetic schedule), Panchatikta Ghrita (medicated ghee) was given as Shamana Sneha (pacifying oleation). An average dose of Krutavedhana was 5.9 g. Krutavedhana could produce a good number of Vega (bouts), Pittanta Lakshana (bile coming out at the end of Vamana), and Pravara Shuddhi (maximum cleansing) in a majority of patients. Madanaphala is the best among all Vamaka (emetic) drugs, but Krutavedhana showed a similar to higher effect on Vamana Karma in terms of Antiki, Maniki, Vaigiki, and Laingiki Shuddhi (cleansing criteria). Vamana Karma by Krutavedhana showed better relief in Matsyashakalopamam (silvery scale), Kandu (itching), and Rukshataa (dryness), while Madanapahala showed better relief in Krishnaruna Varna (erythema). After completion of the Shamana (pacifying) treatment, both the groups showed nearly the same effect on Asvedanam (lack of perspiration), Matsyashakalopamam, Kandu, Rukshataa, Krishnaruna Varna, and Mahaavaastu (bigger lesion). Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/487/96121 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative clinical trial of Chincha kshara and Kadali kshara on Amlapitta Acharya, S Panda, PK Acharya, G Mohanty, N Nathsharma, PK Dash, SC A clinical trial was carried out on 30 patients of Amlapitta aged between 20 to 35 years with complaints of Avipaka, hrit-kanthadaha, tikta-amlodgara, utklesa, udarasula, adhmana and aruchi, who were registered from OPD and IPD of Gopabandhu Ayurveda Mahavidyalaya, Puri. They were equally divided into three groups Chincha kshara, Kadali kshara and placebo (who were administered with fresh wheat powder) for 30 days in a dose of 500 mg thrice daily with water. Investigations was done in order to exclude upper gastrointestinal tract ulcer, carcinoma in stomach, cholecystitis, carcinoma gall bladder, and heart diseases. The clinical assessments were carried out on the 30 <sup>th</sup> day by subjective and objective parameters and it was inferred that both Chincha kshara and Kadali kshara were effective and reduced the symptoms of amlapitta. Chincha kshara was found to be more effective than Kadali kshara. The study shows the effect of Chincha and Kadali kshara which led to cure in 4(40%) and 3(30%) patients respectively, and maximum improvement in 4(40%) and 5(50%) patients affected with amlapitta disease, respectively. No untoward effect was noticed due to administration of ksharas during the clinical trial period. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/494/96122 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative study of Shvasahara Leha and Vasa Haritaki Avaleha in the management of Tamaka Shvasa (Bronchial Asthma) Sharma, M Dave, AR Shukla, VD Tamaka Shvasa is a type of Shvasa Roga associated with difficulty in breathing as a result of which the patient prefers to sit in bed to get relief from his discomfort. Movement of air through Pranavaha Srotas is hampered in this disease resulting in the cry of organ heading toward complete failure for want of air. Tamaka Shvasa is well known for its episodic and chronic course which comes under the life-threatening disease. It is analogous to bronchial asthma due to similarity in symptoms, pathogenesis, onset, causes, and precipitating factors. In this study, 40 patients of Tamaka Shvasa were registered and randomly divided into two groups, out of which 31 patients completed the treatment. In Group A, Shvasahara Leha (5 g twice a day) was given for 2 months, while in Group B Vasa Haritaki Avaleha (5 g twice a day) was given for 2 months and follow-up was done for one month in both groups. The effects of therapy in both groups were assessed by a specially prepared proforma. Diagnosis was done by adult asthma diagnosis questionnaire and differential diagnosis with COPD (Chronic obstructive pulmonary disease) was done by differential diagnosis questionnaire as both these conditions are overlapping. The results of the study indicate that the Vasa Haritaki Avaleha provided better relief than Shvasahara Leha in Tamaka Shvasa. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/500/96123 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study on the effect of Rishyagandha (Withania coagulans) in the management of Prameha (Type II Diabetes Mellitus) Upadhyay, BN Gupta, V The study was conducted with an objective of evaluating the role of Rishyagandha (Withania coagulans) powder in clinically diagnosed cases of Prameha. 53 Registered cases were divided into 3 groups; Group A (Rishyagandha fruits powder), Group B (Oral Hypoglycaemic Agent i.e. OHA), and Group C (Rishyagandha fruits powder and OHA both). Statistically significant improvement was observed in objective and subjective parameters in all 3 groups after completion of the course of treatment. Based on the results, it has been concluded that, Rishyagandha fruits powder is an effective therapeutic regimen in the management of uncomplicated cases of Prameha. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/507/96124 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Fundamental approach in the management of Drava Bahula Amlapitta with Bhringaraja (Eclipta alba) Pol, H More, S Vyas, MK Vyas, H Ravishankar, B The disease Amlapitta has been selected for the clinical trials because it presents two type of manifestations depending upon the involvement of Agni (Ushnagunadhikya) and Jala (Dravagunadhikya) Mahabhuta. The present research work was focused at Drava Guna, with an aim to assess the efficacy of a drug with quality of Ruksha and Ushna predominance like Bhringaraja in treating Amlapitta with Pitta Drava Guna Vriddhi. Randomized open clinical trials were conducted on 22 patients of Amlapitta who were screened on the basis of clinical findings and allocated in to two groups. The criteria for selection were the signs and symptoms of Dravagunadhikya Amlapitta, irrespective of sex, religion, etc. Group A consisting of 15 cases received the trial drug Bhringaraja tablet (4 Tab. two times, 1 tablet=500 mg) and 7 cases in Group B received rice powder tablet as a placebo (4 Tab. two times, 1 tablet=500 mg) for 4 weeks. Special scoring pattern was adopted for the assessment of Amlapitta. Routine pathological tests such as blood, urine, stool, etc. were also carried out. In Group A, 55.33% patients showed marked improvement, whereas moderate improvement was observed in 26.67% patients. Complete cure was found in 06.67% of the patients and mild improvement in the chief complaints was observed in 13.33% patients. All the selected symptoms showed statistically significant results (P<0.01) except the Vidbheda in treated Group A, while in Group B, all symptoms showed statistically insignificant results except the Utklesha and Amlodgara. Total effect of the therapy showed statistically significant effect of the test drug . These results support the hypothesis. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/512/96125 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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An open clinical trial to analyze Samyak Snigdha Lakshana of Shodhananga Snehapana with Mahatikthakam Ghritam in Psoriasis Ramteke, R Vinodkumar, G Meharjan, T An open clinical trial was conducted in Govt. Ayurveda College Hospital, Thiruvananthapuram, Department of Kayachikitsa and Panchakarma. As there is no work done on the Samyak Snigdha Lakshana (SSL), this study was undertaken to work on the different aspects of Samyak Snigdha Lakshana. To minimize variables, subjects suffering with psoriasis and same Ghritam were selected on the basis of strict inclusion and exclusion criteria. Shodhananga Abhyantara Snehapana was advised before Vamana and Virechana. Samyak Snigdha Lakshanas which are described in all texts are different in milieu. Shodhananga Snehapana with Mahatiktakam Ghritam was given according to Koshta and Agni in 30 subjects. Samyak Snigdha Lakshanas were assessed using a special scoring pattern and the biochemical parameters were observed in all subjects. Statistical analysis using paired't' test were done. In all patients Vatanulomana, Diptagni, Snehodvega, Klama and Adhastat Sneha Darshanam were seen; whereas Angalaghava and Twak Snigdhata were noted in less percentage of persons. The onset of various Samyak Snigdha Lakshanas occurs in sequence. There are changes in some biochemical parameters like serum cholesterol, Serum glutamic-oxaloacetic transaminase (SGOT) and fat globules in stool after Snehapana. Shodhananga Snehapana with Mahatikthakam Ghritam decrease features of psoriasis up to some extent. More in depth studies are required to evaluate their importance and for their application in modern medical practice. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/519/96126 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of Shilajatu (Asphaltum) processed with Agnimantha (Clerodendrum phlomidis Linn.) in Sthaulya (obesity) Pattonder, RK Chandola, HM Vyas, SN Obesity is defined as the condition in which excessive amount of fat is accumulated in the body. Classical Ayurvedic texts describe eight types of despicable designated as 'Nindita purusha' including atisthaulya. Corpulent people are characterized by short in longevity, slow movement, difficult to indulge in sex, weak, emission of bad body odor, profuse perspiration, excessive hunger and excessive thirst. Sixty to seventy percent of cardiac patients die of obesity and contribute to develop coronary artery disease, diabetes mellitus, hypertension, hyperlipidaemia. In the present study, 66 patients of obesity were treated with Shilajatu processed with Agnimantha. After complition of therapy, 5.09 ± 0.24 kg and 2.06 ± 0.10 kg/m <sup>2</sup> reduction of body weight and body mass index, respectively were noted. The result was found to be statistically highly significant (P<0.001). No adverse effects were observed in any of the treated patients. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/526/96127 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Ayurvedic herbs on control of plaque and gingivitis: A randomized controlled trial Kadam, A Prasad, BS Bagadia, D Hiremath, VR Ayurveda had mentioned various procedures for maintaining oral hygiene. These include procedures like gandusha, kavala, dantadhavana, and jivha lekhana (cleaning tongue). Various plants have been mentioned in Ayurveda for dantakashta. Various Ayurvedic dental formulations are available in market in the form of powders, paste, etc. Present study was conducted for evaluating the effect of one of such Ayurvedic toothpowder named UDM, in controlling plaque and reducing gum inflammation in patients of moderate gingivitis. Scaling, root planning, and polishing were done for all the patients participating in the study. Oral hygiene instructions were given that included brushing twice/day with assigned tooth powder using BASS method for tooth brushing and also massage over gum tissue with finger. All the patients were recalled after 15 days. Scores of plaque index and gingival index was recorded on day 1 and day 15 of treatment. Total of 15 patients were recruited in each group. The mean reduction in gingival index was 1.15 (P<0.05) and 1.26 (P<0.05) in positive control and UDM treatment groups, respectively. However, the mean reduction in plaque indices were found to be 2.03 (P<0.05) and 2.16 (P<0.05) in positive control and UDM groups, respectively. No significant difference was seen in both the parameters between the two groups. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/532/96128 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative study of Vamana and Virechana Karma in the management of Sthula Pramehi w.s.r. to Type-2 diabetes Pandey, RK Bhatt, NN Singhala, TM Shukla, VD In the present study, Vamana and Virechana along with palliative treatment was given to patients of Sthula Prameha (Diabetes mellitus or DM). An attempt was made to compare and evaluate the role of Shodhana therapy (Vamana and Virechana). Total 47 patients of Sthula Pramehi were registered in this study, out of which 38 completed the treatment. The patients were divided into two groups, viz. Vamana with Shamana (Group A) and Virechana with Shamana (Group B). Eighteen patients completed the treatment in Group A and 20 in Group B. Neem giloy satva capsule was used as Shamana drug at a dose of 500 mg twice daily after meals for 30 days in both the groups. The efficacy of therapy was assessed based on relief in cardinal signs and symptoms and blood sugar, lipid profile and other biochemical parameters etc. The results showed that the Vamana provided better relief in signs and symptoms as well as on fasting blood sugar (FBS) and postprandial blood sugar (PPBS) in comparison to Virechana. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/536/96129 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study on the role of Akshi Tarpana with Jeevantyadi Ghrita in Timira (Myopia) Poonam Manjusha, R Vaghela, DB Shukla, VJ Myopia is a major public health problem pertaining to eye that entails substantial societal, personal, educational, and economical impact. Various surveys in India have found the prevalence of myopia ranging from 6.9% to 19.7%. Myopia progression is irreversible and methods for the correction of myopia are not without complications. Myopia closely resembles Timira involving first and second Patala in terms of symptoms, anatomical structures involved, and the pathogenesis of the disease. The study is aimed at evaluating the efficacy of the Akshi-Tarpana procedure with Jeevantyadi Ghrita in fresh and old myopes. A total of 54 patients (108 eyes) having myopia ≥-6 D were registered for the study and divided into two groups (Group A, Akshi-Tarpana with Jeevantyadi Ghrita, and Group B, Akshi-Tarpana with plain Go Ghrita), by stratified sampling. The procedure was done in 5 sittings of 5 days each with an equal interval of 5 days between each sitting. A total of 22 patients in Group A and 18 in Group B completed the treatment. Obtained data were statistically analyzed using a t-test and the study reveals that objectively, 09.30% and 05.55% eyes were cured, 16.28% and 02.78% markedly improved, and 34.88% and 11.11% moderately improved in Group A and B, respectively. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/540/96130 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Application of Satkaryavada based on theory of Karya-Karana Vada Anupam, A Dwivedi, RR Cikitsa in Ayurveda is based on Karya-Karana Siddhanta. Satkaryavada is an independent view of Samkhyas regarding Karya-Karana. According to this principle, the Karya is present in Karana in subtle form before its manifestation. All the Karyas are possible only by the Sat Karana (existent cause). On this ground a hypothesis has been formulated and applied. The hypothesis was that since Karana is present in a drug it will perform the Karma. The clinical study was planned to study the Anulomana Karma of Haritaki in patients of Anaha. The drug was used in 38 patients. These were divided into two groups. In group "A" 26 patients were provided with haritaki tablet, while in group "B" 12 patients were provided with placebo tablets. In group "A" 7.69% of patients got complete relief, followed by 38.46% patients who got marked relief; 42.31% of patients got moderate relief, while 11.54% patients got mild relief. Group A showed highly significant results in comparison to group B. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/546/96131 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Identification of fruits of Tribulus terrestris Linn. and Pedalium murex Linn.: A pharmacognostical approach Kevalia, J Patel, B Gokshura is a well-known Ayurvedic drug that is used in many preparations. Botonically it is identified as Tribulus terrestris Linn., especially the roots and fruits of the plant. But instead the fruits of another plant Pedalium murex Linn. are commonly used and the drug is frequently substituted. Pharmacognostical study has been carried out to identify the distinguishing features, both morphological and microscopic, of the fruits of Tribulus terrestris Linn. and Pedalium murex Linn. This knowledge should help reduce the problem of substitution of the genuine drug. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/550/96132 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Study on Bhasma Kalpana with special reference to the preparation of Kasisa Bhasma Rajput, DS Tekale, GS Bhasma means ash but according to Ayurveda, Bhasma means conversion of a metal into a form which is irreversible in the sense that one cannot derive the metal back from it again (Apunarbhava). It should be so light so that it must float on the surface of water after sprinkling, called Varitara. Its particle should be so small that it can enter in to the creases of fingers called Rekha-purnatva. The preparative procedure of Bhasma is a bit complicated. Many texts are available regarding the identification, acceptable qualities of metals and minerals, their purification, uses and method of preparation of their Bhasma. But in many texts, the method of Bhasma preparation of some metals and minerals is mentioned very briefly, i.e. their references are available in Sutrarupa. This leads to many practical difficulties in the preparation of Bhasma. Kasisa Bhasma is one of them. The present work was aimed to study the basic concept of Bhasma Kalpana by means preparing Kasisa Bhasma. This study suggests some modifications and ways for standardization of Bhasma procedure. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/554/96133 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Standardization of Shirishavaleha with reference to physico-chemical characteristics Yadav, SS Galib Patgiri, BJ Shukla, VJ Prajapati, PK Ten batches of Shirishavaleha were prepared by using Twak (Bark) and Sara (Heartwood) of Shirisha [Albizzia lebbeck Benth]. The adopted formulation was based on Shirisharishta of Bhaishajya Ratnavali. Though Shirisharishta has significant therapeutic effect in cases of Tamaka swasa, etc.; it has few difficulties during the pharmaceutical procedure like consuming long time, climatic influences etc. Considering these inconveniencies, the formulation composition has been converted in to Shirishavaleha. Avaleha has been prepared by using Twak and Sara of Shirisha. No significant differences were found in pharmaceutical aspects of both the samples of Shirishavaleha and the current method of preparation can be considered as standard. Attempts were also made to develop analytical profile of avaleha, which were almost similar in both the samples, except showing more Rf values in High Performance Thin Layer Chromatography profile of Sara group. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/560/96134 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Standard manufacturing procedure of Rajata Bhasma Chaturvedi, R Jha, CB Rasa Shastra is a branch of Ayurveda which deals with the processing of minerals and metals having therapeutic importance. Rajata comes under the group of metals having high therapeutic value. Minerals and metals are mostly used in the form of Bhasma. During the medieval period Rasacharyas extensively worked and developed a number of processing methods for a single drug. They all are standard manufacturing procedures (SMP) which ensure the quality, safety, efficacy and reproducibility of the product. Earlier Ayurvedic physicians were producing medicines by themselves according to their need. Now a day, due to commercialization of Ayurvedic medicines and ignorance of classical methods, quality of drugs has deteriorated. Presently, the demand of Ayurvedic drugs in the global market is increasing day by day. Hence it is the need of time to develop SMP for Ayurvedic products for global acceptability. This paper aims at providing SMP for the manufacture of Rajata Bhasma and also attempts to study the effect of Shodhana process on Rajata. Rajata was obtained from the local market of Varanasi. Rajata Bhasma was prepared and it was observed that during the preparation of Rajata Bhasma, use of Muffle Furnace instead of conventional Puta is more advantageous due to better temperature control. Use of mercury and sulphur together acts as best medium in the preparation of Rajata Bhasma. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/566/96135 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Physico-chemical analysis of a Herbo-mineral compound Mehamudgara vati - A pilot study Tanna, I Chandola, HM Shukla, VJ Efforts have been made to lay down analytical standards for Mehamudgara vati (MMV), which were not found reported till date. Weight variation showed that 90% tablets of MV manufactured in the Gujarat Ayurved University Pharmacy were within acceptable range (323 mg ± 10%), pH 4.58, and disintegration time 17 min, whereas hardness was 1.25 kg/cm <sup>2</sup> . Loss on drying was found to be 9.3% w/w, acid insoluble ash was 0.9 %w/w, water soluble extract was 24.06% w/w and methanol soluble extract 14.1% w/w. Determination of iron as Fe <sub>2</sub> O <sub>3</sub> was done as Lauha bhasma being the major ingredient of MMV. The result showed that iron content was reduced in the formulation (28.67%) as compared to that in Lauha bhasma (61.19%). In TLC, 5 spots each at 254 nm and 366 nm were found. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/572/96136 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Antiobesity effect of Stellaria media against drug induced obesity in Swiss albino mice Chidrawar, VR Patel, KN Sheth, NR Shiromwar, SS Trivedi, P The whole plant of Stellaria media (family: Caryophyllaceae) has been tested for its antiobesity activity by using progesterone-induced obesity model in female albino mice. The effect of S. media on food consumption pattern, change in body weight, thermogenesis, lipid metabolism, and histology of fat pad. were examined. Methanolic and alcoholic extracts of the S. media were used in the study. Methanolic extract of S. media (MESM) have prevented the increase in body weight, adipose tissue weight and size, and upturned obesity and associated complications. MESM has also shown promising effects compared with alcoholic extract of S. media may be because of its multiple mechanisms. These findings suggest that antiobesity activity produced by MESM is because of its anorexic property mediated by saponin and flavonoid and partly of by its β-sitosterol content. β-Sitosterol in the plant extract was confirmed by thin-layer chromatography study. β-sitosterol is plant sterol having structural similarity with dietary fat which do the physical competition in the gastrointestinal tract and reduces fat absorption. Before carrying in vivo activity detail pharmacognostic and phytochemical analysis of the extracts was carried out. The plant has shown the presence of saponin, flavonoids, steroids and triterpenoids, glycosides, and anthocynidine. By this study, it can be concluded that, MESM is beneficial in suppression of obesity induced by progesterone. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/576/96137 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Antimicrobial and antifungal activities of Cordia dichotoma (Forster F.) bark extracts Nariya, PB Bhalodia, NR Shukla, VJ Acharya, RN Cordia dichotoma Forst.f. bark, identified as botanical source of Shlesmataka in Ayurvedic pharmacopoeias. Present study was carried out with an objective to investigate the antibacterial and antifungal potentials of Cordia dichotoma bark. Antibacterial activity of methanol and butanol extracts of the bark was carried out against two gram negative bacteria (Escherichia coli, and Pseudomonas aeruginosa) and two Gram positive bacteria (St. pyogenes and Staphylococcus aureus). The antifungal activity of the extracts was carried out against three common pathogenic fungi (Aspergillus niger, A.clavatus, and Candida albicans). Zone of inhibition of extracts was compared with that of different standards like Amplicilline, Ciprofloxacin, Norfloxacin and Chloramphenicol for antibacterial activity and Nystain and Greseofulvin for antifungal activity. The extracts showed remarkable inhibition of zone of bacterial growth and fungal growth and the results obtained were comparable with that of standards drugs against the organisms tested. The activity of extracts increased linearly with increase in concentration of extract (mg/ml). The results showed the antibacterial and antifungal activity against the organisms tested. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/585/96138 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Anti-anxiety and anti-depressant activities of Sarasvata choorna in experimental animals Gupta, K Ashok, BK Ravishankar, B Thakar, AB The present study was undertaken to evaluate the anxiolytic and anti-depressant activity of Sarasvata choorna. The anxiolytic activity was evaluated in elevated plus maze (EPM) and the anti-depressant activity was evaluated in forced swimming test (FST). The efficacy of Sarasvata choorna was compared with the standard anti-anxiety (diazepam 2 mg/kg) and anti-depressant (imipramine - 5 mg/kg) drugs. It was observed that Sarasvata choorna at the dose of 390 mg/kg is as effective as standard drugs used in anti-anxiety and anti-depressant activities in mice by increasing time spent in open arm and entries to open arm in EPM model and increasing immobility time in FST model respectively. Hence it can be concluded that Sarasvata choorna may be used as a potent therapeutic agent in treating anxiety and depressive disorders. Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/590/96139 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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"Ayurpathy" - The pharmaceuticalization of Ayurveda Patwardhan, K Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/594/96140 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Mysore Tridosha scale Wiwanitkit, S Wiwanitkit, V Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/595/96141 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Personnel communications Katiyar, CK Medknow Publications 2011-10-01 http://www.ayujournal.org/text.asp?2011/32/4/596/96142 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Need for cultivation to enrich Ayurvedic materia medica Sharma, ML Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/1/100282 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Drug discovery from plant sources: An integrated approach Katiyar, C Gupta, A Kanjilal, S Katiyar, S New drug discovery is facing serious challenges due to reduction in number of new drug approvals coupled with exorbitant rising cost. Advent of combinatorial chemistry provided new hope of higher success rates of new chemical entities (NCEs); however, even this scientific development has failed to improve the success rate in new drug discovery. This scenario has prompted us to come out with a novel approach of integrated drug discovery, where Ayurvedic wisdom can synergize with drug discovery from plant sources. Initial steps in new drug discovery involve identification of NCEs, which can be either sourced through chemical synthesis or can be isolated from natural products through biological activity guided fractionation. The sources of many of the new drugs and active ingredients of medicines are derived from natural products. The starting point for plant-based new drug discovery should be identification of the right candidate plants by applying Ayurvedic wisdom, traditional documented use, tribal non-documented use, and exhaustive literature search. Frequency analysis of the ingredients of the ancient documented formulations and analysis of their Ayurvedic attributes may provide an in-depth idea of the predominance of particular Ayurvedic characteristics based on which appropriate candidate plants may be selected for bioactivity-based fractionation. The integration of Ayurvedic wisdom with drug discovery also brings the need for a paradigm shift in the extraction process from sequential to parallel extraction. Bioassay-guided fractionation of the identified plant may lead to standardized extract or isolated bioactive druggable compound as the new drug. This integrated approach would lead to saving of cost and time, coupled with enhanced success rate in drug discovery. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/10/100295 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Kuberaksha Patra Churna, Vriddhadaru Mula Churna and Kandughna Taila in Shlipada (Manifested filariasis) Prasad, GP Naidu, ML At present there are effective drugs in eradicating microfilariae but treatments to control the progression of manifested filariasis, periodic adenolymphangitis (ADL) and lymphedema are not available in conventional system of medicine. So far National Ayurveda Research Institute for Vector-borne diseases, Vijayawada, has conducted many clinical trails on manifested filariasis patients with the classical Ayurvedic herbal, herbo-mineral drugs and found significant results on ADL, lymphedema and other acute and chronic clinical manifestations. An effort has been made to find the effect of Kuberaksha Patra Churna [Caesalpinia bonduc (L.) Roxb.], Vriddhadaru Mula Churna [Argyreia nervosa (Burm.f.) Boj.] and Kandughna Taila (oil prepared from 10 Ayurvedic drugs) in manifested filarial patients. Based on inclusion criteria 133 patients were included in three groups (45 in Gr.I, 45 in Gr.II and 43 in Gr.III) and 120 patients completed the study (40 in each group). In Gr. I Argyreia nervosa (Burm.f.) Boj. root powder, Caesalpinia bonduc (L.) Roxb. leaf powder mixed equally was given in the dose of 5 g twice a day for 30 days. In Gr.II along with Gr. I internal drugs Kandughna Taila was applied externally in sufficient quantity once a day for 30 days. Gr. III is a control study with Ayurvedic established drug 'Nityananda Rasa' 1 tablet thrice daily for 30 days. Group I and II drugs showed highly significant effect on lymphedema, lymphadenitis, lymphangitis, pain, tenderness, heaviness, deformity, fever and rigors (P<0.0001). Group III drug showed highly significant (P<0.0001) effect on lymphedema, deformity and heaviness; statistically significant (P=0.0018) on pain and tenderness; Significant effect on fever (P=0.0290), rigor (P=0.0290) and in lymphangitis (P=0.0384) and non-significant effect on lymphadenitis (P=0.1033). On statistical analysis effect of treatment on Hb and eosinophil count was found non-significant in three groups. On ESR, effect of treatment was found significant in Gr. III and non-significant in Gr. I and Gr. II. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/102/100324 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Majja Basti (therapeutic enema) and Asthi Shrinkhala (Cissus quadrangularis) in the management of Osteoporosis (Asthi-Majjakshaya) Gupta, AK Shah, N Thakar, AB Osteoporosis is a systemic disorder that affects entire skeleton, which is a metabolic bone disease characterized by low bone mass and microarchitectural deterioration of the skeleton, leading to enhanced bone fragility and a consequent increase in fracture risk. In Ayurveda, it can be correlated with Asthi-Majjakshaya. Basti (therapeutic enema) is the prime therapy for Asthi related diseases and Asthi Shrinkhala (Cissus quadrangularis) is the drug which is being used for strengthening of bone by traditional Vaidya since long. It has been selected for oral administration. In clinical trial, 12 patients treated with Majja Basti along with Asthi Shrinkhala pulp capsules and results are very encouraging. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/110/100326 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Protective role of Ashwagandharishta and flax seed oil against maximal electroshock induced seizures in albino rats Tanna, IR Aghera, HB Ashok, BK Chandola, HM Ashwagandharishta, an Ayurvedic classical formulation, is the remedy for Apasmara (epilepsy), Murchha (syncope), Unmada (psychosis), etc. Recent studies in animal models have shown that n-3 PUFAs can raise the threshold of epileptic seizures. The indigenous medicinal plant, called Atasi (Linum usitatissimum Linn.) in Ayurveda, or flax seed, is the best plant source of omega-3 fatty acids. The present study is designed to investigate whether Ashwagandharishta and Atasi taila (flax seed oil) protect against maximal electroshock (MES) seizures in albino rats. Further, a possible protective role of flax seed oil as an adjuvant to Ashwagandharishta in its anticonvulsant activity has also been evaluated in the study. MES seizures were induced for rats and seizure severity was assessed by the duration of hind limb extensor phase. Phenytoin was used as the standard antiepileptic drug for comparison. Both flax seed oil and Ashwagandharishta significantly decreased convulsion phase. Pre-treatment with flax seed oil exhibited significant anticonvulsant activity by decreasing the duration of tonic extensor phase. Contrary to the expectations, pre-treatment with flax seed oil as an adjuvant to Ashwagandharishta failed to decrease the tonic extensor phase; however, it significantly decreased the flexion phase (P < 0.001) and duration of the convulsions (P < 0.05). Both the drugs exhibited an excellent anti-post-ictal depression effect and complete protection against mortality. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/114/100327 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Anticonvulsant activity of raw and classically processed Vacha (Acorus calamus Linn.) rhizomes Bhat, SD Ashok, BK Acharya, RN Ravishankar, B The rhizome of Vacha (Acorus calamus) has been used in Ayurvedic medicine for the treatment of various ailments, such as epilepsy, headache, eye disorders, insomnia, loss of memory, etc. Previous studies demonstrated that Vacha rhizome is having significant anticonvulsant activity against various induced seizures models in experimental animals. Ayurvedic pharmacopoeia of India has advocated Shodhana (purificatory procedures) to be done prior to its use. In the present study a comparative anticonvulsant activity of raw and Shodhita (classically processed) Vacha rhizomes were screened against Maximal Electro Shock (MES) seizure model to assess the effect of classical purificatory procedure on pharmacological action of Vacha. Phenytoin was used as standard antiepileptic drug for comparison. Pretreatment with both raw and classically processed Vacha samples exhibited significant anticonvulsant activity by decreasing the duration of tonic extensor phase. Further classically processed Vacha statistically decreased the duration of convulsion and stupor phases of MES-induced seizures. The results obtained from the present study clearly confirmed the anticonvulsant activity of raw Vacha and subjecting to classical Shodhana procedure did not alter the efficacy of Vacha rhizomes instead it enhanced the activity profile of the Vacha. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/119/100328 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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In vitro antibacterial and antifungal activities of Cassia fistula Linn. fruit pulp extracts Bhalodia, NR Nariya, PB Acharya, RN Shukla, VJ Aim of the study is to assess the antimicrobial activity Cassia fistula fruit pulp extracts on some bacterial and fungal strains. Hydro alcohol and chloroform extracts of Cassia fistula fruit pulp were evaluated for the potential antimicrobial activity. The antimicrobial activity was determined in both the extracts using the agar disc diffusion method. Extracts were effective on tested microorganisms. The antibacterial and antifungal activities of solvent extracts (5, 25, 50, 100, 250 μg/mL) of C. fistula were tested against two gram positive, two gram negative human pathogenic bacteria and three fungi, respectively. Crude extracts of C. fistula exhibited moderate to strong activity against most of the bacteria tested. The tested bacterial strains were Staphylococcus aureus, Streptococcus pyogenes, Escherichia coil, Pseudomonas aeruginosa, and fungal strains were Aspergillus. niger, Aspergillus. clavatus, Candida albicans. The antibacterial potential of the extracts were found to be dose dependent. The antibacterial activities of the C. fistula were due to the presence of various secondary metabolites. Hence, these plants can be used to discover bioactive natural products that may serve as leads in the development of new pharmaceuticals research activities. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/123/100329 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Pharmacognostical and phytochemical evaluation of Vara Asanadi Kwatha Ramachandran, AP Prasad, MS Chandola, HM Harisha, CR Shukla, VJ Vara Asanadi Kwatha (VAK) is a compound Ayurvedic formulation prescribed in the management of obesity. Pharmacognostical study counting both macroscopic and powder microscopy of raw drug exposed the quality and genuineness of all the constituents of VAK. Organoleptic features of coarse powder made out of the crude drugs were within the standard range. Specific gravity of the decoction was 1.0185 and pH was 5.5.Total solid content present in the Kwatha was 4.525% w/v, total ash 0.949% w/v, and acid insoluble ash was 0.052% w/v. Iron assay showed the presence of Fe <sub>2</sub> O <sub>3</sub> as 0.065% w/v. Qualitative scrutiny demonstrated the presence of flavonoids and tannis. Thin Layer Chromatography (TLC) and High Performance Thin Layer Chromatography (HPTLC) were carried out after organizing appropriate solvent system in which maximum three spots were distinguished in TLC and nine spots in HPTLC and most of the R <sub>f</sub> values were identical when done with different sample extractive methods. This shows the presence of certain definite constituents in the decoction and is helpful for the easy separation of these constituents. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/130/100330 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:100331 2012-01-01 all journal:Ayu
Pharmaceutical standardization of Jala Shukti Bhasma and Mukta Shukti Bhasma Galib Patgiri, BJ Shukti is an important component of Sudha Varga, which is considered as the latest class in the field of Rasa Shastra. Two types of Shukti have been mentioned in Rasa Shastra texts i.e. Jala Shukti and Mukta Shukti according to the availability. In present study, an attempt has been made to develop a standard manufacturing procedure (SMP) of Jala Shukti Bhasma and Mukta Shukti Bhasma. Five batches of Jala Shukti Bhasma and Mukta Shukti Bhasma were prepared and standardization was attempted by maintaining batch manufacturing records of individual batches. During pharmaceutical procedures like Shodhana, Bhavana, Marana, etc. due care of temperature, its duration, percentage of weight gain or loss and the cost factor of the end product, etc. were considered. The average weight loss observed was 12.08 g i.e. 2.42% and 14.62 g i.e. 2.92% during Jala Shukti and Mukta Shukiti Shodhana respectively. Average weight loss found was 38.94 g i.e. 7.79% in Jala Shukti Bhasma while in Mukta Shukti Bhasma, it was 35.24 g i.e. 7.05%. At the end of the pharmaceutical procedure, it was found that Mukta Shukti Bhasma is 2.8 times costlier than Jala Shukti Bhasma. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/136/100331 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:100332 2012-01-01 all journal:Ayu
Identifications studies of Lauha Bhasma by X-ray diffraction and X-ray fluorescence Bhargava, SC Procedures for preparation of Lauha Bhasma are described in ancient texts of Ayurveda. These procedures also begin with different source material for iron such as Teekshna Lauha and Kanta Lauha etc. In the present study, we have selected different source materials viz. magnetite iron ore for Kanta Lauha and pure (Armco grade) iron turnings for Teekshna Lauha. The standard procedures of preparation of Lauha Bhasma are carried out in identical conditions for these two raw materials. The final product from the Puta are characterized by using X-ray diffraction and X-ray fluorescence spectroscopy to understanding the crystallographic form or forms of iron oxides and their composition at the end of each Puta. The iron content at the end of repeated Putas (18 for Kanta Lauha and 20 for Teekshna Lauha) have shown a decrease in case of Teekshna Lauha since the starting material is pure iron while it showed only marginal decreases in the case of Kanta Lauha because the Fe <sub>3</sub> O <sub>4</sub> of magnetite is undergoing oxidation to Fe <sub>2</sub> O <sub>3</sub> . The trace elements remain within the Bhasma in the form of various oxides of Si, Al, Ca, etc. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/143/100332 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Rasanjana Madhu Ashchyotana for a mucopurulent conjunctivitis Joob, B Wiwanitkit, V Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/146/100333 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Author's reply Bhardwaj, A Tanwar, M Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/146/100334 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Medicinal - Agricultural science in Vedic literature Jakhmola, RK Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/147/100335 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Intellectual property rights and patents in perspective of Ayurveda Chaudhary, A Singh, N Ayurveda is getting its due recognition as a rationale system of medicine worldwide despite the fact that medical and scientific fraternity of the globe has very strong opposite opinion regarding safety and efficacy of Ayurvedic medicines. Meanwhile, provisions of Intellectual Property Rights under World Intellectual Property Organization (WIPO) and Patents have attracted many individuals and organizations to explore possibilities of commercial benefits with Ayurvedic traditional knowledge. Although rules are not favoring to grant a patent on prior published knowledge, biopiracy managed grant of Patent on knowledge of Ayurvedic medicinal plants which has been successfully checked with references of data base of Traditional Knowledge Digital Library (TKDL). Current provisions of the Patent law of India are obstructive in nature for getting patent on Ayurvedic medicines. If we have to invite researchers from basic science to ensure quality, safety and efficacy of Ayurvedic medicines, there is an urgent need to amend laws of patent with pragmatic promotional policies. This will encourage more patents on numerous pharmaceutical, nutraceutical and cosmaceutical products based on Ayurveda. As every action of today's world is based on economic criteria so why stakeholders of Ayurveda should be deprived of it. New inventions would drive acceptance of Ayurveda as a global system of medicine. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/20/100298 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A phytopharmacological review on an important medicinal plant - Amorphophallus paeoniifolius Dey, YN Ota, S Srikanth, N Jamal, M Wanjari, M Amorphophallus paeoniifolius is used for long period in various chronic diseases therapeutically. Aim of the current review is to search literature for the pharmacological properties, safety/toxicity studies, pharmacognostic studies and phytochemical investigation of Amorphophallus paeoniifolius tuber. The compiled data may be helpful for the researchers to focus on the priority areas of research yet to be discovered. Complete information about the plant has been collected from various books, journals and Ayurvedic classical texts like Samhitas, Nighantus etc. Journals of the last 20 years were searched. Particulars of pharmacological activities, phytochemical isolation, toxicity studies etc. were extracted from the published reports focussing on the safety profile of the plant. Safety of the whole plant was concluded in the review. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/27/100303 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Ethical prescription writing in Ayurveda Baghel, MS Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/3/100290 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Health awareness and popularity of alternative medicines among people of Jamnagar town: A cross - sectional study Chatterjee, B Biswas, PC Pancholi, J By 2020, it is predicted that non-communicable diseases will be causing seven out of every 10 deaths in developing countries. Indian traditional medicine system with the concept of personalized therapy in Ayurveda has the potential to offer remedies to these challenging health issues. Integration of Ayurveda, Siddha and Unani, the three Indian systems of medicine (ISM), along with homoeopathic and allopathic systems of medicine to ensure health for all citizens across the country is the new Mantra of the Union health ministry. To tap the potentials of our indigenous medicine systems and other popular systems of medicine it is important to assess the awareness among people and make efforts to popularize them. The present study was therefore carried out to assess the awareness among 200 respondents with the help of a multiple choice questionnaire by the interview method. Convenience sampling technique was employed. The awareness about lifestyle, diet, oil consumption needs more vigorous attention as observed in this study. The most popular choice was found to be groundnut oil. Around 4% of the participants used more than one medium of cooking. Forty-two percent of the participants observed fast regularly. Twenty-three percent of the participants did not include any form of exercise in their daily routine while walking was the most popular form of exercise performed by 43%. By using multiple comparisons it was observed that the difference between i) Allopathy- Homeopathy, ii) Allopathy - Ayurvedic and iii) Ayurvedic- Homeopathy as 15.5263, 7.1053 and 8.4211, respectively, are significant at a = 0.05. A larger sample size encompassing various economic strata could be a better index of popularity of various alternative medicine systems existing in different sections of our society. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/33/100306 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical evaluation of Rasayana compound as an adjuvant in the management of tuberculosis with anti-Koch's treatment Vyas, P Chandola, HM Ghanchi, F Ranthem, S Tuberculosis (TB) continues to intimidate the human race since time immemorial not only due to its effects as a medical malady, but also by its impact as a social and economic tragedy. At the dawn of the new millennium, we are still mute witnesses to the silent yet efficient march of this sagacious disease, its myriad manifestations and above all its unequalled, vicious power. Through the millennia, TB never ever disappeared from the developing world. In 1991, the World Health Assembly (WHA) resolution recognized TB as a major global public health problem. The DOTS strategy was launched in 1994, and became the global recommended strategy for TB control since then. The present study deals with clinical evaluation of Rasayana drugs considering of Amalaki (Emblica officinalis Gaertn.), Guduchi (Tinospora cordifolia willd.), Ashwagandha (Withania somnifera L.) Dunal, Yastimadhu (Glycyrrhiza glabra Linn.), Pippali (Piper longum Linn.), Sariva (Hemidesmus indicus R.Br.), Kustha (Saussurea lappa Falc.), Haridra (Curcuma longa Linn.) and Kulinjan (Alpinia galangal Linn.) as an adjuvant therapy with anti-Koch's treatment. The results obtained revealed that Rasayana compound was found to decrease cough (83%), fever (93%), dyspnea (71.3%), hemoptysis (87%) and increase body weight (7.7%) with statistically highly significant (P<0.001). Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/38/100307 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of walking (aerobic isotonic exercise) on physiological variants with special reference to Prameha (diabetes mellitus) as per Prakriti Tiwari, S Gehlot, S Tiwari, SK Singh, G Walking is an isotonic aerobic exercise and has been associated with reduced blood sugar level in diabetic patients and other physiological changes in observational studies. A study was conducted to determine the effect of isotonic aerobic exercise (walking) on blood sugar level and other important physiological parameters as per Prakriti. This study was carried out in Department of Kriya Sharira and Kayachikita, S. S. Hospital; Faculty of Ayurveda, IMS, BHU and some cases were enrolled from Kashi Mumukshu Bhawan, Assi, Varanasi. A total 83 (32 diabetic control and 51 diabetic exercise) diabetic cases were included with age ranging from 35 to 65 years during January 2009 to January 2011. Control cases enrolled in this study had not performed any exercise. The results of the study revealed that, there is a strong association in between Prakriti, Blood pressure and certain other Biochemical parameters. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/44/100308 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Academic and professional interests of Ayurvedic human resource needs protection Chandola, HM Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/5/100292 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Kshara Basti and Nirgundi Ghana Vati on Amavata (Rheumatoid Arthritis) Thanki, K Bhatt, N Shukla, VD Ayurveda has taken the foremost place in the management of crippling disease, one of them is Amavata which can be compared with Rheumatoid Arthritis due to its clinical appearance. Due to wide spectrum of disease, much prevalence in the society and lack of effective medicament, the disease is being chosen for the study. The line of treatment described for the disease in Chakradatta can be summarized under following captions. i.e to bring Agni to normal state to digest Ama, and eliminate vitiated Vata and Ama. Thus, here Kshara Basti is selected for the present study as Samshodhana process which corrects all of above captions. It is mentioned in Chikitsa Sutra described by Chakradatta. Nirgundi has Amavatahara property which is stated by Bhavaprakasha, considering which Nirgundi Patra Ghanavati is selected as Shamana drug. Total 50 randomly selected patients of Amavata were registered among them 45 were completed the treatment. Kshara Basti in the format of Kala Basti was given to these patients and Nirgundi Ghana Vati was given for one month. Statistically significant improvement was found in ESR, RA factor (quantitative) and also highly significant results were found in symptoms of Amavata. Moderate improvement was seen in 40% of patients, 35.56% patients got marked improvement, while mild improvement was found in 24.44% of patients. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/50/100310 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative study of Shankhapushpyadi Ghana Vati and Sarpagandhadi Ghana Vati in the management of "Essential Hypertension" Mishra, J Joshi, NP Pandya, DM Hypertension is a major public health problem of this era. Hypertension related morbidity and mortality rates have dramatically increased over the last 25 years. Stressful life style is one of the leading causes of Hypertension. The treatment of hypertension remains a primary goal in the effort to reduce morbidity and mortality from cardiovascular disease, stroke and kidney disease. In this study, 20 patients were randomly divided in two groups and treated along with restricted diet pattern for 8 weeks. Patients of Group A received poly-herbal compound formulation Shankhapushpyadi Ghana Vati (2gm/day). It was found that, relief in overall symptoms (63.93%) elevated blood pressure (8.91% in Systolic blood pressure and 8.44% in diastolic blood pressure). In group-B, with Sarpagandhadi Ghana Vati (2gm/day) the percent relief was better on elevated blood pressure (12.00% in Systolic blood pressure and 11.02% in diastolic blood pressure). When data is subjected in between both the groups, it is found that, both drugs are equally effective. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/54/100311 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Efficacy of Trikatrayadi Lauha in Panduroga with reference to Iron Deficiency Anemia Khan, SK Vyas, SN Chandola, HM The common nutritional deficiency, iron deficiency, causes Iron Deficiency Anemia (IDA) throughout the world especially in the developing countries. In Ayurveda, different herbal, mineral or herbomineral drugs have been emphasized to combat anemia (Panduroga). Trikatrayadi Lauha and Fersolate-CM (a modern medicine taken as standard control) were administered to the patients to evaluate their role in Panduroga. A simple random sampling method was followed for the clinical study. The 56 iron deficiency anemic patients of both sexes and age group between 16 to 70 years divided into two groups - Group-A (n=34) and Group-C (n=22) were treated with Trikatrayadi lauha and Fersolate-CM, respectively. Both drugs provided significant effect on the signs and symptoms of Shrama (fatigue), Shwasa (dyspnea on exertion), Daurbalya (weakness), Pandu Varna (pallor/yellowish-whitish), Hridspandana (palpitation), Hatanala (diminished digestive capacity), Bhrama (giddiness), Aruchi (anorexia), Arohana Ayasa (exhaustion during climbing), Shiroruja (headache) and Shotha (edema). Trikatrayadi Lauha provided significant results on Hb gm%, RBC, PCV, MCV, serum iron, percent transferrin saturation and TIBC where as insignificant changes were found in MCH and MCHC. Fersolate-CM provided significant results on Hb gm%, RBC, PCV, MCV, MCH, serum iron, percent transferrin saturation and TIBC whereas insignificant change was found in MCHC. Trikatrayadi Lauha showed significant results on Panduroga and Iron Deficiency Anaemia (IDA). Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/62/100313 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Role of Raktamokshana by Jalaukavacharana and Siravedhana in the management of Vicharchika (Eczema) Raval, HN Thakar, AB Eczema is most common skin disease which has social impact. The clinical picture of Eczema resembles with Vicharchika--a skin problem mentioned in Ayurvedic literature with Kapha and Pitta morbidly/pathology. In classical text of Ayurveda, Acharyas emphasize the Shodhana therapy as the line of treatment at various places. Among these various Shodhana therapy, Raktamokshan is indicated specially because Rakta is mainly involved as Dushya in Samprapti Ghataka. In the present comparative study, Raktamokshana with two different methods were selected to find out which method is more appropriate for Raktamokshana in Vicharchika. In A group, Jalaukavacharana Karma with Jalauka (Hirudinea medicinalis) and in B group, Siravedhana Karma with Syringe as method of Raktamokshana was selected. Better result was found in A group. So, it is better to manage Vicharchika using Jalaukavacharana as method of Raktamokshana in place of Siravedhana. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/68/100314 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Beyond a bureaucratic status report on Indian medicine and folk healing Singh, RH Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/7/100293 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A randomized controlled clinical trial to assess the efficacy of Nasya in reducing the signs and symptoms of cervical spondylosis Radhika, C Kumar, GV Mihirjan, K This work was designed to assess the efficacy of Nasya in reducing the signs and symptoms of cervical spondylosis. The patients attending the O. P. D of Department of Kaya Chikitsa and Panchakarma, Government Ayurveda College Hospital, Thiruvananthapuram were enrolled and subjected to the treatment schedule. Total duration of treatment was 21days. The schedule for the first 14 days was similar in both the groups. It included Rooksha Sveda for 7days followed by Patra Pottali Sveda for 7days. During this period, 90 ml Gandharvahastadi Kashaya twice and Guggulu Tiktaka Kashaya once were given internally. After this, in the Nasya group Nasya was done for 7days with Dhanwantaram Tailam (21times Aavartita), Mridu Paka in Madhyama Matra (8Bindu). Along with this Guggulu Tiktaka Kashaya was given thrice. In the control group, Guggulu Tiktaka kashaya alone was given thrice daily. Assessments were done with regard to pain, tenderness, radiation of pain, numbness, range of movements and hand grip strength. These were done before treatment, before nasya, after treatment and after 1month follow-up. The statistical hypothesis was tested using paired 't' test and 'Z' test for proportion. The trial proved that conventional management along with Nasya was more efficacious than conventional management alone in reducing the signs and symptoms of cervical spondylosis. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/73/100316 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Role of Sattvavajaya Chikitsa (Trance therapy) in the management of Manasa-Dosha Ajeerna Vyas, KM Dwivedi, RR In Ayurveda, three modes of healing are narrated, viz. Daiva-Vyapashraya, Yukti-Vyapashraya, and Sattvavajaya Chikitsa. In the present study, an effort has been made to assess the effect of Sattvavajaya Chikitsa on both Shareera and Manasa Doshas. Similarly, the impact of Yukti-Vyapashraya Chikitsa on both kinds of Doshas has been observed. The psychosomatic disease selected for the study was Manasa-Dosha Ajeerna. The standard drug taken for Ajeerna was Shunthi, while for Sattvavajaya "Trance/Clinical Hypnosis" was applied on the patients. The study was carried out on 27 patients suffering from Ajeerna and having a significant stress score. Patients were divided into two groups with simple random sampling method: Group S was treated with Shunthi tablet, while in group PS, placebo (rice powder tablet) along with Sattvavajaya Chikitsa was provided to the patients. Duration of the treatment was 10 days. Classical signs and symptoms of Ajeerna were studied before and after treatment. Amongst the registered patients, 25 patients completed the course of treatment while 2 dropped out. Group S had shown significant improvement in Vataja and Kaphaja symptoms, while group PS showed significant effect on Pittaja symptoms. In Tamasika Manobhavas causing Ajeerna, group PS had shown significant improvement, while group S showed significant and highly significant effect on Rajasika and Tamasika Bhavas, respectively. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/78/100317 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative clinical study of Snuhi Ksheera Sutra, Tilanala Kshara Sutra and Apamarga Kshara Sutra in Bhagandara (Fistula in Ano) Lobo, SJ Bhuyan, C Gupta, SK Dudhamal, TS Bhagandara (Fistula in Ano) at modern parlance is a common anorectal condition prevalent in the populations worldwide and its prevalence is second highest after Arsha (hemorrhoids). Kshara Sutra (K.S.) is one of the chief modality in the treatment of Bhagandara in Ayurvedic science. Exploration of the new plants for the preparation of Kshara as a better substitute to Apamarga Kshara is the need of the hour. To find out an effective alternative to Apamarga K.S. in view of easy processing, a Snuhi Ksheera Sutra without any Kshara and the Tilanala K.S. were opted for their clinical evaluation. Total 33 cases of Bhagandara were divided randomly into 3 groups, having 11 patients in each group. In Group A, Snuhi Ksheera Sutra; in Group B, Tilanala K.S. and in Group C, Apamarga K.S. were used. Assessment was done on objective (Unit Cutting Time - UCT) and subjective parameters. Statistically insignificant difference was observed in the efficacy of treatment by subjective parameters like pain, discharge, etc. between the three groups. It was found that Tilanala K.S. showed higher UCT (9.76 days) while lower in Snuhi Ksheera Sutra (7.42 days) as compared to Apamarga K.S. (8.82 days). Thus Tilanala K.S. can be used as a substitute for Apamarga K.S. and Snuhi Ksheera Sutra can be employed in the recurrent fibrosed cases of Bhagandara. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/85/100319 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Vranaropaka effect of Laksha Churna with Madhu on wound after removal of Danta Sharkara Maurya, M Maurya, DK According to Sushruta, disease in which plaque formed on teeth and hardened by the action of deranged Vayu, lies in a crystallized form at root of teeth is called as Dantasharkara. According to Vagbhata, accumulation of dirt on teeth by not cleaning them daily or of Kapha dehydrated by Vata adhering to the teeth, becoming hard and emits bad odor is known as Dantasharkara (Tartar). Tartar manifests as a deposit of inorganic salts composed primarily of calcium carbonate and phosphate mixed with food debris, bacteria and desquamated epithelial cells which reduce the quality of whiteness and strength of the teeth. Teeth loss is also not uncommon in tartar sufferers. Such deposits tend to destroy the healthy growth and function of teeth. It should be removed in such a way as not to hurt the roots of the teeth and then parts should be rubbed (Pratisarana) with Laksha Churna and Madhu. In trial group, management of tartar is attempted by local rubbing of Laksha Churna with Madhu on the surface of teeth and gingiva. Regeneration, repair and new attachment are the aspects of periodontal healing that are achieved by gingival physiotherapy on scaling wound. Pratisarana of Laksha Churna with Madhu is easy to apply, cost effective and free from side effects in comparison to systemic use of modern drugs. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/92/100321 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative study of Bilvadi Yoga Ashchyotana and eye drops in Vataja Abhishyanda (Simple Allergic Conjunctivitis) Udani, J Vaghela, DB Rajagopala, M Matalia, PD Simple allergic conjunctivitis is the most common form of ocular allergy (prevalence 5 - 22 %). It is a hypersensitivity reaction to specific airborne antigens. The disease Vataja Abhishyanda, which is due to vitiation of Vata Pradhana Tridosha is comparable with this condition. The management of simple allergic conjunctivitis in modern ophthalmology is very expensive and it should be followed lifelong and Ayurveda can provide better relief in such manifestation. This is the first research study on Vataja Abhishyanda. Patients were selected from the Outpatient Department (OPD), Inpatient Department (IPD), of the Shalakya Tantra Department and were randomly divided into two groups. In Group-A Bilvadi Ashchyotana and in Group-B Bilvadi eye drops were instilled for three months. Total 32 patients were registered and 27 patients completed the course of treatment. Bilvadi Ashchyotana gave better results in Toda, Sangharsha, Parushya, Kandu and Ragata as compared with Bilvadi Eye Drops in Vataja Abhishyanda. Medknow Publications 2012-01-01 http://www.ayujournal.org/text.asp?2012/33/1/97/100323 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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New challenges for Ayurveda: How it will stand? Chandola, HM Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/165/105231 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Sushruta-samhitA - A critical Review Part-1 : Historical glimpse Sharma, HS Sharma, HI Sharma, HA In the history of Ayurveda, Sushruta stands before Caraka. He practically applied Vaidika culture for treatment. His treatise translated into nine foreign languages apart from various Indian languages like Hindi, Bengali, Malayalam, etc., Sushruta is the most celebrated physician and surgeon in India. Though he practiced during the 5th century BC, many of his contributions to medicine and surgery preceded similar discoveries in the western world. Sushruta devotes a complete volume of his experiences to ophthalmologic diseases. In the Uttara Tantram, Sushruta enumerates a sophisticated classification of eye diseases complete with signs, symptoms, prognosis, and medical/surgical interventions. In particular, Sushruta describes what may have been the first extracapsular cataract surgery using a sharply pointed instrument with a handle fashioned into a trough. His ability to manage many common eye conditions of the time with limited diagnostic aids is a testament to his virtuosity. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/167/105232 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Self evolution: 1 <sup>st</sup> domain of spiritual health Dhar, N Chaturvedi, SK Nandan, D While measuring physical, mental, and social health as defined by the World Health Organization (WHO), the basis of measurement is in terms of Determinants. Recently with the advent of health promotion activities, the emphasis is on enabling individuals, groups, and societies to have control on these Determinants. To measure the spiritual health, the 4 <sup>th</sup> Dimension, a Spiritual Health Scale consisting of 3 Domains, 6 Constructs, and 27 Determinants of spiritual health were identified through a scientific process. A statistically reliable and valid Spiritual Health Scale (SHS 2011) containing 114 items has been developed. Construct validity and test-retest reliability has been established. The 3 Domains are: Self-Evolution, Self-Actualization, and Transcendence. In this article, the process of self evolution in terms of "Wider Perspective" and "Nurturance-Art" have been captured through the Determinants like Commitment, Introspection, Honesty, Creativity, Contemplation, Prayer, Philanthropy, Extending Self, Empathy, Yoga and Exercise, Questioning Injustice, Aesthetics, Value for Time, and Being Away From Comparisons. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/174/105234 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Medicinal and cosmetic uses of Bee's Honey - A review Bee's honey is one of the most valued and appreciated natural substances known to mankind since ancient times. There are many types of bee's honey mentioned in Ayurveda. Their effects differ and 'Makshika' is considered medicinally the best. According to modern scientific view, the best bee's honey is made by Apis mellifera (Family: Apidae). In Sri Lanka, the predominant honey-maker bee is Apis cerana. The aim of this survey is to emphasize the importance of bee's honey and its multitude of medicinal, cosmetic and general values. Synonyms, details of formation, constitution, properties, and method of extraction and the usages of bee's honey are gathered from text books, traditional and Ayurvedic physicians of Western and Southern provinces, villagers of 'Kalahe' in Galle district of Sri Lanka and from few search engines. Fresh bee's honey is used in treatment of eye diseases, throat infections, bronchial asthma, tuberculosis, hiccups, thirst, dizziness, fatigue, hepatitis, worm infestation, constipation, piles, eczema, healing of wounds, ulcers and used as a nutritious, easily digestible food for weak people. It promotes semen, mental health and used in cosmetic purposes. Old bee's honey is used to treat vomiting, diarrhea, rheumatoid arthritis, obesity, diabetes mellitus and in preserving meat and fruits. Highly popular in cosmetic treatment, bee's honey is used in preparing facial washes, skin moisturizers, hair conditioners and in treatment of pimples. Bee's honey could be considered as one of the finest products of nature that has a wide range of beneficial uses. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/178/105233 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A critical study of Rasamritam and it's applied aspects Mohapatra, S Gupta, RK Reddy, K Jha, CB Historical studies of Rasa shastra reveal the use of metals and minerals, both for alchemical and therapeutical purposes in ancient past. But, gradually the alchemical use of the subject, declines and the therapeutical use takes over. Rasamritam is the latest doctrine in the field of Rasa shastra which compiles the extract of the older books and adopted some new and contemporary concepts. The practical aspects of this text influence both the academicians as well as physicians in large extent. Keeping the wealthier, timely concept of this text in mind, we are trying to review and analyze it critically for the benefit of researchers and practitioners and hope the idea will be fruitful. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/183/105235 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Applicability and importance of Caraka's concept of Aaturaparijnana Hetawah in understanding a patient Wadher, R Dwivedi, RR Many concepts in Ayurveda are untouched or unexplored till date. One of such concepts to understand the healthy and unhealthy persons is that of the Aaturaparijnana Hetawah (APH), which is only mentioned in Caraka Samhita. The descriptions about Dushya, Desha, Bala, Kala, Prakriti, etc. are mentioned very briefly in all the classics. But no standard figure or pattern is maintained while considering them. It is only in the description of Aaturaparijnana Hetawah mentioned in Vimana Sthana that all the factors are pre-arranged in a chronological order to understand an individual according to one's Desha as from birth till grown up stage, and also to understand about the illness and most common disorders. In this article, it is aimed at presenting an in-depth evaluation about description of Aaturaparijnana Hetawah in Ayurveda. For this study, the references of Aturaparijnana Hetu have been collected through the Ayurvedic texts along with their commentaries. By making use of 14 factors described in Aaturaparijnana Hetawah, it is possible to have an in depth understanding about the patient's nature and factors that may be contributing to his health and illness. Aaturaparijnana Hetawah helps in an in-depth understanding of a patient's disease and heath status. More in-depth evaluation studies and application in the modern medical science should be done in order to avail the benefits of this approach. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/188/105236 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Pharmacological attribute of Aloe vera: Revalidation through experimental and clinical studies Gupta, VK Malhotra, S Aloe vera has long been used as a traditional medicine for inducing wound healing. It is a natural product that now a days is used in cosmetic industry. Benefits associated with Aloe vera have been attributed to the polysaccharides contained in the gel of the leaves though there are various indications for its use. Biological activities include promotion of wound healing, antifungal activity, anti-inflammatory, anticancer and immunomodulatory. Gingival fibroblasts play an important role in oral wound healing. Double blind-controlled trials are needed to determine its real efficacy in oral health. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/193/105237 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Safety and efficacy evaluation of Ayurvedic treatment (Arjuna powder and Arogyavardhini Vati) in dyslipidemia patients: A pilot prospective cohort clinical study Kumar, G Srivastava, A Sharma, SK Gupta, YK Cardiovascular disease has multifaceted in which dyslipidemia, inflammation, and immunity play an important role. Arjuna powder and Arogyavardhini Vati used for centuries has potential for combating these factors. Therefore, the objective of this study was to evaluate the safety and efficacy of Ayurvedic treatment (Arjuna powder and Arogyavardhini Vati) for dyslipidemia patients. Total of 108 patients were screened at CGHS Ayurvedic Hospital, New Delhi. Ninety-six patients satisfied inclusion criteria, and signed informed consent and detailed medical history was recorded. Arjuna powder (5 g, BD) for 3 weeks and then Arogyavardhini Vati (500 mg, BD) for 4 weeks were prescribed to the patients. The primary efficacy endpoint was reduction in serum total cholesterol, LDL, triglycerides, and increased HDL levels. Secondary endpoints included reduction in serum C-Reactive Protein (CRP) and blood glucose levels. Safety assessments included hepatic function (aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), bilirubin, and β<sup>2</sup> microglobulin), renal function (urea and creatinine and NGAL) tests, and urine mercury level. The study was completed by 87 patients. The male and female patients were 65.5% (57/87) and 34.5% (30/87), respectively. There was a significant reduction in total cholesterol, LDL, triglycerides, CRP, and blood glucose. However, raised HDL level was also observed. Safety assessment results showed no significant change in serum ALT, AST, ALP and bilirubin, urea, creatinine β<sup>2</sup> microglobulin, and NGAL levels at the end of study as compared to the baseline levels. In conclusion, the results of the present prospective cohort study showed that Ayurvedic treatment (Arjuna powder and Arogyavardhini Vati) is safe and effective for dyslipidemia. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/197/105238 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of Guduchyadi Medhya Rasayana on Senile Memory Impairment Dave, AR Baghel, MS Aging has become one of the distinctive demographic phenomena in the 21 <sup>st</sup> century and its social, economic and health implications are the most challenging issues. Senile Memory Impairment is a common condition characterized by mild symptoms of cognitive decline and occurs as a part of the normal aging process. It can be correlated to "Jarajanya Smrtibhramsha" according to Ayurveda. The present study deals with the efficacy of Guduchyadi Medhya Rasayana on Senile Memory Impairment. A total of 138 patients aged in between 55-75 years were registered and randomly divided into two groups as the trial and control groups. The drugs were administered for 3. The trial drug showed memory enhancement, anti-stress, anti-depressant and anxiolytic properties. The trial group showed better results in the management compared to the control group. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/202/105239 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Development and validation of a Prototype Prakriti Analysis Tool (PPAT): Inferences from a pilot study Rastogi, S Chiappelli, F Prakriti , for its tangible impacts upon decision making in Ayurvedic clinical practice, requires a thorough and fool-proof method of examination. Conventional methods adopted for Prakriti examination are found inconsistent with huge inter- and intra-rater inference variability. By observing the gaps in the field, the present study aims to develop a prototype Prakriti analysis tool and its evaluation on inter-rater validity grounds. The study observes that Vata and Pitta constructs of Prakriti identification in Ayurveda have a significant inter-rater correlation (P < 0.001 and P < 0.01), whereas Kapha has less (P < 0.02) correlation. It is inferred that for less correlated variables like those of Kapha, a better understanding is required to reach a better consensus. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/209/105240 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical evaluation of the efficacy of Dashanga Kwatha Ghana Vati in the management of Urdhwaga Amlapitta (Non-ulcer dyspepsia) Baragi, UC Vyas, MK A study has been designed to evaluate the effectiveness of Dashanga Kwatha Ghana Vati in Urdhwaga Amlapitta (non-ulcer Dyspepsia). Randomized single blind, placebo controlled study was conducted in 138 patients attending O.P.D. of department of Basic Principles, I.P.G.T. and R.A., Gujarat Ayurved University, Jamnagar, and grouped into two. Both the groups consumed two tablets of either Dashanga Kwatha Ghana Vati or placebo, twice daily after food for a period of eight weeks. The patients were followed upto four weeks, 110 patients had completed the treatment and no adverse effects were reported during the treatment. Both groups had improved in the clinical symptoms and overall statistical significance was observed in the differences of scores between the two groups. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/219/105241 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of Shodhana Karma and Shamana Karma in Mandala Kushtha (Psoriasis) Mangal, G Mangal, G Sharma, RS In India an estimated 0.8% of the population is suffering from Psoriasis. It is a papulo-squamous disorder of the skin, characterized by sharply defined erythemato-squamous lesions. It is chronic and is well known for its course of remissions and exacerbations. The exact etiology is still unknown. This condition is comparable with Mandala Kushtha in Ayurvedic system of medicine. Shodhana procedures are reliable to control the disease. Forty patients, fulfilling the inclusion criteria, were selected and randomly divided into four groups with 10 patients in each group. In Group A, Vamana and Virechana was administered once during the trial period. In Group B, Vamana and Virechana followed by Dermo-care in the dose of 5 g twice a day for the period of 2 months. In Group C, only Dermo-care was administered. In Group D, Tab. Neotrexate (Methotrexate) 7.5 mg/week was given under the supervision of dermatologist. Marked improvement was observed in 10% of the patients in Group B. Moderate improvement was observed in 20% of the patients in Group A, 90% in Group B, and 80% in Group D. Mild improvement was observed in 80% of the patients in Group A, 100% in Group C, and 20% in Group D. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/224/105242 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of Shankhapushpi and a herbo-mineral compound in type-II diabetes Patel, DV Chandola, H Baghel, MS Joshi, JR Diabetic population is more than 245 million worldwide and expected to be >380 million by 2025. One of the main causes of increasing rate of diabetes is stress and tension in day-to-day life, disturbing the homeostasis of positive and negative emotions to initiate pathophysiology of stress-induced diabetes. In the present study, in Group A of 34 patients, a herbo-mineral compound containing Shuddha Shilajatu, Shuddha Guggulu, Vijayasara Ghana, Saptarangi Ghana, and Triphala Ghana was administered in the dose of 3 gm/day in three divided doses with luke-warm water before meal for the duration of 8 weeks, which significantly relieved symptoms (60.52%) like Prabhuta Mutrata (54.55%), Avila Mutrata (66.67%), Daurbalya (61.36%), Shrama (59.32%), etc. with fasting blood sugar (4.05%) and postprandial blood sugar (9.95%). In another series of 34 patients (Group B), where psychological health promoting drug Shankhapushpi was administered in the dose of 1.5 gm/day in three divided doses for 8 weeks along with herbo-mineral compound. The percentage relief was found to be more better on symptoms (71.13%) like Prabhuta Mutrata (76.92%), Avila Mutrata (83.33%), Daurbalya (75%), Shrama (70.37%), fasting blood sugar (18.04%) and postprandial blood sugar (27.75%). Group B showed better results on psychological parameters like disturbed Manasabhava (29.16%) and Brief Psychiatry Rating Scale (38.28%). The high significance of χ<sup>2</sup> (15.50) on overall effect of therapy indicated better results in group B. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/230/105243 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical effect of Virechana and Shamana Chikitsa in Tamaka Shwasa (Bronchial Asthma) Ghosh, KA Tripathi, PC To evaluate comparative efficacy of Samshodhana and Samshamana Chikitsa, the current study is planned in 24 patients of Tamaka Shwasa. Thirteen patients (Group A) were treated with Samshodhana, particularly with Virechana Karma. The patients of this group received Abhyantara Snehana with Tila Taila followed by Bahya Snehana with Tila Taila and Saindhava Lavana. After observations of proper signs of Snehana; Virechana Karma was performed with Aragvadha Phala Majja. Samsarjana Krama was followed for five days. Subsequently all the patients were given the trial drug (powder of Badara). The patients of group B, were treated only with the powder of dried ripe fruits of Badara. In both groups, the dose of Badara powder was 5 g, twice a day, with luke warm water, for a period of 60 days. In group A, maximum number of patients (61.45 %) showed good response, while in group B, 45.45 % patients showed good response. No side effects were observed during the clinical trial. Based on the observations, it was concluded that, group A is more effective than group B. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/238/105244 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Shatapushpa Taila Matra Basti and Pathadi Kwatha on Poly Cystic Ovarian Disease Patel, KD Dei, L Donga, SB Anand, N Poly Cystic Ovarian Disease (PCOD) is a complex disorder affecting 5-15% women in their reproductive age and related to ovarian dysfunction, characterized by menstrual irregularities, hyperandrogonism, obesity, and infertility. In Ayurveda, these symptoms are found under various conditions, caused by vitiated Vata and Kapha. Pathadi Kwatha and Shatapushpa Taila Matra Basti were studied in the current attempt to evaluate their comparative efficacy in cases of PCOD. Total 34 patients of PCOD were registered among which, 32 had completed the treatment of 2 months. They were randomly divided in to three groups. In group A Pathadi Kwatha (10 g, bid) and Shatapushpa Taila Matra Basti (60 ml for 7 days after cessation of menses for 2 consecutive cycles) were administered. In group B only Basti, whereas in group C capsules of roosted wheat flour were administered. Better results were obtained in group A especially in menstrual irregularities, achieving follicular growth and in weight reduction. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/243/105245 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of Shiva Guggulu and Simhanada Guggulu in Amavata (Rheumatoid Arthritis) Pandey, SA Joshi, NP Pandya, DM Amavata is the second most common joint disorders. Nowadays erroneous dietary habits, lifestyle and environment have led to various autoimmune disorders i.e. Amavisajanya Vikaara and Amavata is one among them. Rheumatoid arthritis can be correlated with Amavata in view of its clinical features. Many research studies have been done to solve this clinical enigma, but an effective, safe, less complicated treatment is still required for the management of Amavata. In the present study, 24 patients of Amavata were registered and randomly grouped into two. In group A, Shiva Guggulu 6 g/day in divided doses and in group B, Simhanada Guggulu 6 g/day in divided doses were given for 8 weeks. On analysis of the results, it was found that Simhanada Guggulu provided better results as compared to Shiva Guggulu in the management of Amavata. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/247/105246 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of two different samples of Shirishavaleha in Tamaka Shwasa (Bronchial Asthma) Yadav, SS Galib Patgiri, B Prajapati, PK Incidences of Bronchial Asthma have been raised in recent decades due to increased industrialization and pollution. This miserable condition can be compared with Tamaka Shwasa in Ayurveda. Modern synthetic drugs will provide instant relief in these cases, but are tend to develop a number of adverse drug reactions. Knowing this, the current suffering population is looking towards few remedies from other systems of medicines, that are comparatively safe and provide better relief. Shirisha [Albizzia lebbeck Benth] is a drug with multi-dimensional activities emphasized in Ayurveda for different disease conditions. Considering this, two types of Shirishavaleha (confection of Shirisha) were prepared by Kwatha (decoction) of Twak (bark) and Sara (heartwood) of Shirisha to evaluate its comparative efficacy in Tamaka Shwasa (bronchial asthma). The results were assessed in terms of clinical recovery, symptomatic relief and pulmonary function improvement. A significant increase in Hb and considerable decrease in total eosinophil count, AEC and ESR were observed. The study revealed that Shirishavaleha can be used as an effective drug in bronchial asthma. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/255/105247 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of Jalaukawacharana (leech application) in Thrombosed piles Bhagat, PJ Raut, SY Lakhapati, AM 'Arsha' (hemorrhoids) is an ailment that affects all economical groups of population. Though the disease is within the limits of management, it has its own complications like severe hemorrhage, inflammation, and thrombosis, by which a patient gets severe pain and is unable to continue his routine work. Prior to surgical treatment of hemorrhoids, associated conditions like inflammation, strangulation, thrombosis, etc. need to be managed. Thrombosed piles possibly occur due to high venous pressure associated with severe anal pain. Leech (Hirudina medicanalis) application is found to be effective in reducing pain. In thrombosed piles, leech application has shown thrombolytic action, which contributes in re-establishment of circulation. It is observed in the study that, pus and mucous discharge have been reduced after leech application; which may be due to antimicrobial and mucolytic properties of leech. This method of treatment is found to be effective and increase the quality of life in patients suffering with thrombosed piles. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/261/105248 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Critical study of Jara (aging) and its management Parmar, N Vyas, M Vyas, H Jara Avastha (stage of old age) is the later phase of life in which maximum decline of bodily elements is observed. Paramanuvibhaga (cell division) takes place at every moment; particularly in old age, it will be fast in comparison with other phases of life. Some organ related changes also take place during this period, which are the decades of Balya, Vridhhi, Chhavi, Medha, Twak, etc., In this study, applied aspects of Medha Hani, Twak Hani, and Drishti Hani were evaluated subjectively as well as objectively. Patients were selected from the OPD of Department of Basic Principles, I.P.G.T. and R.A., Gujarat Ayurved University, Jamnagar, irrespective of their sex, caste, religion, etc., and randomly divided into two groups. Patients in Group A were treated with Panchagavya Ghrita and Group B with plain Go Ghrita for 90 days and the dose of drug was 10 g/day at Nirannakala (early morning with empty stomach). Both groups showed significant results, the difference in between the groups is statistically insignificant. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/264/105249 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Urushiol-induced contact dermatitis caused during Shodhana (purificatory measures) of Bhallataka (Semecarpus anacardium Linn.) fruit llanchezhian, R Joseph, CR Rabinarayan, A Bhallataka (Semecarpus anacardium Linn.; Ancardiaceae) is mentioned under Upavisha group in Ayurvedic classics and it is described as a poisonous medicinal plant in Drugs and Cosmetics Act (India), 1940. Fruit of Bhallataka is used either as a single drug or as an ingredient in many compound formulations of Indian systems of medicine to cure many diseases. Tarry oil present in the pericarp of the fruit causes blisters on contact. The major constituent of the tarry oil is anacardic acid and bhilawanol, a mixture of 3-n-pentadec(en)yl catechols. Bhilawanol A and B are known as Urushiols, and also, anacardic acid is closely related to Urushiol. Urushiol-induced contact dermatitis is the medical name given to allergic rashes produced by the oil Urushiol. This paper deals with five case reports of contact dermatitis caused during different stages of Shodhana (purificatory measures) of Bhallataka fruit due to improper handling of the utensils and disposal of media used in Shodhana procedure and their Ayurvedic management. To combat these clinical conditions, the affected persons were advised external application with pounded Nimba (Azadirachta indica A. Juss.) leaves on the affected parts and internal administration of Sarivadyasava 30 ml thrice daily after food and Triphala Churna 5 g before food twice daily. Reduction of itching and burning sensation was observed after topical application. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/270/105250 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Pharmacognostical and analytical study of Tulsi-Amla-Yasti Ghrita Datta, D Chandola, H Agarwal, SK Shukla, VJ Pandya, PN Tulasi Amla Yashti Ghrita is an Ayurvedic formulation, which is beneficial in the management of the side effects of Head and Neck Malignancies induced by Radiotherapy and Chemotherapy. A pharmacognostical study involving both the macroscopic and powder microscopy of raw drugs of Tulasi Amla Yashti Ghrita and a physicochemical analysis of the finished product were carried out, to evaluate the quality of the formulation. The specific gravity of the formulation was 0.9130 and pH was 3.5. Thin layer chromatography (TLC) and high performance thin layer chromatography (HPTLC) were carried out after organizing the appropriate solvent system, in which five spots were distinguished in TLC and nine spots in HPTLC. Most of the R <sub>f</sub> values for the spots observed were identical. The observations could be considered to be the reference standards in future studies. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/274/105251 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Development of Random Amplified Polymorphic DNA markers for authentification of Cissus repanda vahl. Harisha, CR Acharya, R Chauhan, MG Cissus repanda Vahl. belongs to the family Vitaceae, commonly known in Hindi as "Panivel," is a large climber distributed all over India. The crushed or powder of root is prescribed by tribal people and traditional medical practitioners of Orissa for its healing properties in cases of bone fracture, cuts and wounds, swellings, and so on. In spite of its reputation, its leaves have not been investigated scientifically. The present study deals with pharmacognostical and molecular characterization by Random Amplified Polymorphic DNA (RAPD) markers and their role in laying down standardization and pharmacopoeial parameters. Genomic isolation of DNA from fresh leaves was amplified by RAPD markers. The diagnostic characters are mucilage, calcium oxalate rosette crystals, spiral vessels, and fibers. The unique bands obtained in Polymerase Chain Reaction (PCR) amplification clearly discriminated having, many bright and light bands indicating the genuinity of the plant. RAPD may serve as a complementary tool in quality control of many herbal sources. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/279/105252 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Pharmacognostical and phytochemical studies of Curcuma neilgherrensis (Wight) leaf - A folklore medicine Prasad, MS Ramachandran, AP Chandola, H Harisha, CR Shukla, VJ Curcuma neilgherrensis Wight is a folk medicinal plant used in the management of diabetes mellitus. The leaves of this herb are said to be successful in managing high blood glucose levels. This study is aimed at assessing the scientific appraisal of C. neilgherrensis in the course of pharmacognostical characters and phytochemical parameters, as these are not yet been done. Pharmacognostic study mainly covered the macroscopic and microscopic features of the leaves including powder microscopy, and revealed the presence of trichomes, spiral vessels etc. Phytochemical parameters such as pH, total ash value, water-soluble extract and MeOH extract values were assessed in the preliminary physicochemical screening. Qualitative analysis revealed the existence of certain chemical constituents such as flavonoids, tannins, organic acids and saponin glycosides. The crude extract of leaves was subjected to TLC and HPTLC for the separation of components. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/284/105253 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Analytical profile of Brahmi Ghrita: A polyherbal Ayurvedic formulation Gubbannavar, JS Chandola, H Harisha, CR Kalyani, R Shukla, VJ Brahmi Ghrita, a polyherbal Ayurvedic formulation is recommended in the management of various psychological disorders like Unmada, Apasmara and Graharogas. The present study deals with the pharmacognostical identification of ingredients of Brahmi Ghrita and its physico-chemical analysis. Pharmacognostical study containing both macroscopic and powder microscopy of raw drug revealed the quality and genuineness of all the constituents of Brahmi Ghrita. Organoleptic features of coarse powder made out of the crude drugs were within the standards prescribed. Acid value was 0.16075, saponification value 184.17, Refractive Index value 1.467 at room temperature, Iodine value 26.715, Specific gravity at room temperature was 0.9133. HPTLC was carried out after organizing appropriate solvent system in which maximum 9 spots were distinguished and most of the R <sub>f</sub> values were identical in alcoholic extract which shows the presence of certain definite constituents in Brahmi Ghrita. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/289/105254 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Pharmaceutical standardization of Mamajjaka (Enicostemma littorale Auct. non Bl) Ghana Tanna, SP Patgiri, B Shukla, VJ Prajapati, PK Mamajjaka (Enicostemma littorale Auct. non Bl) is a well known folklore medicine frequently used for the treatment of Madhumeha (diabetes mellitus). There is no direct reference available for its antihyperglycaemic activity in Ayurvedic classics. Considering this, a study is planned towards developing pharmaceutical standardization of Mamajjaka Ghana. In this study, five batches of Mamajjaka Ghana were prepared and findings were systematically recorded to maintain the Standard Operating Procedure (SOP). An average of 14.78% Ghana was obtained. The physico-chemical parameters, qualitative test for various functional groups, quantitative estimation of total alkaloids, HPTLC profile, heavy metal analysis and microbial overload were carried out of Mamajjaka Ghana. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/294/105255 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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In vitro antimicrobial and brine shrimp lethality of Allophylus cobbe L. Islam, MT Noor, MA Karon, B Plants are rich source of pharmacologically active agents, which could be explored in disease management. Methanol, ethanol, and petroleum ether extracts of the whole plant of Allophylus cobbe L. were evaluated for antimicrobial and cytotoxic activities. In vitro antimicrobial sensitivity by disk diffusion method was conducted against four Gram-positive and seven Gram-negative pathogenic bacteria and seven fungi. In the antibacterial and antifungal sensitivity tests, growth inhibition was found to be within the range of 10.0-17.67 mm. Strong zone of inhibition by the ethanol extract of A. cobbe (EEAC) was found against Trichophyton spp. With some exceptions, a mild to strong antimicrobial activity was observed in this study. Significant minimum inhibitory concentration (MIC; 15.625 μg/ml) was found against Trichophyton spp. Other detected MICs were within the range of 31.25-125 μg/ml. The petroleum ether extract of the plant exhibited strong cytotoxicity in the brine shrimp lethality bioassay test. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/299/105256 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Toxicological evaluation of Panchakola Avaleha, an Ayurvedic classical formulation, in albino rats Singh, RK Banerjee, R Upadhyay, S Mitra, A Hazra, J The present study was carried out to assess the safety of standardized Panchakola Avaleha on albino rats (Wistar strain). Animals were administered three doses of Panchakola Avaleha by oral routes, viz. higher (500 mg/kg/day), middle (250 mg/kg/day), and therapeutic dose (50 mg/ kg/ day) for 28 consecutive days. Effects of the test drug on hematological, biochemical, and histopathologic parameters were evaluated. This study revealed normal behavior, no mortality, and no significant changes in hematological, biochemical, and histopathological examinations. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/303/105257 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Anti-inflammatory activity of two varieties of Pippali (Piper longum Linn.) Kumari, M Ashok, BK Ravishankar, B Pandya, TN Acharya, R The present study has beenundertaken to evaluate the anti-inflammatory activity of two varieties of Pippali in acute and sub-acute experimental models of inflammation in albino rats. Four different market samples of each variety of Pippali were procured from different regions of India. The samples collected from South India which have given more extractive values were selected for screening of anti-inflammatory activity. Randomly selected animals were divided into four groups of six animals each. The test drugs were administered orally at a dose of 200 mg/kg and the activity was compared with standard anti-inflammatory drugs in both models. Among the two different test samples studied, it was found that Chhoti variety of Pippali suppressed inflammation of both acute and sub acute phase, while Badi variety of Pippali only of acute phase. Thus for the therapeutic utility, Chhoti variety of Pippali may be considered over the Badi variety. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/307/105258 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of fennel on pain intensity in dysmenorrhoea: A placebo-controlled trial Omidvar, S Esmailzadeh, S Baradaran, M Basirat, Z The aim of this study was to determine the clinical effect of Foeniculum vulgare on primary dysmenorrhoea. Sixty virgin girls with complaints of dysmenorrhoea were enrolled in this study, out of which 50 cases were completed the course of treatment and were divided in two groups (study and placebo) and were under treatment for two cycles. In study group a capsule of 30 mg fennel extract, four times a day for three days from start of their menstrual period and in placebo a capsule containing wheat flour in same dose was administered. Intensity of pain was reported by using a 10 - point linear analogue technique. In study group the mean age of menarche was 13.1 ± 0.1 and onset age of dysmenorrhoea was 14.5 ± 0.1 years. Both groups were relieved but there was significant difference between study and placebo group. Study group shown more effective results than placebo in pain relief (P<0.05). Based on the observations, it can be concluded that, fennel is an effective herbal drug for menstrual pain. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/311/105259 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Anti-ulcer activity of Lucer against experimentally induced gastric ulcers in rats Shah, JS Patel, JR The present study is designed to explore the mechanism of action of herbal formulation Lucer against experimentally induced gastric ulcers. The aqueous extract (120 and 180 mg/kg) of Lucer was tested against aspirin and ethanol-induced gastric ulcer model in rats. The drug has been found to be very effective in inhibiting gastric ulceration. This is evident from reduction in ulcer index parameters. Besides, significant reduction in acid secretory parameters such as total acidity, total acid output and volume of gastric secretion were also observed. It is concluded from this study that the drug possesses anti-ulcer activity in both the models. The anti-ulcer activity of the drug can be attributed to inhibition of acid secretary parameters and strengthening of gastric mucosal barrier. Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/314/105260 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:105261 2012-04-01 all journal:Ayu
Water purification Wiwanitkit, S Wiwanitkit, V Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/317/105261 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Aerobic isotonic exercise and Prameha (diabetes mellitus) as per Prakriti Joob, B Wiwanitkit, V Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/317/105262 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effect of Majja Basti (therapeutic enema) and Asthi Shrinkhala (Cissus quadrangularis) in the management of Osteoporosis (Asthi-Majjakshaya) Potu, BK Rao, MS Sirasanagandla, SR Medknow Publications 2012-04-01 http://www.ayujournal.org/text.asp?2012/33/2/317/105263 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Lifestyle disorders: Ayurveda with lots of potential for prevention Chandola, HM Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/327/108814 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Bhattar Harichandra: The first commentator of Charaka Samhita Gaur, BL Bhattar Harichandra was the first commentator who wrote 'Charakanyasa' commentary on Charaka Samhita after completion of redaction process by Dridhabala. Two manuscripts of this commentary are available with number 9290 and 13092 in Asiatic Society of Kolkata and Government East Library, Chennai respectively. Yadavji opines that Bhattar Harichandra belongs to the period of Chandragupta - II (375 A.D. - 413 A.D.) while Acharya Priyavrat Sharma considers the period of Yashodharaman (6 A.D.) as the period of Bhattar Harichandra. As far as external evidence is considered Banabhatta another notable Sanskrit poet quoted Bhattar Harichandra in his work Harshacharitam. Banabhatta was contemporary to Chandragupta. Charaka Samhita enjoyed much reputation during Chandragupta Mourya - II period. Agnivesha Tantra was redacted during the period of Kanishka (2 A.D.) and then onwards it was referred by titles like Sahasanka and Vikramaditya. Among Navaratna (Nine gems), Shanku and Vaitala Bhatta are included. But in the authors opinion it should be commented as "Shankuvaitala" and "Bhatta". The name Bhatta in his context may be referring to Bhattar Harichandra. Based on the external evidences it may be concluded that Bhattar Harichandra was contemporary to Chandragupta period i.e. 375 A.D. - 413 A.D. (4th to 5th century). Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/328/108815 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Viruddha Ahara : A critical view Sabnis, M Viruddha Ahara is a unique concept described in Ayurveda. The present article deals with the critical review of Viruddha Ahara referred in terms of food-food interactions, food processing interactions. Ayurveda clearly defines that certain diet and its combinations, which interrupts the metabolism of tissue, which inhibits the process of formation of tissue and which have the opposite property to the tissue are called as Viruddha Anna or incompatible diet. The food which is wrong in combination, which has undergone wrong processing, which is consumed in incorrect dose, which is consumed in incorrect time of day and in wrong season can lead to Viruddha Ahara. The article narrates the modern perspective of Samskar Viruddha, Veerya Viruddha, Samyoga Viruddha, and so on. It also enlists a variety of incompatible dietary articles consumed in today's day-to-day life and its hazardous effects on health. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/332/108817 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Critical appraisal of Doshavaha Srotas Byadgi, PS Tridoshas viz Vata, Pitta, and Kapha are responsible for health and disease depending on their normalcy and disequilibrium state. Improper usage of foods and drinks along with abnormal activities manifests diseases of respective Doshik predominance. Sira (vein) is the synonym of Srotas, keeping this in mind, Vatavaha Sira is correlated with Vatavaha Srotas, Pittavaha Sira with Pittavaha Srotas, Kaphavaha Sira with Kaphavaha Srotas, and Sarvavaha Sira with Sarvavaha Srotas. The purpose of detail understanding of Doshavaha Srotas is essential to understand the role of Doshas in the manifestation of diseases. One can easily predict by observing the color changes in particular area to be able to predict the predominance of Doshas in that area. Manifestation of a disease occurs in the body as a result of the defective Srotas favoring the Dosha-Dushya conglomeration. Hence, any defect in the Srotas must be corrected quickly for the restoration of normal health. Present article emphasis on the proper understanding of Doshavaha Srotas in a systematic manner to understand its root, causative factors, signs and symptoms, and diseases produced due to their vitiation. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/337/108819 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A critical review on two types of Laghupanchamula Ghildiyal, S Joshi, VK A group of five roots of small plants i.e., Shalaparni, Prshniparni, Brhati, Kantakari and Gokshura or Eranda is known as Laghupanchamula under Mishraka Varga (group of drugs). It is used as such or with Mahat Panchamula i.e., Bilva, Gambhari, Shyonaka, Agnimantha and Patala, constituting Dashamula, a well recognized and popular Ayurvedic preparation or as an ingredient of different dosage forms. Classical texts of Ayurveda differs regarding components of this Mishraka Varga. Four out of five drugs of Laghupanchamula are similar in all the Ayurvedic texts, but either Gokshura or Eranda is considered as the fifth drug. So a comphrenesive review of Veda, Samhita Grantha, Cikitsa Grantha and Nighantus, with regards to synonyms, contents, Guna- Karma, origin of variation in contents and possible thought behind two kinds of Laghupanchamula, to throw light for rational use of either Eranda or Gokshura under Laghupanchamula was conducted. It was observed that both the traditions were in practice however Acharya Kashyapa and Ravigupta were in view of Eranda as a fifth drug of Laghupanchamula where as Acharya Charaka, Sushruta, Vagabhatta, Yogaratnakara and Chakradatta are in favour of Gokshura. Infact, the variation in content depends on the need i.e Dosha, Dushya and Vyadhi. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/343/108820 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Physiological and biochemical changes with Vamana procedure Gupta, B Mahapatra, SC Makhija, R Kumar, A Jirankalgikar, NM Padhi, MM Devalla, RB Vamana Karma (therapeutic emesis) primarily a Samshodhana Karma (purification procedure) is one of the five Pradhana Karmas (chief procedures) of Panchakarma. It is mentioned in Ayurvedic texts that a person after Samyak Vamana (proper Vamana) experiences lightness of the body, Hrit (precordium), Kantha (throat/voice), and Shirah (head) and weakness. This procedure is effectively used in healthy and ailing persons for purification of body and extraction of Doshas (especially Kapha) in Ayurvedic system. It has been found worth to observe the physiological and biochemical changes during Vamana and after the procedure to understand the effect/safety margins of the procedure in healthy volunteers. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/348/108821 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical study of Tribulus terrestris Linn. in Oligozoospermia: A double blind study Sellandi, TM Thakar, AB Baghel, MS Infertility is a problem of global proportions, affecting on an average 8-12% of couples worldwide. Low sperm count (Oligozoospermia) is one of the main causes of male infertility and it is correlated with Kshina Shukra. The fruits of Gokshura (Tribulus terrestris. Linn) are considered to act as a diuretic and aphrodisiac; they used for urolithiasis, sexual dysfunctions, and infertility. Hence, it was planned to study the effect of Gokshura in the management of Kshina Shukra (Oligozoospermia), and to evade the preconception, a double-blind, randomized, placebo-controlled study was designed. In this study, eligible subjects between the age of 21 and 50 years, with a complaint of Kshina Shukra (Oligozoospermia), were randomized to receive either Gokshura granules or placebo granules for 60 days. The primary outcome measures were percentage changes in the Pratyatmaka Lakshanas (cardinal symptoms) of Kshina Shukra, Agni bala, Deha bala, Satva bala, the semenogram, and in the Quality of the Sexual Health Questionnaire. The placebo granules showed 70.95% improvement, whereas, the Gokshura granules showed 78.11% improvement in Rogi bala (Agni bala, Deha bala, Satva Bala, and the Quality of Sexual Health) and Rogabala (Semen Analysis and Pratyatmaka Lakshanas). The Gokshura granules have shown superior results in the management of Kshina Shukra, as compared to the placebo granules. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/356/108822 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Swarna Bhasma in cancer: A prospective clinical study Das, S Das, MC Paul, R Despite the advances in the treatment of cancer, mortality is still high. Complementary and alternative medicine is emerging as a potent modality in cancer treatment. 'Swarna Bhasma' (SB), containing gold particles, is an ancient Indian medicine has shown its anticancer activity. This present study was conducted to detect the effect of SB on solid malignancies. A total of 43 patients were included in this study received SB for 1 year. Seventeen patients showed response. The response was best in rectal cancer group 70% (7/10). Nearly 41.02% patients survived for 1 year after treatment but after 5 years this came down to 15.38%. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/365/108823 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:108825 2012-07-01 all journal:Ayu
Evaluation of Saptarangyadi Ghanavati in the management of Apathyanimittaja Prameha w.s.r. to type-2 diabetes mellitus Singh, KS Chandola, H Kaur, M Ravishankar, B Type-2 diabetes mellitus is a persistent health problem that requires innovative strategies to improve health and needs a multifactorial approach for the treatment. Saptarangyadi Ghanavati, a new formulated Ayurvedic compound consists of herbs with anti-diabetic potential, in addition to a folklore herb Saptarangi (Salacia chinensis) has been evaluated. In a total of 67 patients, 36 patients were of newly detected type-2 diabetes mellitus and 31 patients were of chronic type-2 diabetes mellitus and they were divided into group A and group B, respectively. Group A consisted newly detected subjects of type-2 diabetes and were not taking any regular medication and group B consisted of chronic cases of type-2 diabetes mellitus, who were taking modern ant-diabetic medication, but their blood-glucose level was not controlled to desired level. Patients in group A were administered Saptarangyadi Ghanavati each of 200 mg, 5 Vatis, 3-times a day-after breakfast, lunch, and dinner. Patients in group B were administered Saptarangyadi Ghanavati, in the same dose in addition to the concomitant anti-diabetic (Allopathic) medication. Serum insulin investigation, both fasting and post-prandial levels were evaluated in six patients of group B, showed a highly significant increase in first-phase insulin response. Glycosylated hemoglobin (serum HbA1c) evaluated in six patients of group A showed statistically significant reduction. There was also statistically significant reduction in the fasting blood sugar (FBS) and post prandial blood sugar (PPBS) parameters, both in newly detected cases as well as chronic cases of type-2 diabetes mellitus. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/368/108825 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Wound healing activity of honey: A pilot study Kumari, KV Nishteswar, K Vrana (wound) and its sequels play a major concern in the field of surgery as Vrana Ropana (wound healing) requires uneventful healing. The aim of the study was to evaluate the changes in physical and morphological properties due to topical application of Madhu (honey) on fresh traumatic wounds or cutaneous wounds. Ten patients of wounds of either sex were randomly selected. Site of the wound, shape, size, floor, and margin were recorded on day 0 and observed on day 7, 15, 20, and till the end of the healing for the progression of granulation, scar type, shape, size, and clinical symptoms. There was significant improvement in the healing process as Madhu possesses antibacterial, wound cleansing, wound healing properties and showed beneficiary effects. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/374/108827 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Observational study on external social and lifestyle related factors and their role in pathogenesis of premature ageing and stress Deole, YS Thakar, AB Chandola, H Ravishankar, B In the present era of stress, when lifestyle disorders are high on rise, premature ageing is also one of the most prevalent disorders. It is needed to study the external environmental psychological causative factors in premature ageing and stress. An observational study was carried out to evaluate the relationship of lifestyle, occupational and social factors and mental makeup in individuals diagnosed with premature ageing. A total of 108 patients of premature ageing and stress fulfilling the criteria of inclusion as per ageing scale were selected from outpatient Department of Panchakarma and Manasa Roga, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar. The diagnosed patients of premature ageing were subjected to specialized proforma enlisting all the factors as well as ageing scale, Manasa Bhava Pariksha, and Manasa Vibhrama Pariksha. The method of survey was by a questionnaire about the points regarding the lifestyle causative factors. Maximum patients had shown signs of premature ageing with Mana-Buddhi-Smriti-Bhakti Vibhrama (100% each) and involvement of negative Manasa Bhava. The 78.70% patients in this study felt of having excess responsibility on them in family. The 52.77% patients had average good relationship with their family members, while remaining 47.22% narrated history of disturbed relationship. The center of stress was found to be at personal level in all patients; at family level in 73.14%; at professional or work level in 64.81%. Various external, occupational, social and familial factors play significant role in the pathology of premature ageing by disturbing the overall psychological status. This proves the link of Manasa affecting Sharira and vice versa with reference to modern contemporary concept of psycho-neuro endocrinology. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/378/108828 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Mootrala Karma of Kusha [Imperata cylindrica Beauv.] and Darbha [Desmostachya bipinnata Stapf.] - A comparative study Shah, NT Pandya, TN Sharma, PP Patel, BR Acharya, R Kusha (Imperata cylindrica Beauv.) and Darbha (Desmostachya bipinnata Stapf.) are enlisted among Trinapanchamoola, which is a well-known diuretic and are individually enumerated in the Mootravirechaneeya Dashemani. The article deals with the evaluation and comparison of the individual Mootrala (diuretic) action of the two drugs in healthy volunteers. In this study, 29 healthy volunteers were divided into three groups administered with Darbha Moola Churna, Kusha Moola Churna, and placebo in each group for 14 days. The volunteers were subjected to evaluation of diuretic activity by maintaining the daily total input-output charts during the course of the study. The volunteers were advised to consume a minimum 2 l of water daily. Results show that Darbha and Kusha leaded to a percentage increase in urine volume as compared to placebo group, but the result was statistically insignificant. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/387/108829 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of Ayurvedic management in computer vision syndrome: A pilot study Dhiman, KS Ahuja, DK Sharma, SK Improper use of sense organs, violating the moral code of conduct, and the effect of the time are the three basic causative factors behind all the health problems. Computer, the knowledge bank of modern life, has emerged as a profession causing vision-related discomfort, ocular fatigue, and systemic effects. Computer Vision Syndrome (CVS) is the new nomenclature to the visual, ocular, and systemic symptoms arising due to the long time and improper working on the computer and is emerging as a pandemic in the 21 <sup>st</sup> century. On critical analysis of the symptoms of CVS on Tridoshika theory of Ayurveda, as per the road map given by Acharya Charaka, it seems to be a Vata-Pittaja ocular cum systemic disease which needs systemic as well as topical treatment approach. Shatavaryaadi Churna (orally), Go-Ghrita Netra Tarpana (topically), and counseling regarding proper working conditions on computer were tried in 30 patients of CVS. In group I, where oral and local treatment was given, significant improvement in all the symptoms of CVS was observed, whereas in groups II and III, local treatment and counseling regarding proper working conditions, respectively, were given and showed insignificant results. The study verified the hypothesis that CVS in Ayurvedic perspective is a Vata-Pittaja disease affecting mainly eyes and body as a whole and needs a systemic intervention rather than topical ocular medication only. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/391/108831 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A study on the method of Taila Bindu Pariksha (oil drop test) Kar, AC Sharma, R Panda, BK Singh, VP Taila Bindu Pariksha, an ancient method of urine examination for ascertaining the prognosis of diseases, was very popular in the medieval period, the use of which became obsolete after 17 <sup>th</sup> Century AD. Technique of this test is very crude and there are chances of variations in the observations. To revive this technique, it is necessary that the methodology of this test should be standardized so that the observations could be reproducible. To standardize the technique, apparently healthy volunteers were selected and various parameters were standardized for doing this test, i.e., shape and size of Patra (testing containers), volume of the urine, size of the oil drop, height of the oil drop from the surface of urine, variety of sesame oil, etc., Based on the literature, the parameters were changed one by one and observations were noted down. The whole method was recorded in the form of video clips for proper evaluation. The parameters standardized on the basis of observations can be considered as standard to be referred in future studies. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/396/108851 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Importance of Rookshana Karma (dehydrating therapy) in the management of transverse myelitis Jindal, N Shamkuwar, MK Berry, S In Charak Samhita, all the treatment modalities have been classified broadly into six types, i.e., Langhana (depleting therapy), Brimhana (nourishing therapy), Rookshana (dehydrating therapy), Snehana (oleation therapy), Swedana (sudation therapy) and Stambhana (astringent therapy). Out of these six types, Rookshana is of the same importance as others but is used less frequently as main line of treatment. Since decades, Ayurveda treatment is considered most promising treatment for neurological disorders. Most of the neurological disorders are generally considered to be Vata Vyadhis in which Snehana Karma is recommended. In case of neurological disorders if symptoms are suggestive of Kapha dominance, then Rookshana must be done initially. Transverse myelitis is a neurological disease, which has an autoimmune process involved in its pathology. It is an acute, subacute, generally monophasic inflammatory disease of the spinal cord. In the present case of transverse myelitis, the patient was found having Kapha dominant symptoms such as coldness of feet, loss of appetite etc., and so the patient was subjected to Rookshana Karma in various forms. Just after 15 days, all these symptoms were subsided and tremendous improvement was found thereafter. The paraplegic patient under study was able to walk independently in just two and half months of treatment. All other typical features related to the disease were also improved. This particular case has proved the importance of Rookshana therapy in neurological disorders. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/402/108852 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Characterization of Tarakeshwara Rasa: An Ayurvedic herbomineral formulation Kumar, N Tarakeshwara Rasa (TR) is an Ayurvedic herbomineral compound formulation used in the intervention of Prameha vis-à-vis diabetes mellitus. The present study was executed to establish a fingerprint for this unique formulation, which can be adopted by the Ayurvedic pharmacies for drug standardization. TR is a formulation prepared by the trituration of four ingredients Abhraka Bhasma (AB), Loha Bhasma (LB), Vanga Bhasma (VB) and Rasa Sindhura (RS) in equal quantities with honey for one day. Each of the ingredients were prepared according to the norms of Ayurvedic classical texts and by employing Electric Muffle Furnace as heating device for incineration. To ensure the proper preparation of Bhasmas, standard tests (Bhasma Pariksha) were employed. After Bhasma complies these tests, TR was prepared and subjected for qualitative analysis, X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM) studies. LB, AB, VB, RS and TR were also studied for free metal presence by employing phosphomolybdic acid. Chemical analysis of TR reveals that it contains Fe, Sn, Hg, Al, Mn, Ca and Mg. XRD study indicates that TR contains Fe <sub>2</sub> O <sub>3</sub> (maghamite) in major phase and SnO <sub>2</sub> (cassiterite), HgS, SiO <sub>2</sub> , HgO in minor phases. SEM study revealed that the compound is an agglomeration of particles. The particle size was in between 0.5 and 2 μ. Free metal detection by phosphomolybdic acid revealed the absence of free metals in the final Bhasmas. This is the first study establishing the characterization of Tarakeshwara Rasa. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/406/108854 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:108856 2012-07-01 all journal:Ayu
Pharmaceutical study of Triguna and Shadguna Balijarita Makaradhwaja Dhundi, SN Patgiri, B Prajapati, PK Shukla, VJ Ravishankar, B Makaradhwaja is a herbo-minaral drug prepared by Kupipakwa method. In the present study Makaradhwaja was prepared by Triguna and Shadguna Balijarana using Ashtasamskarita Parada. Total five batches of Triguna Makaradhwaja (TM) were prepared by taking 330 g of Kajjali in each batch, average product obtained was 29.12 g. In the preparation of Shadguna Makaradhwaja (SM) too, five batches were prepared, taking 250 g of Kajjali, average product obtained was 16.8 g. The average time taken for flame in TM was 3.01 h and that in SM was 4.58 h. Kupipaka was carried out for 18 and 36 h in TM and SM, respectively. Inductive Coupled Plasma - Optical Emission Spectrometry (ICPOES) revealed the presence of 7.2976 ppm gold in TM, whereas 663.14 ppm in SM. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/412/108856 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:108858 2012-07-01 all journal:Ayu
Evaluation of subchronic genotoxic potential of Swarna Makshika Bhasma Savalgi, PB Patgiri, B Thakkar, JH Ravishankar, B Gupta, VB Extremely diminutive published information is available on the mutagenic activity of Ayurvedic Bhasmas. Genotoxicity of few Bhasmas were reported on single maximum dose, but no reference is available on the sub-chronic level. Hence the present study was carried to generate and evaluate genotoxic potentials of Swarna Makshika Bhasma (mineral preparation) administered at therapeutic dose for 14 days. Chromosomal aberrations and abnormal sperm assay parameters were taken in this study. Cyclophosphamide (CP) was taken as positive group and results were compared. The results revealed a lack of generation of structural deformity in above parameters by tested drugs compared to CP treated group. Observed data indicate that the Bhasmas tested were non-genotoxic under the experimental conditions. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/418/108858 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Evaluation of three medicinal plants for anti-microbial activity Sujatha, B Sreedevi, E Herbal remedies have a long history of use for gum and tooth problems such as dental caries. The present microbiological study was carried out to evaluate the antimicrobial efficacy of three medicinal plants (Terminalia chebula Retz., Clitoria ternatea Linn., and Wedelia chinensis (Osbeck.) Merr.) on three pathogenic microorganisms in the oral cavity (Streptococcus mutans, Lactobacillus casei, and Staphylococcus aureus). Aqueous extract concentrations (5%, 10%, 25%, and 50%) were prepared from the fruits of Terminalia chebula, flowers of Clitoria ternatea, and leaves of Wedelia chinensis. The antimicrobial efficacy of the aqueous extract concentrations of each plant was tested using agar well diffusion method and the size of the inhibition zone was measured in millimeters. The results obtained showed that the diameter of zone of inhibition increased with increase in concentration of extract and the antimicrobial efficacy of the aqueous extracts of the three plants was observed in the increasing order - Wedelia chinensis0 < Clitoria ternatea < Terminalia chebula. It can be concluded that the tested extracts of all the three plants were effective against dental caries causing bacteria. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/423/108859 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Evaluation of anti-urolithiatic activity of Pashanabhedadi Ghrita against experimentally induced renal calculi in rats Gupta, SK Baghel, MS Bhuyan, C Ravishankar, B Ashok, BK Patil, PD Population in an industrialized world is afflicted by urinary stone disease. Kidney stones are common in all kinds of urolithiasis. One distinguished formulation mentioned by Sushruta for management of Ashmari (urolithiasis) is Pashanabhedadi Ghrita (PBG), which is in clinical practice since centuries. Validation of drug is the requirement of time through the experimental study. In this study, trial of PBG has been made against ammonium oxalate rich diet and gentamicin injection induced renal calculi in albino rats. The calculi were induced by gentamicin injection and ammonium oxalate rich diet. Test drug was administered concomitantly in the dose of 900 mg/kg for 15 consecutive days. Rats were sacrificed on the 16 <sup>th</sup> day. Parameters like kidney weight, serum biochemical, kidney tissue and histopathology of kidney were studied. Concomitant treatment of PBG attenuates blood biochemical parameters non-significantly, where as it significantly attenuated lipid peroxidation and enhanced glutathione and glutathione peroxidase activities. It also decreased crystal deposition markedly into the renal tubules in number as well as size and prevented damage to the renal tubules. The findings showed that PBG is having significant anti-urolithiatic activities against ammonium oxalate rich diet plus gentamicine injection induced urolithiasis in rats. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/429/108860 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative study on chronic administration of Go Ghrita (cow ghee) and Avika Ghrita (ewe ghee) in albino rats Shukla, DJ Vyas, HA Vyas, MK Ashok, BK Ravishankar, B Ghrita (ghee) is the foremost substance of Indian cuisine from centuries. Ayurvedic classics described eight kinds of ghee from eight different animal milk, among them ghee made from cow milk is said to be the superior and ghee of ewe milk is said to be the inferior and also detrimental to heart. The present study was undertaken to evaluate chronic administration of cow ghee (Go Ghrita) and ghee of ewe milk (Avika Ghrita) to experimental animals. Experiment was carried out on Wistar strain albino rats and study was done at two dose levels. The test drugs were administered orally for 45 consecutive days. Parameters, such as gross behavior, body weight, weight of important organs, total fecal fat content, electrocardiogram, serum biochemical parameters, and histopathology of different organs were studied. Both the test drugs did not alter the gross behavior, body weight, weight of organs, and cytoarchitecture of different organs to significant extent. Avika Ghrita at a low dose significantly decreased triglyceride content, significantly prolonged QTc and at both dose levels it significantly shortened the PR interval. This study shows chronic administration of Avika Ghrita and Go Ghrita has no marked differences between them except the QTc prolongation in Avika Ghrita. This may be the basis for the classics to categorize Avika Ghrita as Ahridya. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/435/108862 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Comparative powder microscopy of Alpinia calcarata Roscoe and Alpinia galanga (Linn.) Willd Wijayasiriwardena, C Premakumara, S Medicinal plant materials are being adulterated in commerce due to many reasons such as similar morphological features, same name as written in classical text, presence of similar active principles in the substituted plant etc., that may badly affect the therapeutic activity of the finished products. Therefore, systematic identification is becoming essential in order to produce standardized finished herbal products. The present study includes two medicinal plant rhizomes; Alpinia calcarata Roscoe (Heenaratta) and A. galanga (Linn.) Willd (Aratta) whose microscopical build up was different from each other and was assessed by standard Pharmacognostical methods. Diagnostic identification characters of A. calcarata were compound starch grins, triangular-shaped starch grains, and plenty of simple starch grains in one parenchyma cell compared to that of A. galanga. Diamond-shaped silica crystals were found only on A. galanga rhizome powder. Present study has revealed an easy technique to identify two similar medicinal plant materials microscopically and this method can also be employed to detect the degree of adulteration in powdered raw medicinal plant materials as well. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/441/108863 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:108864 2012-07-01 all journal:Ayu
A comparative analytical study of Prasarani [Merremia tridentata Hallier. f. and Paederia foetida Linn.] Rajashekhara, N Vasanth, P Kumar, DV Prasarani is one of the drugs used in Vata Rogas such as Amavata, Avabahuka, etc. Among the different source plants of Prasarani, the plant Merremia tridentata Haller.f. is mostly used in South India and the plant Paderia foetida Linn. in North India, hence taken in the present work for comparative analytical study. It was observed that there is a common constituent (having 350 mm absorbance maxima) present in both the drug samples indicating that both works on a similar disease. It was also found that the whole plant powder sample of P. foetida has more number of constituents than that of M. tridentata which indicates P. foetida may have a better efficacy than M. tridentata. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/444/108864 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative evaluation of intestinal transit time of two dosage forms of Haritaki [Terminalia chebula Retz.] Jirankalgikar, YM Ashok, BK Dwivedi, RR Haritaki is praised as the best salutary drug which can be used in almost all ages of human life and is reputed for its Anulomana property. In Ayurveda, it has been mentioned that fruits of Haritaki when used in different forms give different type of actions. As the prime therapeutic utility of Haritaki is Anulomana, in the present study, two dosage forms of Haritaki fruits namely Churna and Vati were evaluated for intestinal transit time to evaluate its effect in two different dosage forms. Mature fruits were collected, authenticated, and processed as per classics to get Churna and Vati. Test drugs were administered in the dose of 550 mg/kg and evaluation on intestinal transit time was carried out by adopting kaolin expulsion test in mice. The results show that both the dosage forms of Haritaki significantly shortened intestinal transit time and between them Churna form is found to be better. Medknow Publications 2012-07-01 http://www.ayujournal.org/text.asp?2012/33/3/447/108866 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Reinvent the system of Education in Ayurveda Chandola, H Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/459/110502 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Status of Indian medicine and folk healing: With a focus on integration of AYUSH medical systems in healthcare delivery Chandra, S Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/461/110504 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Management of rheumatoid arthritis (Aamavata) using symbiohealth healthcare system Basisht, GK Singh, RH Chandola, H Rheumatoid Arthritis (RA), according to modern medicine, and Aamavata according to Ayurveda, has an etiological and clinical relationship. Aamavata is a disease complex of which RA is a part. A comparative study of the pathophysiology of this disease by both systems reveals that modern medicine has investigated the mechanism of inflammation and has developed an offense strategy to control it. Ayurveda follows a defense strategy and it focuses its search on the etiological process, where disequilibrium at a higher level of physiology affects the gastrointestinal tract, causing an immune response that results in inflammation. Understanding the pathophysiology of both systems will help the treating physician to institute a dual treatment plan of modern medicine's offense strategy and Ayurvedic medicine's defense strategy at appropriate stages of the disease. Studying the pathophsiology of the two systems also gives insight into the genetic and epigenetic phenomenon in the treatment of disease and opens the doors for groundbreaking research. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/466/110513 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
oai:medknow.com:110515 2012-10-01 all journal:Ayu
Alternative medicine and anesthesia: Implications and considerations in daily practice Panda, A Nowadays, herbal medicines are widely used by most of the people, including the pre-surgical population. These medicines may pose numerous challenges during perioperative care. The objective of the current literature review is to dwell upon the impact of the use of herbal medicines during the perioperative period, and to review the strategies for managing their perioperative use. The data was generated from various articles of different journals, text books, web source, including, Entrez Pubmed, Medscape, WebMD, and so on. Selected only those herbal medicines for which information on, safety, usage, and precautions during the perioperative period was available. Thereafter, the information about safety, pharmacokinetics, and pharmacodynamics from selected literature was gathered and analyzed. The whole review focused on the fact that these commonly used alternative medicines could sometimes pose as a concern during the perioperative period, in various ways. These complications could be due to their direct action, pharmacodynamic effect, or pharmacokinetic effect. In view of the serious impacts of herbal medicine usage in perioperative care, the anesthesiologist should take a detailed history, especially stressing on the use of herbal medicine during the preoperative anesthetic assessment. The anesthesiologist should also be aware of the potential perioperative effects of those drugs. Accordingly, steps should to be taken to prevent, recognize, and treat the complications that may arise due to their use or discontinuation. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/475/110515 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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An overview of the causes of current practices in Pratinidhi Dravyas (substitution of drugs) in Ayurveda including newer techniques for their evaluation Joshi, PR Patel, BR Shukla, VJ Many Pratinidhi Dravyas in Ayurvedic classics are mentioned and certainly are based on a methodical approach, which involves many aspects. These principles on which Pratinidhis were decided are quoted nowhere; so both to understand the established Pratinidhis and to find new ones a rational approach is the need of the hour. This article is an effort in the direction to study this concept meticulously in light of modern techniques for its better understanding and application. As there are very few established parameters, which help for selection and evaluation of Pratinidhi Dravyas. A rational technique like Fourier transform infrared spectroscopy may be incorporated to set a new dimension. As most of the routine analytical techniques are separation based, overall component load cannot be predicted. Thus, it is prime necessity to compare the drugs with a whole aspect, which goes in hand by hand with a holistic approach of Ayurveda "Treat the man as Whole - Take the drug as whole." Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/481/110518 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Dyslexia: A solution through Ayurveda evidences from Ayurveda for the management of dyslexia in children: A review Sharma, A Gothecha, VK Ojha, NK Dyslexia is one of the commonest learning disability. It is defined as a disorder where a child, in spite of all the classroom teaching, is not able to attain the language skills of reading, writing and spelling according to their level of intelligence. Dyslexia individuals often have difficulty in relating to the association between sound and their respective letters. Reversing or transposing the letters while writing is characteristic with letters such as b and d, P and q, etc., The prevalence among school children is reported as 9.87% and in the selected families, it is 28.32%. Dyslexia significantly interferes with academic achievement or activities of daily life and are not primarily due to sensory, motor or mentally handicaps. About 40% of dyslexic children and adolescents dropout of schools. According to Ayurveda, learning is a result of successive and complex interaction of Indriyas (cognitive and motor organs), Indriyartha (sense organs), Mana (psyche), Atma and Buddhi (intellect). Above all, the functioning of these factors is governed by Tridosha (vata, pitta and kapha) and Triguna (Sattva, Raja and Tama) in a specific coordination and balance Any disturbance in these Tridosha and Triguna will cause disordered functioning of Indriya, Mana and Buddhi leading to impaired learning or dyslexia Ayurvedic drugs can help in the management of dyslexia by making these Tridosha and Triguna in well-balanced state and also by providing Medhya (intellect promoting) drugs to improve the learning ability in these children. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/486/110521 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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sushruta-samhitA: A critical review Part - 2: Few new additions Sharma, HS Sharma, HI Sharma, HA In this part importace and specialize of sushruta are specified. In Part - 1 all the translation works in all the available languages is narrated. After studying all those books and keeping in to mind about a comprehensive work of sushruta it is necessary to elaborate in this present text. This part is divided into 5 sections. (A) All available commentaries taken in to consideration for this part is written, (B) Specialities of sushruta are most important as he has narrated all eight sections of Ayurveda elabroted widely where as caraka has only narrated mainly selected part of kAya-cikitsA and left other sections for other authors e.g., "atra dhAnavantareyaNAM adhikArah" etc., Specifying a list of all sections and chapters with the numbers of prose + poetery, (C) None of the translator or commentator touched the importance of sushruta in the literature of samskRta, where as sushruta was a great poet. Giving similar resemblance of common use by mass, he tried to explain the tough subject in simpler mode of knowledge for proper understanding to all public. He has specifically selected the prosody for the specified subject. Examples are given in this section. (D) sushruta has written prosody in14 metres and long sentences too in samskRta that shows his ability and wast knowledge in the literature. All references of each and every metre is noted from all sections of sushruta with complete reference numbers. And no where this subject is published till now- (E) A challenging word regarding the work of sushruta "shArIre sushruto naSTah" is turned back while quoting various references of shArIra-sthAnam and placing its world wide importance by various writers. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/491/110523 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms of dementia Hishikawa, N Takahashi, Y Amakusa, Y Tanno, Y Tuji, Y Niwa, H Murakami, N Krishna, UK We describe here three patients with the Alzheimer's Disease (AD) whose behavioral symptoms were improved remarkably as a result of the turmeric treatment, which is the traditional Indian medicine. Their cognitive decline and Behavioral and Psychological Symptoms of Dementia (BPSD) were very severe. All three patients exhibited irritability, agitation, anxiety, and apathy, two patients suffer from urinary incontinence and wonderings. They were prescribed turmeric powder capsules and started recovering from these symptoms without any adverse reaction in the clinical symptom and laboratory data. After 12 weeks of the treatment, total score of the Neuro-Psychiatric Inventory-brief questionnaire decreased significantly in both acuity of symptoms and burden of caregivers. In one case, the Mini-Mental State Examination (MMSE) score was up five points, from 12/30 to 17/30. In the other two cases, no significant change was seen in the MMSE; however, they came to recognize their family within 1 year treatment. All cases have been taking turmeric for more than 1 year, re-exacerbation of BPSD was not seen. The present cases suggest a significant improvement of the behavioral symptoms in the AD with the turmeric treatment, leading to probable benefit of the use of turmeric in individuals with the AD with BPSD. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/499/110524 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Role of Virechana Karma in cure and prevention of recurrence of Vicharchika (Eczema) Kaur, M Chandola, H Mandip and Chandola reported that administration of Rasayana (Guduchi and Bhringaraja) after Koshtha Shuddhi with Aragvadha Hima and simultaneous giving of Shirishadi decoction orally and applying of Snuhyadi Lepa externally provided complete remission to 22.6% patients of Vicharchika (Eczema) and checked the recurrences of the disease in the 89.5% patients. As in this group, cure rate was not up to the expectation; therefore, it was thought desirable to see whether performing of Virechana Karma instead of Koshtha Shuddhi prior to the administration of the above drugs enhances the cure rate for the Vicharchika (Eczema) patients. For the present study, 39 patients of Vicharchika (Eczema) were registered, of which 32 patients completed the full course of the treatment. These patients were given Virechana after preparing with the proper internal Snehana, Abhyanga, and Svedana as per classical method. After the Samsarjana Krama, they were administered the Shirishadi decoction and Guduchi-Bhringraja Rasayana powder orally with simultaneous local application of Snuhyadi Lepa on the eczematous lesions. The results of this study showed that when Virechana Karma was performed prior to the administration of Guduchi-Bhringaraja Rasayana and Shirishadi decoction orally and SnuhyadiLepa externally, it not only increased the cure rate to 81.3% in the patients of Vicharchika (Eczema) but also checked the recurrences to great extent as only negligible number of the patients reported the recurrence. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/505/110526 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical evaluation of Ashokarishta, Ashwagandha Churna and Praval Pishti in the management of menopausal syndrome Modi, MB Donga, SB Dei, L Menopause is a gradual and natural transitional phase of adjustment between the active and inactive ovarian function and occupies several years of a women's life and involves biological and psychological changes adjustments. The present clinical trial was designed as per Ayurveda clinical trials protocol to evaluate the efficacy of Ashokarishta, Ashwagandha Churna and Praval Pishti in the management of menopausal syndrome. It was directed by Central Council for Research in Ayurvedic Sciences as randomized open clinical trial. Total 52 patients were registered in the study, out of which 51 patients completed the study. Specialized rating scales like Kupperman Index Score as well as Menopause Rating Scale (MRS) and Menopause Specific Quality of Life (MENQOL) questionnaires were adopted for diagnostic as well as assessment criteria. The effects were examined based on MRS and MENQOL. Results were analyzed statistically using Wilcoxon matched paired test and 't' test. Highly significant (P < 0.01) reduction was found in the symptoms of MRS as well as MENQOL. Finally, it can be stated that combined treatment of above drugs gives better result in both somatic as well as psychological complaints in women with mild to moderate symptoms of menopausal syndrome. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/511/110529 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative clinical study on standardization of Vamana Vidhi by classical and traditional methods Dass, RK Bhatt, NN Thakar, AB Shukla, VD Vamana Karma (process of emesis) is considered as Pradhana Karma (prime procedure) meant for inducing therapeutic vomiting, indicated for the purification of Urdhwa Bhaga (upper part) of the body. It is the process by which contents of stomach, including Kapha and Pitta are expelled out of the body through oral route. Acharya Charak and Sushruta have advocated various procedures for Vamana Karma known as classical methods, whereas some traditional methods are also being followed. As very little works has been carried out in the direction of Vamana Karma and as not a single work has been carried out on standardization of Vamana Vidhi comparing to both classical and traditional methods, the present study had been selected. The clinical trial was conducted in a randomized sample of 50 individuals (Both patients and volunteers) resolved into two sub-groups, viz. individuals in Group A was performed Vamana with classical methods and Group B with traditional methods. From the observations and results obtained in the present clinical study, it can be concluded that the method mentioned in classics is very much beneficial from every point of view in comparison to the traditional method. It is very easy, safest, less time-consuming and clinically as well as statistically most effective method without producing any type of complications. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/517/110531 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of Bhringarajasava as Naimittika Rasayana in Rajayakshma with special reference to pulmonary tuberculosis Dornala, SN The clinical study was conducted at the Out Patient Department of State TB Training and Demonstration Centre, S.R. Nagar, Hyderabad, Andhra Pradesh, India, during June 2003 to December 2004. A group of 60 patients of PTB were included in the study and were divided into two equal groups. Both the groups were on the Directly Observed Treatment Short - course chemotherapy (DOTS) regime. The test group was given DOTS + Bhringarajasava (30 ml thrice a day) and the control group was only on DOTS. The study was to evaluate whether the addition of Bhringarajasava as Naimittika Rasayana (complementary drug) is beneficial in providing faster and better relief or not. Both subjective and objective parameters were considered for the assessment of results. Among the specific symptomatology, Amsaparsabitapah (pain in costal and scapular region), Kasa (cough), Jwara (pyrexia), Swasa (dyspnoea) and Bhaktadwesha (anorexia) were the symptoms manifested by all the patients. Results of the present study indicate that better, safer, and faster relief provided by the addition of Bhringarajasava to DOTS. This is an effort to utilize drugs from the vast Ayurvedic pharmacopoeia as safe adjuvant to DOTS regime so that toxicity and associated side effects of the DOTS can be ameliorated. This process of using therapies from two disparate systems of medicine could potentially lead to further enhancements in the field of complementary medicine and create a symbiosis between the different systems, which may lead to Rasayana DOTS (R-DOTS) in future. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/523/110536 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Provocative dietary factors in geriatric hypertension: A surveillance study Jagtap, MV Deole, YS Chandola, H Ravishankar, B Hypertension is the most common psychosomatic disorder affecting 972 million people worldwide being more prevalent in old age. The present survey of hypertensive patients fulfilling the standard diagnostic criteria of WHO/ISH (2004) is carried out in geriatric age group from the Saurashtra region of Gujarat in India to observe the dietary pattern and provocative factors. Total 120 patients of 50 to 80 years of age having systolic blood pressure >140 mm Hg and ≤180 mm Hg and diastolic blood pressure >90 mm Hg and ≤110 mm Hg irrespective of gender and religion were selected for the present study. They were interviewed for list of provocative factors enlisted in Ayurveda. As observed, the study supported the facts described in Ayurveda that dietary etiological factors, such as excess intake of Lavana (salty), Amla (sour), Katu (pungent), Tikshna, Ushna (hot), Vidahi (producing burning sensation), Viruddha (incompatible), Snigdha (unctuous), Abhishyandi (leading to obstruction), Madhura (sweet), Guru (heavy to digest) dietary articles, Ajirnashana (taking diet before complete digestion of previous meal), Adhyashana (repeated eating at short intervals), will vitiate Rakta dhatu as well as Pitta dosha in the body leading to disorders like hypertension. Hypertension in old age is found to be a disease of Vata-Pitta dominant vitiation with the involvement of Rasa, Rakta, Meda as main Dushya (vitiated factors) and dietary factors can contribute to worsening of the disease. The etiological factors having role in the pathogenesis can also be applied for preventive guidelines for the management of hypertension. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/530/110537 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Clinical efficacy of Gokshura-Punarnava Basti in the management of microalbuminuria in diabetes mellitus Ramteke, RS Thakar, AB Trivedi, AH Patil, PD Microalbuminuria is the strong predictor of diabetic nephropathy, which is the main cause of morbidity and mortality in patients with diabetes mellitus (DM). Microalbuminuria is also characterized by increased prevalence of arterial hypertension, proliferative retinopathy, and peripheral neuropathy. The study was planned to evaluate the effect of Gokshura-Punarnava Basti in the management of microalbuminuria in DM (Madhumeha). Eligible diabetic patients with urine albumin excretion between 30 and 300 mg in 24 h were randomly divided into two groups. Asthapana Basti (decoction enema) of Gokshura and Punarnava Kwatha (decoction), Kalka (paste), Taila (medicated oil), Madhu (honey), and Saindhava (rock salt) for 6 consecutive days and Anuvasana (unctuous enema) of Gokshura-Punarnava Taila on 1 <sup>st</sup> and 8 <sup>th</sup> day by traditional Basti Putaka method was given in study group. Tablet Enalapril 5 mg, twice daily for 30 days was given to the patients in control group. The primary outcome measures were percentage change in the presenting complaints of diabetes, urine microalbumin, Blood Sugar Level (BSL), and Blood Pressure (BP). Enalapril showed 33.33% improvement, where as Gokshura-Punarnava Basti showed 79.59% improvement in the presenting complaints of diabetes, urine microalbumin, BSL and BP. Gokshura-Punarnava Basti has shown superior results in the management of microalbuminuria in DM as compared to control drug. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/537/110535 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A clinical study to evaluate the efficacy of Trataka Yoga Kriya and eye exercises (non-pharmocological methods) in the management of Timira (Ammetropia and Presbyopia) Gopinathan, G Dhiman, KS Manjusha, R Timira is a disease that can be attributed to wide range of clinical conditions starting from mild blurring of vision and having potential risk of permanent vision loss. According to the involvement of Dhatus (body elements) the condition can be grouped into two stages. The initial stage or Uttana, where the involvement of Dhatus is limited to Rasa, Rakta (blood), and Mamsa Dhatu (muscle tissue). When the Doshas are localized in the first and second Patala refractive error do happen and in presbyopia more emphasis is given to Mamsa Dhatu. In this study only Uttana stage of Timira was considered. The clinical study was done on 66 patients of Timira in two groups of four sub groups each of myopia, hypermetropia, astigmatism, and presbyopia. Group A was subjected to eye exercises (Bates method) and Group B was subjected to Trataka Yoga Kriya. After the enrolment of patients for this study, signs and symptoms were assessed both subjectively and objectively before, during, and after treatment. The study indicates that subjectively there are significant results in both the groups but objectively there is not much improvement. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/543/110534 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Gokshuradi Vati and Dhanyaka-Gokshura Ghrita Matra Basti in the management of Benign Prostatic Hyperplasia Bhalodia, SG Bhuyan, C Gupta, SK Dudhamal, TS Benign Prostatic Hyperplasia (BPH) is a burning senile problem of elderly men and no definitive conservative cure is available. The present available surgical and minimal invasive methods have their own limitations. Hence, to find out a suitable Ayurvedic approach, an effort has been made towards the management of BPH, In this study, 32 selected patients of Mootraghata at par to BPH were divided into three groups randomly and treated accordingly. In group A, Gokshuradi compound (GC) Vati (GV) 500 mg was given three times a day with luke-warm water after food; while in group B, Dhanyaka-Gokshura Ghrita (DGG) as Matra Basti (MB) of 60 ml, once in a day, just after lunch and combined therapy of both formulations in group C was administered. Out of 32 patients, total 30 patients (10 in each group) were completed the treatment course of 21 days. In results, 54.09% improvement was seen in group C, 45.67% in group A and 47.99% in group B. The size of prostate gland was found reduced highly significant in group C. Hence, it is concluded that combined therapy of GV and DGG MB is beneficial without developing any adverse drug reactions and can be prescribed safely for Mootraghata (BPH). Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/547/110532 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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A comparative pharmacognostical profile of Desmodium gangeticum DC. and Desmodium laxiflorum DC. Vaghela, BD Patel, BR Pandya, PN Shaliparni is one of the Laghupanchamoola ingredients. Desmodium gangeticum DC. is an accepted source of Shaliparni as per Ayurvedic Pharmacopoea of India (API). Desmodium laxiflorum DC. is the drug commonly used instead of D. gangeticum in the Saurashtra region. The study is an attempt to compare the above said two species on the basis of their pharmacognostical profiles. The macroscopy and microscopy of roots of both plants were studied as per standard procedures. Root powders of both Desmodium species used in the experimental study to ascertain its Rasa by dilution method. Both the species show the same Rasa and Anurasa i.e., Madhura and Kashaya and almost same morphological and microscopical characters like prismatic crystals, starch grains etc. Hence it is concluded that D. laxiflorum may be considered as a substitute for D. gangeticum on the basis of present pharmacognostical study. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/552/110522 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Phyto-chemical evaluation of dried aqueous extract of Jivanti [Leptadenia reticulata (Retz.) Wt. et Arn] Pal, A Sharma, PP Pandya, TN Acharya, R Patel, BR Shukla, VJ Ravishankar, B Jivanti (Leptadenia reticulata(Retz.) Wt. et Arn) is a well known climber used for its innumerable therapeutic properties like antioxidant, antibacterial, vasodilator, galactogogue, Jivaniya, etc., Its use in veterinary practice is tremendous due to its lactogenic effect. The Ghana (dried aqueous extract) of the whole plant was prepared and evaluated phyto-chemically by subjecting it to various tests like physico-chemical, qualitative analysis; TLC and HPTLC. Qualitative tests revealed the presence of flavonoids and TLC also inferred positive Rf value (0.30), indicating the presence of quercetin in the Ghana. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/557/110525 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Standard manufacturing procedure of Tamra Bhasma Jagtap, CY Prajapati, PK Patgiri, B Shukla, VJ Tamra Bhasma (incinerated copper) is one of the main weapons in the archery of Ayurvedic practitioners. Though several methods of preparation of Tamra Bhasma (TB) are found in Rasashastra classics, several difficulties occur during the preparation of a good-quality Bhasma. In this study, TB was prepared and analyzed to develop the standard manufacturing procedure. Each unit operative procedure was considered as an independent processing and an attempt was made to validate each procedure. Wire used for the purpose of electrical earthing was taken for the preparation of Bhasma. Procedures of Shodhana, Marana, and Amritikarana were followed as per the classical references. Specific temperature pattern was adopted for Puta in the electrical muffle furnace. From 500 g of Tamra, 483.4 g of black colored TB was obtained after subjecting to three Putas. Final product was detected to be cupric sulfide in X-ray diffraction. In particle size distribution analysis 10% of the material was below the size of 2 μm, while in inductive coupled plasma - atomic absorption spectrometry 58.56 wt% copper and 22.48 wt% of sulfur were found present in the final product along with the elements such as arsenic, lead, zinc, mercury, and manganese in traces. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/561/110528 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Evidence for safety of Ayurvedic herbal, herbo-metallic and Bhasma preparations on neurobehavioral activity and oxidative stress in rats Kumar, G Gupta, YK Heavy metals in Ayurvedic formulations have been used for centuries with claimed efficacy and safety. However, concerns are often raised about the toxicity due to heavy metals used in Ayurvedic formulations. The aim of present study is to explore the effect of Calcury tablet, Energic-31 capsule and Basanta Kusumakara Rasa (BKR) on neurobehavioral activity and oxidative stress in rats. Male wistar rats weighing 200-250 g were used and divided into normal control, positive control (mercury chloride, lead acetate, cadmium chloride, sodium arsenite, each 10 mg/kg, p.o for 28 days) and treated group (Calcury tablets at doses of 130, 650, 1300 mg/kg, Energic-31 capsule at doses of 150, 750, 1500 mg/kg and BKR at doses of 26, 130, 260 mg/kg, p.o. for 28 days). After performing the behavioural parameters on the 29 <sup>th</sup> day, homogenate of rat's brain was used to determine malondialdehyde (MDA) and glutathione (GSH) levels and heavy metal level in brain. Results showed that there were no significant change in cognitive function, motor coordination, MDA and GSH levels as compared to normal control group at all doses of Calcury tablet, Energic-31 capsule and Basant Kusumkar Rasa. However, heavy metals level in rat's brain was higher as compared to normal control group at all doses of Calcury tablet, Energic-31 capsule and BKR. In conclusion, Calcury tablet, Energic-31 capsule and BKR in doses equivalent to the human dose does not have appreciable adverse effects on brain which demonstrates the non-toxic nature of metal based Ayurvedic formulations. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/569/110514 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Diuretic activity of Linaria ramosissima (wall.) Janch. leaves in albino rats Pandya, PN Aghera, HB Ashok, BK Acharya, R Linaria ramosissima (Wall.) Janch., Scrophulariaceae, a folklore plant, has been claimed for its diuretic activities by traditional practitioners. The present study was undertaken to investigate the diuretic activity of L. ramosissima leaves in albino rats. Suspension of leaf powder in 2% gum acacia was administered to experimental rats orally at doses of 450 mg/kg. The diuretic effect was evaluated by measuring the urine volume, pH of urine, and urinary electrolyte excretion. Administration of the test drug increased the urine volume in a non-significant manner, while it enhanced the urinary excretion of sodium, chloride, and potassium significantly, in comparison to the control group. From the present study it can be concluded that the leaves of L. ramosissima have a significant diuretic activity. Medknow Publications 2012-10-01 http://www.ayujournal.org/text.asp?2012/33/4/576/110517 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Herbal research vis a vis Ayurvedic clinical research Sharma, ML Medknow Publications 2013-01-01 http://www.ayujournal.org/text.asp?2013/34/1/1/115430 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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Standardization of Shadbindu Taila: An Ayurvedic oil based medicine Shailajan, S Menon, SN Tiwari, BR Singh, AS Shadbindu Taila (ST) is an Ayurvedic formulation used as a remedy for loosening of tooth, weakness of the eyesight, loss of hair, diseases of head, etc., Present study is an attempt to develop some newer approaches for the quality control and standardization of ST. Standardized operating procedure for the preparation of ST was developed in accordance with Ayurvedic Formulary of India. Preliminary phytochemical, physicochemical, and chromatographic evaluation of ST was carried out. Safety of ST was evaluated in terms of skin irritation test and presence of heavy metals. Chemical characterization of ST was done on the basis of kaempferol using validated -High Performance Thin Layer Chromatographic (HPTLC) method. ST did not show presence of any of the heavy metals analyzed and was found non-irritant on rabbit skin. The quality control parameters resulted after scientific evaluation of ST can be used as reference standard for quality control/assurance laboratory of a pharmaceutical firm in order to have a proper quality check over its preparation and processing. Medknow Publications 2013-01-01 http://www.ayujournal.org/text.asp?2013/34/1/103/115442 en Copyright 2014 AYU (An international quarterly journal of research in Ayurveda).
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In vitro α -amylase and α-glucosidase inhibitory potential of Trigonella foenum-graecum leaves extract Ganeshpurkar, A Diwedi, V Bhardwaj, Y Trigonella foenum-graecum is one of the widely used herbs in food and medicine. The seeds of the plants are investigated for antidiabetic potential; however, no efforts have been done to explore the potential of leaves to modify carbohydrate metabolizing enzymes viz. α-amylase and α-glucosidase. The present work was designed to investigate the inhibitory potential of ethyl acetate and water extract of T. foenum-graecum on enzymes α-amylase and α-glucosidase. Different concentrations of extracts were used to study inhibition of enzymatic activity of α-amylase and